An animal model and method for assessing the hair growth and / or pigmentation effects of a substance

By injecting the substance to be evaluated and the control solution into the whiskers or beard pads of experimental animals, the symmetry of these substances is used to assess hair growth and staining, thus solving the problems of complex operation and low sensitivity in existing technologies and achieving efficient and quantitative evaluation results.

CN116008026BActive Publication Date: 2026-07-07JINSU BIOTECHNOLOGY (SHANGHAI) CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINSU BIOTECHNOLOGY (SHANGHAI) CO LTD
Filing Date
2022-12-14
Publication Date
2026-07-07

AI Technical Summary

Technical Problem

Existing technologies for evaluating the effects of substances on hair growth and coloration suffer from problems such as complex operation, poor accuracy, and low sensitivity, making it difficult to achieve efficient and quantitative evaluation.

Method used

By utilizing the symmetry of the whiskers of experimental animals, a solution containing the substance to be evaluated was injected subcutaneously or via microneedle into the whisker pads or beard pads. The substance to be evaluated and the control solution were injected into the whisker follicles on both sides, and changes in hair growth and coloring were observed.

Benefits of technology

This method enables highly sensitive and accurate in vivo quantitative assessment of the regulatory effects of substances on hair growth and staining, simplifies the operation, and improves the feasibility and sensitivity of detection.

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Abstract

The application discloses an animal model and a detection method for evaluating the effects of a substance on hair growth and / or coloring. The evaluation steps are as follows: the experimental animal is plucked, and then the substance to be evaluated is injected into the tentacle pad or the mustache pad or the hair follicle cavity on one side of the experimental animal, and a control solution is injected into the tentacle pad or the mustache pad or the opposite symmetrical hair follicle cavity on the other side of the experimental animal; after a certain number of injections, the hair on the side injected with the control solution grows, while the hair on the side injected with the solution containing the substance to be evaluated grows or does not grow; the length and / or coloring of the grown hair are quantitatively detected and compared, so that the effects of the substance on hair growth and / or coloring can be accurately evaluated. The application utilizes the symmetry of the hair of the experimental animal, and a simple, direct and high-sensitivity method for quantitatively evaluating the effects of a substance on hair growth in vivo is obtained, which can be used for the research on skin diseases and the development of related drugs, cosmetics and the like, and has important scientific significance and application value.
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