Sample slide cleaning box and staining machine

Abstract

This invention provides a sample slide cleaning box and a slide preparation machine. The sample slide cleaning box includes a cleaning chamber and a cleaning solution injection channel. The cleaning chamber contains cleaning solution and sample slides, and the cleaning solution injection channel injects cleaning solution into the cleaning chamber. The cleaning chamber accommodates vertically inserted sample slides, with the blood-coated side of the slides facing the cleaning solution injection channel. The cleaning solution injection channel is located on a first side wall of the cleaning chamber and injects cleaning solution into the cleaning chamber to rinse the sample slides. This invention's sample slide cleaning box simulates rinsing the front of the sample slides with a water tap by using the cleaning solution injection channel. By employing a method of rinsing the front of the sample slides and immersing and then aspirating the solution on the back, the sample slides are cleaned more thoroughly and conveniently.

Description

Technical Field

[0001] This invention relates to the field of in vitro diagnostic technology, and more specifically, to a sample slide cleaning box and a slide spreading machine. Background Technology

[0002] Currently, hospital pathology departments, research institutes, and biopharmaceutical companies all require the preparation and staining of exfoliated cells (such as cervical screening), biological tissues (such as local tissues of animals or humans), or blood. Doctors can only make accurate diagnoses of various diseases by observing the variations in cell nuclei and cytoplasm under a microscope, such as determining whether there is inflammation, whether it is a benign tumor or a malignant tumor.

[0003] In existing technologies, the sample slides need to be cleaned after preparation and staining; otherwise, staining residue will adhere to the blood film on the sample slides, affecting the reading work of doctors or slide analysis instruments and reducing work quality and efficiency.

[0004] Currently, most methods for cleaning stains involve immersing the slide in cleaning solution or rinsing with the nozzle facing the side edge of the slide. However, none of these methods directly clean the front of the slide. The back of the slide is smooth and free of blood film, making it difficult for stains to adhere. The two methods mentioned above easily clean the stains on the back. However, the front of the slide is coated with blood film, making it easier for stains to adhere to the blood film. Therefore, neither of the two methods mentioned above is effective in cleaning the stains on the front. Summary of the Invention

[0005] In view of this, this application provides a sample slide cleaning box and a slide spreading machine to solve at least one of the above-mentioned technical problems, and provides a sample slide cleaning box and slide spreading machine with simple structure and good cleaning effect.

[0006] A sample slide cleaning box according to the present invention includes a cleaning cavity and a cleaning injection channel communicating with the interior of the cleaning cavity. The cleaning cavity is used to accommodate a vertically inserted sample slide, and the side of the sample slide coated with blood film faces the cleaning injection channel. The cleaning injection channel is disposed on a first side wall of the cleaning cavity and is used to inject cleaning fluid into the cleaning cavity to rinse the sample slide.

[0007] In a preferred embodiment, the cleaning cavity is a cuboid structure formed by circumferential sidewalls and a bottom wall.

[0008] In a preferred embodiment, the cleaning chamber is provided with a guide portion, which includes a guide slot for the sample slide to pass through, so as to guide and stabilize the sample slide contained in the cleaning chamber.

[0009] In a preferred embodiment, the bottom of the cleaning chamber is provided with a negative pressure liquid extraction channel to discharge the waste liquid after cleaning.

[0010] In a preferred embodiment, an overflow cavity is provided on a second sidewall opposite to the first sidewall where the cleaning injection channel is located. The overflow cavity is located on the side of the second sidewall away from the first sidewall. An overflow port is provided on the second sidewall to allow excess liquid in the cleaning cavity to overflow into the overflow cavity. A natural overflow port is provided at the bottom of the overflow cavity.

[0011] In a preferred embodiment, the guide portion is respectively disposed on one side of the third sidewall and the fourth sidewall adjacent to the first sidewall of the cleaning chamber, and the guide portion is respectively connected to at least one of the first sidewall, the second sidewall, the third sidewall and the fourth sidewall, wherein the guide portion on each side includes a first guide portion and a second guide portion, the first guide portion including a first insert port for guiding; the second guide portion including a second insert port for guiding; the first insert port and the second insert port are coaxially arranged.

[0012] In a preferred embodiment, the first guide portion and the second guide portion are coaxially arranged in the vertical direction, and the first guide portion and the second guide portion are discontinuously arranged.

