Pressure calibration method for blood purification equipment, blood purification equipment and computer-readable storage medium

Abstract

The present invention provides a pressure calibration method for a blood purification device, a blood purification device, and a computer-readable storage medium. The pressure calibration method for the blood purification device includes: detecting the temperature of the blood in the venous line to obtain the blood return temperature; determining whether the blood return temperature is within a first preset temperature range, and if so, controlling a first pressure monitor to detect the pressure of the blood in the venous line to obtain a first pressure detection value; selecting a corresponding preset temperature-pressure fitting formula according to the blood return temperature, and calibrating the first pressure detection value according to the selected preset temperature-pressure fitting formula to obtain a first calibrated pressure detection value. The pressure calibration method for the blood purification device of the present invention can effectively reduce the interference error caused by temperature variation on the pressure detection of the blood in the extracorporeal circulation circuit, improve the pressure detection precision and accuracy of the blood in the extracorporeal circulation circuit, ensure the control safety of the blood purification device, and make blood purification treatment safer and more reliable.

Description

Technical Field

[0001] The present invention relates to the field of control technology of blood purification equipment, and in particular to a pressure calibration method for blood purification equipment, a blood purification equipment for implementing the pressure calibration method, and a computer-readable storage medium. Background Art

[0002] Blood purification equipment is a medical device. When used clinically, it removes blood from the patient's body and transfers it to an extracorporeal circulation circuit. The blood is then transferred to a blood purifier, which purifies the patient's blood and removes specific substances from the blood. The purified blood is then returned to the patient, completing the blood purification process and achieving the goal of purifying the blood and treating the disease. Blood purification equipment can implement different blood purification treatment modes, such as hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasma exchange, and immunoadsorption. Each blood purification treatment mode has specific clinical treatment indications. Long-term clinical practice has proven that blood purification treatment implemented by blood purification equipment can achieve good clinical treatment results. It is widely used to treat acute renal failure, chronic renal failure, uremia, multiple organ failure, drug poisoning, poison poisoning, heroin poisoning, alcohol poisoning, nephrotic syndrome with severe fluid retention, and diabetic nephropathy with severe fluid retention.

[0003] During the blood purification treatment of a patient using a blood purification device, the patient's blood needs to be drawn into the extracorporeal circulation circuit of the blood purification device. In order to ensure the safety of the patient undergoing blood purification treatment, it is necessary to perform various parameter tests on the blood drawn into the extracorporeal circulation circuit to prevent the blood purification device from malfunctioning. For example, it is necessary to detect the pressure of the blood in the extracorporeal circulation circuit to prevent the pressure of the blood in the extracorporeal circulation circuit from being too high. Once the pressure of the blood in the extracorporeal circulation circuit is too high, it will cause the patient to experience discomfort symptoms, such as chest tightness, etc., and in severe cases, it will endanger the patient's life. However, in the process of detecting the pressure of the blood in the extracorporeal circulation circuit, it will be interfered with by other factors. For example, the pressure detection process will be affected by changes in ambient temperature and changes in the temperature of the blood in the extracorporeal circulation circuit, thereby affecting the accuracy of the pressure detection results. However, when detecting the pressure of the blood in the extracorporeal circulation circuit, the existing technology lacks the ability to eliminate the interference factors of the pressure detection, thereby reducing the pressure detection accuracy of the blood in the extracorporeal circulation circuit, causing the blood in the extracorporeal circulation circuit to easily have abnormal flow phenomena, thereby reducing the control safety of the blood purification device. Summary of the Invention

[0004] The first purpose of the present invention is to provide a pressure calibration method for blood purification equipment, which can effectively reduce the interference error caused by temperature changes on the pressure detection of blood in the extracorporeal circulation circuit, thereby improving the pressure detection precision and accuracy of blood in the extracorporeal circulation circuit, and then ensuring the control safety of the blood purification equipment, making blood purification treatment safer and more reliable.

[0005] A second object of the present invention is to provide a blood purification device that implements the above-mentioned pressure calibration method.

[0006] A third object of the present invention is to provide a computer-readable storage medium for implementing the above pressure calibration method.

[0007] In order to achieve the first purpose of the present invention, the present invention provides a pressure calibration method for a blood purification device, wherein the extracorporeal circulation circuit of the blood purification device includes a first pressure monitor, an arterial line, a blood purifier and a venous line, wherein the input end of the arterial line is used to connect with the human artery, the output end of the arterial line is connected with the input end of the blood purifier, the output end of the blood purifier is connected with the input end of the venous line, and the output end of the venous line is used to connect with the human vein. The first pressure monitor is arranged on the venous line and is used to detect the pressure of the blood in the venous line. The pressure calibration method of the blood purification device includes: detecting the temperature of the blood in the venous line to obtain a return blood temperature; judging whether the return blood temperature is within a first preset temperature range, and if so, controlling the first pressure monitor to detect the pressure of the blood in the venous line to obtain a first pressure detection value; selecting a corresponding preset temperature-pressure fitting formula according to the return blood temperature, and calibrating the first pressure detection value according to the selected preset temperature-pressure fitting formula to obtain a first calibrated pressure detection value.

[0008] It can be seen from the above scheme that the pressure calibration method of the blood purification equipment of the present invention selects the corresponding preset temperature-pressure fitting formula according to the return blood temperature, and calibrates the first pressure detection value according to the selected preset temperature-pressure fitting formula to obtain a calibrated first pressure detection value. The calibrated first pressure detection value eliminates the interference of temperature change, and can effectively reduce the interference error caused by temperature change to the pressure detection of blood in the extracorporeal circulation circuit, thereby improving the pressure detection precision and accuracy of blood in the extracorporeal circulation circuit, and then ensuring the control safety of the blood purification equipment, making blood purification treatment safer and more reliable.

[0009] A preferred solution is to divide the first preset temperature range into several temperature levels, each temperature level corresponds to a preset temperature interval, and each temperature level corresponds to a preset temperature-pressure fitting formula, and the preset value corresponding to the coefficient in the preset temperature-pressure fitting formula is selected according to the first pressure detection value.

[0010] A further solution is that after obtaining the first pressure detection value of the first calibration, the pressure calibration method of the blood purification equipment also includes: detecting the external atmospheric temperature of the venous line to obtain the ambient temperature; judging whether the ambient temperature is within a second preset temperature range, and if not, re-calibrating the first pressure detection value of the first calibration according to the ambient temperature to obtain the first pressure detection value of the second calibration.

[0011] A further solution is to select a corresponding preset pressure calibration value according to the ambient temperature, and add the first pressure detection value of the primary calibration to the preset pressure calibration value to obtain the first pressure detection value of the secondary calibration.

