An electronic non-affinity friction nanogenerator and a heart disease detector and a preparation method thereof

Abstract

The present application relates to the technical field of medical devices, in particular to an electronic non-affinity friction nanogenerator and a heart disease detector and a preparation method thereof. The generator comprises a first friction layer, a second friction layer, a first electrode and a second electrode; by adjusting the composition of the same material, the electron gain and loss ability of the material is changed, the first friction layer and the second friction layer are made of the same material, and the composition of the material used by the first friction layer and the second friction layer is different, so that the electron gain and loss ability of the first friction layer and the second friction layer is different, thereby realizing electronic non-affinity friction nanogeneration, using the high sensitivity to pressure to extract the characteristic signal points of the pulse wave, realizing the function of self-powered single-point detection of human heart rate, diastolic pressure and systolic pressure; in addition, it is sensitive and high, and can detect the subtle changes of the pulse wave, and since the pulse wave of a patient with heart disease is different from the normal pulse wave, it can be applied to the preparation of a heart disease detector.

Description

Technical Field

[0001] This invention relates to the field of medical device technology, and in particular to an electronic non-affinity triboelectric nanogenerator and a heart disease detector, and its preparation method. Background Technology

[0002] With social development and improved living standards, people are paying more and more attention to their health. Blood pressure monitors are one of the commonly used methods for health monitoring and play an important role in monitoring people's health. Portable electronic blood pressure monitors are also gradually entering people's lives.

[0003] Currently, most portable electronic blood pressure monitors on the market use the oscillometric method to measure blood pressure. This method requires applying a certain pressure to the blood vessel. When the applied pressure is higher than the heart's systolic pressure, the pressure is slowly released, and the blood pressure value is obtained during the pressure release process. Blood vessels need time to recover their original elasticity after being subjected to pressure, and the blood pressure value measured after the blood vessels have recovered is accurate. Therefore, this method is not suitable for continuous blood pressure measurement.

[0004] Modern smartwatches can also measure blood pressure, primarily using photoplethysmography (PPG). A light beam is shone onto the skin; components in the blood absorb the light. A photodetector analyzes the transmitted or reflected light to determine the blood pressure value. While this method can continuously measure blood pressure, the resulting readings have a relatively large margin of error. Furthermore, both of these commonly used methods are battery-dependent, requiring a power source. Additionally, it's well known that people with heart disease not only experience abnormal blood pressure readings but also abnormal pulse waveforms. Since the two commonly used methods cannot capture these pulse waveform changes, they cannot detect subtle changes in the pulse wave to assess heart disease. Summary of the Invention

[0005] To address the shortcomings of existing technologies, namely the oscillometric method for measuring blood pressure is not suitable for continuous measurement, and the large error in blood pressure readings using photoplethysmography, both of which rely on batteries for power, this invention proposes an electron-affinity-insensitive triboelectric nanogenerator. The technical solution is as follows:

[0006] The electronic non-affinity triboelectric nanogenerator provided by this invention includes:

[0007] First friction layer and second friction layer: The first friction layer and the second friction layer are arranged at a relative interval to form a hollow structure between them;

[0008] First electrode: It is disposed on the upper surface of the first friction layer away from the second friction layer;

[0009] Second electrode: It is disposed on the lower surface of the second friction layer away from the first friction layer;

[0010] The first friction layer and the second friction layer are made of the same material, but the composition of the materials used in the first friction layer and the second friction layer is different, so that the first friction layer and the second friction layer have different electron gain and loss capabilities; when an external force is applied to the first friction layer and / or the second friction layer, the first friction layer and the second friction layer come into contact with each other; when the external force is released, the first friction layer and the second friction layer separate to form the hollow structure.

[0011] In one embodiment, the first friction layer and the second friction layer are made of polyimide film.

[0012] In one embodiment, the first electrode and / or the second electrode is a transparent metal nanowire network layer formed by metal nanowire deposition.

[0013] In one embodiment, the first friction layer is a Kapton film, and the second friction layer is a PI film.

[0014] In one embodiment, the lower surface of the first friction layer is opposite to the upper surface of the second friction layer, and the edges of the first friction layer and the edges of the second friction layer are separated by a partition, so that the hollow structure is formed between the first friction layer and the second friction layer.

