Silica aerogel loaded ivermectin drug-loaded particle processing line

Abstract

The application belongs to the field of anti-parasitic drugs, especially a silica aerogel loaded ivermectin drug-loaded particle processing production line. The existing problems of the need to transport the prepared drug-loaded solid, complicated operation, the need for multiple power devices to stir, mix, high cost, incomplete discharge and complicated operation are solved. The scheme comprises a first mixing box and a collecting box, the outer wall of the first mixing box is fixedly connected with three support rods, the collecting box is located directly below the first mixing box, and the top of the first mixing box is fixedly communicated with a hollow circular table cylinder. In the application, the stirring assembly can fully stir the material, the first mixing box and the second mixing box utilize the power of one servo motor, the cost is greatly reduced, the first support block and the second support block can be lifted by the lifting assembly, the feeding and discharging process is completed, and the loading and unloading are not needed, so the work load is greatly reduced.

Description

Technical Field

[0001] This invention relates to the field of antiparasitic drug technology, and more particularly to a production line for processing ivermectin-loaded particles supported on silica aerogel. Background Technology

[0002] Animal parasitic diseases are common in my country's livestock industry, with numerous types and wide distribution, causing significant harm to livestock farming. Among antiparasitic drugs, ivermectin is effective against both internal and external parasites, exhibiting good killing effects against internal nematodes and external arthropods. Ivermectin is an abamectin derivative, belonging to the macrolide antibiotic class. It is highly lipid-soluble, almost insoluble in water, and possesses characteristics of high efficacy, broad spectrum, low toxicity, and no cross-resistance, providing good preventive and therapeutic effects against internal and external parasitic diseases in livestock and poultry.

[0003] The invention with announcement number CN111991357A belongs to the field of antiparasitic drug formulations, specifically involving ivermectin-loaded particles supported on silica aerogel. The preparation method includes the following steps: (1) dissolving ivermectin in a low-boiling-point organic solvent to prepare a saturated ivermectin solution; (2) dispersing silica aerogel powder in the saturated ivermectin solution, stirring under reflux to remove the solvent, and obtaining ivermectin-loaded particles supported on silica aerogel; the low-boiling-point organic solvent is one or more of chloroform, ethyl acetate, methanol, acetone, and ethanol. This invention loads ivermectin onto porous silica aerogel, resulting in a large drug loading capacity and a smooth curve in in vitro sustained-release tests.

[0004] This method requires two mixing devices and has the following drawbacks;

[0005] 1. The prepared drug-loaded solid needs to be transferred, which is a cumbersome operation;

[0006] 2. Multiple power units are required to stir and mix the components, resulting in higher costs.

[0007] 3. The discharge is not complete and the operation is cumbersome. Therefore, we propose a silica aerogel-loaded ivermectin drug-loaded particle processing production line to solve the above-mentioned problems. Summary of the Invention

[0008] The purpose of this invention is to address the shortcomings of existing technologies, such as the need to transfer the prepared drug-loaded solid, cumbersome operation, the need for multiple power devices to stir and mix the equipment, high cost, incomplete material discharge, and complicated operation. The invention proposes a silica aerogel-loaded ivermectin drug-loaded particle processing production line.

[0009] To achieve the above objectives, the present invention adopts the following technical solution:

[0010] A production line for processing ivermectin-loaded particles supported by silica aerogel includes a first mixing chamber and a collecting chamber. Three support rods are fixedly connected to the outer wall of the first mixing chamber. The collecting chamber is located directly below the first mixing chamber. A hollow frustum is fixedly connected to the top of the first mixing chamber. A second mixing chamber is fixedly connected to the top of the hollow frustum. Two symmetrically arranged arc-shaped plates are fixedly connected to the top of the second mixing chamber. The tops of the two arc-shaped plates are fixedly connected to the same top plate. A sliding sleeve slides through the inner wall of the top plate. A stirring component for stirring materials is provided inside the sliding sleeve.

[0011] One side of one of the arc-shaped plates is fixedly connected to a fixing plate, and the fixing plate is provided with a lifting assembly for driving the sliding sleeve to rise and fall.

[0012] Preferably, the stirring assembly includes a first rotating shaft that rotates through a sliding sleeve, a plurality of stirring blades are fixedly sleeved on the outer wall of the first rotating shaft, a first support block and a second support block are fixedly sleeved on the outer wall of the first rotating shaft, the second support block is used in conjunction with a first mixing box, the first support block is used in conjunction with a hollow frustum cylinder, and a first spur gear is fixedly connected to the top of the first rotating shaft for stirring materials and improving working efficiency.