[0013] In a preferred embodiment, the first guide portion is connected to the first sidewall and the second sidewall respectively, and the second guide portion is connected to the first sidewall and the second sidewall respectively.

[0014] In a preferred embodiment, the cleaning chamber is further provided with a bottom support portion for supporting the sample slide. The bottom support portion includes a third slide inlet for guidance. The third slide inlet is coaxially arranged with the second slide inlet and the first slide inlet, respectively. The opening diameter of the first slide inlet is smaller than the opening diameter of the second slide inlet, and the opening diameter of the third slide inlet is smaller than the opening diameter of the second slide inlet.

[0015] In a preferred embodiment, the cleaning fluid injection direction of the cleaning injection channel is inclined toward the bottom of the cleaning chamber, and the angle between the channel and the center line of the sample slide housed in the cleaning chamber is in the range of 30° to 45°.

[0016] In a preferred embodiment, the cleaning injection channel includes a first cleaning injection channel and a second cleaning injection channel, which are arranged side by side at the same horizontal level.

[0017] In a preferred embodiment, the distances between the circumferential sidewalls and bottom wall of the cleaning chamber and the sample glass slide contained in the cleaning chamber are both greater than 0.

[0018] In a preferred embodiment, the distance between the first sidewall and the sample slide housed in the cleaning chamber is a first distance, and the distance between the second sidewall, which is opposite to the first sidewall where the cleaning injection channel is located, and the sample slide housed in the cleaning chamber is a second distance, wherein the ratio between the first distance and the second distance is in the range of 1:1.5 to 1:3.

[0019] In a preferred embodiment, the cleaning chamber further includes vents, which are respectively disposed on both sides of the guide portion of the cleaning chamber. The vents are respectively surrounded by the main body of the guide portion and the third or fourth side wall adjacent to the first side wall of the cleaning chamber, and communicate with the interior of the cleaning chamber.

[0020] In a preferred embodiment, the cleaning chamber is further provided with a cleaning fluid guiding surface, which is located on the inner bottom side of the cleaning chamber. The cleaning fluid guiding surface faces the opposite side of the cleaning injection channel and is inclined towards the bottom of the cleaning chamber. The negative pressure suction channel is located at the lowest point of the cleaning fluid guiding surface.

[0021] In a preferred embodiment, the cleaning fluid guiding surface is an arc surface or a plane.

[0022] Based on the sample slide cleaning box provided above, the present invention also provides a staining slide machine, comprising:

[0023] The smear module is used to prepare blood film smears;

[0024] The staining module is used for staining blood film smears;

[0025] It also includes at least one of the aforementioned sample slide cleaning kits for cleaning blood smears.

[0026] In one embodiment, the dyeing module further includes a washing tank, a dyeing solution tank, and a fixing solution tank;

[0027] The sample slide cleaning box can be detachably placed in the cleaning tank;

[0028] The cleaning tank is arranged side by side with the dyeing tank and the fixing liquid tank.

[0029] Compared with the prior art, the sample slide cleaning box of the present invention simulates the cleaning of the front of the sample slide by setting a cleaning liquid injection channel, and adopts a combination of rinsing the front of the sample slide and immersing the back of the sample slide for cleaning, so as to make the sample slide cleaner and more convenient.

[0030] The above-mentioned technical features can be combined in various technically feasible ways to produce new implementation schemes, as long as the purpose of the present invention can be achieved. Attached Figure Description

[0031] Figure 1 This is a left view of the sample slide cleaning box provided in an embodiment of the present invention;

[0032] Figure 2 A perspective view of the sample slide cleaning box provided in an embodiment of the present invention;

[0033] Figure 3 A cross-sectional view of the sample slide cleaning box provided in an embodiment of the present invention;

[0034] Figure 4 Another cross-sectional view of the sample slide cleaning box provided in an embodiment of the present invention;

[0035] Figure 5 Another cross-sectional view of the sample slide cleaning box provided in an embodiment of the present invention;

[0036] Figure 6 A perspective view of the sample slide cleaning box provided in an embodiment of the present invention;

[0037] Figure 7 This is an application structure diagram of the sample slide cleaning box provided in an embodiment of the present invention;

[0038] Figure 8 This is another application structural diagram of the sample slide cleaning box provided in an embodiment of the present invention.

