A simulation system for regulating skin inflammation and pigmentation based on LED light modulation and an LED phototherapy device

Abstract

This invention belongs to the field of phototherapy technology, specifically a simulation system and device for regulating skin inflammation and pigmentation based on LED light modulation. The simulation system includes an ultraviolet phototherapy device and an LED instrument. The ultraviolet phototherapy device emits excimer light with a wavelength of 308 nm to establish an experimental model of inflammation and pigmentation. The LED instrument emits LED light with a wavelength of 830 nm to regulate inflammation and pigmentation in the experimental model. This system is safe and effective, and can be used to prepare research models of inflammation and pigmentation. Furthermore, it can lead to LED phototherapy devices for treating inflammation and pigmentation. The LED phototherapy device is a head-mounted device, including a light-emitting module, a control module, and a power supply module.

Description

Technical Field

[0001] This invention belongs to the field of phototherapy technology, specifically relating to a simulation system for regulating skin inflammation and pigmentation based on the light modulation effect of LEDs, and an LED phototherapy device. Background Technology

[0002] Existing technologies disclose photomodulation, a photobiological phenomenon that utilizes lasers, light-emitting diodes (LEDs), or other light sources to stimulate intracellular photobiochemical reactions and regulate cell activity through non-photothermal effects at low energy levels. Because it does not cause tissue heating or damage, it is also known as low-energy laser therapy, commonly referred to as cold laser therapy. Clinically, photomodulation uses light with wavelengths of 390-1100 nm and relatively low doses (0.04-50 J / cm²). 2 ) and strength (<100mW / cm 2 LEDs, known as the fourth generation of lighting sources and green light sources, can efficiently convert electrical energy into light energy. They are characterized by energy saving, environmental friendliness, long lifespan, and small size, and have been widely used in lighting, flat panel displays, medical devices, and other fields. Some of the world's most economically developed countries have engaged in fierce technological competition surrounding the development of LEDs.

[0003] Post-inflammatory hyperpigmentation (PIH) is a pigmentary disorder characterized by localized darkening of the skin following an inflammatory response. It has a high incidence rate, impacting patient adherence and overall well-being. Current clinical treatment of PPH remains challenging. Treatment options include hydroquinone, retinoic acid, triple therapy (hydroquinone / retinoic acid / corticosteroids), azelaic acid, and chemical peels. However, these treatments can cause side effects such as localized irritant contact dermatitis and hyperpigmentation, with higher drug concentrations increasing the risk of irritant contact dermatitis. Currently, there is a lack of standardized research models and definitively effective, safer treatment options for PPH.

[0004] Based on existing technologies, this invention provides a system for regulating skin inflammation and pigmentation simulation using LED light modulation, employing 830nm near-infrared LED light. This method can be used for clinical research, model preparation, and treatment of post-inflammatory hyperpigmentation. Summary of the Invention

[0005] The purpose of this invention is to provide a simulation system for regulating skin inflammation and pigmentation by utilizing the light modulation effect of LEDs, and thereby establish an LED phototherapy device for regulating skin inflammation and pigmentation.

[0006] This invention provides a simulation system for regulating inflammation and pigmentation based on LED light modulation, comprising an ultraviolet phototherapy device and an LED instrument; the ultraviolet phototherapy device emits excimer light with a wavelength of 308 nm to establish an experimental model of inflammation and pigmentation; the LED instrument emits LED light with a wavelength of 830 nm to regulate inflammation and pigmentation in the experimental model; wherein:

[0007] The ultraviolet phototherapy device emits ultraviolet light with a wavelength of 308±2nm and a dose of 1.5 minimum erythema dose (MED).