[0013] Preferably, the lifting assembly includes an electromagnetic clutch fixedly sleeved inside a fixed plate. The two output shafts of the electromagnetic clutch are respectively fixedly connected to a second rotating rod and a first rotating rod. A fifth spur gear is fixedly sleeved on the outer wall of the first rotating rod. A connecting plate is fixedly connected to one side of the sliding sleeve, and a rack is fixedly connected to one side of the connecting plate. The rack meshes with the fifth spur gear to drive the sliding sleeve to rise and fall, thereby driving the first support block and the second support block to rise and fall, completing the feeding and discharging process.

[0014] Preferably, a first bevel gear is fixedly sleeved on the outer wall of the second rotating rod, and a servo motor is fixedly connected to the top of the top plate. The output shaft of the servo motor rotates through the top plate and is fixedly sleeved with a fourth spur gear and a second bevel gear. The second bevel gear meshes with the first bevel gear and is used to drive the first bevel gear to rotate using the power of the servo motor, thereby controlling the feeding and discharging of materials.

[0015] Preferably, the inner wall of the top plate is rotatably connected by a second rotating shaft, and the outer wall of the second rotating shaft is fixedly fitted with a third spur gear that meshes with a fourth spur gear. The outer wall of the second rotating shaft is also fixedly fitted with a second spur gear that meshes with a first spur gear, which is used to transmit the power of the servo motor to the first spur gear and reduce costs.

[0016] Preferably, a slide rod is fixedly connected to the top of the rack, and the top of the slide rod slides through the top plate and is fixedly connected to a limit block to prevent the rack from falling off.

[0017] Preferably, the thickness of the first spur gear is greater than that of the second spur gear.

[0018] Preferably, both the outer walls of the first support block and the second support block are provided with sealing rings to improve the sealing performance of the device.

[0019] Compared with the prior art, the beneficial effects of the present invention are:

[0020] 1. Methanol is added to the second mixing chamber, ethanol is added to the first mixing chamber, and silica aerogel powder is added to the second mixing chamber. The servo motor is started, and the output shaft of the servo motor drives the fourth spur gear and the second bevel gear to rotate. The fourth spur gear drives the third spur gear to rotate, the third spur gear drives the second shaft to rotate, the second shaft drives the second spur gear to rotate, the second spur gear drives the first spur gear to rotate, the first spur gear drives the first shaft to rotate, and the first shaft drives multiple stirring blades to rotate. This allows the raw materials to be fully mixed, so that the silica aerogel powder is dispersed in methanol. The mixture is stirred under heating and reflux to remove the solvent and obtain a drug-loaded solid.

[0021] 2. When the electromagnetic clutch is energized, the second bevel gear drives the first bevel gear to rotate, the first bevel gear drives the second rotating rod to rotate, the second rotating rod drives the first rotating rod to rotate, the first rotating rod drives the fifth spur gear to rotate, the fifth spur gear drives the rack to move vertically upward, the rack drives the connecting plate to move vertically upward, the rack drives the sliding sleeve to move vertically upward, the sliding sleeve drives the first rotating shaft to move vertically upward, and the first rotating shaft drives the first support block and the second support block to move vertically upward. At this time, the drug-loaded solid inside the second mixing box directly enters the inside of the first mixing box.

[0022] 3. Reset the device and continue stirring. After stirring is complete, drug-loaded particles are obtained. Then, start the servo motor in reverse. At this time, the first and second support blocks move vertically downwards, and the material is discharged. The next operation can then be carried out. It is convenient to use, does not require transportation, and greatly reduces the workload.

[0023] In this invention, by setting up a stirring component, the materials can be thoroughly stirred. Furthermore, the first and second mixing boxes utilize the power of a servo motor, which significantly reduces costs. Additionally, the lifting component can drive the first and second support blocks to rise and fall, completing the feeding and discharging process. At the same time, there is no need for loading and unloading, which greatly reduces the workload and makes it convenient to use. Attached Figure Description

[0024] Figure 1This is a first-view three-dimensional structural schematic diagram of the ivermectin drug-loaded particle processing production line supported by silica aerogel proposed in this invention.