[0012] A further solution is that the pressure calibration method of the blood purification equipment also includes: controlling the display screen of the blood purification equipment to display a curve of the change of the calibrated first pressure detection value over time; judging whether the fluctuation amplitude of the change curve exceeds the preset fluctuation range, and if so, controlling the blood purification equipment to send an alarm signal.

[0013] A further solution is that the extracorporeal circulation circuit also includes a second pressure monitor, which is arranged on the arterial line and is used to detect the pressure of the blood in the arterial line. The pressure calibration method of the blood purification equipment also includes: detecting the flow rate of blood in the arterial line to obtain the blood flow rate; judging whether the blood flow rate is greater than a preset minimum flow rate, and if so, controlling the second pressure monitor to detect the pressure of the blood in the arterial line to obtain a second pressure detection value; detecting the temperature of the blood in the arterial line to obtain the blood inlet temperature; selecting the corresponding preset pressure correction value according to the blood inlet temperature, and adding the preset pressure correction value to the second pressure detection value to obtain a calibrated second pressure detection value.

[0014] A further solution is that the pressure calibration method of the blood purification equipment also includes: obtaining the pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value; judging whether the pressure difference is greater than a preset difference, and if so, controlling the display screen of the blood purification equipment to display a pressure alarm message; if not, controlling the display screen of the blood purification equipment to display normal working information of the blood purification equipment.

[0015] A further solution is that after selecting the corresponding preset pressure correction value according to the inlet blood temperature, and before adding the preset pressure correction value to the second pressure detection value to obtain a calibrated second pressure detection value, the pressure calibration method of the blood purification equipment also includes: detecting the inner hole diameter of the arterial pipeline; judging whether the inner hole diameter of the arterial pipeline is greater than the preset safety diameter, and if so, calibrating the preset pressure correction value.

[0016] In order to achieve the second purpose of the present invention, the present invention provides a blood purification device, including a host and a display screen. The host is provided with a circuit board that can interactively communicate with the display screen. The circuit board is provided with a processor and a memory. The memory stores a computer program. When the computer program is executed by the processor, the various steps of the pressure calibration method of the above-mentioned blood purification device are implemented.

[0017] In order to achieve the third object of the present invention, the present invention provides a computer-readable storage medium having a computer program stored thereon, which implements the various steps of the pressure calibration method of the above-mentioned blood purification equipment when the computer program is executed by a processor. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a structural diagram of an embodiment of the blood purification device of the present invention.

[0019] Figure 2 It is a working principle diagram of an embodiment of the blood purification device of the present invention.

[0020] Figure 3 It is a flow chart of an embodiment of a pressure calibration method for a blood purification device of the present invention.

[0021] Figure 4 This is a curve showing the change of the first pressure detection value calibrated over time in an embodiment of the pressure calibration method for blood purification equipment of the present invention.

[0022] Figure 5 This is a graph showing the relationship between a preset pressure correction value and an inlet blood temperature in an embodiment of a pressure calibration method for a blood purification device of the present invention.

[0023] The present invention will be further described below with reference to the accompanying drawings and embodiments. DETAILED DESCRIPTION

[0024] Example of a pressure calibration method for a blood purification device:

[0025] The pressure calibration method of the blood purification device of this embodiment is applied to the blood purification device, see Figure 1The blood purification device includes components such as a host 1 and a display screen 2. The display screen 2 is a human-computer interactive touch screen. A circuit board that can interact with the display screen 2 is provided in the host 1. The circuit board is provided with a processor and a memory. The memory stores a computer program. When the computer program is executed by the processor, the various steps of the pressure calibration method of the blood purification device in this embodiment are implemented, so that interactive communication can be achieved between the display screen 2 and the host 1. Medical staff can input instructions on the display screen 2 to enable the blood purification device to execute the various steps of the pressure calibration method of the blood purification device in this embodiment according to the operation requirements of the medical staff to ensure the safety of the patient's blood purification treatment, and the display screen 2 can display various parameters and related information of the blood purification device during operation, so that medical staff can understand the operating status of the blood purification device in a timely manner.

[0026] See also Figure 2 The extracorporeal circulation circuit of the blood purification equipment includes a first pressure monitor, a second pressure monitor, an arterial clamp 31, a blood pump 32, a heparin pump 33 (i.e., an anticoagulation pump), a blood purifier 34, a venous pot 36, a liquid level detector 35, a bubble detector 37, a blood detector 38, a venous clamp 39, an arterial line 310, and a venous line 311. The input end of the arterial line 310 is used to be connected to the human artery, the output end of the arterial line 310 is connected to the input end of the blood purifier 34, the output end of the blood purifier 34 is connected to the input end of the venous line 311 through the venous pot 36, and the output end of the venous line 311 is used to be connected to the human vein. The first pressure monitor is arranged on the venous line 311 and is used to detect the pressure of the blood in the venous line 311. The second pressure monitor is arranged on the arterial line 310 and is used to detect the pressure of the blood in the arterial line 310. The arterial line 310 outputs the human body's blood to the blood purifier 34, and the blood pump 32 is used to provide driving force so that the blood circulates between the arterial line 310 and the venous line 311. When the blood passes through the blood purifier 34, the blood purifier 34 can filter out and purify specific molecular substances in the blood, and then return the purified blood to the human body through the venous line 311, so as to achieve the purpose of purifying the blood and treating diseases.

[0027] Among them, the pressure monitor can convert the pressure of the blood in the pipeline from a non-electrical signal to an electrical signal to realize the pressure detection process of the blood in the pipeline. In clinical practice, when a pressure sensor is used as a pressure monitor to detect the pressure of the blood in the pipeline, the pressure detection value of the pressure sensor is affected by the pressure of the liquid in the pipeline. At the same time, the pressure detection value of the pressure sensor is also affected by the temperature, which is reflected in two aspects: 1. The temperature of the detected liquid causes the "thermal expansion and contraction" effect. When the temperature of the detected liquid changes, the pressure detection value of the pressure sensor will also change, thereby affecting the pressure detection accuracy of the pressure sensor. The obtained pressure detection value has a large error, which is the main interference factor; 2. The external environment temperature of the pressure sensor will affect the device detection accuracy of the pressure sensor itself, thereby reducing the pressure detection accuracy of the pressure sensor. The obtained pressure detection value has a certain error, which is a secondary interference factor. Normally, the temperature of the liquid being detected and the external environment temperature of the pressure sensor are both uncertain factors. However, the pipelines of blood purification equipment are different from other types of pipelines (such as oil pipelines, tap water pipelines, etc.). The temperature changes of the blood in the pipelines of blood purification equipment are regular, and under normal circumstances, the temperature of the blood in the pipelines of blood purification equipment is within a safe control range. Therefore, in the field of blood purification, the impact of temperature changes on the pressure detection accuracy of the pressure monitor can be studied to reduce the interference error caused by temperature changes on the pressure detection of the blood in the extracorporeal circulation circuit of the blood purification equipment, thereby improving the pressure detection precision and accuracy of the blood in the extracorporeal circulation circuit, and then ensuring the control safety of the blood purification equipment, making blood purification treatment safer and more reliable.

