Transdermal patch for children with short stature

Abstract

The application discloses a transdermal patch special for children with dwarfism, and relates to the technical field of medical treatment, which comprises a patch main body and a needle cylinder, and a fixed plate is fixedly connected to the inside of the patch main body, and the top and the bottom of the fixed plate are penetrated by the needle cylinder; the top of the needle cylinder is provided with a pressing plate, the bottom of the pressing plate is provided with a stand column on the two sides of the needle cylinder, the bottom of the two stand columns is arranged in the inside of the fixed plate and is slidably connected with the fixed plate; the two stand columns are both sleeved with a spring one; the top of the pressing plate is provided with a clamping groove, the bottom of the clamping groove is communicated with the needle cylinder, and a clamping seat is arranged in the clamping groove; the top of the pressing plate is provided with a fence; the two sides of the pressing plate are both provided with a connecting rod, one end of the connecting rod is connected with the pressing plate, and the other end penetrates through the top of the patch main body; the two sides of the patch main body close to the bottom are both provided with a sticking layer; and the two sides of the inside of the patch main body are both provided with a negative pressure sponge layer. The burden of the children with dwarfism is relieved, growth hormone injection treatment is facilitated, and the skin redness and swelling caused after growth hormone injection can be effectively prevented and treated.

Description

Technical Field

[0001] This invention relates to the field of medical technology, and more specifically, to a transdermal patch for children with short stature. Background Technology

[0002] Idiopathic short stature (ISS) is the most common type of short stature in children. Its cause is unclear, growth hormone levels are normal, and conditions such as chromosomal abnormalities, small for gestational age, inherited metabolic disorders, organic diseases, and psychological deprivation that cause short stature are defined as being more than two standard deviations below the average height of children of the same race, sex, and age. With the improvement of people's living standards, children's height has received increasing attention. Numerous studies have reported that short stature not only affects children's growth and development but can also have adverse effects on their life, work, and relationships in adulthood. Therefore, the treatment of children with ISS has received increasing attention. In 2003, the US FDA officially approved the use of rhGH in the treatment of ISS, making it a major treatment method.

[0003] Currently, many children with short stature in high-altitude areas of western China are treated with growth hormone injections. Each injection requires a separate injection, which places a burden on the children and can easily damage the surrounding skin. Summary of the Invention

[0004] The purpose of this invention is to provide a transdermal patch specifically for children with short stature, in order to solve the above-mentioned technical problems.

[0005] The above-mentioned technical objective of the present invention is achieved through the following technical solution: a transdermal patch for children with short stature, comprising a patch body and a syringe, wherein a fixing plate is fixedly connected inside the patch body, and the syringe penetrates the top and bottom of the fixing plate; a pressure plate is provided at the top of the syringe, and columns are provided on both sides of the bottom of the pressure plate, the bottoms of the two columns are placed inside the fixing plate and slidably connected to the fixing plate; a spring is sleeved on each of the two columns; a slot is provided at the top of the pressure plate, the bottom of the slot is connected to the syringe, and a seat is provided in the slot; a fence is provided at the top of the pressure plate; connecting rods are provided on both sides of the pressure plate, one end of the connecting rod is connected to the pressure plate, and the other end penetrates the top of the patch body, and the two connecting rods are connected to the same pressure rod at one end penetrating the patch body; an adhesive layer is provided on both sides of the patch body near the bottom; and a negative pressure sponge layer is provided on both sides of the inside of the patch body.