[0015] This invention also provides a method for preparing an electron-affinity-insensitive triboelectric nanogenerator as described above, comprising the following steps:

[0016] Polyimide films of different compositions are respectively made into a first friction layer and a second friction layer;

[0017] Metal nanowires are transferred to the upper surface of the first friction layer and the lower surface of the second friction layer, respectively, so that the metal nanowire network located on the upper surface of the first friction layer forms the first electrode, and the metal nanowire network located on the lower surface of the second friction layer forms the second electrode.

[0018] By placing the lower surface of the first friction layer opposite to the upper surface of the second friction layer, and setting partitions on both sides of the first and second friction layers to separate them into a hollow structure, a triboelectric nanogenerator is obtained.

[0019] In one embodiment, metal nanowires are deposited onto the upper surface of the first friction layer and the lower surface of the second friction layer using nanoimprinting technology.

[0020] The present invention also provides a blood pressure monitor, comprising a triboelectric nanogenerator, connecting electrodes, and an external circuit board; the triboelectric nanogenerator is used to generate a voltage signal according to changes in pulse wave; the first and second electrodes of the triboelectric nanogenerator are electrically connected to the external circuit board via connecting electrodes, so that the voltage signal of the triboelectric nanogenerator is converted by the external circuit board and transmitted to a receiving terminal electrically connected to the external circuit board, and the receiving terminal converts it into blood pressure information; the triboelectric nanogenerator is a triboelectric nanogenerator as described above; or, a triboelectric nanogenerator prepared by the preparation method of the triboelectric nanogenerator as described above.

[0021] The present invention also provides a heart disease detection device, which includes a blood pressure monitor; the blood pressure monitor is the same as described above.

[0022] The present invention also provides an application of a triboelectric nanogenerator in the preparation of a heart disease detection device, wherein the triboelectric nanogenerator is a triboelectric nanogenerator as described above; or, a triboelectric nanogenerator prepared by the method described above.

[0023] Based on the above, compared with the prior art, the present invention has the following beneficial effects:

[0024] The electronic non-affinity triboelectric nanogenerator provided by this invention utilizes the high sensitivity of this triboelectric nanogenerator to pressure to extract characteristic signal points of the pulse wave. Combined with an artificial neural network, it establishes the relationship between pulse wave characteristic parameters and blood pressure, achieving a self-powered single-point detection function for human heart rate, diastolic blood pressure, and systolic blood pressure. Its high sensitivity ensures the accuracy of its detection of pulse wave changes, thereby guaranteeing the data accuracy of the single-point detection function for human heart rate, diastolic blood pressure, and systolic blood pressure. It has a self-powered characteristic; due to the characteristics of this triboelectric nanogenerator, no external power supply is required for measurement, making the blood pressure monitor made from it a passive blood pressure monitor. It can not only detect human blood pressure but also detect subtle changes in the pulse waveform. Because it has both blood pressure detection and pulse waveform subtle change detection functions, it can be applied to the preparation of cardiac disease detection instruments.

[0025] In addition, it is highly sensitive and can detect subtle changes in pulse waves. Since the pulse waveform of patients with heart disease is different from that of normal pulse waveforms, it can be used to develop heart disease detection instruments.

[0026] Other features and beneficial effects of the invention will be set forth in the following description, and will be apparent in part from the description, or may be learned by practicing the invention. The objects and other beneficial effects of the invention can be realized and obtained by means of the structures particularly pointed out in the description, claims and drawings. Attached Figure Description

[0027] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort. Unless otherwise specified, the positional relationships shown in the drawings in the following description are based on the direction in which the components are drawn in the figure.

[0028] Figure 1 A partial structural decomposition diagram of a triboelectric nanogenerator in one embodiment of the present invention;

[0029] Figure 2 A schematic diagram of the structure of a triboelectric nanogenerator in one embodiment of the present invention;

[0030] Figure 3 A schematic diagram of the usage process of a self-powered blood pressure monitor based on a triboelectric nanogenerator in one embodiment of the present invention;

[0031] Figure 4 A physical image of the transparent triboelectric nanogenerator prepared in Experiment 1 of this invention;

[0032] Figure 5 The triboelectric nanogenerator prepared in Experiment 1 of this invention was used in 10 -3 A curve of the voltage generated under the pressure of N;

[0033] Figure 6 The curve showing the effect of different pressures on the electrical energy generated by the triboelectric nanogenerator prepared in Experiment 1 of this invention.

