High-precision nerve electrical stimulation device and control method thereof

Abstract

This invention provides a high-precision neurostimulation device and its control method. The device includes: stimulation modules connected to stimulation electrodes for applying electrical stimulation signals to the cerebral cortex; an interaction module for receiving user commands to enable user interaction; a main control module for receiving commands from the interaction module and driving the stimulation modules to output electrical stimulation signals; and a stimulation module for outputting high-precision electrical stimulation signals to each stimulation electrode, and through a preset channel control module, combining the stimulation electrodes in three configurations—cathode, anode, and electrode suspension—to form an M×N high-precision electrical stimulation. Based on traditional transcranial electrical stimulation technology, this invention improves the stimulation circuitry, making the channel states flexibly adjustable, achieving flexible and high-precision electrical stimulation with more pronounced stimulation effects and more precise stimulation sites. The high-precision electrodes can be combined in various ways, possessing strong scalability and meeting the needs of complex application scenarios.

Description

Technical Field

[0001] This invention relates to the field of brain nerve modulation, and more specifically, to a high-precision neural electrical stimulation device and its control method. Background Technology

[0002] With improved living conditions, sub-health conditions are attracting increasing attention. Brain-related sub-health conditions such as insomnia, forgetfulness, and poor concentration can affect normal work and life, and long-term sub-health can develop into brain dysfunction and neurodegenerative diseases such as depression and schizophrenia. Brain dysfunction and neurodegenerative diseases, including schizophrenia, Alzheimer's disease, epilepsy, depression, and autism, seriously impact people's lives. Furthermore, with the accelerating aging of society and exacerbating environmental problems, the number of these patients is increasing daily, placing a significant economic burden on families and society.

[0003] The brain is an organ composed of hundreds of billions of neurons, forming an interwoven neural network. Information is transmitted and integrated between these networks through the firing of membrane potentials in neurons. Therefore, abnormalities in neural circuits can be considered as disturbances in the electrical activity of the brain's neural network. To regulate these disordered neural circuits, scientists have developed neuromodulation techniques, which use invasive or non-invasive methods to modulate the brain's electrical activity, thereby achieving the goal of regulating the brain's state. Currently, techniques for neural circuit modulation include natural stimulation, drug intervention, and electrical, magnetic, and mechanical stimulation, all of which essentially alter the electrical activity of the neural network. Among these, natural stimulation is the most easily accepted by patients, with very few side effects, but its effects are minimal; drug intervention is the most widely used, but its influence on neural circuits is indirect and accompanied by significant side effects; electrical, magnetic, and mechanical stimulation have more direct effects, especially through external, non-invasive stimulation, which can alleviate patient suffering. Currently, non-invasive transcranial electrical stimulation (tES) is widely used in the field of neuromodulation due to its non-invasiveness and convenience, becoming one of the main methods in cognitive neuroscience, brain science research, and the treatment of mental illnesses. Furthermore, when combined with neuroimaging techniques such as fMRI, EEG, and MEG, more precise and efficient modulation can be achieved. However, traditional non-invasive tES uses a pair of stimulating electrodes to form a current loop acting on the cerebral cortex, but due to uneven electric field distribution, the efficiency of modulating neural circuits needs improvement. High-precision tES introduces the definitions of auxiliary electrodes and a central electrode, arranging multiple auxiliary electrodes around the central electrode. Current flows between the auxiliary and central electrodes, with controllable flow direction and electric field distribution. Compared to traditional tES, the point of application is more focused, resulting in higher modulation efficiency.

[0004] However, existing technologies can often only achieve electrical stimulation in a fixed form. For example, high-precision electrodes achieved by 1x4 or 4x1 electrodes are limited to only four electrodes, and the methods are singular, with poor scalability, which cannot meet the needs of complex application scenarios. Summary of the Invention

[0005] To address the problems existing in current technologies, this invention provides a high-precision neural electrical stimulation device and its control method. The specific solution is as follows:

[0006] A high-precision neuro-electrical stimulation device includes a wearable support device, a main control module, a stimulation module, an interaction module, and a power supply module for power supply. The wearable support device integrates stimulation electrodes with X channels, where X > 2.