[0039] The attached figures are labeled as follows:

[0040] 1. Cleaning injection channel; 2. Negative pressure suction channel; 3. Natural overflow port; 4. Overflow chamber; 5. Cleaning chamber; 51. Cleaning chamber opening; 511. First side wall; 52. Overflow port; 53. Vent; 531. Third side wall; 54. Rinsing area; 55. Dye accumulation area; 6. Guide section; 61. First guide section; 611. First slide insertion port; 62. Second guide section; 621. Second slide insertion port; 63. Bottom support section; 631. Third slide insertion port; 7. Cleaning fluid guide surface; 8. Cleaning fluid impact point; 10. Sample slide; 11. Small area. Detailed Implementation

[0041] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0042] It should be noted that, unless otherwise defined, the technical or scientific terms used in this invention should have the ordinary meaning understood by one of ordinary skill in the art to which this invention pertains. The terms "first," "second," and similar words do not indicate any order, quantity, or importance, but are merely used to distinguish different components. Words such as "comprising" or "including" mean that the element or object preceding the word encompasses the elements or objects listed after the word and their equivalents, without excluding other elements or objects. In the description of this invention, the terms "upper," "lower," "vertical," "horizontal," "top," "bottom," "inner," and "outer," etc., indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. When the absolute position of the described object changes, the relative positional relationship may also change accordingly, and therefore should not be construed as a limitation of the invention.

[0043] Techniques not mentioned in this invention can be achieved using existing technologies.

[0044] First, some of the terms used in the embodiments of the present invention will be explained to facilitate understanding by those skilled in the art.

[0045] The front side of the sample slide: the side of the sample slide coated with the blood film.

[0046] The back of the sample slide: the side of the sample slide that is not coated with blood film, that is, the side opposite to the front of the sample slide.

[0047] like Figure 1-6 As shown, the sample slide cleaning box provided in this embodiment of the invention includes a cleaning chamber 5 and a cleaning liquid injection channel 1. The cleaning chamber 5 is used to contain cleaning liquid and sample slides 10. The sample slides 10 are vertically inserted and placed in the cleaning chamber 5 with the bottom edge away from the printing end facing the bottom of the cleaning chamber 5. The front side of the sample slide faces the cleaning liquid injection channel 1. The cleaning liquid injection channel 1 is used to inject cleaning liquid into the cleaning chamber 5 to rinse the sample slides 10. The cleaning liquid injection channel 1 is provided on the first side wall 511 of the cleaning chamber 5 and communicates with the inside of the cleaning chamber 5.

[0048] Research and analysis revealed that in practice, medical staff almost always rinse sample slides directly with a tap, either directly on the front or back. This invention provides a sample slide cleaning box that simulates the manual cleaning method used by medical staff, while also offering advantages over manual cleaning. Its simple structure combines rinsing the front of the slide with immersion cleaning of the back, resulting in a more thorough cleaning.

[0049] In this embodiment, the sample slide 10 is vertically inserted into the cleaning chamber 5 by the scheduling mechanism. The sample slide 10 is inserted vertically into the cleaning chamber 5 with its bottom edge away from the printing end facing the bottom of the cleaning chamber 5. The front side of the sample slide 10 faces the cleaning injection channel 1. The cleaning solution is injected from the cleaning injection channel 1, which is connected to the inside of the cleaning chamber 5, to rinse the front side of the sample slide 10. At the same time, the liquid is drawn away from the negative pressure extraction channel 2 at the bottom of the cleaning chamber 5, thereby cleaning the stains attached to the blood film on the sample slide 10. Of course, the cleaning solution can also be injected into the cleaning chamber 5 for soaking and cleaning, so that both the front and back sides of the sample slide are cleaned more thoroughly. Because stains adhere more easily to the blood film, the front of the sample slide 10 is cleaned by simulating a tap, while the back of the sample slide 10 is smooth and has no blood film, making it less likely for stains to adhere. Therefore, the back of the sample slide 10 can be cleaned by soaking and then draining the liquid, eliminating the need for a separate rinsing design for the back. This makes the structure simpler, the control simpler, and the cleaning more thorough.