[0008] The LED instrument emits LED light with a wavelength of 830±10nm and a light intensity of 50-80mW / cm². 2 Depending on the set time, the energy is 40-80 J / cm³. 2 (Energy = Light Intensity * Time)

[0009] The LED light modulation simulation system for regulating inflammation and pigmentation provided by this invention has the following specific operating procedure:

[0010] An experimental model of inflammation and pigmentation was established using an ultraviolet phototherapy device. Specifically, on the first day, the device emitted ultraviolet light to irradiate the skin, inducing a skin PIH model. On days 0, 1, 3, 6, and 8 after establishing the experimental model, LED light was emitted from an LED device at an intensity of 50-80 mW / cm². 2 With an energy of 40-80 J / cm2, it regulates skin inflammation and pigmentation; thereby determining the light intensity, energy, and time for eliminating skin inflammation and pigmentation, thus constructing an LED phototherapy device for regulating skin inflammation and pigmentation.

[0011] More specifically:

[0012] The LED light irradiation can reduce the delta erythema index (ΔEI) increase after excimer light modeling, and related LED phototherapy instruments can be prepared to reduce the delta erythema index (ΔEI) increase after excimer light modeling.

[0013] The LED light irradiation can reduce the up-regulated melanin index increment (ΔMI) after excimer light modeling, and related LED phototherapy instruments can be prepared to reduce the up-regulated melanin index increment (ΔMI) after excimer light modeling.

[0014] The LED light irradiation can reduce the delta trans-epidermal index (ΔTEWL) that is upregulated after excimer light modeling, and related LED phototherapy instruments can be prepared to reduce the delta trans-epidermal index (ΔTEWL) that is upregulated after excimer light modeling.

[0015] Combining the three phototherapy devices described above yields an LED phototherapy device for regulating (treating) skin inflammation and pigmentation. Specifically, it's a head-mounted device comprising a light irradiation module, a control module, and a power module. The light irradiation module consists of a mask-type circuit board, an LED array light source, a diffuser, and a heat dissipation device, and is used to irradiate the face. The control module includes a dimming chip, buttons, and associated circuitry, used to receive user commands and set the pulse wavelength, frequency, light intensity, power, and irradiation time. The power module supplies power to both the control and light irradiation modules. During use, the light irradiation module is worn on the face, the control module is used to adjust the time, light intensity, and dosage, and the power module is activated to supply power. A light intensity of 50-80 mW / cm² is recommended. 2 Depending on the set time, the energy is 40-80 J / cm³. 2 (Energy = Light Intensity * Time)

[0016] The invention provides a simulation system for regulating inflammation and pigmentation based on the light modulation effect of LEDs, which can be further used to design LED phototherapy instruments utilizing the light modulation effect of LEDs. These LED phototherapy instruments employ high-purity, high-power LED light, expanding the application range of LEDs. By promoting the resolution of skin inflammation, promoting collagen synthesis, and inhibiting pigment synthesis, LED phototherapy instruments can effectively treat skin problems such as acne and pigmentation.

[0017] Based on the above description of the present invention, it will be apparent to those skilled in the art that various modifications can be easily made to the present invention (e.g., modifying LED treatment parameters, altering inflammation and pigmentation models), and the general principles of the present invention can be applied to other embodiments without inventive effort. Therefore, any improvements and modifications made by those skilled in the art based on the disclosure of the present invention, without departing from the scope of the present invention, should be within the protection scope of the present invention. Attached Figure Description

[0018] Figure 1 The regulatory effect of 830nm LED on inflammation. A: Statistical analysis of the parameter changes in the erythema index increment ΔEI; B: Erythema images from the C-Cube multifunctional skin imaging analysis system.

[0019] Figure 2 The regulatory effect of 830nm LED on pigment, where A: statistical changes in the parameter of melanin index increment ΔMI, and B: melanin images under the C-Cube multifunctional skin imaging analysis system.

[0020] Figure 3 The effect of 830nm LED on skin barrier function.

[0021] Figure 4 : Diagram of the structure of a head-mounted LED phototherapy device.

[0022] The diagram is labeled as follows: 1 is the lighting module, 2 is the control module, 3 is the power supply module, 4 is the heat dissipation device, 5 is the diffuser, and 6 is the LED array. Detailed Implementation

[0023] The present invention will be further described in conjunction with the embodiments and accompanying drawings. The following embodiments are for illustrative purposes only and are not intended to limit the scope of the present invention.