[0007] Each stimulation electrode is connected to the stimulation module and is used to apply electrical stimulation signals to the cerebral cortex.

[0008] The interaction module is used to receive user commands to enable user interaction;

[0009] The main control module is connected to the power module, the interaction module and the stimulation module respectively, and is used to receive instructions from the interaction module and drive the stimulation module to output electrical stimulation signals.

[0010] The stimulation module is used to output high-precision electrical stimulation signals to each stimulation electrode, and through a preset channel control module, the stimulation electrodes are combined into M×N high-precision electrical stimulation in three forms: cathode, anode, and electrode suspension.

[0011] Where M represents the number of central electrodes and N represents the number of auxiliary electrodes, both M and N are greater than zero, and M+N≤X.

[0012] In one specific embodiment, it also includes a smart terminal and a communication module;

[0013] The smart terminal establishes a communication connection with the main control module through the communication module, and is used to send instructions to the main control module.

[0014] In one specific embodiment, the polarity of the electrical stimulation signal output by the stimulation module is adjustable;

[0015] The electrical stimulation signal includes DC signal, AC signal, pulse signal, random noise signal, or spurious stimulation signal.

[0016] In one specific embodiment, for the stimulating electrodes with 9 channels, the high-precision electrical stimulation takes the form of a 3×3 array, which specifically includes:

[0017] Nine stimulation electrodes are divided into cathodes and anodes, arranged in a 3×3 row and column format, and combined to form a 1×8 high-precision electrical stimulation.

[0018] Alternatively, the five stimulation electrodes are divided into cathodes and anodes, and four electrodes are suspended in the air. They are arranged in a 3×3 matrix format to form a 1×4 high-precision electrical stimulation.

[0019] In one specific embodiment, "the nine stimulation electrodes are divided into cathodes and anodes" specifically includes:

[0020] The nine stimulation electrodes are divided into eight cathodes and one anode, with the anode surrounding the eight cathodes in a 3×3 row and column configuration.

[0021] Alternatively, the nine stimulation electrodes are divided into one cathode and eight anodes, with the cathode surrounding the eight anodes in a 3×3 row and column configuration;

[0022] In one specific embodiment, "five stimulation electrodes are divided into cathodes and anodes, with four electrodes suspended" specifically includes:

[0023] The five stimulation electrodes are divided into four cathodes and one anode. A cross structure is constructed around the four cathodes with the anode as the center, and another cross structure is constructed around the four suspended electrodes with the anode as the center.

[0024] Alternatively, the five stimulation electrodes can be divided into one cathode and four anodes, forming a cross structure around the four anodes with the cathode as the center, and another cross structure around the four suspended electrodes with the cathode as the center.

[0025] In one specific embodiment, for the stimulation electrodes with 9 channels, the high-precision electrical stimulation also includes a double-cross type consisting of two cross structures connected together.

[0026] The double cross shape specifically includes:

[0027] The nine stimulation electrodes are divided into seven cathodes and two anodes. The two anodes serve as the center of each cross structure, and four cathodes surround each anode. The two cross structures are connected through one cathode, forming a 2×7 high-precision electrical stimulation.

[0028] Alternatively, the nine stimulation electrodes are divided into two cathodes and seven anodes. The two cathodes serve as the center of each cross structure, and four anodes surround each cathode. The two cross structures are connected through one anode, forming a 2×7 high-precision electrical stimulation.

[0029] In one specific embodiment, the stimulation module is provided with multiple constant current source circuits with bipolar power supplies, each of which includes a high-precision adjustable resistor to achieve flexible adjustment of the current.

[0030] In one specific embodiment, the smart terminal is used to generate a trigger signal and transmit it to the main control module through the communication module, and the main control module is used to adjust the operation of the stimulation module according to the trigger signal;

[0031] And / or, the smart terminal is used to generate a stimulation signal sequence and transmit it to the main control module through the communication module, and the main control module is used to output an electrical stimulation signal of the corresponding type according to the stimulation signal sequence.

[0032] In one specific embodiment, the channel control module includes multiple multiplexers, each of which is connected to the main control module and is used to realize the on / off state of each channel electrode.