[0034] Figure 7 Open-circuit voltage curve of the triboelectric nanogenerator prepared in Experiment 1 for the present invention;

[0035] Figure 8 The short-circuit current curve of the triboelectric nanogenerator prepared in Experiment 1 provided for this invention;

[0036] Figure 9 The pulse waveform of the human body before exercise was measured by the triboelectric nanogenerator prepared in Experiment 1 of this invention (the right figure is a partial magnified view);

[0037] Figure 10 The pulse waveform of the human body after exercise was measured by the triboelectric nanogenerator prepared in Experiment 1 of this invention (the right figure is a partial magnified view).

[0038] Figure 11A comparison of the Fourier transform infrared (FTIR) spectra of PI and Kapton materials used in Experiment 1 of this invention.

[0039] Figure label:

[0040] 100 First electrode 200 Second electrode 300 First friction layer

[0041] 400 Second friction layer 500 Spare plate 600 Connecting electrode Detailed Implementation

[0042] To make the objectives, technical solutions, and advantages of the embodiments of the present invention clearer, the technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. The technical features designed in the different embodiments of the present invention described below can be combined with each other as long as they do not conflict with each other. All other embodiments obtained by those skilled in the art based on the embodiments of the present invention without creative effort are within the scope of protection of the present invention.

[0043] In the description of this invention, it should be noted that all terms used in this invention (including technical and scientific terms) have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains, and should not be construed as limiting the invention; it should be further understood that the terms used in this invention should be understood to have the same meaning as those in the context of this specification and in the relevant field, and should not be understood in an idealized or overly formal sense, except as expressly defined in this invention.

[0044] This invention provides a blood pressure monitor, the technical solution of which is as follows:

[0045] It includes, for example Figure 1-2 The embodiment illustrates an electronically incompatible triboelectric nanogenerator, a connecting electrode 600, and an external circuit board. The triboelectric nanogenerator generates a voltage signal based on pulse wave changes. The first electrode 100 and the second electrode 200 of the triboelectric nanogenerator are electrically connected to the external circuit board via the connecting electrode 600, so that the voltage signal from the triboelectric nanogenerator is converted by the external circuit board and transmitted to a receiving terminal electrically connected to the external circuit board. The receiving terminal converts this signal into blood pressure information. Preferably, the blood pressure monitor also includes an energy storage element; the triboelectric nanogenerator converts externally applied mechanical energy into voltage, and the energy storage element stores the electrical energy converted from the triboelectric nanogenerator and powers the receiving terminal.

[0046] Among them, the triboelectric nanogenerator includes:

[0047] First friction layer 300 and second friction layer 400: The first friction layer 300 and the second friction layer 400 are arranged at a distance from each other to form a hollow structure between them;

[0048] First electrode 100: It is disposed on the upper surface of the first friction layer 300 away from the second friction layer 400;

[0049] Second electrode 200: It is disposed on the lower surface of the second friction layer 400 away from the first friction layer 300;

[0050] The first friction layer 300 and the second friction layer 400 are made of the same material, but the compositions of the materials used in the first friction layer 300 and the second friction layer 400 are different, so that the electron gain and loss capabilities of the first friction layer 300 and the second friction layer 400 are different. When an external force is applied to the first friction layer 300 and / or the second friction layer 400, the first friction layer 300 and the second friction layer 400 come into contact with each other. When the external force is released, the first friction layer 300 and the second friction layer 400 separate to form the hollow structure. Preferably, for the hollow structure, the lower surface of the first friction layer 300 is opposite to the upper surface of the second friction layer 400, and the edges of the first friction layer 300 and the edges of the second friction layer 400 are separated by a partition 500, so that the hollow structure is formed between the first friction layer 300 and the second friction layer 400.

[0051] Regarding the material selection for each structure, preferably, the first friction layer 300 and the second friction layer 400 are made of polyimide film; more preferably, the first friction layer 300 is a Kapton film and the second friction layer 400 is a PI film. Preferably, the first electrode 100 and / or the second electrode 200 are transparent metal nanowire network layers deposited from metal nanowires; more preferably, the metal nanowires are copper nanowires. Preferably, the separator 500 is made of PI double-sided adhesive. Preferably, the connecting electrode 600 is a thin strip-shaped metal electrode.