[0028] In addition, the blood purification device of this embodiment can realize a variety of blood purification treatment modes, such as hemodialysis, hemofiltration, hemodiafiltration, hemoperfusion, plasma exchange, immunoadsorption and other treatment modes. When the blood purification device is in different blood purification treatment modes, the type of the blood purifier 34 will be different. For example, in the hemoperfusion treatment mode, the blood purifier 34 is a hemoperfusion device. For example, in the hemodialysis treatment mode, the blood purifier 34 is a dialyzer. For example, in the hemofiltration treatment mode, the blood purifier 34 is a filter, etc. When the blood purification device is in different blood purification treatment modes, the components of the extracorporeal circulation circuit of the blood purification device will also change, including Figure 2 The most basic structure diagram of the extracorporeal circulation circuit of the blood purification device is shown. When the blood purification device is in different blood purification treatment modes, the extracorporeal circulation circuit of the blood purification device will be Figure 2 Improve or transform based on.

[0029] See also Figure 3 , Figure 3is a flow chart of the pressure calibration method for the blood purification device of this embodiment, and the specific execution steps of the pressure calibration method for the blood purification device of this embodiment are as follows.

[0030] Step S1 , detecting the continuous purification time of the blood purifier 34 , and detecting the temperature of the blood in the venous line 311 to obtain the blood return temperature.

[0031] Step S2, determine whether the continuous purification time of the blood purifier 34 is greater than the preset safety time. If so, execute step S3; if not, execute step S1, continue to detect the continuous purification time of the blood purifier 34, and detect the temperature of the blood in the venous line 311 to obtain the blood return temperature.

[0032] In step S3, it is determined whether the return temperature of the blood in the venous line 311 is within a first preset temperature range. If so, step S5 is executed; if not, step S4 is executed.

[0033] Step S4: When it is determined in step S3 that the return temperature of the blood in the venous line 311 exceeds the first preset temperature range, step S4 controls the blood purification device to send a return temperature fault signal.

[0034] Step S5, when step S3 determines that the return temperature of the blood in the venous line 311 is within the first preset temperature range, step S5 controls the first pressure monitor to detect the pressure of the blood in the venous line 311 to obtain a first pressure detection value.

[0035] Specifically, the first preset temperature range represents the normal physiological temperature range of human blood temperature. The first preset temperature range is a standard value, such as 35°C to 37°C. The blood in the venous line 311 represents the blood that is returned to the patient's body. Only when the return temperature of the blood in the venous line 311 is within the first preset temperature range will the return temperature of the blood in the venous line 311 be in a safe state. When the return temperature of the blood in the venous line 311 exceeds the first preset temperature range, it indicates that the return temperature of the blood in the venous line 311 is too high or too low, and the return temperature of the blood in the venous line 311 is in a fault state, thereby controlling the blood purification device to issue a return temperature fault signal. Therefore, only when the return temperature of the blood in the venous line 311 is within the first preset temperature range will the pressure of the blood in the venous line 311 be detected to obtain a first pressure detection value, and then the subsequent steps of the pressure calibration method of the blood purification device of this embodiment will be performed.

[0036] Step S6, select the corresponding preset temperature-pressure fitting formula according to the return temperature of the blood in the venous line 311, calibrate the first pressure detection value according to the selected preset temperature-pressure fitting formula to obtain a calibrated first pressure detection value, and control the display screen 2 to display the calibrated first pressure detection value.

[0037] Specifically, the working process of the blood purification device is divided into: blood drawing stage, blood purification stage and blood return stage. In the blood drawing stage, the patient's blood is drawn into the arterial line 310; in the blood purification stage, the patient's blood is purified by the blood purifier 34; in the blood return stage, when the patient's blood purification treatment is about to end, the blood remaining in the arterial line 310, the blood purifier 34, and the venous line 311 needs to be returned to the patient's body to end the patient's blood purification treatment. The preset safety time is used to distinguish the blood drawing stage and the blood purification stage of the blood purification device. The preset safety time is set in advance by the technician based on clinical technical experience. For example, the preset safety time is 3 minutes. Only when the continuous purification time of the blood purifier 34 is greater than the preset safety time, the blood purification device will be in the blood purification stage. In the blood purification stage, the pressure of the blood in the venous line 311 is detected by the first pressure monitor to obtain the first pressure detection value, which has practical significance for ensuring the safety of treatment. Only then can it be judged whether there is a pressure failure in the blood in the venous line 311 based on the first pressure detection value. If the first pressure detection value is obtained by detecting the pressure of the blood in the venous line 311 by the first pressure monitor during the blood drawing stage, there will be great fluctuations. Therefore, there is no need to detect the pressure of the blood in the venous line 311 during the blood drawing stage.

[0038] It should be noted that the continuous purification time of the blood purifier 34 starts from the time when there is flowing blood in the arterial line 310, and the continuous purification time of the blood purifier 34 cannot include cumulative time. For example, when the continuous time of flowing blood in the arterial line 310 is 5 minutes, it is suddenly interrupted, and then the continuous time of flowing blood in the arterial line 310 is 2 minutes, then the continuous purification time of the blood purifier 34 is 2 minutes.

[0039] The return temperature of the blood in the venous line 311 is different, so that the return temperature of the blood in the venous line 311 is at different temperature levels. A preset temperature-pressure fitting formula corresponding to the return temperature of the blood in the venous line 311 is selected, and the first pressure detection value is calibrated according to the selected preset temperature-pressure fitting formula to obtain a single-calibrated first pressure detection value. The preset temperature-pressure fitting formula has a one-to-one correspondence with the return temperature of the blood in the venous line 311. After the first pressure detection value is calibrated to obtain a single-calibrated first pressure detection value, the first pressure detection value may increase or decrease. For example, if the first pressure detection value detected by the first pressure monitor is 100 mmHg, the first pressure detection value obtained after calibration is 120 mmHg.

[0040] The preset temperature-pressure fitting formula of the pressure calibration method for the blood purification device in this embodiment takes into account the interference factor of the return temperature of the blood in the venous line 311. Therefore, the first pressure detection value obtained after calibration eliminates the interference of the blood temperature variation, reducing the pressure detection error caused by the blood temperature variation in the venous line 311. Therefore, the pressure calibration method for the blood purification device in this embodiment can effectively reduce the interference error caused by the temperature variation on the pressure detection of the blood in the extracorporeal circulation circuit, thereby improving the precision and accuracy of the pressure detection of the blood in the extracorporeal circulation circuit, thereby ensuring the control safety of the blood purification device and making blood purification treatment safer and more reliable.