[0025] Figure 2 This is a two-dimensional structural schematic diagram of the silica aerogel-loaded ivermectin drug-loaded particle processing production line proposed in this invention, from a second perspective.

[0026] Figure 3 This is a three-dimensional cross-sectional view of the first mixing box and the second mixing box in this invention;

[0027] Figure 4 This is a schematic diagram of the structure of the first spur gear and the second spur gear in this invention;

[0028] Figure 5 This is a schematic diagram of the structure of the first rotating shaft and the sliding sleeve in this invention;

[0029] Figure 6 This is a schematic diagram of the servo motor and rack in this invention;

[0030] Figure 7 This is a schematic diagram of the structure of the first bevel gear and the second bevel gear in this invention.

[0031] In the diagram: 1. Collection box; 2. Support rod; 3. First mixing box; 4. Second mixing box; 5. Arc plate; 6. Top plate; 7. First spur gear; 8. Second spur gear; 9. First rotating shaft; 10. Hollow cylindrical drum; 11. Stirring blade; 12. Second rotating shaft; 13. Sliding sleeve; 14. First support block; 15. Second support block; 16. Servo motor; 17. Fixing plate; 18. First bevel gear; 19. Rack; 20. Third spur gear; 21. Fourth spur gear; 22. Second bevel gear; 23. Electromagnetic clutch; 24. Connecting plate; 25. Slide rod; 26. Limiting block; 27. First rotating rod; 28. Fifth spur gear; 29. ​​Second rotating rod. Detailed Implementation

[0032] The technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments.

[0033] Example 1

[0034] Reference Figure 1-7A production line for processing ivermectin-loaded particles supported by silica aerogel includes a first mixing chamber 3 and a collecting chamber 1. Three support rods 2 are fixedly connected to the outer wall of the first mixing chamber 3. The collecting chamber 1 is located directly below the first mixing chamber 3. A hollow frustum cylinder 10 is fixedly connected to the top of the first mixing chamber 3. A second mixing chamber 4 is fixedly connected to the top of the hollow frustum cylinder 10. Two symmetrically arranged arc-shaped plates 5 are fixedly connected to the top of the second mixing chamber 4. The tops of the two arc-shaped plates 5 are fixedly connected to the same top plate 6, and the inner wall of the top plate 6 slides through it. There is a sliding sleeve 13, and a stirring assembly for stirring materials is provided inside the sliding sleeve 13. The stirring assembly includes a first rotating shaft 9 that rotates through the sliding sleeve 13. Multiple stirring blades 11 are fixedly sleeved on the outer wall of the first rotating shaft 9. A first support block 14 and a second support block 15 are fixedly sleeved on the outer wall of the first rotating shaft 9. The second support block 15 is used in conjunction with the first mixing box 3. The first support block 14 is used in conjunction with the hollow frustum cylinder 10. A first spur gear 7 is fixedly connected to the top of the first rotating shaft 9 for stirring materials and improving working efficiency.

[0035] One side of one of the arc-shaped plates 5 is fixedly connected to a fixed plate 17. The fixed plate 17 is equipped with a lifting assembly for driving the sliding sleeve 13 to rise and fall. The lifting assembly includes an electromagnetic clutch 23 fixedly sleeved inside the fixed plate 17. The two output shafts of the electromagnetic clutch 23 are respectively fixedly connected to a second rotating rod 29 and a first rotating rod 27. A fifth spur gear 28 is fixedly sleeved on the outer wall of the first rotating rod 27. A connecting plate 24 is fixedly connected to one side of the sliding sleeve 13. A rack 19 is fixedly connected to one side of the connecting plate 24. The rack 19 meshes with the fifth spur gear 28 to drive the sliding sleeve 13 to rise and fall, thereby driving the first support block 14 and the second support block 15 to rise and fall, completing the feeding and discharging process.