[0052] Specifically, the process and principle of using the above-mentioned electron-affinity-insensitive triboelectric nanogenerator are as follows:

[0053] This triboelectric nanogenerator relies on the coupling effect of contact electrification and electrostatic induction. When an external force is applied to the first friction layer 300 and / or the second friction layer 400, the first and second friction layers 300 come into contact with each other. Due to the different material compositions of the first and second friction layers 300 and 400, their electron-gaining and loss capabilities differ. One friction layer tends to gain electrons, while the other tends to lose electrons, resulting in surface charges of opposite signs on the surfaces of the two contacting friction layers. When no external force is applied or when the external force is released, the first and second friction layers 300 are in a neutral state. Figure 1-2 In the separated state, a hollow structure forms between the two electrodes. This hollow structure creates a small air gap, inducing a potential difference between the two electrodes. To balance this electrostatic field, electrons flow from one electrode to the other through an external circuit, creating a reverse potential difference. This generates a current in the external circuit until equilibrium is reached. Similarly, when the contact surfaces of the two friction layers re-contact, electrons flow back through the external circuit, generating a reverse current.

[0054] A self-powered blood pressure monitor based on a triboelectric nanogenerator includes a triboelectric nanogenerator, a connecting electrode 600, and an external circuit board; the triboelectric nanogenerator is electrically connected to the external circuit board via the connecting electrode 600 (e.g., Figure 2 As shown, a thin strip-shaped metal electrode (600) is disposed on the upper side of the copper nanowire network layer to serve as a connection electrode, so that the voltage signal of the triboelectric nanogenerator is converted by an external circuit board and transmitted to a receiving terminal electrically connected to the external circuit board. The specific usage process and principle are as follows:

[0055] like Figure 3 The diagram illustrates the usage of the blood pressure monitor. The triboelectric nanogenerator is attached to the wrist pulse point or other body location capable of sensing pulse vibrations. The pulse vibrations cause the first friction layer 300 or the second friction layer 400 of the triboelectric nanogenerator to undergo a contact-separation-re-contact cycle, generating voltage. Changes in the voltage signal reflect subtle changes in the pulse wave (such as…). Figure 8-9 As shown in Experiment 1, the voltage signal is converted by an external circuit board and transmitted to a receiving terminal (e.g., a microcomputer) that is electrically connected to the external circuit board. The receiving terminal extracts the pulse wave signal based on the voltage signal, thereby extracting the pulse wave waveform feature points. Then, it combines the pulse wave feature parameters with an artificial neural network to establish the relationship between the pulse wave feature parameters and blood pressure. In this way, the function of self-powered single-point detection of human heart rate, diastolic blood pressure and systolic blood pressure can be realized.

[0056] It should be noted that:

[0057] In this embodiment, the receiving terminal is a microcomputer as an example to illustrate its usage process and principle. The receiving terminal can be an existing terminal with functions of receiving electrical signals, recording and analyzing data, and outputting information, such as a mobile phone or PC, including but not limited to the embodiment scheme.

[0058] Furthermore, in this embodiment, the external circuit board converts the voltage signal collected by the triboelectric nanogenerator and transmits it directly to the microcomputer installed on the blood pressure monitor via a transmission line for analysis, processing, and display of the processing results. Alternatively, other methods can be used to transmit or store the voltage signal data. For example, the external circuit board can convert the voltage signal collected by the triboelectric nanogenerator and store it in a memory (e.g., a memory card), or it can transmit it remotely to a receiving terminal such as a mobile phone or PC via Bluetooth for analysis and processing, and output the results (e.g., text display output or voice broadcast output). This includes, but is not limited to, the solution in this embodiment.

[0059] The external circuit board and receiving terminal described in this article are both existing devices. Those skilled in the art can select the appropriate type according to their needs. In addition, the working process and principle of the external circuit board converting the voltage signal collected by the triboelectric nanogenerator and transmitting it to the receiving terminal, as well as the working process and principle of the receiving terminal receiving, recording, analyzing and processing signals and outputting results, are all existing technologies and will not be described in detail here.