[0033] A control method for a high-precision neural electrical stimulation device, used to control the high-precision neural electrical stimulation device described in any of the above claims, includes the following steps:

[0034] Users issue commands through the interactive module;

[0035] The main control module receives instructions from the interaction module and drives the stimulation module to output electrical stimulation signals according to the instructions.

[0036] In the stimulation module, a preset channel control module enables the stimulation electrodes to be combined in three forms—cathode, anode, and electrode suspension—to form a high-precision electrical stimulation of M×N, and outputs a high-precision electrical stimulation signal to each stimulation electrode; where M represents the number of central electrodes, N represents the number of auxiliary electrodes, both M and N are greater than zero, and M+N≤X; where X>2.

[0037] X channels of stimulation electrodes output electrical stimulation signals to the user's cerebral cortex.

[0038] In one specific embodiment, it further includes:

[0039] The smart terminal generates a trigger signal and transmits it to the main control module through the communication module. The main control module adjusts the operation of the stimulation module according to the trigger signal.

[0040] The smart terminal generates a stimulation signal sequence and transmits it to the main control module through the communication module. The main control module is used to output an electrical stimulation signal of the corresponding type according to the stimulation signal sequence.

[0041] Beneficial effects:

[0042] This invention provides a high-precision neurostimulation device and its control method. Based on traditional transcranial electrical stimulation (TCS) technology, it improves the stimulation circuit to make the channel state flexibly adjustable, achieving highly precise electrical stimulation with more pronounced stimulation effects and more accurate stimulation sites. The high-precision electrodes can be combined in various ways, possessing strong scalability to meet the needs of complex application scenarios.

[0043] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, preferred embodiments are described below in detail with reference to the accompanying drawings. Attached Figure Description

[0044] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. It should be understood that the following drawings only show some embodiments of the present invention and should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can be obtained based on these drawings without creative effort.

[0045] Figure 1 This is a module relationship diagram of the nerve electrical stimulation device of the present invention;

[0046] Figure 2 This is a schematic diagram of the digital-to-analog conversion module circuit of the present invention;

[0047] Figure 3 This is a schematic diagram of the constant current source module circuit of the present invention;

[0048] Figure 4 This is a schematic diagram of the channel control module circuit of the present invention;

[0049] Figure 5 This is a schematic diagram of the channel multiplexing module circuit of the present invention;

[0050] Figure 6 This is a schematic diagram of the analog-to-digital conversion module circuit of the present invention;

[0051] Figure 7 This is a schematic diagram of the one-yang-eight-yin high-precision stimulation method of the present invention;

[0052] Figure 8 This is a schematic diagram of the one-yin-eight-yang high-precision stimulation of the present invention;

[0053] Figure 9 This is a schematic diagram of the one-positive-four-negative high-precision stimulation method of the present invention;

[0054] Figure 10 This is a schematic diagram of the one-yin-four-yang high-precision stimulation of the present invention;

[0055] Figure 11This is a schematic diagram of the two-yang and seven-yin high-precision stimulation method of the present invention;

[0056] Figure 12 This is a schematic diagram of the high-precision stimulation of two yin and seven yang in this invention;

[0057] Figure 13 This is a schematic diagram of the control method of the present invention.

[0058] Reference numerals: 1-Communication module; 2-Main control module; 3-Stimulation module; 4-Interaction module; 5-Power supply module; 6-Smart terminal; 7-Wearable support device. Detailed Implementation

[0059] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only a part of the embodiments of the present invention, and not all of them. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the scope of protection of the present invention.

[0060] It should be noted that the appendix Figure 7-12 The diagrams provided are just a few typical examples of MxN high-precision electrical stimulation. In practical applications, corresponding modes can be designed according to specific application scenarios.

[0061] It should be noted that this invention targets multi-channel stimulation electrodes, and different numbers of channels will produce different levels of high-precision electrical stimulation. The 9-channel stimulation electrode described in the embodiments is only a preferred embodiment.