[0041] Display screen 2 can display the first pressure detection value of a calibration. Once the user sees the information displayed on display screen 2, he can directly know the precise pressure of the liquid in the venous line 311. Based on the first pressure detection value of a calibration, the user can clearly know whether the pressure of the blood in the venous line 311 is in a fault state or a normal state, thereby ensuring the control safety of the blood purification equipment and making the patient's blood purification treatment safer.

[0042] The pressure calibration method of the blood purification equipment of this embodiment selects the corresponding preset temperature-pressure fitting formula according to the return blood temperature of the blood in the venous line 311. Specifically, the first preset temperature range is divided into several temperature gears, each temperature gear corresponds to a preset temperature interval, and each temperature gear corresponds to a preset temperature-pressure fitting formula. For example, the first preset temperature range is 34°C to 37°C, and the first preset temperature range is divided into six temperature gears (the number of temperature gears is determined by the technicians. For example, when the technicians need higher accuracy for pressure detection, the number of divided temperature gears is greater), wherein each temperature gear corresponds to a preset temperature-pressure fitting formula, as shown in Table 1 below.

[0043] Table 1 Correspondence between temperature gears and preset temperature and pressure fitting formulas

[0044]

[0045]

[0046] As shown in Table 1 above, a corresponding preset temperature-pressure fitting formula is set for each temperature level divided by the first preset temperature range. When the return temperature of the blood in the venous line 311 is detected, the temperature level at which the return temperature of the blood in the venous line 311 is located is determined. According to the corresponding relationship in Table 1 above, the preset temperature-pressure fitting formula corresponding to the temperature level can be selected to calibrate the first pressure detection value. For example, when the return temperature of the blood in the venous line 311 is 35.3°C, the return temperature of the blood in the venous line 311 is at the third temperature level, and the corresponding preset temperature-pressure fitting formula is selected as Y=aX 3 +bX 2 +cX+d, according to the selected preset temperature and pressure fitting formula Y=aX 3 +bX 2 The first pressure detection value can be calibrated by using the formula: +cX+d to obtain a calibrated first pressure detection value. Because the preset temperature-pressure fitting formula takes into account the change in blood temperature, the effect of changes in blood temperature on the pressure detection of the blood in the venous line 311 can be eliminated after the first pressure detection value is calibrated using the preset temperature-pressure fitting formula.

[0047] The pressure calibration method for the blood purification equipment of this embodiment sets the most appropriate preset temperature-pressure fitting formula according to each temperature gear, and uses different preset temperature-pressure fitting formulas to perform temperature-grade fitting and calibration on the first pressure detection value to ensure that the calibrated first pressure detection value has higher precision and accuracy, and improves the scope of application of the pressure calibration method for the blood purification equipment of this embodiment.

[0048] In addition, the pressure calibration method of the blood purification device of this embodiment selects the preset value corresponding to the coefficient in the preset temperature pressure fitting formula according to the first pressure detection value of the blood in the venous line 311. Specifically, each preset temperature pressure fitting formula has a coefficient. Taking Table 1 as an example, at the first temperature gear, the coefficients of the preset temperature pressure fitting formula Y=kX+b are k and b. At the second temperature gear, the preset temperature pressure fitting formula Y=aX 2The coefficients of +bX+c are a, b, c, and so on. The pressure calibration method of the blood purification equipment in this embodiment selects the preset values ​​corresponding to the coefficients in the preset temperature-pressure fitting formula according to the first pressure detection value. After the preset values ​​corresponding to the coefficients are selected, the preset temperature-pressure fitting formula is equivalent to having only the dependent variable (Y) and the independent variable (X). The return blood temperature of the blood in the venous line 311 is used as the independent variable, and the calibrated first pressure detection value is used as the dependent variable. For example, when the first pressure detection value is 100 mmHg and the return temperature of the blood in the venous line 311 is 34°C, the corresponding preset temperature-pressure fitting formula is selected as Y=kX+b according to the return temperature of the blood in the venous line 311, and the preset values ​​corresponding to the coefficients in the preset temperature-pressure fitting formula are selected according to the first pressure detection value: k=3.0, b=10.0, as shown in Table 2 below. The preset temperature-pressure fitting formula is used to calibrate the first pressure detection value to obtain a first calibrated pressure detection value Y=3×34+10=112 mmHg. The first calibrated pressure detection value is 112 mmHg. The first pressure detection value after the first calibration can completely compensate for the interference error caused by the temperature change of the blood in the venous line 311 on the pressure detection process.

[0049] Based on clinical trials, a table is compiled that shows the correspondence between the coefficients in the preset temperature and pressure fitting formula and the first pressure detection value. Based on the first pressure detection value, the preset values ​​corresponding to the coefficients in the preset temperature and pressure fitting formula are found in the corresponding table to obtain a complete preset temperature and pressure fitting formula. For example, when the corresponding preset temperature and pressure fitting formula is selected as Y = kX + b, the corresponding preset values ​​between the coefficients (k, b) in the preset temperature and pressure fitting formula and the first pressure detection value are shown in Table 2 below.

[0050] Table 2

[0051] First pressure detection value (unit: mmHg) Coefficient k Coefficient b Less than or equal to 90 2 10 Greater than 90 and less than or equal to 100 3 10 Greater than 100 and less than or equal to 110 3 20 Greater than 110 and less than or equal to 120 4 -20 Greater than 120 4 -10

[0052] When the first pressure detection value is detected, the preset values ​​corresponding to the coefficients in the preset temperature and pressure fitting formula can be found according to the corresponding relationship determined in Table 2. For example, when the first pressure detection value is 90 mmHg, according to Table 2, the preset values ​​corresponding to the coefficients in the preset temperature and pressure fitting formula are: k=2, b=10, and the complete preset temperature and pressure fitting formula is Y=2X+10, so that the preset values ​​corresponding to the coefficients in the preset temperature and pressure fitting formula can be accurately and conveniently obtained.

[0053] It should be noted that Table 2 above only shows the corresponding preset values ​​between the coefficients (k, b) in the preset temperature and pressure fitting formula and the first pressure detection value when the preset temperature and pressure fitting formula is selected as Y=kX+b. When the selected preset temperature and pressure fitting formula is of another type, other corresponding tables between the coefficients in the preset temperature and pressure fitting formula and the first pressure detection value may exist. Since the corresponding tables of coefficients in different preset temperature and pressure fitting formulas are similar, the corresponding tables of coefficients in other types of preset temperature and pressure fitting formulas will not be described in detail here.