[0060] The present invention also provides a method for preparing the electron-affinity triboelectric nanogenerator and blood pressure monitor as described above, which includes the following steps:

[0061] (1) Polyimide films of different compositions are respectively made into a first friction layer 300 and a second friction layer 400;

[0062] (2) Transfer metal nanowires to the upper surface of the first friction layer 300 and the lower surface of the second friction layer 400, respectively, so that the metal nanowire network located on the upper surface of the first friction layer 300 forms the first electrode 100, and the metal nanowire network located on the lower surface of the second friction layer 400 forms the second electrode 200; wherein, preferably, the metal nanowires are deposited on the upper surface of the first friction layer 300 and the lower surface of the second friction layer 400 by nanoimprinting technology (e.g., vacuum filtration, spraying, scraping, roller coating, etc.).

[0063] (3) The lower surface of the first friction layer 300 is aligned with the upper surface of the second friction layer 400 (i.e., the non-metallic deposition surfaces of the first friction layer 300 and the second friction layer 400 are aligned), and partitions 500 are provided on both sides of the first friction layer 300 and the second friction layer 400 to separate them and form a hollow structure, resulting in the following: Figure 1The self-supporting transparent triboelectric nanogenerator is fabricated from the same triboelectric layer material shown.

[0064] (4) After the triboelectric nanogenerator is obtained, a connecting electrode 600 is introduced into the triboelectric nanogenerator, and the first electrode 100 and the second electrode 200 of the triboelectric nanogenerator are electrically connected to the external circuit board through the connecting electrode 600, thus obtaining the single-point self-powered blood pressure monitor.

[0065] To verify the function and effect of the triboelectric nanogenerator and blood pressure monitor provided by this invention, the following experiment and its test data are provided:

[0066] Experiment 1:

[0067] Polyimide films of different compositions (PI film and Kapton film, PI film layer thickness 25) were used.

[0068] The PI film (40μm thick Kapton film) is cut into approximately 1×1cm pieces to serve as the first friction layer 300 and the second friction layer 400; the PI film is a 0.025×520mm model produced by Guangdong Dianjin New Material Technology Co., Ltd., and the Kapton film is a 0.04×520mm model produced by Guangzhou Beilong Electronics Co., Ltd.

[0069] Then, copper nanowires were transferred to the surface of PI and Kapton films respectively using nanoimprinting technology to serve as the first electrode 100 and the second electrode 200. During the transfer process, the copper nanowire solution was prepared according to the method disclosed in the patent entitled "A Method for Continuous Synthesis of Nanomaterials in Liquid Phase" (patent number: CN201810588079.2). The concentration of the copper nanowire solution was 1 mg / mL, the copper nanowire diameter was 16 nm and the length was 40 μm, and the layer thickness of the first electrode 100 and the second electrode 200 was 500 nm.

[0070] Then, the non-metallic deposition surfaces of the first friction layer 300 and the second friction layer 400 are placed face to face and separated by PI double-sided adhesive on both sides to form a hollow structure, thus obtaining a self-supporting transparent triboelectric nanogenerator made of the same friction layer material; wherein, the height of the hollow structure formed by the PI double-sided adhesive is 240μm, and the PI double-sided adhesive tape is 0.08×50mm from Shenzhen Changdasheng Electronics Co., Ltd.

[0071] Thin strip-shaped metal electrodes (made of copper tape, using 0.05×10mm type, 40μm thickness from Shenzhen Hongxingwang Tape Co., Ltd.) are introduced onto the surface of the first electrode 100 or the second electrode 200 on both sides of the triboelectric nanogenerator for connection to external circuits, forming a structure as shown in the figure. Figure 4 The self-powered blood pressure monitor shown.

[0072] The triboelectric nanogenerator and sphygmomanometer prepared in Experiment 1 were subjected to relevant performance tests:

[0073] 1. The sensing function of triboelectric nanogenerators in response to external pressure (i.e., pulsed pressure):

[0074] Figure 5 The triboelectric nanogenerator prepared in Experiment 1 was used in 10 -3 A curve of the voltage generated under the pressure of N; Figure 6 The graph shows the effect of different pressures on the electrical energy generated by the fabricated triboelectric nanogenerator; Figure 5-6 The content clearly shows that this triboelectric nanogenerator has a performance of 10 -3 Under pressure N, it generates a voltage of 0.1V, and its electrical energy shows a significant change trend with increasing external pressure. This indicates that the triboelectric nanogenerator has high sensitivity and accuracy, possessing sufficient sensitivity to detect subtle changes in pulse waveforms, reaching up to 10. -4 N / cm 2 ,like Figure 6 As shown, its pressure is far lower than that generated by human blood pressure (0.799 N / cm). 2 ~1.199 N / cm 2 This ensures that the triboelectric nanogenerator can accurately detect changes in the pulse wave.