[0050] More specifically, such as Figure 2 As shown, the cleaning chamber 5 is a cavity structure formed by four circumferential sidewalls and one bottom wall, preferably a cuboid structure. The four circumferential sidewalls are a first sidewall 511 connected to the cleaning liquid injection channel 1, a second sidewall opposite to the first sidewall 511, a third sidewall 531 adjacent to the first sidewall 511, and a fourth sidewall opposite to the third sidewall 531; the bottom wall is located at the bottom of the cleaning chamber 5. This structural design facilitates manufacturing. The surface of the third sidewall 531 or the fourth sidewall has no protruding structures. This flat sidewall structure allows the sample slide cleaning box to be positioned during installation, preventing Z-axis rotational offset after installation, and further enabling the positioning adjustment of the scheduling mechanism in the direction of movement.

[0051] like Figure 2 and Figure 3As shown, in a preferred embodiment, a guide portion 6 is further provided inside the cleaning chamber 5. The guide portion 6 is used to guide and stabilize the sample slide 10 contained in the cleaning chamber 5. The guide portion 6 is respectively disposed on one side of the third side wall 531 and the fourth side wall adjacent to the first side wall 511 of the cleaning chamber 5, and the guide portion 6 is connected to at least one of the first side wall 511, the second side wall, the third side wall 531, and the fourth side wall. In a more preferred embodiment, as shown... Figure 3 As shown, each guide portion 6 on each side includes a first guide portion 61 and a second guide portion 62, which are not continuously arranged. In this embodiment, the first guide portion 61 and the second guide portion 62 are coaxially arranged in the vertical direction, that is, in Figure 2 The guide portions are spaced apart along the Z-axis, with the first guide portion 61 positioned above the second guide portion 62 along the Z-axis. (See diagram.) Figure 4 As shown, the sample slide 10 is inserted into the cleaning chamber 5 through the first guide part 61 and the second guide part 62. The front and back sides of the sample slide 10 divide the interior of the cleaning chamber 5 into two regions: the rinsing region 54 and the dye residue accumulation region 55. The discontinuous arrangement of the first guide part 61 and the second guide part 62 can reduce the resistance of water flow in the cleaning chamber 5 and allow water to flow from the rinsing region 54 into the dye residue accumulation region 55 more quickly, increasing the drainage flow rate of the rinsing region 54, thereby causing the dye residue to quickly accumulate in the dye residue accumulation region 55.

[0052] It is understood that the guide part 6 can guide the sample slide 10 on the side where the width direction is located, or the guide part 6 can be set in other ways to guide the sample slide 10. This embodiment does not limit this.

[0053] More preferably, the guide portion 6 located on one side of the third sidewall 531 and the guide portion 6 located on one side of the fourth sidewall can be symmetrically arranged or staggered vertically.

[0054] Furthermore, such as Figure 3As shown, the first guide portion 61 includes a first slide insertion port 611 for guidance; the second guide portion 62 includes a second slide insertion port 621 for guidance; the first slide insertion port 611 and the second slide insertion port 621 are coaxially arranged. The coaxial arrangement of the first slide insertion port 611 and the second slide insertion port 621 ensures that the sample slide 10 is guided through the slide insertion ports of the first guide portion 61 and the second guide portion 62 when inserted, which ensures that the sample slide 10 is placed more stably. More specifically, a bottom support portion 63 may also be provided inside the cleaning chamber 5 for supporting the sample slide 10. The bottom support portion 63 may also include a third slide insertion port 631 for guidance and a support platform for supporting the sample slide 10. The third slide insertion port 631, the first slide insertion port 611, and the second slide insertion port 621 are coaxially arranged. The opening diameter of the first slide insertion port 611 is smaller than that of the second slide insertion port 621, and the opening diameter of the third slide insertion port 631 is smaller than that of the second slide insertion port 621. It can be understood that the channel diameters of these three slide insertion ports for stabilizing the sample slide 10 are the same. This design can ensure that the sample slide 10 can be smoothly inserted into the first guide portion 61, the second guide portion 62, and the bottom support portion 63 in sequence, ensuring the reliability of the sample slide cleaning box and the stability of the sample slide 10 when being rinsed, thereby indirectly ensuring the cleaning quality and cleaning efficiency of the sample slide 10.