[0062] Example 1

[0063] This embodiment proposes a high-precision neurostimulation device based on multiple channel stimulation electrodes. The state of each channel can be flexibly controlled to form an MxN high-precision electrical stimulation system. It eliminates the need for electrode disassembly and assembly, thus expanding its application scenarios. The module relationship diagram of the neurostimulation device is shown in the attached specification. Figure 1 As shown, the specific solution is as follows:

[0064] A high-precision neurostimulation device includes a wearable support device 7, a main control module 2, a stimulation module 3, an interaction module 4, and a power supply module 5. The stimulation module 3 is connected to electrodes on the wearable support device 7, and the main control module 2 is connected to the power supply module 5, the interaction module 4, and the stimulation module 3. A communication module 1 and a smart terminal 6 can also be added as auxiliary expansion components; the device can operate normally even without the communication module 1 and the smart terminal 6. A schematic diagram of the device's modules is attached. Figure 1As shown, the smart terminal 6 establishes a communication connection with the main control module 2 through the communication module 1. The main control module 2 receives operation commands through the interaction module 4 and displays the system status data in the interaction module 4. Based on the operation commands, the main control module 2 drives the stimulation module 3 to output high-precision electrical signals. These electrical signals act on the brain through the wearable support device 7. Simultaneously, the stimulation module 3 monitors the status of the electrical signals and transmits them to the main control module 2. The power module 5 provides the electrical energy required for the system to operate normally. Furthermore, the self-developed software on the smart terminal 6 can input trigger signals and specially designed stimulation sequences through the communication module 1, and can also detect system information.

[0065] The wearable support device 7 integrates multiple channels of stimulation electrodes, each connected to the stimulation module 3, used to apply electrical stimulation signals to the cerebral cortex. The number of channels can be set according to actual needs. It should be noted that different numbers of channels can generate different types of high-precision electrical stimulation. The head-mounted wearable device fits the user's head and can be worn directly on the user's head, allowing the current output from the stimulation module 3 to act on the user's cerebral cortex through the stimulation electrodes, achieving a neuromodulation effect. For example, the wearable support device 7 integrates an electrode cap and several detachable stimulation electrodes mounted on the electrode cap. The electrode cap is made of elastic material and has 128 electrode mounting holes to meet the needs of different individuals and different brain regions. The detachable stimulation electrodes can be made of Ag / AgCl material, and can be used with a highly conductive conductive paste.

[0066] Interaction module 4 is used to receive user commands to enable user interaction. It includes a button adjustment unit and a screen display unit, which together realize the user interaction of the system and control the operation of the system. Users can control channel control, current magnitude, waveform selection, start and stop, etc. through interaction module 4.

[0067] Stimulation module 3 outputs high-precision electrical stimulation signals to each stimulation electrode. Through a preset channel control module, the stimulation electrodes are combined in three configurations—cathode, anode, and electrode suspension—to form an M×N high-precision electrical stimulation system. Here, M represents the number of central electrodes, and N represents the number of auxiliary electrodes. Both M and N are greater than zero, and M+N≤X, where X is greater than 2. Preferably, stimulation module 3 includes multiple bipolar power supply constant current source circuits, each containing a high-precision adjustable resistor to achieve flexible current adjustment. This embodiment allows for an unlimited number of stimulation channels. Through electrodes mounted on electrode caps, the system acts on the brain, and the state of each channel can be arbitrarily adjusted to form an M×N high-precision electrical stimulation system. M and N can be adjusted arbitrarily without the need to disassemble or reassemble the electrodes.