[0036] Example 2

[0037] Reference Figure 1-7A production line for processing ivermectin-loaded particles supported by silica aerogel includes a first mixing chamber 3 and a collecting chamber 1. Three support rods 2 are fixedly connected to the outer wall of the first mixing chamber 3. The collecting chamber 1 is located directly below the first mixing chamber 3. A hollow frustum cylinder 10 is fixedly connected to the top of the first mixing chamber 3. A second mixing chamber 4 is fixedly connected to the top of the hollow frustum cylinder 10. Two symmetrically arranged arc-shaped plates 5 are fixedly connected to the top of the second mixing chamber 4. The tops of the two arc-shaped plates 5 are fixedly connected to the same top plate 6, and the inner wall of the top plate 6 slides through it. There is a sliding sleeve 13, and a stirring assembly for stirring materials is provided inside the sliding sleeve 13. The stirring assembly includes a first rotating shaft 9 that rotates through the sliding sleeve 13. Multiple stirring blades 11 are fixedly sleeved on the outer wall of the first rotating shaft 9. A first support block 14 and a second support block 15 are fixedly sleeved on the outer wall of the first rotating shaft 9. The second support block 15 is used in conjunction with the first mixing box 3. The first support block 14 is used in conjunction with the hollow frustum cylinder 10. A first spur gear 7 is fixedly connected to the top of the first rotating shaft 9 for stirring materials and improving working efficiency.

[0038] One side of one of the arc-shaped plates 5 is fixedly connected to a fixed plate 17. The fixed plate 17 contains a lifting assembly for driving the sliding sleeve 13 to rise and fall. The lifting assembly includes an electromagnetic clutch 23 fixedly fitted inside the fixed plate 17. The two output shafts of the electromagnetic clutch 23 are respectively fixedly connected to a second rotating rod 29 and a first rotating rod 27. A fifth spur gear 28 is fixedly fitted onto the outer wall of the first rotating rod 27. A connecting plate 24 is fixedly connected to one side of the sliding sleeve 13. A rack 19 is fixedly connected to one side of the connecting plate 24. The rack 19 meshes with the fifth spur gear 28 to drive the sliding sleeve 13 to rise and fall, thereby driving the first support block 14 and the second support block 15 to rise and fall, completing the feeding and discharging process. A first bevel gear 18 is fixedly fitted onto the outer wall of the second rotating rod 29. A servo motor 16 is fixedly connected to the top of the top plate 6. The output shaft of the servo motor 16 rotates through the top plate 6 and is fixed... A fourth spur gear 21 and a second bevel gear 22 are fixedly mounted. The second bevel gear 22 meshes with the first bevel gear 18 and is used to drive the first bevel gear 18 to rotate using the power of the servo motor 16, thereby controlling the feeding and discharging of materials. A second rotating shaft 12 is rotatably passed through the inner wall of the top plate 6. A third spur gear 20 that meshes with the fourth spur gear 21 is fixedly mounted on the outer wall of the second rotating shaft 12. A second spur gear 8 that meshes with the first spur gear 7 is also fixedly mounted on the outer wall of the second rotating shaft 12. This is used to transmit the power of the servo motor 16 to the first spur gear 7, reducing costs. A slide rod 25 is fixedly connected to the top of the rack 19. The top of the slide rod 25 slides through the top plate 6 and is fixedly connected to a limit block 26 to prevent the rack 19 from falling off. The thickness of the first spur gear 7 is greater than that of the second spur gear 8. Sealing rings are provided on the outer walls of the first support block 14 and the second support block 15 to improve the sealing performance of the device.

[0039] Working principle: During use, methanol is added to the second mixing chamber 4, ethanol is added to the first mixing chamber 3, and silica aerogel powder is added to the second mixing chamber 4. The servo motor 16 is started, and its output shaft drives the fourth spur gear 21 and the second bevel gear 22 to rotate. The fourth spur gear 21 drives the third spur gear 20 to rotate, which in turn drives the second rotating shaft 12 to rotate. The second rotating shaft 12 drives the second spur gear 8 to rotate, which in turn drives the first spur gear 7 to rotate. The first spur gear 7 then drives the first rotating shaft 9 to rotate, which in turn drives multiple stirring blades 11 to rotate. This allows for thorough mixing of the raw materials, dispersing the silica aerogel powder in the methanol. Stirring is performed under reflux heating to remove the solvent and obtain a drug-loaded solid. The electromagnetic clutch 23 is then energized, causing the second bevel gear 22 to drive the first bevel gear 11... Rotating the first bevel gear 18 drives the second rotating rod 29 to rotate, which in turn drives the first rotating rod 27 to rotate. The first rotating rod 27 then drives the fifth spur gear 28 to rotate, which in turn drives the rack 19 to move vertically upward. The rack 19 then drives the connecting plate 24 to move vertically upward, which in turn drives the sliding sleeve 13 to move vertically upward. The sliding sleeve 13 then drives the first rotating shaft 9 to move vertically upward, which in turn drives the first support block 14 and the second support block 15 to move vertically upward. At this point, the drug-loaded solid inside the second mixing box 4 directly enters the first mixing box 3. The device is then reset, and stirring continues. After stirring is complete, drug-loaded particles are obtained. The servo motor 16 is then started in reverse. At this point, the first support block 14 and the second support block 15 move vertically downward, and the material is discharged, allowing for the next operation. This method is convenient to use, eliminates the need for transfer, and significantly reduces workload.