[0055] More preferably, such as Figure 2 , 3 As shown, the main body of the first guide portion 61 is connected to the first side wall 511 and the second side wall in the Y-axis direction. A first insert port 611 is provided on the main body of the first guide portion 61. The first insert port 611 penetrates the main body of the first guide portion 61 in the Z-axis direction. The width of the first insert port 611, i.e., the opening degree of the first insert port 611 in the Y-axis direction, is slightly larger than the thickness of the sample slide. The first guide portions 61 located on the third side wall 531 and the fourth side wall respectively guide the left and right sides of the sample slide 10 in the width direction. The first guide portion 61, the first side wall 511, and the second side wall form a cleaning chamber opening 51. The first insert port 611 does not penetrate the main body of the first guide portion 61 in the X-axis direction. The surface of the main body of the first guide portion 61 close to the third side wall 531 or the fourth side wall respectively forms a vent 53 with the third side wall 531 and the fourth side wall. The arrangement of the second guide portion 62 and the bottom support portion 63 is similar to that of the first guide portion 61, and will not be described again here.

[0056] In a more preferred embodiment, such as Figure 2 As shown, two cleaning injection channels 1 can be provided, including a first cleaning injection channel and a second cleaning injection channel. The first and second cleaning injection channels are arranged side by side at the same horizontal level. After the cleaning solution is injected from the cleaning injection channel 1, it impacts the cleaning solution impact point 8 on the sample slide 10, and then the water flows outwards, as shown. Figure 5 The arrows in the diagram illustrate this. It's understandable that this setup ensures the water flow remains within a reasonable pressure range, without damaging the blood film on the sample slide, while also allowing for a wider area of ​​blood film to be washed, resulting in a cleaner wash.

[0057] Furthermore, such as Figure 4 As shown, the cleaning fluid injection direction of the cleaning fluid injection channel 1 is inclined towards the bottom of the cleaning chamber 5, and the angle β between it and the center line of the sample slide 10 contained in the cleaning chamber 5 is in the range of 30° to 45°. This can prevent the cleaning water from rising upwards and overflowing from the cleaning chamber opening 51.

[0058] In a preferred embodiment, an overflow cavity 4 is also connected to the second sidewall. The overflow cavity 4 is located on the outer side of the second sidewall, i.e., the side away from the first sidewall. A natural overflow port 3 is provided at the bottom of the overflow cavity 4. The overflow cavity 4 is used to contain excess liquid in the cleaning cavity 5. An overflow port 52 is also provided at the cleaning cavity opening 51 on the second sidewall. Excess liquid in the cleaning cavity 5 can flow into the overflow cavity 4 through the overflow port 52 and then be discharged through the natural overflow port 3 at the bottom. This design can buffer and cushion the overflowing liquid.

[0059] Because the cleaning fluid has a high surface tension, it will form a concave water surface at the overflow outlet 52, thereby raising the overflow water level. Setting a lower overflow outlet can increase the overflow cross-sectional area, compensate for the water level raised by the concave water surface, and form a stable overflow.

[0060] More specifically, when the sample slide 10 is vertically inserted with its bottom edge away from the printing end facing the bottom of the cleaning chamber 5, the distances between the sample slide 10 contained in the cleaning chamber 5 and the four circumferential sidewalls and one bottom wall of the cleaning chamber 5 are all greater than 0. More specifically, such as... Figure 5As shown, the sample slide 10 is securely housed in the cleaning chamber 5 via the first insertion port 611 of the first guide portion 61, the second insertion port 621 of the second guide portion 62, the third insertion port 631 of the bottom support portion 63, and the support platform of the bottom support portion 63. The distance between the sample slide 10 housed in the cleaning chamber 5 and the four circumferential side walls and one bottom wall of the cleaning chamber 5 is greater than 0. With this design, in addition to maintaining a certain distance between the front and back sides of the sample slide 10 and the circumferential side walls of the cleaning chamber 5, there are also gaps (i.e., small areas 11) between the side of the sample slide 10 in the width direction and its adjacent third side wall 531 and fourth side wall, and a gap is also maintained between the bottom edge of the sample slide 10 away from the printing end and the bottom wall of the cleaning chamber 5. After the cleaning solution hits the sample slide 10, it spreads outwards along the surface of the sample slide 10. The gaps on the left and right sides of the sample slide 10 in the width direction increase the space for water flow, making the water flow smoother. This allows the cleaning solution to flow more smoothly from the rinsing area 54 into the stain accumulation area 55, resulting in a better cleaning effect.