[0054] After selecting a corresponding preset temperature-pressure fitting formula according to the return temperature of the blood in the venous line 311 in step S6, and calibrating the first pressure detection value according to the selected preset temperature-pressure fitting formula to obtain a calibrated first pressure detection value, step S7 is executed.

[0055] Step S7 : detecting the external atmospheric temperature where the venous line 311 is located to obtain the ambient temperature.

[0056] In step S8 , it is determined whether the ambient temperature of the venous line 311 is within a second preset temperature range. If so, step S9 is executed; if not, step S10 is executed.

[0057] Step S9, when step S8 determines that the ambient temperature of the venous line 311 is within the second preset temperature range, step S9 executes an operation without recalibrating the first pressure detection value calibrated once, that is, the first pressure detection value calibrated once is displayed as the accurate pressure of the blood in the venous line 311 through the display screen 2.

[0058] It should be noted that there is a difference between ambient temperature and return blood temperature. Ambient temperature refers to the temperature of the air outside the venous line 311. The air outside temperature is closely related to the external environment of the blood purification device. For example, in cold winter weather, the ambient temperature is relatively low. Return blood temperature refers to the temperature of the blood in the venous line 311 as it is returned to the patient's body.

[0059] In step S10, when step S8 determines that the ambient temperature of the venous line 311 exceeds the second preset temperature range, step S10 recalibrates the first pressure detection value of the first calibration according to the ambient temperature to obtain the first pressure detection value of the second calibration, and controls the display screen 2 to display the first pressure detection value of the second calibration, that is, the first pressure detection value of the second calibration is displayed on the display screen 2 as the accurate pressure of the blood in the venous line 311.

[0060] Specifically, the second preset temperature range represents the temperature range in which the ambient temperature of the blood purification equipment will not interfere with the pressure detection process of the first pressure monitor, wherein the second preset temperature range is related to the working principle of the first pressure monitor. For example, the second preset temperature range is 35°C to 37°C. When the ambient temperature of the venous line 311 is within the second preset temperature range, there is no need to recalibrate the first pressure detection value of the first calibration. At this time, the ambient temperature of the venous line 311 will not interfere with the pressure detection process of the first pressure monitor. When the ambient temperature of the venous line 311 exceeds the second preset temperature range, it means that the ambient temperature of the venous line 311 will interfere with the pressure detection process of the first pressure monitor, and the first pressure detection value of the first calibration needs to be recalibrated. The second calibration to obtain the second calibrated first pressure detection value can eliminate the interference of the ambient temperature on the pressure detection process of the blood in the venous line 311. The second calibrated first pressure detection value has higher accuracy and anti-interference performance. The first pressure detection value of the secondary calibration is displayed on the display screen 2 as the accurate pressure of the blood in the venous line 311. The user can directly see on the display screen 2 that the first pressure detection value of the secondary calibration can reflect the actual pressure of the blood in the venous line 311.

[0061] As an optional embodiment, a corresponding preset pressure calibration value can be selected based on the ambient temperature of venous line 311, and the first pressure detection value of the primary calibration can be added to the preset pressure calibration value to obtain the first pressure detection value of the secondary calibration. Specifically, there is a one-to-one correspondence between the ambient temperature of venous line 311 and the preset pressure calibration value, where the preset pressure calibration value may be greater than or less than 0. Therefore, the first pressure detection value of the secondary calibration after recalibration may increase or decrease. The first pressure detection value of the secondary calibration can more accurately reflect the blood pressure in venous line 311.

[0062] In this embodiment, there is a negative correlation between the ambient temperature of the venous line 311 and the preset pressure calibration value. Specifically, a comparison table between the ambient temperature and the preset pressure calibration value is preset, as shown in Table 3 below. The corresponding preset pressure calibration value can be found in Table 3 according to the ambient temperature of the venous line 311, and the first pressure detection value calibrated once can be recalibrated as the preset pressure calibration value.

[0063] Table 3

[0064]

[0065]

[0066] When the ambient temperature of the venous line 311 is detected, the corresponding preset pressure calibration value can be found according to the corresponding relationship in Table 3. For example, if the ambient temperature of the venous line 311 is detected to be 38.5°C, the corresponding preset pressure calibration value found in Table 3 is -10 mmHg. If the first pressure detection value is calibrated in step S6 to obtain a first calibrated first pressure detection value of 110 mmHg, then in step S10, the first calibrated first pressure detection value is recalibrated to obtain a second calibrated first pressure detection value of: 110 mmHg + (-10 mmHg) = 100 mmHg. Therefore, the pressure calibration method of the blood purification equipment in this embodiment can perform two calibration processes on the pressure detection value in the venous line 311, thereby eliminating the interference error caused by the blood temperature in the venous line 311 and the ambient temperature of the venous line 311 on the pressure detection of the blood in the venous line 311, and can effectively reduce the interference error caused by the temperature change on the pressure detection of the blood in the venous line 311, thereby improving the pressure detection precision and accuracy of the blood in the venous line 311, thereby ensuring the control safety of the blood purification equipment, and making blood purification treatment safer and more reliable.

[0067] As an optional implementation, after step S6 or step S9 or step S10, step S11 is performed.

[0068] Step S11, controlling the display screen 2 of the blood purification device to display a curve showing the change of the calibrated first pressure detection value over time, such as Figure 4 shown.

[0069] Specifically, Figure 4 A curve showing the change of the calibrated first pressure detection value displayed on the display screen 2 over time is shown. The calibrated first pressure detection value is the first pressure detection value of the first calibration or the first pressure detection value of the second calibration. The user can clearly know the fluctuation of the pressure of the blood in the venous line 311 over time by seeing the change curve displayed on the display screen 2, and then more accurately determine whether the pressure of the blood in the venous line 311 is in a fault state, such as determining whether the pressure of the blood in the venous line 311 is in an overpressure state or an underpressure state. Therefore, the user can intuitively obtain the actual pressure change of the blood in the venous line 311 based on the change curve of the calibrated first pressure detection value displayed on the display screen 2 over time, further improving the pressure control safety of the blood purification equipment.

[0070] While the display screen 2 displays the curve showing the change of the calibrated first pressure detection value over time, step S12 is executed.

[0071] Step S12, determining whether the fluctuation amplitude of the change curve exceeds the preset fluctuation range, if yes, executing step S13; if not, executing step S11, the display screen 2 continues to display the change curve of the calibrated first pressure detection value changing with time.

[0072] Step S13: When the fluctuation amplitude of the change curve determined in step S12 exceeds the preset fluctuation range, step S13 controls the blood purification device to send an alarm signal.