[0024] Example 1: The regulatory effect of 830nm LED on inflammation

[0025] A skin PIH model was induced by irradiating the thigh skin of volunteers with 308nm excimer light (dose of 1.5MED) on day 1. 830nm LED irradiation was administered on days 0, 1, 3, 6, and 8. Subjects were followed up on days 0, 1, 2, 3, 6, 8, and 9, and standard photographs of the irradiated areas were taken. The erythema index was measured using a C-Cube instrument. The C-Cube is a multifunctional skin imaging analysis system; at each specified follow-up time, the erythema index of the wound was measured using the C-Cube. For analysis, three regions were selected from each donor site, and the average value was taken.

[0026] The skin index on day 1 was taken as the baseline level. The erythema index increment (ΔEI) was defined as: erythema index at follow-up – baseline erythema index. Repeated measures ANOVA was used for overall statistical analysis, and the main effects and interactions were further analyzed using the sphericity test. A p-value < 0.05 was considered statistically significant. Graphpad Prsim 9 software was used for plotting.

[0027] The results are as follows Figure 1 As shown, 830nm LED irradiation can significantly reduce ΔEI and the erythema reaction can be significantly reduced.

[0028] Example 2: The effect of 830nm LED on pigment regulation

[0029] A skin implantation-hemorrhage (PIH) model was induced on the thigh skin of volunteers by irradiating with 308nm excimer light (dose of 1.5MED) on day 1. 830nm LED irradiation was administered on days 0, 1, 3, 6, and 8. Subjects were followed up on days 0, 1, 2, 3, 6, 8, and 9, and standard photographs of the irradiated areas were taken. Melanin index was measured using a C-Cube instrument. The C-Cube is a multifunctional skin imaging analysis system; at each specified follow-up time, the melanin index of the wound was measured using the C-Cube. Three regions were selected from each donor site for analysis, and the average value was taken.

[0030] The skin index on day 1 was taken as the baseline level. The melanin index increment (ΔMI) was defined as: melanin index at follow-up – baseline melanin index. Repeated measures ANOVA was used for overall statistical analysis, and the main effects and interactions were further analyzed using the sphericity test. A p-value < 0.05 was considered statistically significant. Graphpad Prsim 9 software was used for plotting.

[0031] The results are as follows Figure 2 As shown, 830nm LED irradiation can significantly reduce ΔMI and significantly alleviate pigmentation.

[0032] Example 3: The effect of 830nm LED on skin barrier function

[0033] A skin PIH model was induced by irradiating the thigh skin of volunteers with 308nm excimer light (dose of 1.5MED) on day 1. On days 0 and 1, 830nm LED irradiation was administered. Subjects were followed up on day 2. Transepidermal water loss (TEWL) was measured using a Delfin instrument, which detects water loss through the stratum corneum; lower TEWL indicates better skin barrier function.

[0034] The skin index on day 1 was taken as the baseline. The incremental transepidermal water loss (ΔTEWL) was defined as: transepidermal water loss at follow-up – baseline transepidermal water loss. One-way ANOVA was used. If statistically significant differences were found, pairwise post-hoc comparisons between groups were performed using the LSD test. If no statistically significant differences were found, the Friedman test was used. A p-value < 0.05 was considered statistically significant. GraphpadPrsim 9 software was used for plotting.

[0035] The results are as follows Figure 3 As shown, 830nm LED irradiation significantly reduces ΔTEWL on the second day after modeling with 308nm excimer light.