[0061] Furthermore, such as Figure 4 As shown, the distance between the first sidewall 511 and the sample slide 10 contained in the cleaning chamber 5 is the first distance l1, and the distance between the second sidewall and the sample slide 10 contained in the cleaning chamber 5 is the second distance l2. The ratio between the first distance l1 and the second distance l2 is in the range of 1:1.5 to 1:3. More specifically, the ratio range can also be 1:2.5. Reducing the volume of the rinsing area 54 and increasing the volume of the stain accumulation area 55 can increase the impact force of the water flow on the blood film surface of the sample slide 10, making the stain more thoroughly rinsed. This allows the water flow to move quickly from the smaller rinsing area 54 to the larger stain accumulation area 55, slowing down the water flow speed in the stain accumulation area 55. This allows the stain to accumulate as much as possible in the stain accumulation area 55, making it easier to remove and resulting in a cleaner stain cleaning.

[0062] In a preferred embodiment, such as Figure 2 and Figure 6 As shown, the cleaning chamber 5 also includes a vent 53, which is adjacent to the outer side of the cleaning chamber opening 51. The vent 53 is formed by the outer wall of the guide body and the third side wall 531 or the fourth side wall of the cleaning chamber 5 and communicates with the interior of the cleaning chamber 5. Figure 8 As shown, when too much cleaning fluid is injected or there is another malfunction, and the drainage volume of the overflow port 52 cannot keep up, the overflowed cleaning fluid can flow back into the cleaning chamber 5 through the vent 53 from the gap between the cleaning box mounting plate MP and the sample slide cleaning box CB, thus playing an auxiliary role in drainage.

[0063] In addition, the vent 53 also has the function of assisting in exhaust. When the cleaning fluid in the cleaning chamber 5 is injected into the front of the sample slide 10, the cleaning fluid flows into the small area 11 on both sides of the guide part 6 near the third or fourth side wall (that is, the space between the side of the sample slide 10 in the width direction and the third or fourth side wall), so that the small area 11 is connected to the atmosphere, and the cleaning fluid flows more smoothly into the small area 11 after injection.

[0064] In a more preferred embodiment, such as Figures 3-5 As shown, a cleaning fluid guide surface 7 is also provided inside the cleaning chamber 5, and the cleaning fluid guide surface 7 is located on the inner bottom side of the cleaning chamber 5. The cleaning fluid guide surface 7 is located on the first side wall, that is, it is inclined towards the bottom wall of the cleaning chamber 5 from the side wall where the cleaning injection channel is located towards the opposite side of the cleaning injection channel 1 (that is, towards the back of the sample slide 10); the negative pressure suction channel 2 is located at the lowest point of the cleaning fluid guide surface 7 and communicates with the interior of the cleaning chamber 5.

[0065] The presence of the cleaning fluid guide surface 7 allows the cleaning fluid at the bottom of the cleaning chamber 5 to gather in the stain accumulation area 55 and be drawn away by the negative pressure suction channel 2. On the other hand, it allows the stain to vortex and gather at the bottom of the stain accumulation area 55 and then be quickly drawn away by the negative pressure suction channel 2, resulting in cleaner cleaning and less stain suspension on the front side of the sample slide 10.

[0066] The cleaning fluid guide surface 7 is inclined towards the back of the sample slide 10 and towards the bottom wall of the cleaning chamber 5. The gap between the sample slide 10 and the four side walls and the bottom wall also allows the water flow to carry the washed-down stains to quickly diffuse and discharge to the stain accumulation area 55, thereby improving the stain cleaning rate of the blood film area of ​​the sample slide 10.

[0067] In a more preferred embodiment, the guiding surface of the cleaning fluid guiding surface 7 can be an arc surface or a plane. Both the arc surface and the plane are facing the back of the sample slide 10 and inclined towards the bottom wall of the cleaning chamber 5. The specific choice can be made according to the actual situation, and this embodiment does not limit it.