[0073] Specifically, the fluctuation amplitude of the calibrated first pressure detection value over time refers to the difference between the maximum and minimum values ​​of the calibrated first pressure detection value during the process of detecting the blood pressure in the venous line 311. The preset fluctuation range represents the allowable fluctuation range of the blood pressure in the venous line 311 under normal circumstances. The preset fluctuation range is related to factors such as the blood flow rate in the venous line 311 and the patient's physical condition. For example, the preset fluctuation range is 0 to 10 mmHg. When the fluctuation amplitude of the calibrated first pressure detection value over time is greater than 10 mmHg, it indicates that the pressure fluctuation amplitude of the blood in the venous line 311 is too large. Typically, factors that cause such excessive pressure fluctuation amplitude include an abnormal blood flow rate setting in the venous line 311 or blood blockage in the venous line 311. In this case, the blood purification device is controlled to emit an audible and visual alarm signal to notify the user of the abnormal pressure fluctuation amplitude of the blood in the venous line 311, so that the user can promptly address the pressure fluctuation amplitude problem in the venous line 311.

[0074] When it is determined that the fluctuation amplitude of the calibrated first pressure detection value changing with time is within the preset fluctuation range, no sound or light alarm signal is issued. At this time, the pressure of the blood in the venous line 311 is in a stable state, and the display screen 2 continues to display the change curve of the calibrated first pressure detection value changing with time.

[0075] As an optional implementation, during the execution of the above steps S1 to S13, the following steps may be executed simultaneously.

[0076] Step S14: detecting the blood flow in the arterial line 310 to obtain the blood flow.

[0077] In step S15 , it is determined whether the blood flow rate is greater than a preset minimum flow rate. If so, step S16 is executed; if not, step S14 is executed to continue detecting the blood flow rate in the arterial line 310 to obtain the blood flow rate.

[0078] Step S16, when it is determined in step S15 that the blood flow rate of the arterial line 310 is greater than the preset minimum flow rate, step S16 controls the second pressure monitor to detect the pressure of the blood in the arterial line 310 to obtain a second pressure detection value.

[0079] Specifically, the preset minimum flow rate represents the minimum flow rate for normal blood flow within arterial line 310. Only when the blood flow within arterial line 310 exceeds the preset minimum flow rate is the blood flow within arterial line 310 determined to be in a normal flow state. When the blood flow within arterial line 310 is less than or equal to the preset minimum flow rate, it indicates that the blood flow within arterial line 310 is blocked or the blood purification device is in a stopped state. The preset minimum flow rate is a value pre-set by a technician, such as 1.5 ml / min. Only when the blood flow within arterial line 310 exceeds the preset minimum flow rate is the blood flow within arterial line 310 in a normal flow state, and the second pressure monitor is used to detect the blood pressure within arterial line 310 to obtain a second pressure detection value. The obtained second pressure detection value is then meaningful, and can be used to determine whether the blood pressure within arterial line 310 is in a pressure fault state based on the second pressure detection value. If the blood flow within arterial line 310 is detected to be less than or equal to the preset minimum flow rate, there is no need to use the second pressure monitor to detect the blood pressure within arterial line 310.

[0080] Step S17 , detecting the temperature of the blood in the arterial line 310 to obtain the blood inlet temperature.

[0081] In step S18, a corresponding preset pressure correction value is selected according to the blood inlet temperature of the blood in the arterial line 310, and the second pressure detection value is added with the preset pressure correction value to obtain a calibrated second pressure detection value, and the display screen 2 is controlled to display the calibrated second pressure detection value.

[0082] Specifically, when the blood flow in the arterial line 310 is in a normal flow state, the second pressure monitor is controlled to detect the pressure of the blood in the arterial line 310 to obtain a second pressure detection value, and the temperature of the blood in the arterial line 310 is detected to obtain the blood inlet temperature. The corresponding preset pressure correction value is selected according to the blood inlet temperature of the blood in the arterial line 310, and the second pressure detection value is added to the preset pressure correction value to obtain a calibrated second pressure detection value, so that the calibrated second pressure detection value can accurately reflect the pressure change of the blood in the arterial line 310. According to the calibrated second pressure detection value, it can be accurately judged whether the pressure of the blood in the arterial line 310 has an overpressure fault or an underpressure fault.

[0083] Among them, the preset pressure correction value is related to the blood inlet temperature of the arterial line 310. When the blood inlet temperature of the arterial line 310 fluctuates, this will cause errors in the pressure detection process of the blood in the arterial line 310. Therefore, the preset pressure correction value can compensate for the pressure detection error caused by the fluctuation of the blood temperature, and the calibrated second pressure detection value displayed on the display screen 2 has higher accuracy.

[0084] It should be noted that step S16 uses a second pressure monitor to detect the pressure of the blood in the arterial line 310 to obtain a second pressure detection value, and step S5 uses a first pressure monitor to detect the pressure of the blood in the venous line 311 to obtain a first pressure detection value. The pressure of the blood in the arterial line 310 is different from the pressure of the blood in the venous line 311, and their uses are also different. The pressure of the blood in the arterial line 310 is mainly used to determine whether there is a fault in the blood pressure output by the patient's artery, and the pressure of the blood in the venous line 311 is used to determine whether there is a fault in the blood pressure returned to the patient's vein.

[0085] The second pressure detection value of the blood in the arterial line 310 is added with the preset pressure correction value to obtain a calibrated second pressure detection value. The calibrated second pressure detection value may increase or decrease. The calibrated second pressure detection value can reduce the pressure detection error caused by the temperature change of the blood in the arterial line 310, thereby improving the pressure detection accuracy and pressure detection anti-interference ability of the blood in the arterial line 310.

[0086] In this embodiment, the preset pressure correction value is negatively correlated with the blood inlet temperature of the arterial line 310. Specifically, a relationship curve between the preset pressure correction value and the blood inlet temperature is pre-established, such as Figure 5 As shown, the relationship curve between the preset pressure correction value and the blood inlet temperature includes a one-to-one correspondence between the blood inlet temperature of the blood in the arterial line 310 and the preset pressure correction value. Whenever the blood inlet temperature of the blood in the arterial line 310 is obtained (equivalent to obtaining Figure 5 ), according to Figure 5 The relationship curve in the figure can be used to find the corresponding preset pressure correction value (equivalent to obtaining Figure 5 ordinate in ).

[0087] The calibrated second pressure detection value = the second pressure detection value + the preset pressure correction value, wherein the preset pressure correction value may be greater than 0 or less than 0. Figure 5 For example, if the blood temperature in the arterial line 310 is 35°C, Figure 4 The corresponding preset pressure correction value is 10 mmHg, and the second pressure detection value of the blood in the arterial line 310 is 120 mmHg. The calibrated second pressure detection value = 120 mmHg + 10 mmHg = 130 mmHg, and the calibrated second pressure detection value displayed on the display screen 2 is 130 mmHg. Therefore, the pressure calibration method of the blood purification device of this embodiment accurately calibrates the second pressure detection value of the blood in the arterial line 310 using the preset pressure correction value, thereby eliminating interference caused by changes in the blood temperature in the arterial line 310 on the pressure detection process.