[0006] By adopting the above technical solution, a horizontal fixing plate is installed inside the dressing body for fixed connection. The syringe penetrates the middle of the fixing plate and is slidably connected to it. A pressure plate is fixedly connected to the top of the syringe. The top of the pressure plate has a slot that communicates with the inside of the syringe. In use, the indwelling needle is engaged and fixed through the slot, so that the tip of the indwelling needle is placed inside the syringe. Connecting rods are provided on both sides of the pressure plate. One end of the connecting rod is fixedly connected to the pressure plate, and the other end penetrates the top of the dressing body. The two connecting rods are connected to the same pressure rod at the same end penetrating the top of the dressing body. A column is provided on both sides of the syringe at the bottom of the pressure plate. The bottom of the column is placed inside the fixing plate (the top of the fixing plate has a vertical groove, and the column is placed in the groove and slidably connected to the fixing plate). A spring is fitted on the column between the pressure plate and the fixing plate. By pressing down the lever, the pressure plate moves downward, forcing the spring to deform. This causes the syringe to slide between itself and the fixing plate, lowering the bottom of the syringe and allowing the tip of the indwelling needle inside to pierce the skin for injection. After injection, the spring returns to its original shape, causing the pressure plate to move upward and removing the indwelling needle. A railing is provided at the top of the pressure plate to hold the injection tubing coiled inside. Adhesive layers on both sides of the patch provide fixation, and negative pressure sponge layers are located on both sides of the inside of the patch. These negative pressure sponge layers have good absorbency, improving the effectiveness of skin medication treatment.

[0007] The invention is further configured such that: a first clamp is provided on both sides of the pressure plate near the bottom; a stand and a push rod are provided on the top of the fixing plate near both sides, one end of the push rod is provided with a sliding post, and the other end penetrates the side of the application body, the sliding post penetrates the opposite sides of the adjacent clamp, a second spring is sleeved on the sliding post, the second spring is located between the push rod and the stand; a second clamp is provided on the top of the push rod near the sliding post, and the second clamp engages with the first clamp.

[0008] By adopting the above technical solution, clamps are installed on both sides of the pressure plate near the bottom, and opposing supports and push rods are installed on the top of the fixing plate near both sides. One end of the push rod penetrates the side of the dressing body, and the other end has a sliding post, which penetrates the opposing sides of the supports and is slidably connected to the supports. A spring is fitted on the sliding post, and clamps are installed on the top of the push rod near the sliding post, engaging with clamp one. When the pressure plate moves downward, the tip of the indwelling needle pierces the skin. At this time, the pressure rod is not pressed down further, and because clamps one and two are engaged, the pressure plate will not move upward to dislodge the indwelling needle from the skin. This reduces workload and makes it more convenient to use. After injection, pushing the push rods on both sides of the dressing body inward causes the sliding post to slide relative to the support and compresses and deforms the spring two. At this time, clamps one and two separate, and the pressure plate moves under the action of spring one, separating the tip of the indwelling needle from the skin. The push rod returns to its initial position under the action of spring two.

[0009] The invention is further configured such that: both of the columns penetrate the top and bottom of the fixing plate and are slidably connected to the fixing plate at the penetration point; the bottom of the columns is provided with a pressure block; and suction cups are provided on both sides of the negative pressure sponge layer that are close to each other.

[0010] By adopting the above technical solution, the bottom of the uprights on both sides of the syringe penetrates the top and bottom of the fixing plate and slides with the fixing plate at the penetration point. Each of the two uprights has a pressure block at its bottom, which squeezes the suction cups located on both sides of the negative pressure sponge layer that are close to each other, further fixing the syringe to the skin near the insertion point.

[0011] The present invention is further configured such that: a flexible tube is provided inside the negative pressure sponge layer, one end of the flexible tube is connected to a suction cup, and the other end penetrates through the side of the main body and forms a liquid inlet hole at the penetration point.

[0012] By adopting the above technical solution, a flexible tube is installed inside the negative pressure sponge layer. One end of the tube is connected to the suction cup, and the other end penetrates the side of the applicator, forming a liquid inlet at the penetration point. A small amount of liquid is injected into the suction cup through the liquid inlet. The liquid inlet is sealed when not in use, allowing the suction cup to better adhere to the skin surface. After injection, opening the liquid inlet causes the suction cup to detach from the skin surface.

