Taming of mucor circinelloides and its application

By domesticating *Rhizopus racemosa* to grow in an anaerobic environment at 36–38°C, the limitations of *Rhizopus racemosa* culture conditions were overcome, enabling simulated culture in an in vitro intestinal environment. This significantly improved the symptoms of radiation-induced diseases, especially intestinal radiation damage.

CN116286390BActive Publication Date: 2025-10-24NANKAI UNIV
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Patent Information

Application Number
CN202310014154.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-01-05
Publication Date
2025-10-24
Estimated Expiration
2043-01-05

AI Technical Summary

Technical Problem

In the existing technology, the culture conditions of *Rhizopus racemosa* are limited to an aerobic environment below 30°C, and cannot be carried out in a higher temperature and/or anaerobic environment, which limits its functional development and application.

Method used

Domestication of *Rhizopus racemosa* and its growth in an anaerobic environment at 36–38°C, mimicking the intestinal environment, is used to prepare drugs for treating radiation-induced diseases. Specific methods include culturing in a culture medium containing human or animal feces.

Benefits of technology

This study expands the functional application of *Rhizopus racemosa*, enabling it to be cultured in vitro in a simulated in vivo intestinal environment. It significantly improves symptoms of radiation-induced diseases, especially intestinal radiation damage, such as increased colon length, recovery of small intestinal villi, and reduced expression of inflammatory factors.

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Abstract

The application discloses a domesticated total Mucor and application thereof. The application provides the domesticated total Mucor, which is preserved in the China General Microbiological Culture Collection Center on September 19, 2022, and the preservation number is CGMCC NO. 40320. The application research finds that the domesticated total Mucor can grow in an anaerobic environment at 36-38 DEG C, can be used for preventing and / or treating radioactive diseases, expands the application field of the total Mucor, and provides theoretical guidance for clinical application. Experimental data show that the domesticated total Mucor can improve the inflammation level, integrity and function of the colon and small intestine of a mouse with intestinal type radiation injury.
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