Droplet tribological nanomotor and method for detecting content of effective component of natural medicine

Abstract

This invention relates to a droplet triboelectric nanoengine for detecting the content of active ingredients in natural medicines, its detection method, and its application. The triboelectric nanoengine includes a support, a lower electrode, a negative triboelectric material, an upper electrode, and an electrical signal detection device. The lower electrode is mounted on the support. A negative triboelectric layer is mounted on the upper surface of the lower electrode, with its upper surface inclined. The negative triboelectric layer carries droplets of the natural medicine and allows the droplets to spread. The upper electrode is mounted on the upper surface of the negative triboelectric layer. The electrical signal detection device is electrically connected to the upper and lower electrodes and is used to detect and display the electrical signal generated when the droplets of the natural medicine fall onto the surface of the negative triboelectric layer and spread, contacting and rubbing against the negative triboelectric layer. The content of the active ingredient in the natural medicine is determined based on the electrical signal. This invention's droplet triboelectric nanoengine is used for detecting the content of active ingredients in natural medicines; it has a simple structure, low cost, and fast response.

Description

Technical Field

[0001] This invention relates to the field of natural medicine active ingredient content detection technology, and in particular to a droplet triboelectric nanoengine, method and application for detecting the active ingredient content of natural medicine. Background Technology

[0002] Natural medicines are an important source of medical drugs. With the development of modern medicine, to achieve higher levels of medical care, it is necessary to extract more medicinal chemical components from plants, animals, microorganisms, and minerals. Take kudzu root as an example. Kudzu root comes from the dried root of the kudzu plant (Pueraria lobata), a legume. Ancient Chinese texts record its effects of relieving muscle tension and fever, promoting body fluid production and quenching thirst, and raising yang energy to stop diarrhea. Its efficacy is definite, making it a widely used natural medicine in clinical practice. The active ingredients in kudzu root are isoflavones, including daidzein, daidzeinogen, and puerarin. Puerarin is present in higher amounts and has antipyretic, antihypertensive, and hypoglycemic effects, and can be used as a standard for evaluating the quality of kudzu root.

[0003] To achieve better results, it is crucial to detect the content of active ingredients in natural medicines. Currently, the commonly used methods for determining the content of active ingredients in natural medicines are high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS). However, these two methods involve expensive instruments, require a wide variety of solvents, demand specialized skills, and are time-consuming. Summary of the Invention

[0004] Therefore, it is necessary to address the technical problems of high instrument cost, numerous solvents required, specialized operation, and long detection time in commonly used methods for detecting the content of effective components in natural medicines, and to provide a droplet triboelectric nanoengine for detecting the content of effective components in natural medicines, along with its detection method and application.

[0005] This invention provides a droplet triboelectric nanoengine for detecting the content of active ingredients in natural medicines, the droplet triboelectric nanoengine comprising:

[0006] Support components;

[0007] The lower electrode is mounted on the support member;

[0008] A negative triboelectric layer is installed on the upper surface of the lower electrode and its upper surface is inclined. The negative triboelectric layer is used to carry the dripping natural drug droplets and allow the droplets to spread.

[0009] The upper electrode is mounted on the upper surface of the negative triboelectric layer;

[0010] An electrical signal detection device is electrically connected to the upper and lower electrodes. The electrical signal detection device is used to detect and display the electrical signals generated when the droplet falls onto the surface of the negative triboelectric layer and during the process of contacting and rubbing with the negative triboelectric layer during spreading. The content of the effective ingredients in the natural medicine can be determined based on the electrical signals.

[0011] In a preferred embodiment of the present invention, the upper surface of the negative triboelectric layer has an inclination angle of 0 degrees to 90 degrees;

[0012] And / or, the negative triboelectric layer is a thin film or sheet;

[0013] And / or, the negative triboelectric layer is made of polystyrene, polyethylene, polypropylene, polyimide, polyvinyl chloride, polydimethylsiloxane, polytetrafluoroethylene, or fluorinated ethylene propylene copolymer.

[0014] In a preferred embodiment of the present invention, the support member includes:

[0015] Fixing plate;

[0016] The support base is a long strip or a right-angled trapezoidal structure, and its bottom is connected to the top surface of the fixed plate; and

[0017] The support plate is square in shape and connected to the top of the support base. The top surface of the support plate is inclined.

[0018] And / or, the support is made of acrylic sheet, metal sheet or wood;

[0019] And / or, the inclination angle of the top surface of the support plate is 0 degrees to 90 degrees.

[0020] In a preferred embodiment of the present invention, the lower electrode is made of aluminum foil, copper foil, tin foil or zinc foil;

[0021] And / or, the upper electrode is made of aluminum foil, copper foil, tin foil or zinc foil;

[0022] And / or, the area of ​​the upper electrode is smaller than the area of ​​the negative triboelectric layer and there is a gap between the edge of the upper electrode and the edge of the negative triboelectric layer;

[0023] And / or, when the droplet falls onto the surface of the negative triboelectric layer and spreads completely, the droplet is completely located within the negative triboelectric layer and simultaneously contacts the negative triboelectric layer and the upper electrode.