[0040] However, as is well known to those skilled in the art, the working principle and wiring method of the servo motor 16 and the electromagnetic clutch 23 are commonplace and are all conventional methods or common knowledge. They will not be described in detail here. Those skilled in the art can make any selections according to their needs or convenience.

[0041] The above description is only a preferred embodiment of the present invention, but the scope of protection of the present invention is not limited thereto. Any equivalent substitutions or modifications made by those skilled in the art within the scope of the technology disclosed in the present invention, based on the technical solution and inventive concept of the present invention, should be covered within the scope of protection of the present invention.

Claims

1. A production line for processing ivermectin-loaded particles supported on silica aerogel, comprising a first mixing chamber (3) and a collecting chamber (1), wherein three support rods (2) are fixedly connected to the outer wall of the first mixing chamber (3), characterized in that, The collection box (1) is located directly below the first mixing box (3). The top of the first mixing box (3) is fixedly connected to a hollow truncated cone (10). The top of the hollow truncated cone (10) is fixedly connected to a second mixing box (4). The top of the second mixing box (4) is fixedly connected to two symmetrically arranged arc plates (5). The tops of the two arc plates (5) are fixedly connected to the same top plate (6). The inner wall of the top plate (6) is slidably penetrated by a sliding sleeve (13). The interior of the sliding sleeve (13) is provided with a stirring component for stirring materials. One of the arc-shaped plates (5) is fixedly connected to a fixed plate (17) on one side, and the fixed plate (17) is provided with a lifting assembly for driving the sliding sleeve (13) to rise and fall. The stirring assembly includes a first rotating shaft (9) that rotates through a sliding sleeve (13). A plurality of stirring blades (11) are fixedly sleeved on the outer wall of the first rotating shaft (9). A first support block (14) and a second support block (15) are fixedly sleeved on the outer wall of the first rotating shaft (9). The second support block (15) is used in conjunction with a first mixing box (3). The first support block (14) is used in conjunction with a hollow frustum cylinder (10). A first spur gear (7) is fixedly connected to the top of the first rotating shaft (9). The lifting assembly includes an electromagnetic clutch (23) fixedly sleeved inside a fixed plate (17). The two output shafts of the electromagnetic clutch (23) are respectively fixedly connected to a second rotating rod (29) and a first rotating rod (27). A fifth spur gear (28) is fixedly sleeved on the outer wall of the first rotating rod (27). A connecting plate (24) is fixedly connected to one side of the sliding sleeve (13). A rack (19) is fixedly connected to one side of the connecting plate (24). The rack (19) meshes with the fifth spur gear (28). The outer wall of the second rotating rod (29) is fixedly fitted with a first bevel gear (18), and the top of the top plate (6) is fixedly connected with a servo motor (16). The output shaft of the servo motor (16) rotates through the top plate (6) and is fixedly fitted with a fourth spur gear (21) and a second bevel gear (22). The second bevel gear (22) meshes with the first bevel gear (18). The inner wall of the top plate (6) is rotatably connected by a second rotating shaft (12). The outer wall of the second rotating shaft (12) is fixedly fitted with a third spur gear (20) that meshes with the fourth spur gear (21). The outer wall of the second rotating shaft (12) is fixedly fitted with a second spur gear (8) that meshes with the first spur gear (7).

2. The production line for processing ivermectin-loaded particles supported on silica aerogel according to claim 1, characterized in that, The top of the rack (19) is fixedly connected to a slide rod (25), the top of the slide rod (25) slides through the top plate (6) and is fixedly connected to a limit block (26).

3. The production line for processing ivermectin-loaded particles supported on silica aerogel according to claim 1, characterized in that, The thickness of the first spur gear (7) is greater than that of the second spur gear (8).

4. The production line for processing ivermectin-loaded particles supported on silica aerogel according to claim 1, characterized in that, The outer walls of the first support block (14) and the second support block (15) are both provided with sealing rings.

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