[0013] The present invention is further configured such that a cover is provided on the top of the dressing body.

[0014] By adopting the above technical solution, a cover is provided on the top of the dressing body, which facilitates the installation of the indwelling needle on the top of the pressure plate and the flexible tube coiled inside the enclosure, and also facilitates the injection of drugs.

[0015] The present invention is further configured such that: the adhesive layer includes an adhesive substrate and a surface protective layer, and a three-dimensional mesh structure of nanofiber felt is provided between the adhesive substrate and the surface protective layer; the overall thickness of the nanofiber felt is 0.01-1 mm, the nanofiber felt is a single-layer structure or at least two layers, and the fiber diameter of the nanofiber felt is 10-1000 nm; the adhesive substrate is pressure-sensitive adhesive tape; and the surface protective layer is release paper.

[0016] By adopting the above technical solution, the nanofiber felt has an extremely high specific surface area, high porosity, and an interconnected three-dimensional network structure, which acts as a tissue scaffold, improves the fit, breathability, and comfort of adhesive dressings, and can prevent tissue adhesion. It also has high water absorption and moisturizing functions. Compared with existing woven or nonwoven fabrics, the functional nanofiber felt prepared by electrospinning has a longer working time on wounds, and the fit, breathability, and comfort of the nanofiber felt are better.

[0017] In summary, the present invention has the following beneficial effects:

[0018] 1. This invention uses a slot and syringe in conjunction with an indwelling needle to facilitate the injection of growth hormone into children with short stature, reducing the burden of treatment for these children and making growth hormone injection therapy more convenient.

[0019] 2. In this invention, a small amount of liquid is injected into the suction cup through the liquid inlet via a flexible tube, allowing the suction cup to better adhere to the skin surface of the human body and achieve a better fixation effect.

[0020] 3. By connecting clip one and clip two, the pressure rod does not need to be pressed down continuously during the injection process, making it more convenient to use.

[0021] 4. The negative pressure sponge layer absorbs medications that treat skin conditions caused by growth hormone injections, thus effectively treating these skin conditions. Attached Figure Description

[0022] Figure 1 This is a cross-sectional structural diagram of Embodiment 1 of the present invention;

[0023] Figure 2 This is a cross-sectional structural diagram of Embodiment 2 of the present invention;

[0024] Figure 3 This is an embodiment of the present invention. Figure 1 , Figure 2 Enlarged structural diagram at point A;

[0025] Figure 4 This is a schematic diagram of the layered structure of the adhesive layer in an embodiment of the present invention.

[0026] In the diagram: 1. Main body of the dressing; 2. Fixing plate; 3. Pressure plate; 4. Pressure rod; 5. Cover; 6. Connecting rod; 7. Fence; 8. Card slot; 9. Card seat; 10. Column; 11. Spring 1; 12. Card 1; 13. Push rod; 14. Pressure block; 15. Syringe; 16. Suction cup; 17. Negative pressure sponge layer; 18. Tube; 19. Adhesive layer; 20. Sliding column; 21. Stand; 22. Spring 2; 23. Card 2; 24. Liquid inlet; 25. Adhesive base; 26. Surface protective layer; 27. Nanofiber felt. Detailed Implementation

[0027] The following is in conjunction with the appendix Figure 1-4 The present invention will be described in further detail below.