[0075] Figure 9 The pulse waveform of the human body before exercise was measured using the triboelectric nanogenerator prepared in Experiment 1. Figure 10 The image shows the pulse waveform of a human body after exercise, measured using the triboelectric nanogenerator prepared in Experiment 1. Figure 9-10 The results clearly show that the time t1 of a single pulse wave vibration before exercise is approximately 0.743 s, while the time t2 of a single pulse wave vibration after 1 minute of running is approximately 0.64 s. This fully demonstrates that the triboelectric nanogenerator has sufficient sensitivity to detect subtle changes in the pulse waveform. Subsequently, by extracting the characteristic signal points of the pulse wave and combining them with an artificial neural network to establish the relationship between the characteristic parameters of the pulse wave and blood pressure, the function of self-powered single-point detection of human heart rate, diastolic blood pressure, and systolic blood pressure can be realized.

[0076] 2. Self-powered characteristics of the blood pressure monitor:

[0077] 2.1 Open-circuit voltage test:

[0078] A mechanical rod was used to simulate mechanical energy at different frequencies (applied force 0.5N, frequency 2Hz). The two electrodes of the triboelectric nanogenerator were then connected to the test port of a Keithley 2450 digital source meter using wires. The test mode was adjusted to current source mode, and the current input was set to zero. Data was collected as follows: Figure 7The open-circuit voltage signal curve is shown.

[0079] 2.2 Short-circuit current test:

[0080] A mechanical rod was used to simulate mechanical energy at different frequencies (applied force 0.5N, frequency 2Hz). The two electrodes of the triboelectric nanogenerator were then connected to the test port of a Keithley 2450 digital source meter using wires. The test mode was adjusted to voltage source mode, and the voltage input was set to zero to acquire data such as... Figure 8 The short-circuit current curve is shown.

[0081] in, Figure 7 The open-circuit voltage curve of the triboelectric nanogenerator prepared in Experiment 1; Figure 8 The curve shows the short-circuit current generated by the triboelectric nanogenerator prepared in Experiment 1; from Figure 7-8 The content clearly shows that, due to the characteristics of this triboelectric nanogenerator (requiring no external power source), the self-powered blood pressure monitor is a passive blood pressure monitor. Furthermore, the triboelectric nanogenerator can convert the mechanical energy generated by human movement into electrical energy, producing an open-circuit voltage of approximately 40V and a short-circuit current of 100nA. Therefore, by utilizing the electrical energy converted from mechanical energy and incorporating a rectifier circuit and energy storage element into the blood pressure monitor design, the power supply for the receiving terminal (such as a microcomputer) can be met, truly realizing the self-powered function of the blood pressure monitor.

[0082] This invention provides an electronic non-affinity triboelectric nanogenerator and a blood pressure monitor, including the following inventive concept, inventive principle, and beneficial effects:

[0083] (1) Existing traditional triboelectric nanogenerators are all made of two different materials, while the triboelectric nanogenerator provided by the present invention is made of only one material, and the electron affinity of the material is adjusted by regulating the chemical composition of the same material (for example, by adjusting the chemical composition of polyimide material, changing a certain chemical bond of the material, two materials with different electron affinity are obtained as friction materials). Figure 11 The image shows a comparison of the Fourier transform infrared (FTIR) spectra of PI and Kapton materials in Experiment 1. As can be seen, both materials retain the basic chemical bonds of polyimide but also add some functional bonds. Specifically, Kapton adds CO bonds, while PI adds NH bonds. The CO bonds increase the acidity of the materials, regulating their electron-donating ability and achieving electron-affinity-controlled triboelectric nanogenerators. This design breaks the limitation that highly sensitive triboelectric nanogenerators cannot be fabricated due to identical electron-donating and losing abilities in the same material, providing a framework for the future fabrication of higher-performance triboelectric nanogenerators.