[0068] In one specific embodiment, the stimulation module 3 includes a digital-to-analog conversion module, a constant current source module, a channel control module, a channel multiplexing module, and an analog-to-digital conversion module. The digital-to-analog conversion module mainly comprises a 16-bit high-precision digital-to-analog conversion chip, capable of outputting stimulation waveforms including DC signals, AC signals, pulse signals, random noise signals, or spurious stimulation signals, with a maximum current of ±2mA and an adjustment accuracy of 0.01mA. Its circuit diagram is shown below. Figure 2 As shown in the diagram. The constant current source module mainly consists of eight bipolar power supply constant current source circuits. Each constant current source circuit contains a high-precision adjustable resistor, which can realize flexible adjustment of the current. Its circuit diagram is shown in the diagram. Figure 3 As shown in the diagram. The channel control module mainly consists of eight bipolar power supplies and low-impedance multiplexers, controlled by the GPIO interface of the main control module 2, to achieve independent control of the electrode states of the eight channels. Its circuit diagram is shown in the diagram. Figure 4 As shown in the diagram. The channel multiplexing module mainly consists of multiple 8-to-1 multiplexer chips, controlled by the GPIO interface of the main control module 2, used to select any one of the eight channels. Its circuit diagram is shown in the diagram. Figure 5 As shown in the diagram. The analog-to-digital conversion module mainly includes a 16-bit high-precision analog-to-digital converter chip, which is connected to the main control module 2 via an SPI interface. It transmits the acquired voltage and impedance information to the main control module 2. Its circuit diagram is shown in the diagram. Figure 6 As shown.

[0069] As the core control unit of the device, the main control module 2 is responsible for executing the control work of each module and controlling the normal operation of the system. For example, its functions are: 1) receiving data and signals from the smart terminal 6 through the communication module 1; 2) sending system status information to the smart terminal 6 through the communication module 1; 3) controlling the status of each channel in the stimulation module 3; 4) controlling the stimulation module 3 to output high-precision electrical stimulation; 5) detecting the high-precision electrical stimulation current output by each channel of the stimulation module 3; 6) completing system interaction through the interaction module 4; and 7) monitoring the battery information in the power supply module 5.

[0070] For example, the main control module 2 mainly consists of an embedded microcontroller, which performs the following functions: 1) connecting to the serial communication module 1 and the wireless communication module 1 through a serial data transmission interface to achieve data communication with the smart terminal 6, including input of stimulus sequences, input of trigger signals, and output of system information; 2) connecting to the digital-to-analog converter chip through a serial peripheral interface (SPI) to drive the digital-to-analog converter chip to output analog signals; 3) connecting to the digital-to-analog converter chip through a general purpose input / output interface (GPIO). The Input / Output (GPIO) control channel control module controls the state of each stimulation channel, including anode, cathode, and floating; 4) the channel multiplexing module selects a stimulation channel through the GPIO interface and collects information from each stimulation channel; 4) the SPI interface connects to the analog-to-digital converter module to collect data from each channel, including voltage and impedance; 5) the GPIO interface connects to the internal analog-to-digital converter interface and the button adjustment module to control the system, including channel state selection, current adjustment, waveform selection, start and stop; 6) the serial data transmission interface connects to the screen display module to display the system's operating status; 7) the IIC (Inter-Integrated Circuit, also called I2C) interface connects to the battery management module to monitor battery information, including battery level and charging status.

[0071] Power module 5 includes a battery, a battery management module, and a voltage conversion module. The battery is a high-capacity 12V lithium battery, which can power the system for 4 hours continuously. The battery management module mainly contains a battery management chip, which can realize on-board charging of the battery, power acquisition, and monitoring of charging and discharging information. The voltage conversion module contains multiple voltage conversion chips, which convert the 12V voltage into 3.3V, ±12V, etc., to provide voltages for use by various modules.

[0072] For example, the smart terminal 6 can generate a trigger signal and transmit it to the main control module 2 via the communication module 1. The main control module 2 adjusts the operation of the stimulation module 3 according to the trigger signal. The smart terminal 6 can also generate a stimulation signal sequence and transmit it to the main control module 2 via the communication module 1. The main control module 2 outputs an electrical stimulation signal of the corresponding type according to the stimulation signal sequence. The smart mobile terminal realizes wired or wireless data transmission with the hardware system through a self-developed application. Its main functions include: 1) sending a special stimulation sequence to the hardware system; 2) sending a special trigger signal to the hardware system to trigger the system to start or stop working; 3) detecting system information, including hardware version, firmware version, and working status. The self-developed application can be used across platforms, including Windows, Android, or iOS. Therefore, the smart terminal 6 includes devices such as computers, mobile phones, or tablets based on these platforms.