[0028] Example 1:

[0029] A transdermal patch specifically for children with short stature, such as Figure 1 , Figure 3 and Figure 4As shown, the dressing includes a main body 1 and a syringe 15. A fixing plate 2 is fixedly connected inside the main body 1. The syringe 15 passes through the top and bottom of the fixing plate 2. A pressure plate 3 is provided at the top of the syringe 15. A column 10 is provided on both sides of the bottom of the pressure plate 3. The bottom of the two columns 10 is placed inside the fixing plate 2 and slidably connected to the fixing plate 2. A spring 11 is sleeved on both columns 10. A slot 8 is provided at the top of the pressure plate 3. The bottom of the slot 8 is connected to the syringe 15. A seat 9 is provided in the slot 8. A fence 7 is provided at the top of the pressure plate 3. A connecting rod 6 is provided on both sides of the pressure plate 3. One end of the connecting rod 6 is connected to the pressure plate 3, and the other end passes through the top of the main body 1. The two connecting rods 6 are connected to the same pressure rod 4 at one end passing through the main body 1. An adhesive layer 19 is provided on both sides of the main body 1 near the bottom. A negative pressure sponge layer 17 is provided on both sides inside the main body 1. Near the bottom of both sides of the pressure plate 3, there are clips 12; near the top of the fixing plate 2, there are uprights 21 and push rods 13 opposite each other. One end of the push rod 13 is equipped with a sliding post 20, and the other end passes through the side of the application body 1. The sliding post 20 passes through the opposite sides of the adjacent clips 9. A spring 22 is sleeved on the sliding post 20, and the spring 22 is located between the push rod 13 and the uprights 21. Near the sliding post 20, there is a clip 23 on the top of the push rod 13, which engages with clip 12. The top of the application body 1 is equipped with a cover 5. The adhesive layer includes an adhesive substrate 25 and a surface protective layer 26. A three-dimensional mesh structure of nanofiber felt 27 is also provided between the adhesive substrate 25 and the surface protective layer 26. The overall thickness of the nanofiber felt 27 is 0.01-1 mm. The nanofiber felt 27 is a single-layer structure or at least two layers. The fiber diameter of the nanofiber felt 27 is 10-1000 nm. The adhesive substrate 25 is a pressure-sensitive adhesive tape. The surface protective layer 26 is release paper.

[0030] A horizontal fixing plate 2 is fixedly connected inside the dressing body 1. The syringe 15 passes through the middle of the fixing plate 2 and is slidably connected to the fixing plate 2. The top of the syringe 15 is fixedly connected to the pressure plate 3. The top of the pressure plate 3 is provided with a slot 8 and the slot 8 communicates with the inside of the syringe 15.