[0036] Example 4: Based on the above-described simulation system for regulating skin inflammation and pigmentation of the present invention, an LED phototherapy device for regulating skin inflammation and pigmentation is further constructed. Its structure is described below. Figure 4 As shown, the device is specifically designed as a head-mounted display, comprising a light-emitting module 1, a control module 2, and a power module 3. The light-emitting module 1 consists of a mask-type circuit board, an LED array light source 6, a diffuser 5, and a heat dissipation device 4, used to illuminate the face. The control module 2 includes a dimming chip, buttons, and associated circuitry, used to receive user commands and set the pulse wavelength, frequency, light intensity, power, and illumination duration. The power module 3 supplies power to the control module 2 and the light-emitting module 1. In use, the light-emitting module is worn on the face, and the control module 2 adjusts the time, light intensity, and dosage, while the power module 3 is activated to supply power. The light intensity is 50-80 mW / cm². 2 Depending on the set time, the energy is 40-80 J / cm³.2 This allows for phototherapy of skin inflammation and pigmentation (refer to ΔEI, ΔMI, ΔTEWL respectively).

Claims

1. A simulation system for regulating skin inflammation and pigmentation based on LED light modulation, characterized in that, The system comprises an ultraviolet phototherapy instrument and an LED instrument. The ultraviolet phototherapy instrument is used for emitting excimer light to establish an experimental model of inflammation and pigmentation, and the LED instrument is used for emitting LED light to regulate inflammation and pigmentation of the experimental model. The ultraviolet phototherapy instrument emits ultraviolet light with a wavelength of 308 ± 2 nm and a dose of 1.5 minimum erythema dose (MED). The LED instrument emits LED light with a wavelength of 830 ± 10 nm and an intensity of 50 - 80 mW / cm 2 , and an energy of 40 - 80 J / cm 2 , according to a set time. The operation process is as follows: An experimental model of inflammation and pigmentation is established by the ultraviolet phototherapy instrument, specifically, on the first day, ultraviolet light is emitted by the ultraviolet phototherapy instrument to irradiate the skin to induce a skin PIH model; on days 0, 1, 3, 6, and 8 after the experimental model is established, LED light is emitted by the LED instrument to irradiate, the light intensity is 50-80 mW / cm 2 , and the energy is 40-80 J / cm 2 , to regulate the inflammation and pigmentation of the skin; The light intensity, energy and time for eliminating skin inflammation and pigmentation are determined to construct an LED phototherapy instrument for regulating skin inflammation and pigmentation.

2. The simulation system according to claim 1, characterized in that: (1) The LED light irradiation can reduce the erythema index increment (ΔEI) increased by the excimer light modeling, and the related LED phototherapy instrument for reducing the erythema index increment (ΔEI) increased by the excimer light modeling can be prepared; (2) The LED light irradiation can reduce the melanin index increment (ΔMI) increased by the excimer light modeling, and the related LED phototherapy instrument for reducing the melanin index increment (ΔMI) increased by the excimer light modeling can be prepared; (3) The LED light irradiation can reduce the trans-epidermal water loss increment (ΔTEWL) increased by the excimer light modeling, and the related LED phototherapy instrument for reducing the trans-epidermal water loss increment (ΔTEWL) increased by the excimer light modeling can be prepared.

3. An LED phototherapy device for treating skin inflammation and pigmentation, characterized in that, The three LED phototherapy instruments obtained from the simulation system of claim 2 are included: The related LED phototherapy instrument for reducing the erythema index increment (ΔEI) increased by the excimer light modeling; The related LED phototherapy instrument for reducing the melanin index increment (ΔMI) increased by the excimer light modeling; The related LED phototherapy instrument for reducing the trans-epidermal water loss increment (ΔTEWL) increased by the excimer light modeling; The three kinds of LED phototherapy instruments are combined to obtain an LED phototherapy instrument for treating skin inflammation and pigmentation.

4. The LED phototherapy device for treating skin inflammation and pigment according to claim 3, wherein, Specifically include illumination module, control module and power module; illumination module by mask type circuit board, LED array light source, diffusion sheet and heat dissipation device is composed, with head-mounted irradiation face; control module contains light adjusting chip, button and its supporting circuit, for receiving user instruction and setting pulse light wavelength, frequency, light intensity, power and illumination time; power module for power supply to control module and light source module; use will be worn in the face of illumination module, using control module to regulate time and light intensity, dose, start power module power supply; recommended light intensity is 50-80 mW / cm 2 , according to the setting time, the energy is 40-80 J / cm 2 .

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