[0073] Communication module 1 includes serial communication module 1 and wireless communication module 1. Serial communication module 1 mainly consists of a level conversion chip. Since the logic levels of the main control module 2 and the smart terminal 6 are inconsistent, level conversion is required to achieve wired communication between the main control module 2 and the smart terminal 6. Wireless communication module 1 mainly consists of a low-power WIFI transmission module, which is used to complete wireless data communication between the smart mobile terminal and the main control module 2.

[0074] In one specific embodiment, the serial communication module 1, wireless communication module 1, main control module 2, digital-to-analog conversion module, constant current source module, channel control module, channel multiplexing module, analog-to-digital conversion module, button adjustment module, screen display module, battery, battery management module, and voltage conversion module are integrated on a single circuit board and housed in a main unit box. The main unit box is wired to the smart terminal 6 via the serial communication module 1 or wirelessly connected to the smart terminal 6 via the wireless communication module 1. The main unit box is connected to detachable electrodes via insulated metal wires.

[0075] The high-precision neurostimulation device of this embodiment is based on multiple-channel stimulation electrodes, each with three configurations, thus enabling various forms of high-precision electrical stimulation. The appropriate configuration can be selected based on different application conditions. The three electrode configurations are cathode, anode, and electrode suspension. Electrode suspension means that the electrode does not contact the skin and therefore cannot transmit electrical signals to the cerebral cortex. For example, for a 9-channel stimulation electrode, this embodiment proposes two preferred high-precision electrical stimulation configurations: a 3×3 array and a double-cross configuration.

[0076] Specifically, the 3×3 array includes: 9 stimulation electrodes divided into cathodes and anodes, arranged in a 3×3 row and column format to form a 1×8 high-precision electrical stimulation; or, 5 stimulation electrodes divided into cathodes and anodes, combined with 4 electrodes suspended, arranged in a 3×3 row and column format to form a 1×4 high-precision electrical stimulation.

[0077] The nine stimulation electrodes can be configured in either a one-cathode-eight-anode or a one-anode-eight-cathode configuration. The one-anode-eight-cathode configuration specifically involves dividing the nine electrodes into eight cathodes and one anode, arranged in a 3×3 row and column pattern around the anode, as shown in the attached diagram. Figure 7 As shown. The "one cathode, eight anodes" configuration specifically includes: nine stimulating electrodes divided into one cathode and eight anodes, arranged in a 3×3 row and column pattern around the eight anodes, with the cathode at the center. See attached diagram for details. Figure 8 As shown.

[0078] Five stimulation electrodes combined with four suspended electrodes can be configured to create one cathode and four anode or one anode and four cathode configurations. The one anode and four cathode configuration specifically involves dividing the five stimulation electrodes into four cathodes and one anode. A cross structure is constructed around the four cathodes with the anode at the center, and another cross structure is constructed around the four suspended electrodes with the anode at the center. See attached diagram for details. Figure 9 As shown in the attached diagram. The "one cathode, four anodes" configuration specifically includes: five stimulating electrodes divided into one cathode and four anodes. A cross structure is constructed around the four anodes with the cathode at the center, and another cross structure is constructed around the four suspended electrodes with the cathode at the center. See the attached diagram for details. Figure 10 As shown.

[0079] Similarly, a 5-channel stimulation electrode can achieve one negative and four positive, or one positive and four negative, without needing to be suspended. A 10-channel stimulation electrode with 5 electrodes suspended can also achieve one negative and four positive, or one positive and four negative.

[0080] The double-cross type consists of two connected cross structures. The nine stimulation electrodes can be configured in two-negative-seven-positive or two-positive-seven-negative configurations. Specifically, the two positive-seven-negative configuration involves dividing the nine stimulation electrodes into seven cathodes and two anodes. The two anodes serve as the center of each cross structure, with four cathodes surrounding each anode. The two cross structures are connected by a cathode, forming a 2×7 high-precision electrical stimulation pattern, as detailed in the attached diagram. Figure 11 As shown in the attached diagram. The two-negative-seven-positive configuration specifically includes: nine stimulation electrodes divided into two cathodes and seven anodes. The two cathodes serve as the center of each cross-shaped structure, with four anodes surrounding each cathode. Two cross-shaped structures are connected by a single anode, forming a 2×7 high-precision electrical stimulation. See the attached diagram for details. Figure 12 As shown.