[0031] In use, the indwelling needle is secured by the retainer 9 in the slot 8, placing the needle tip inside the syringe 15. Connecting rods 6 are located on both sides of the pressure plate 3. One end of each connecting rod 6 is fixedly connected to the pressure plate 3, and the other end passes through the top of the dressing body 1. Both connecting rods 6, passing through the top of the dressing body 1, are connected to the same pressure rod 4. At the bottom of the pressure plate 3, on both sides of the syringe 15, are uprights 10. The bottom of each upright is placed inside the fixing plate 2 (the top of the fixing plate 2 has a vertical groove, and the upright 10 is slidably connected to the fixing plate 2 within the groove). A spring 11 is fitted onto each upright 10, positioned between the pressure plate 3 and the fixing plate 2. By pressing down the pressure rod 4, the pressure plate 3 moves downward, forcing the spring 11 to deform. The sliding between the syringe 15 and the fixing plate 2 causes the bottom of the syringe 15 to move downward, allowing the needle tip of the indwelling needle inside the syringe 15 to pierce the skin for injection. After injection, the spring 11 returns to its original shape, causing the pressure plate 3 to move upwards and allowing the indwelling needle to be removed. A railing 7 is provided at the top of the pressure plate 3 to hold the injection tube coiled inside. The adhesive layers 19 on both sides of the dressing body 1 serve a fixing function. Negative pressure sponge layers 17 are provided on both sides of the inside of the dressing body 1. The negative pressure sponge layers 17 are used because they have good adsorption capacity; they adsorb the medication used to treat skin conditions caused by the injected growth hormone, thus improving the therapeutic effect. Clamping devices 12 are provided on both sides of the pressure plate 3 near the bottom. Opposite supports 21 and push rods 13 are provided on the top of the fixing plate 2 near both sides. One end of the push rod 13 penetrates the side of the dressing body 1, and the other end has a sliding post 20, which penetrates the opposite sides of the supports 21 and slides through them. A spring 22 is fitted onto the sliding post 20, and a clamping device 23 is provided at the top of the push rod 13 near the sliding post 20, engaging with clamping device 12. When the pressure plate 3 moves downward, the tip of the indwelling needle pierces the skin. At this time, the pressure rod 4 is no longer pressed downward. Because the locking parts 12 and 23 are engaged, the pressure plate 3 will not move upward and cause the indwelling needle to detach from the skin. This reduces workload and makes it more convenient to use. After injection, push the push rods 13 on both sides of the dressing body 1 inward. This causes the sliding column 20 to slide relative to the stand 21 and compresses and deforms the spring 22. At this time, the locking parts 12 and 23 separate, and the pressure plate 3 moves under the action of the spring 11, causing the tip of the indwelling needle to separate from the skin. The push rod 13 returns to its initial position under the action of the spring 22. The top of the dressing body 1 is provided with a cover 5, which facilitates the installation of the indwelling needle on the top of the pressure plate 3 and the tubing 18 coiled inside the enclosure 7, and also facilitates drug injection.Nanofiber felt 27 has an extremely high specific surface area, high porosity, and an interconnected three-dimensional network structure, which acts as a tissue scaffold, improves the fit, breathability, and comfort of adhesive dressings, and can prevent tissue adhesion. It also has high water absorption and moisturizing functions. Compared with existing woven or nonwoven fabrics, functional nanofiber felt 27 prepared by electrospinning has a longer working time when applied to wounds. Moreover, nanofiber felt 27 has better fit, breathability, and comfort, making it suitable for use in low-pressure, high-altitude, and plateau regions.

[0032] Example 2:

[0033] A transdermal patch specifically for children with short stature, such as Figure 2 and Figure 3 As shown, it is basically the same as in Embodiment 1, except that both columns 10 penetrate the top and bottom of the fixing plate 2 and are slidably connected to the fixing plate 2 at the penetration point. A pressure block 14 is provided at the bottom of the column 10, and suction cups 16 are provided on both sides of the negative pressure sponge layer 17 that are close to each other. A flexible tube 18 is provided inside the negative pressure sponge layer 17. One end of the flexible tube 18 is connected to the suction cup 16, and the other end penetrates the side of the applicator body 1 and forms a liquid inlet hole 24 at the penetration point.

[0034] The bottom of the two uprights 10 on both sides of the syringe 15 penetrates the top and bottom of the fixing plate 2 and slides through the plate. Each upright 10 has a pressure block 14 at its bottom, which compresses the suction cups 16 positioned on either side of the negative pressure sponge layer 17, further securing them to the skin insertion site. A flexible tube 18 is located inside the negative pressure sponge layer 17. One end of the tube 18 is connected to the suction cup 16, and the other end penetrates the side of the applicator body 1, forming an inlet hole 24. A small amount of liquid (water) is injected into the suction cup 16 through the inlet hole 24. When not in use, the inlet hole 24 is sealed to allow the suction cup 16 to adhere better to the skin surface. After injection, the inlet hole 24 is opened, causing the suction cup 16 to detach from the skin surface. The negative pressure sponge layer 17 contains medication for treating skin conditions caused by injected growth hormone.

