Bacillus coagulans strain using d-psicose as carbon source, and derivative products and applications thereof

By screening out Bacillus coagulans strain CGMCC No.25689, which can utilize D-allulose as a carbon source, and combining it with D-allulose to form a probiotic composition, the problem of the inability to effectively utilize D-allulose in the prior art was solved. This resulted in a significant reduction in body weight and fasting blood glucose in obese mice, providing a treatment option for obesity and diabetes.

CN115851542BActive Publication Date: 2026-06-19QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES)
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
QILU UNIVERSITY OF TECHNOLOGY (SHANDONG ACADEMY OF SCIENCES)
Filing Date
2022-12-16
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing technologies lack Bacillus coagulans strains that can effectively utilize D-allulose as a carbon source, making it difficult to effectively reduce the weight and fasting glucose levels of obese patients, and lacking treatment options for obese or diabetic patients.

Method used

A Bacillus coagulans strain CGMCC No. 25689 with D-allulose as a carbon source and its culture method are provided. When used in combination with D-allulose, a probiotic composition is formed for the preparation of drugs for the prevention and treatment of obesity and diabetes.

Benefits of technology

It significantly reduces the body weight of obese mice and rapidly lowers fasting blood glucose levels, outperforming the effects of using D-allulose or Bacillus coagulans alone, and has a synergistic therapeutic effect on obesity and diabetes.

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Abstract

This invention provides a *Bacillus coagulans* strain using D-allulose as a carbon source, its derivatives, and applications, belonging to the field of functional strain technology. This invention isolates a *Bacillus coagulans* strain 217-176, which can use D-allulose as its sole carbon source, from plant surfaces; its accession number is CGMCC No. 25689. The combined use of *Bacillus coagulans* strain and D-allulose is more effective than either in reducing body weight, fasting blood glucose concentration, and glucose tolerance in diabetic models, indicating that *Bacillus coagulans* strain and D-allulose have a synergistic effect in preventing and / or treating obesity.
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