[0068] like Figure 7 and Figure 8 As shown, a second aspect of the present invention also provides a slide cleaning machine, comprising: a smear module for preparing blood film smears, a staining module for staining blood film smears, and a sample slide cleaning box for cleaning blood film smears, for any one or a combination of the above.

[0069] In a preferred embodiment, the staining module further includes a washing tank, a staining solution tank, and a fixative tank; the sample slide washing box is detachably placed in the washing tank; the washing tank is arranged side by side with the staining solution tank and the fixative tank.

[0070] The slide cleaning machine of the present invention has all the beneficial effects of the sample slide cleaning box of the present invention.

[0071] [Application Scenario 1]

[0072] like Figure 7 As shown, there is a sample slide cleaning box CB, a cleaning tank GC for placing the sample slide cleaning box CB, a staining tank GD, and a fixative tank GH. Figure 8 and Figure 7 The difference is that a mounting plate MP is installed at the opening of the cleaning tank GC. In this application scenario, the fixation tank GH, the dye tank GD, and the cleaning tank GC are arranged side by side along the first direction, and a plurality of sample slide cleaning boxes CB are arranged along the second direction and placed in the cleaning tank GC. The sample slide cleaning boxes CB are first fixed to the mounting plate MP by the mounting positions provided on the top of the third side wall 531 and the fourth side wall, and then placed in the cleaning tank GC together with the mounting plate MP. The mounting plate MP can cover the opening of the cleaning tank GC, and the mounting plate MP has an opening for the overflow cavity 4 of the sample slide cleaning box CB and a reserved opening for the cleaning cavity 51.

[0073] <Instructions for using the sample slide cleaning box>

[0074] The cleaning solution flows in through the cleaning injection channel 1 and is drawn out through the negative pressure extraction channel 2. The overflowing liquid is discharged from the natural overflow port 3. The sample slide 10 is inserted into the cleaning chamber 5 through the first slide insertion port 611 by the gripper, with the front of the sample slide 10 facing the cleaning injection channel 1. After the sample slide 10 is inserted into the cleaning chamber 5, the interior of the cleaning chamber 5 is divided into a smaller rinsing area 54 and a larger stain accumulation area 55, and the sample slide 10 is cleaned by a combination of rinsing and soaking.

[0075] Because stains adhere more easily to the blood film, while the back of sample slide 10 is smooth and has no blood film, making it difficult for stains to adhere, the front of sample slide 10 is cleaned by simulating a tap, while the back of sample slide 10 can be cleaned by soaking and then extracting the liquid. There is no need to design a separate rinse for the back, making the structure simpler, the control simpler, and the cleaning more thorough.

[0076] Based on the sample slide cleaning box provided in the above embodiments, this embodiment also provides a slide-staining machine, which includes a smear module and a staining module; the smear module is used to prepare blood film smears; the staining module is used to stain the blood film smears; and it also includes the sample slide cleaning box in the above embodiments for cleaning the stained blood film smears.

[0077] Furthermore, such as Figure 7-8As shown, the staining module also includes a washing tank GC, a fixative tank GH, and a staining tank GD; the sample slide washing box CB is detachably placed in the washing tank GC; the washing tank, fixative tank GH, and staining tank GD are arranged side by side. The structure is compact and easy to install, forming a matrix-like layout of sample slide insertion positions within the entire staining module, thus reducing the overall size of the staining module.

[0078] Since the sample slide cleaning box provided in the above embodiments has the above-mentioned technical effects, and the above-mentioned slide spreading machine includes the above-mentioned sample slide cleaning box, the above-mentioned slide spreading machine also has the corresponding technical effects, which will not be repeated here.

[0079] The above description of the disclosed embodiments will enable those skilled in the art to implement or use the invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the invention. Therefore, the invention is not to be limited to the embodiments shown herein, but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A sample slide cleaning cassette, characterized by, The sample slide cleaning box comprises a cleaning cavity and a cleaning liquid injection channel connected with the inside of the cleaning cavity, wherein the cleaning cavity is used for accommodating a vertically inserted sample slide, and the sample slide is coated with a blood film on one side facing the cleaning liquid injection channel, the cleaning liquid injection channel is arranged on the first side wall of the cleaning cavity, and is used for injecting cleaning liquid into the cleaning cavity to flush the sample slide; The cleaning liquid injection direction of the cleaning liquid injection channel is inclined towards the bottom of the cleaning cavity, an overflow cavity is arranged on the second side wall opposite to the first side wall, a cleaning liquid flow guide surface inclined towards the second side wall and the bottom is arranged on the inside of the bottom of the cleaning cavity, the lowest point of the cleaning liquid flow guide surface is provided with a negative pressure liquid suction channel in communication with the outside, the distance between the first side wall and the sample slide is a first distance l1, the distance between the second side wall and the sample slide is a second distance l2, the ratio between the first distance l1 and the second distance l2 is 1:1.5-1:3, and the distance between the circumferential side wall and the bottom wall of the cleaning cavity and the sample slide accommodated in the cleaning cavity is greater than 0.