[0084] (2) The role and advantages of using metal nanowire networks (preferably copper nanowires) as electrodes in this invention: Due to the nanoscale size effect, metal nanowires can further increase the flexibility of the device while ensuring conductivity, making the triboelectric nanogenerator more closely connected to human skin and measuring pulse waves more accurately; Copper nanowire networks have excellent light transmittance, which can make the device retain its original color or make the device more colorful, rather than just reddish-brown (the color of copper), increasing aesthetics and applicability; Compared with the scheme of using bulk copper and preparing copper electrodes through physical vapor deposition, electron beam deposition and other methods, the cost of preparing electrodes using copper nanowire networks is lower; Compared with the scheme of using bulk copper and preparing copper electrodes through physical vapor deposition, electron beam deposition and other methods, copper nanowire networks have better heat dissipation performance, which is conducive to improving the heat dissipation effect of triboelectric nanogenerators.

[0085] (3) Currently, the methods for calculating blood pressure values ​​through pulse waves are all two-point methods. The existing single-point method for measuring blood pressure uses photoplethysmography pulse wave method, but the accuracy of the blood pressure values ​​obtained by this method still needs to be improved. This invention measures the pulse wave at a single point, and then extracts the characteristic signal points of the pulse wave, and combines them with an artificial neural network to establish the relationship between the characteristic parameters of the pulse wave and blood pressure, thereby realizing the function of single-point detection of human heart rate, diastolic blood pressure and systolic blood pressure.

[0086] In summary, the present invention has the following effects:

[0087] (1) The electronic non-affinity triboelectric nanogenerator provided by the present invention can realize self-powered blood pressure measurement. It utilizes the high sensitivity of the triboelectric nanogenerator to pressure to extract the characteristic signal points of the pulse wave, and combines the artificial neural network to establish the relationship between the characteristic parameters of the pulse wave and blood pressure, so as to realize the function of self-powered single-point detection of human heart rate, diastolic blood pressure and systolic blood pressure.

[0088] (2) The high sensitivity of this electron-affinity-insensitive triboelectric nanogenerator ensures the accuracy of its detection of changes in pulse waves, thereby ensuring the data accuracy of the function of point detection of human heart rate, diastolic blood pressure and systolic blood pressure.

[0089] (3) It has self-powered characteristics. Due to the characteristics of this triboelectric nanogenerator, no external power supply is required during measurement. The blood pressure monitor made from it is a passive blood pressure monitor.

[0090] (4) This invention provides a transparent, flexible, highly sensitive, and easy-to-operate triboelectric nanogenerator and blood pressure monitor, which can successfully detect subtle changes in the human pulse, laying a solid foundation for the development and application of passive wearable health monitoring.

[0091] For the application of this electron-affinity-insensitive triboelectric nanogenerator and blood pressure monitor in the fabrication of a cardiac disease detection device:

[0092] As is known to those skilled in the art, people with heart disease not only have abnormal blood pressure values, but also abnormal pulse waveforms.

[0093] The present invention also proposes a heart disease detection device, which adopts a blood pressure monitor designed as described above. Its sensing process is consistent with that of a blood pressure monitor: the vibration of the pulse causes the first friction layer 300 or the second friction layer 400 of the triboelectric nanogenerator to perform a contact-separation-re-contact cycle, thereby generating a voltage. The voltage signal is converted by an external circuit board and transmitted to a receiving terminal electrically connected to the external circuit board.

[0094] The difference between this heart disease detector and a blood pressure monitor lies in the processing of voltage data transmitted from the triboelectric nanogenerator by the receiving terminal. The receiving terminal extracts pulse wave signals based on the voltage signals, thereby extracting pulse wave waveform feature points. Then, it combines these with an artificial neural network to establish the relationship between pulse wave feature parameters and blood pressure, thus enabling the self-powered single-point detection of human heart rate, diastolic blood pressure, and systolic blood pressure. At the same time, the triboelectric nanogenerator can detect subtle changes in the pulse waveform. Therefore, the receiving terminal can compare the pulse waveform changes received by the triboelectric nanogenerator with the characteristic pulse waveforms of heart diseases, thus achieving preliminary detection of heart diseases.

[0095] In summary, the operation of the aforementioned cardiac disease detector demonstrates that by detecting subtle changes in blood pressure and pulse waveforms, it can detect abnormalities in the blood pressure and pulse waveforms of patients with cardiac diseases, thus enabling preliminary detection of cardiac diseases. Therefore, the triboelectric nanogenerator and blood pressure monitor provided by this invention can be applied to the preparation of cardiac disease detectors.