[0035] Working Principle: During use, the indwelling needle is secured by the retainer 9. The injection tube connected to the tail of the indwelling needle is coiled and placed inside the enclosure 7. During use, medication is injected through the injection tube connected to an external drug delivery device (such as a syringe). Multiple injections are possible. Disinfecting alcohol is injected into the sterile cotton 16 through the inlet hole 24. Pressing down firmly on the lever 4 moves the pressure plate 3 downwards, causing the pressure block 14 to squeeze the suction cup 16, further securing it near the insertion site on the skin. The needle tip of the indwelling needle pierces the skin, and the retainer 12 and retainer 23 engage, allowing for the injection of growth hormone. After injection, pushing the push rods 13 on both sides of the dressing body 1 inwards separates the retainer 12 and retainer 23. Under the action of spring 11, the pressure plate 3 moves upward, disengaging the needle tip of the indwelling needle from the skin. This method can effectively treat skin conditions resulting from growth hormone injection. This transdermal patch can be used for repeated injections 2-3 times. Combined with the dosage and frequency of the treatment plan, one patch can complete three injections per week, with a minimum dose of 0.1 U / kg per application. -1 ·d -1 rhGH, maximum dose 0.2 U·kg -1 ·d -1 Injection of rhGH.

[0036] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

Claims

1. A transdermal patch for a child with dwarfism, characterized by: The utility model provides a kind of needle applicator, including the main body (1) and needle cylinder (15), the inside fixed connection of the main body (1) is fixed plate (2), the top and bottom of needle cylinder (15) are penetrated through fixed plate (2);The top of needle cylinder (15) is equipped with pressing plate (3), the bottom of pressing plate (3) is equipped with stand (10) on both sides of needle cylinder (15);2 The spring one (11) is sleeved with stand (10);The top of pressing plate (3) is equipped with clamping groove (8), the bottom of clamping groove (8) is communicated with needle cylinder (15), and clamping groove (8) is equipped with clamping seat (9) inside;The top of pressing plate (3) is equipped with fence (7);The both sides of pressing plate (3) are equipped with connecting rod (6), one end of connecting rod (6) is connected with pressing plate (3), the other end is penetrated through the top of main body (1), and the one end of 2 connecting rod (6) is penetrated through main body (1) and is equipped with same pressure lever (4);The both sides of main body (1) are equipped with adhesive layer (19) close to bottom;The both sides of main body (1) are equipped with negative pressure sponge layer (17) inside; The both sides of pressing plate (3) are equipped with clamping piece one (12) close to bottom;The top of fixed plate (2) is equipped with stand (21) and push rod (13) opposite on both sides, one end of push rod (13) is equipped with sliding column (20), the other end is penetrated through the side of main body (1), sliding column (20) is penetrated through the opposite two side surfaces of adjacent clamping seat (9), spring two (22) is sleeved on sliding column (20), and spring two (22) is located between push rod (13) and stand (21);The top of push rod (13) is equipped with clamping piece two (23) close to one end of sliding column (20), and clamping piece two (23) is clamped with clamping piece one (12). 2 The stand (10) is penetrated through the top and bottom of fixed plate (2) and is slidably connected with fixed plate (2) at penetration, and the bottom of stand (10) is equipped with pressing block (14), and the two sides of negative pressure sponge layer (17) are equipped with suction disc (16) close to each other.

2. The transdermal patch for a child with short stature according to claim 1, characterized by: The inside of negative pressure sponge layer (17) is equipped with hose (18), one end of hose (18) is connected with suction disc (16), the other end is penetrated through the side of main body (1) and forms liquid inlet hole (24) at penetration.

3. The transdermal patch for a child with dwarfism according to claim 1, wherein the patch is characterized by: The top of main body (1) is equipped with cover body (5).

4. The transdermal patch for a child with short stature according to claim 1, characterized by: The adhesive layer includes adhesive base (25) and surface protective layer (26), and a three-dimensional mesh nano-fiber felt (27) is further arranged between the adhesive base (25) and the surface protective layer (26); the overall thickness of the nano-fiber felt (27) is 0.01-1mm, the nano-fiber felt (27) is a single-layer structure or at least two layers, and the fiber diameter of the nano-fiber felt (27) is 10-1000nm; the adhesive base (25) is a pressure-sensitive adhesive tape; and the surface protective layer (26) is a release paper.

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