2. The sample slide washing cassette of claim 1, wherein, The cleaning cavity is provided with a guide portion, the guide portion comprises a guide insertion port for the sample slide to pass through, so as to guide and stabilize the sample slide accommodated in the cleaning cavity.

3. The slide cleaning cassette of claim 1, wherein, The overflow cavity is arranged on the side of the second side wall away from the first side wall, an overflow port is arranged on the second side wall, so as to overflow the excess liquid in the cleaning cavity to the overflow cavity through the overflow port, and a natural overflow port is arranged at the bottom of the overflow cavity.

4. The sample slide washing cassette of claim 2, wherein, The guide portions are respectively arranged on the third side wall and the fourth side wall adjacent to the first side wall of the cleaning cavity, and the guide portions are respectively connected with at least one of the first side wall, the second side wall, the third side wall and the fourth side wall, wherein each side of the guide portion comprises a first guide portion and a second guide portion, the first guide portion comprises a first insertion port for guiding, and the second guide portion comprises a second insertion port for guiding; the first insertion port and the second insertion port are coaxially arranged in the vertical direction.

5. The slide cleaning cassette of claim 4, wherein, The first guide portion and the second guide portion are coaxially arranged in the vertical direction, and the first guide portion and the second guide portion are discontinuously arranged.

6. The slide cleaning cassette of claim 4 or 5, wherein, The first guide portion is connected with the first side wall and the second side wall respectively, and the second guide portion is connected with the first side wall and the second side wall respectively.

7. The slide cleaning cassette of claim 6, wherein, The cleaning cavity is further provided with a bottom bearing portion for supporting the sample slide, the bottom bearing portion comprises a third insertion port for guiding, the third insertion port is coaxially arranged with the second insertion port and the first insertion port respectively, wherein the opening diameter of the first insertion port is smaller than the opening diameter of the second insertion port, and the opening diameter of the third insertion port is smaller than the opening diameter of the second insertion port.

8. The sample slide washing cassette of claim 1, wherein, The included angle between the cleaning liquid injection direction of the cleaning liquid injection channel and the center line of the sample slide accommodated in the cleaning cavity ranges from 30° to 45°.

9. The slide cleaning cassette of claim 1, wherein, The cleaning liquid injection channel comprises a first cleaning liquid injection channel and a second cleaning liquid injection channel, which are arranged side by side at the same horizontal level.

10. The sample slide washing cassette of claim 2, wherein, The cleaning cavity further comprises air vents arranged on both sides of the guiding part of the cleaning cavity, which are surrounded by the third and fourth side walls adjacent to the first side wall of the cleaning cavity and the main body of the guiding part and communicate with the inside of the cleaning cavity.

11. The sample slide washing cassette of claim 1, wherein, The cleaning liquid flow guide surface is inclined towards the opposite side of the cleaning liquid injection channel and the bottom of the cleaning cavity.

12. The sample slide washing cassette of claim 11, wherein, The flow guide surface of the cleaning liquid flow guide surface is an arc surface or a plane.

13. A push-dyeing slide machine, characterized in that, comprising: a smearing module for preparing a blood film smear; a dyeing module for dyeing the blood film smear; and further comprising at least one sample slide cleaning box according to any one of claims 1-12 for cleaning the blood film smear.

14. The push-dyeing slide machine according to claim 13, characterized in that, the dyeing module further comprises a cleaning tank, a dyeing tank and a fixing tank; the sample slide cleaning box is detachably placed in the cleaning tank; the cleaning tank is arranged side by side with the dyeing tank and the fixing tank.

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