[0096] Furthermore, those skilled in the art should understand that although many problems exist in the prior art, each embodiment or technical solution of the present invention can be improved in only one or a few aspects, without necessarily solving all the technical problems listed in the prior art or the background art simultaneously. Those skilled in the art should understand that any content not mentioned in a claim should not be construed as a limitation on that claim.

[0097] Although terms such as first friction layer, second friction layer, and first electrode are frequently used in this document, the possibility of using other terms is not excluded. These terms are used merely for the convenience of describing and explaining the essence of the invention; interpreting them as any additional limitation would contradict the spirit of the invention. The terms "first," "second," etc. (if present) in the specification, claims, and accompanying drawings of the embodiments of the invention are used to distinguish similar objects and are not necessarily used to describe a specific order or sequence.

[0098] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An electronic non-affinity frictional nanogenerator, characterized in that: include: First friction layer (300) and second friction layer (400): The first friction layer (300) and the second friction layer (400) are arranged at a distance from each other to form a hollow structure between them; First electrode (100): It is disposed on the upper surface of the first friction layer (300) away from the second friction layer (400); Second electrode (200): It is disposed on the lower surface of the second friction layer (400) away from the first friction layer (300); The first friction layer (300) and the second friction layer (400) are made of the same material, but the materials used in the first friction layer (300) and the second friction layer (400) have different compositions, so that the first friction layer (300) and the second friction layer (400) have different electron gain and loss capabilities; when an external force is applied to the first friction layer (300) and / or the second friction layer (400), the first friction layer (300) and the second friction layer (400) come into contact with each other; when the external force is released, the first friction layer (300) and the second friction layer (400) separate to form the hollow structure; The first friction layer (300) and the second friction layer (400) are made of polyimide film; The first electrode (100) and / or the second electrode (200) are transparent metal nanowire network layers deposited from metal nanowires; The first friction layer (300) is a Kapton film, and the second friction layer (400) is a PI film; The lower surface of the first friction layer (300) is opposite to the upper surface of the second friction layer (400), and the edges of the first friction layer (300) and the second friction layer (400) are separated by a partition (500) to form the hollow structure between the first friction layer (300) and the second friction layer (400).

2. The method for fabricating the electronic non-coherent frictional nanogenerator according to claim 1, characterized in that: Includes the following steps: Polyimide films of different compositions are respectively made into a first friction layer (300) and a second friction layer (400). Metal nanowires are transferred to the upper surface of the first friction layer (300) and the lower surface of the second friction layer (400), respectively, so that the metal nanowire network located on the upper surface of the first friction layer (300) forms the first electrode (100), and the metal nanowire network located on the lower surface of the second friction layer (400) forms the second electrode (200). The lower surface of the first friction layer (300) is placed opposite the upper surface of the second friction layer (400), and partitions (500) are provided on both sides of the first friction layer (300) and the second friction layer (400) to separate them into a hollow structure, thus obtaining a triboelectric nanogenerator.

3. The method for preparing the electron-affinity-insensitive triboelectric nanogenerator according to claim 2, characterized in that: Metal nanowires were deposited onto the upper surface of the first friction layer (300) and the lower surface of the second friction layer (400) using nanoimprinting technology.

4. A blood pressure monitor, characterized in that: It includes a triboelectric nanogenerator, connecting electrodes (600), and an external circuit board; The triboelectric nanogenerator is used to generate a voltage signal based on changes in pulse waves. The first electrode (100) and the second electrode (200) of the triboelectric nanogenerator are electrically connected to an external circuit board via connecting electrodes (600), so that the voltage signal of the triboelectric nanogenerator is converted by the external circuit board and transmitted to a receiving terminal electrically connected to the external circuit board, and the receiving terminal converts it into blood pressure information. The triboelectric nanogenerator is the triboelectric nanogenerator as described in claim 1; or, it is the triboelectric nanogenerator prepared by the method described in any one of claims 2-3.

5. A heart disease detection device, characterized in that: Including blood pressure monitors; The blood pressure monitor is the blood pressure monitor as described in claim 4.

6. The application of a triboelectric nanogenerator in the fabrication of a cardiac disease detection device, characterized in that: The triboelectric nanogenerator is the triboelectric nanogenerator as described in claim 1; or, it is the triboelectric nanogenerator prepared by the method described in any one of claims 2-3.

Images