Palonosetron transdermal patch and preparation method thereof

By designing a transdermal patch containing the free base of palonosetron and a mixed pressure-sensitive adhesive, the problems of palonosetron storage stability and drug administration compliance were solved, achieving stable sustained release and high adhesion of the drug, and simplifying the preparation process.

CN116421581BActive Publication Date: 2026-07-07NEW LEADING (CHONGQING) PHARM TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-03-28
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

Existing palonosetron formulations suffer from crystallization and precipitation issues, resulting in poor storage stability. Furthermore, traditional administration methods such as injection and oral capsules lead to side effects and poor patient compliance.

Method used

The transdermal patch consists of a backing layer, a drug-loaded pressure-sensitive adhesive layer, and an anti-adhesive layer. The drug-loaded pressure-sensitive adhesive layer contains palonosetron free base, antioxidants, polyacrylate pressure-sensitive adhesives containing carboxyl and hydroxyl functional groups, and transdermal absorption promoters. The mixed pressure-sensitive adhesive layer improves adhesion and stability, and the preparation process is simple.

Benefits of technology

This approach achieves stable and slow release of palonosetron, reduces drug crystallization and precipitation, improves patient compliance and efficacy, and simplifies the preparation process.

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Abstract

The present application belongs to the technical field of medicine, and particularly relates to a palonosetron transdermal patch and a preparation method thereof. The transdermal patch is composed of a backing layer, a drug-loaded pressure-sensitive adhesive layer and an anti-adhesion layer. The drug-loaded pressure-sensitive adhesive layer comprises palonosetron free base, pressure-sensitive adhesive, antioxidant and transdermal absorption promoter. The palonosetron free base accounts for 5% to 20% of the total weight, preferably 5% to 15%; the antioxidant accounts for 0.01% to 0.1% of the total weight; the transdermal absorption promoter accounts for 5% to 10% of the total weight; and the pressure-sensitive adhesive accounts for 74.9% to 89.99%. The palonosetron transdermal patch provided by the present application uses mixed pressure-sensitive adhesive of different groups to improve its adhesion and stability, and can realize slow release of palonosetron free base within 7 days.
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Citation Information

Patent Citations

  • Palonosetron Transdermal Absorption Patch and its Preparation Method

    CN104069505B

  • Transdermal preparation containing palonosetron

    WO2009139411A1

  • Percutaneous-absorption palonosetron patch and preparation method thereof

    CN104069505A

  • Rivastigmine transdermal patch and preparation method thereof

    CN107929267A

  • Palonosetron transdermal patch and preparation method thereof

    CN109875982A