[0088] As an optional implementation, after obtaining the calibrated second pressure detection value, step S19 is performed.

[0089] Step S19: obtaining a pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value.

[0090] In step S20 , it is determined whether the pressure difference is greater than a preset difference. If so, step S21 is executed; if not, step S22 is executed.

[0091] Step S21, when step S20 determines that the pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value is greater than the preset difference, step S21 controls the display screen 2 of the blood purification device to display a pressure alarm message.

[0092] Step S22, when step S20 determines that the pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value is less than or equal to the preset difference, step S22 controls the display screen 2 of the blood purification device to display normal working information of the blood purification device.

[0093] Specifically, after calibrating the first pressure detection value and the second pressure detection value, respectively, the pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value can be used to determine whether the blood pressure difference between the arterial line 310 and the venous line 311 is abnormal. The calibrated second pressure detection value represents the patient's arterial blood pressure, and the calibrated first pressure detection value represents the patient's venous blood pressure. The calibrated first pressure detection value is either a first-calibration first pressure detection value or a second-calibration first pressure detection value. According to basic knowledge of human blood pressure, the arterial blood pressure of a person is greater than the venous blood pressure of a person. Therefore, the calibrated second pressure detection value will also be greater than the calibrated first pressure detection value. Furthermore, the difference between the arterial blood pressure and the venous blood pressure of a person will also be within a certain safe range, so that the person's blood circulation process is normal. In the pressure calibration method of the blood purification equipment of this embodiment, only when the following conditions are met: the preset difference ≥ the calibrated second pressure detection value - the calibrated first pressure detection value > 0, the blood pressure difference between the arterial line 310 and the venous line 311 is within a safe range. When the user sees the normal working information of the blood purification equipment displayed on the display screen 2, the user knows that the patient's blood is in a safe extracorporeal circulation flow state, and blood can be safely drawn from the patient's artery through the arterial line 310, and the purified blood can be safely returned to the patient's vein through the venous line 311. When the pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value is greater than the preset difference, the blood pressure difference between the arterial line 310 and the venous line 311 is too large, which may cause the patient's blood to flow too fast during extracorporeal circulation, the patient's heart rate to be too fast, and other symptoms, thereby controlling the display screen 2 to display a pressure alarm message. When the user receives the pressure alarm message, he will know that the blood pressure difference between the arterial line 310 and the venous line 311 is in a fault state. The user will promptly deal with the pressure fault state between the arterial line 310 and the venous line 311, and promptly eliminate the pipeline pressure fault of the blood purification equipment.

[0094] It should be noted that the preset difference is used to measure whether the difference between the human body's arterial blood pressure and the human body's venous blood pressure is within a safe range. For example, the preset difference is 30 mmHg. Only when the pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value is less than or equal to 30 mmHg, the blood pressure difference between the arterial line 310 and the venous line 311 is within a safe range, thereby ensuring that the patient's blood is in a normal extracorporeal circulation flow state.

[0095] After selecting a corresponding preset pressure correction value according to the blood inlet temperature of the blood in the arterial line 310 and before adding the preset pressure correction value to the second pressure detection value to obtain a calibrated second pressure detection value, step S23 is executed.

[0096] Step S23 , detecting the inner diameter of the arterial tube 310 .

[0097] In step S24, it is determined whether the inner diameter of the arterial line 310 is greater than the preset safety diameter. If so, step S25 is executed to calibrate the preset pressure correction value; if not, there is no need to calibrate the preset pressure correction value.

[0098] Step S25 , when it is determined in step S24 that the inner diameter of the arterial line 310 is greater than the preset safety diameter, step S25 calibrates the preset pressure correction value.

[0099] Specifically, the inner diameter of arterial line 310 interferes with the accuracy of blood pressure measurement within arterial line 310, particularly when the inner diameter is relatively large, i.e., when the inner diameter is larger than a preset safety diameter. This can severely reduce the accuracy of blood pressure measurement within arterial line 310. As the inner diameter of arterial line 310 increases, the pressure measurement accuracy of the second pressure monitor disposed on arterial line 310 decreases, resulting in greater errors in blood pressure measurement within arterial line 310. Therefore, in the pressure calibration method of the blood purification device of this embodiment, when it is determined that the inner bore diameter of the arterial line 310 is greater than the preset safety diameter, the preset pressure correction value needs to be calibrated. Taking into account the size of the inner bore diameter of the arterial line 310, the calibrated preset pressure correction value can simultaneously eliminate the interference error caused by both the inner bore diameter of the arterial line 310 and the temperature of the blood in the arterial line 310 in the pressure detection process of the blood in the arterial line 310, so that the calibrated second pressure detection value can accurately reflect the actual pressure of the blood in the arterial line 310. When it is determined that the inner bore diameter of the arterial line 310 is less than or equal to the preset safety diameter, there is no need to calibrate the preset pressure correction value. In this case, the inner bore diameter of the arterial line 310 will not affect the pressure detection accuracy of the blood in the arterial line 310, or the degree of influence is negligible.

[0100] It should be noted that the preset safety pipe diameter is a value preset in advance by the user after testing, for example, the preset safety pipe diameter is 5 cm.

[0101] As an optional embodiment, the preset pressure correction value is calibrated. The specific calibration method is to set a calibration formula and calculate the calibrated preset pressure correction value according to the calibration formula. Preferably, the calibration formula is Q=R+(DE)×2, where R represents the preset pressure correction value before calibration, D represents the inner diameter of the arterial line 310, E represents the preset safety diameter, and Q represents the calibrated preset pressure correction value. For example, the preset safety diameter E is 5 cm, the inner diameter D of the arterial line 310 is 7 cm, and Figure 5If the preset pressure correction value R selected in the relationship curve is 10 mmHg, then according to the calibration formula above, the calibrated preset pressure correction value Q = 10 + (7 - 5) × 2 = 14 mmHg. Therefore, calibrating the second pressure detection value based on the calibrated preset pressure correction value Q improves the calibration accuracy of the second pressure detection value.

[0102] Blood purification equipment embodiment:

[0103] The blood purification device of this embodiment includes components such as a host 1 and a display screen 2. The display screen 2 is a human-machine interactive touch screen. A circuit board that can interact with the display screen 2 is provided in the host 1. A processor and a memory are provided on the circuit board. The memory stores a computer program. When the computer program is executed by the processor, each step of the pressure calibration method of the above-mentioned blood purification device is implemented.

[0104] For example, a computer program can be divided into one or more modules, one or more of which are stored in a memory and executed by a processor to implement the various modules of the present invention. One or more modules can be a series of computer program instruction segments that can perform specific functions, and the instruction segments are used to describe the execution process of the computer program in a terminal device.