[0081] This embodiment provides a high-precision neurostimulation device. Based on traditional transcranial electrical stimulation technology, it improves the stimulation circuit to make the channel state flexibly adjustable, achieving flexible and high-precision electrical stimulation with more obvious stimulation effects and more precise stimulation sites. The high-precision electrodes can be combined in various ways, possessing strong scalability to meet the needs of complex application scenarios.

[0082] Example 2

[0083] This embodiment provides a control method for a high-precision neural electrical stimulation device, used to control a high-precision neural electrical stimulation device of Embodiment 1. A flowchart of the control method is shown in the attached specification. Figure 13 As shown, the specific solution is as follows:

[0084] A control method for a high-precision nerve electrical stimulation device includes the following steps:

[0085] 101. Users issue commands through the interaction module;

[0086] 102. The main control module receives instructions from the interaction module and drives the stimulation module to output electrical stimulation signals according to the instructions;

[0087] 103. In the stimulation module, through the preset channel control module, each stimulation electrode is combined into a high-precision electrical stimulation of M×N in three forms: cathode, anode, and electrode suspension, and outputs a high-precision electrical stimulation signal to each stimulation electrode; where M represents the number of central electrodes, N represents the number of auxiliary electrodes, M and N are both greater than zero, and M+N≤X, X is greater than 2.

[0088] 104. The X-channel stimulation electrodes output electrical stimulation signals to the user's cerebral cortex.

[0089] Control methods also include:

[0090] The smart terminal generates a trigger signal and transmits it to the main control module through the communication module. The main control module adjusts the operation of the stimulation module according to the trigger signal.

[0091] The smart terminal generates a stimulation signal sequence and transmits it to the main control module through the communication module. The main control module is used to output the corresponding type of electrical stimulation signal according to the stimulation signal sequence.

[0092] This embodiment provides a control method for a high-precision neurostimulation device, used to control a high-precision neurostimulation device of Embodiment 1, making it more practical.

[0093] This invention provides a high-precision neurostimulation device and its control method. Based on traditional transcranial electrical stimulation (TCS) technology, it improves the stimulation circuit to make the channel state flexibly adjustable, achieving highly precise electrical stimulation with more pronounced stimulation effects and more accurate stimulation sites. The high-precision electrodes can be combined in various ways, possessing strong scalability to meet the needs of complex application scenarios.

[0094] Those skilled in the art will understand that the modules of the present invention described above can be implemented using general-purpose computing systems. They can be centralized on a single computing system or distributed across a network of multiple computing systems. Optionally, they can be implemented using computer-executable program code, thereby allowing them to be stored in a storage system for execution by the computing system. Alternatively, they can be fabricated as separate integrated circuit modules, or multiple modules or steps can be fabricated as a single integrated circuit module. Thus, the present invention is not limited to any particular combination of hardware and software.

[0095] Note that the above description is merely a preferred embodiment of the present invention and the technical principles employed. Those skilled in the art will understand that the present invention is not limited to the specific embodiments described herein, and various obvious changes, readjustments, and substitutions can be made without departing from the scope of protection of the present invention. Therefore, although the present invention has been described in detail through the above embodiments, the present invention is not limited to the above embodiments, and may include many other equivalent embodiments without departing from the concept of the present invention, the scope of which is determined by the scope of the appended claims.

[0096] The above-disclosed examples are only a few specific implementation scenarios of the present invention. However, the present invention is not limited thereto, and any variations that can be conceived by those skilled in the art should fall within the protection scope of the present invention.

Claims

1. A high-precision nerve electrical stimulation device, characterized in that, It includes a wearable support device, a main control module, a stimulation module, an interaction module, and a power supply module for power supply. The wearable support device integrates stimulation electrodes with X channels; where X > 2. Each stimulation electrode is connected to the stimulation module and is used to apply electrical stimulation signals to the cerebral cortex. The interaction module is used to receive user commands to enable user interaction; The main control module is connected to the power module, the interaction module and the stimulation module respectively, and is used to receive instructions from the interaction module and drive the stimulation module to output electrical stimulation signals. The stimulation module includes a digital-to-analog conversion module, a constant current source module, a channel control module, a channel multiplexing module, and an analog-to-digital conversion module. It is used to output high-precision electrical stimulation signals to each stimulation electrode. Through the channel control module, the stimulation electrodes are combined into M×N high-precision electrical stimulation in three forms: cathode, anode, and electrode suspension. The electrode suspension refers to the form in which the electrode does not contact the skin and cannot transmit electrical signals. Where M represents the number of central electrodes and N represents the number of auxiliary electrodes, both M and N are greater than zero, and M+N≤X; The constant current source module is equipped with multiple bipolar power supply constant current source circuits, each of which contains a high-precision adjustable resistor to achieve flexible current adjustment. The channel control module includes multiple bipolar power supply multiplexers, each of which is connected to the main control module and is used to control the on / off state of each channel electrode.

2. The high-precision nerve electrical stimulation device according to claim 1, characterized in that, It also includes smart terminals and communication modules; The smart terminal establishes a communication connection with the main control module through the communication module, and is used to send instructions to the main control module.

3. The high-precision nerve electrical stimulation device according to claim 1, characterized in that, The polarity of the electrical stimulation signal output by the stimulation module is adjustable; The electrical stimulation signal includes DC signal, AC signal, pulse signal, random noise signal, or spurious stimulation signal.

4. The high-precision nerve electrical stimulation device according to claim 1, characterized in that, For the stimulating electrodes with 9 channels, the high-precision electrical stimulation can be in the form of a 3×3 array, which specifically includes: Nine stimulation electrodes are divided into cathodes and anodes, arranged in a 3×3 row and column format, and combined to form a 1×8 high-precision electrical stimulation. Alternatively, the five stimulation electrodes are divided into cathodes and anodes, and four electrodes are suspended in the air. They are arranged in a 3×3 matrix format to form a 1×4 high-precision electrical stimulation.

5. The high-precision nerve electrical stimulation device according to claim 4, characterized in that, The "nine stimulation electrodes are divided into cathodes and anodes" specifically include: The nine stimulation electrodes are divided into eight cathodes and one anode, with the anode surrounding the eight cathodes in a 3×3 row and column configuration. Alternatively, the nine stimulation electrodes can be divided into one cathode and eight anodes, with the cathode surrounding the eight anodes in a 3×3 matrix.

6. The high-precision nerve electrical stimulation device according to claim 4, characterized in that, "The five stimulation electrodes are divided into cathodes and anodes, with four electrodes suspended" specifically includes: The five stimulation electrodes are divided into four cathodes and one anode. A cross structure is constructed around the four cathodes with the anode as the center, and another cross structure is constructed around the four suspended electrodes with the anode as the center. Alternatively, the five stimulation electrodes can be divided into one cathode and four anodes, forming a cross structure around the four anodes with the cathode as the center, and another cross structure around the four suspended electrodes with the cathode as the center.

7. The high-precision nerve electrical stimulation device according to claim 1, characterized in that, For the stimulation electrodes with 9 channels, the high-precision electrical stimulation also includes a double-cross type consisting of two cross structures connected together. The double cross shape specifically includes: The nine stimulation electrodes are divided into seven cathodes and two anodes. The two anodes serve as the center of each cross structure, and four cathodes surround each anode. The two cross structures are connected through one cathode, forming a 2×7 high-precision electrical stimulation. Alternatively, the nine stimulation electrodes are divided into two cathodes and seven anodes. The two cathodes serve as the center of each cross structure, and four anodes surround each cathode. The two cross structures are connected through one anode, forming a 2×7 high-precision electrical stimulation.

8. The high-precision nerve electrical stimulation device according to claim 2, characterized in that, The smart terminal is used to generate a trigger signal and transmit it to the main control module through the communication module. The main control module is used to adjust the operation of the stimulation module according to the trigger signal. And / or, the smart terminal is used to generate a stimulation signal sequence and transmit it to the main control module through the communication module, and the main control module is used to output an electrical stimulation signal of the corresponding type according to the stimulation signal sequence.

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