[0105] The processor referred to in the present invention may be a central processing unit (CPU), other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field-programmable gate arrays (FPGA), other programmable logic devices, discrete gate or transistor logic devices, discrete hardware components, etc. A general-purpose processor may be a microprocessor or any conventional processor. The processor is the control center of an electrical appliance, connecting various parts of the entire appliance using various interfaces and lines.

[0106] The memory can be used to store computer programs and / or modules. The processor implements the various functions of the appliance by running or executing the computer programs and / or modules stored in the memory, as well as accessing data stored in the memory. The memory can primarily include a program storage area and a data storage area. The program storage area can store an operating system, at least one application required for a function, and the data storage area can store data generated based on the use of the appliance. Furthermore, the memory can include high-speed random access memory and non-volatile memory, such as a hard disk, internal memory, a plug-in hard disk, a Smart Media Card (SMC), a Secure Digital (SD) card, a flash card, at least one disk storage device, a flash memory device, or other volatile solid-state storage device.

[0107] Computer readable storage medium embodiment:

[0108] If the computer program stored in the memory of the blood purification device is implemented in the form of a software functional unit and sold or used as an independent product, it can be stored in a computer-readable storage medium. Based on this understanding, the present invention can implement all or part of the processes in the above-mentioned embodiment method by instructing the relevant hardware through a computer program. The computer program can be stored in a computer-readable storage medium. When the computer program is executed by a processor, it can implement each step of the pressure calibration method of the above-mentioned blood purification device.

[0109] Among them, computer programs include computer program code, which can be in source code form, object code form, executable file, or some intermediate form. Computer-readable media may include: any entity or device capable of carrying computer program code, recording media, USB flash drives, mobile hard drives, magnetic disks, optical disks, computer memory, read-only memory (ROM), random access memory (RAM), electric carrier signals, telecommunications signals, and software distribution media. It should be noted that the content contained in computer-readable media can be appropriately increased or decreased based on the requirements of legislation and patent practice within a jurisdiction. For example, in some jurisdictions, based on legislation and patent practice, computer-readable media does not include electric carrier signals and telecommunications signals.

[0110] The above embodiments are only preferred examples of the present invention and are not intended to limit the scope of implementation of the present invention. Therefore, any equivalent changes or modifications made based on the structure, features and principles of the patent application scope of the present invention should be included in the scope of the patent application of the present invention.

Claims

1. A blood purification device, characterized in that: The device comprises a host and a display screen, and the extracorporeal circulation circuit of the blood purification device comprises a first pressure monitor, an arterial line, a blood purifier and a venous line, wherein the input end of the arterial line is used to connect to the human artery, the output end of the arterial line is connected to the input end of the blood purifier, the output end of the blood purifier is connected to the input end of the venous line, and the output end of the venous line is used to connect to the human vein, the first pressure monitor is arranged on the venous line and is used to detect the pressure of the blood in the venous line, the host is provided with a circuit board that can realize interactive communication with the display screen, the circuit board is provided with a processor and a memory, the memory stores a computer program, and when the computer program is executed by the processor, the pressure calibration method of the blood purification device as described below is implemented, including: detecting the temperature of the blood in the venous line to obtain the return blood temperature; determining whether the blood return temperature is within a first preset temperature range, and if so, controlling the first pressure monitor to detect the pressure of the blood in the venous line to obtain a first pressure detection value; Selecting a corresponding preset temperature-pressure fitting formula according to the blood return temperature, and calibrating the first pressure detection value according to the selected preset temperature-pressure fitting formula to obtain a calibrated first pressure detection value; After obtaining a first pressure detection value of a calibration, the pressure calibration method of the blood purification device further includes: detecting the external atmospheric temperature where the intravenous line is located to obtain the ambient temperature; It is determined whether the ambient temperature is within a second preset temperature range; if not, the first pressure detection value of the primary calibration is recalibrated according to the ambient temperature to obtain a second-calibrated first pressure detection value.

2. The blood purification device according to claim 1, characterized in that: The first preset temperature range is divided into several temperature gears, each temperature gear corresponds to a preset temperature interval, and each temperature gear corresponds to a preset temperature-pressure fitting formula, and the preset value corresponding to the coefficient in the preset temperature-pressure fitting formula is selected according to the first pressure detection value.

3. The blood purification device according to claim 1, characterized in that: A corresponding preset pressure calibration value is selected according to the ambient temperature, and the first pressure detection value of the primary calibration is added to the preset pressure calibration value to obtain the first pressure detection value of the secondary calibration.

4. The blood purification device according to claim 1, characterized in that: The pressure calibration method of the blood purification equipment further includes: Controlling the display screen of the blood purification device to display a curve of the change of the calibrated first pressure detection value over time; It is determined whether the fluctuation amplitude of the change curve exceeds a preset fluctuation range. If so, the blood purification device is controlled to send an alarm signal.

5. The blood purification device according to any one of claims 1 to 4, characterized in that: The extracorporeal circulation circuit further includes a second pressure monitor, which is disposed on the arterial line and is used to detect the pressure of blood in the arterial line. The pressure calibration method of the blood purification device further includes: detecting the flow rate of blood in the arterial line to obtain the blood flow rate; determining whether the blood flow rate is greater than a preset minimum flow rate, and if so, controlling the second pressure monitor to detect the pressure of the blood in the arterial line to obtain a second pressure detection value; detecting the temperature of the blood in the arterial line to obtain the blood inlet temperature; A corresponding preset pressure correction value is selected according to the blood inlet temperature, and the second pressure detection value is added to the preset pressure correction value to obtain a calibrated second pressure detection value.

6. The blood purification device according to claim 5, characterized in that: The pressure calibration method of the blood purification equipment further includes: Obtaining a pressure difference between the calibrated second pressure detection value and the calibrated first pressure detection value; Determine whether the pressure difference is greater than a preset difference. If so, control the display screen of the blood purification device to display pressure alarm information; if not, control the display screen of the blood purification device to display normal working information of the blood purification device.

7. The blood purification device according to claim 5, characterized in that: After selecting the corresponding preset pressure correction value according to the blood inlet temperature and before adding the preset pressure correction value to the second pressure detection value to obtain a calibrated second pressure detection value, the pressure calibration method of the blood purification device further includes: detecting the inner diameter of the arterial line; Determine whether the inner diameter of the arterial line is greater than a preset safety diameter; if so, calibrate the preset pressure correction value.

8. A computer-readable storage medium having a computer program stored thereon, characterized in that: When the computer program is executed by a processor, each step of the pressure calibration method of the blood purification device described in any one of claims 1 to 7 is implemented.

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