[0024] In a preferred embodiment of the present invention, the triboelectric nanoengine further includes:

[0025] A charge storage layer is located between the lower electrode and the negative triboelectric layer and is connected to the lower electrode and the negative triboelectric layer. The shape of the charge storage layer is the same as that of the negative triboelectric layer, and its area and thickness are the same as those of the negative triboelectric layer, respectively.

[0026] And / or, the charge storage layer is a thin film or sheet;

[0027] And / or, the charge storage layer is made of polyimide, polyvinyl chloride, polydimethylsiloxane, polytetrafluoroethylene, or fluorinated ethylene propylene copolymer.

[0028] In a preferred embodiment of the present invention, the triboelectric nanoengine further includes:

[0029] A droplet delivery device for continuously supplying natural drug droplets to a negatively charged triboelectric layer.

[0030] In a preferred embodiment of the present invention, the electrical signal detection device is an electrometer;

[0031] And / or, the electrical signal includes voltage and current.

[0032] This invention also proposes a method for detecting the content of the aforementioned active ingredients in natural medicines using a droplet-triboelectric nanoengine, comprising the following steps:

[0033] S1. Soak the natural medicine in water to obtain a natural medicine solution;

[0034] S2. The natural drug solution obtained in step S1 is continuously dripped onto the negative triboelectric layer in the form of droplets;

[0035] S3. Observe and record the electrical signal data of the electrical signal detection device. If the electrical signal is strong, it is determined that the content of effective ingredients in the natural medicine is low; if the electrical signal is weak, it is determined that the content of effective ingredients in the natural medicine is high.

[0036] In a preferred embodiment of the present invention, in step S1, the ratio of natural medicine to hot water is 1:10 to 150;

[0037] And / or, in step S1, the temperature of the water is 25°C to 100°C;

[0038] And / or, in step S1, the soaking time is 1 to 20 minutes.

[0039] In a preferred embodiment of the present invention, in step S2, the dropping rate of the droplet is 1 drop / second;

[0040] And / or, in step S3, the electrical signal includes voltage and current.

[0041] This invention also proposes the application of a droplet triboelectric nanoengine for detecting the content of active ingredients in natural medicines.

[0042] Compared with the prior art, the present invention has the following beneficial effects:

[0043] 1. This invention relates to a droplet triboelectric nanoengine for detecting the content of active ingredients in natural medicines. When a droplet of natural medicine falls onto the surface of a negative triboelectric layer and spreads and rubs against the layer, the electrical energy generated during the process is converted into an electrical signal output by an electrical signal detection device. The content of active ingredients in the natural medicine can be determined based on the strength of the output electrical signal. This invention is not only simple in structure, easy to manufacture, and low in cost, but also has high output performance, fast response, short detection time, and high detection accuracy. It has a high electrical response characterizing the concentration of active ingredients and a large concentration detection range, and can be performed without the need for professional personnel.

[0044] 2. In detecting the content of active ingredients in natural medicines, this invention involves dropping natural medicine solutions with different active ingredient contents onto the surface of a droplet-triggered nanogenerator. Due to the difference in electron gain and loss, the magnitude of the output electrical signal shows a certain regularity and correlation with the concentration of active ingredients in the medicine solution. The content of active ingredients in natural medicines is determined by the output electrical signals of different magnitudes. This invention effectively utilizes the potential energy of the falling natural medicine solution and converts it into electrical energy, thereby realizing the detection of the content of active ingredients in natural medicines. It has certain application value in the field of detecting the content of active ingredients in natural medicines.

[0045] 3. The droplet triboelectric nanoengine for detecting the content of active ingredients in natural medicines of this invention maintains the structural advantages of the original droplet triboelectric generator, and retains more triboelectric charge by adding a charge storage layer, thereby greatly improving the output performance.

[0046] 4. The detection equipment for the method of detecting the content of effective components in natural medicines of the present invention is simple to prepare, green and environmentally friendly, sustainable, low in cost, small in size, requires no external driving energy, has a fast response, high sensitivity, long service life, and stable output. It can achieve rapid response to drug solutions of different concentrations and can be applied to the content determination of effective components in various drugs. Thus, it solves the technical problems of high cost of detection instruments, many types of solvents used in detection, professional operation, and long detection time in the current methods for detecting the content of effective components in natural medicines. Attached Figure Description

[0047] Figure 1 This is a schematic diagram of the droplet triboelectric nanoengine for detecting the content of effective components in natural medicines proposed in Example 1 of the present invention;

[0048] Figure 2 for Figure 1A schematic diagram of the support structure for a droplet-triboelectric nanoengine used to detect the content of active ingredients in traditional Chinese medicines;

[0049] Figure 3 for Figure 1 A schematic diagram of a droplet-triboelectric nanoengine used for detecting the content of active ingredients in natural Chinese medicines;

[0050] Figure 4 for Figure 1 Output voltage diagram of droplet triboelectric nanoengine at different drop rates for detecting the content of active ingredients in traditional Chinese medicines;

[0051] Figure 5 for Figure 1 Output current diagram of droplet triboelectric nanoengine at different drop rates for detecting the content of active ingredients in traditional Chinese medicines;

[0052] Figure 6 for Figure 1 Voltage-power graph of droplet triboelectric nanoengine used for detecting the content of active ingredients in traditional Chinese medicines at a drop rate of 1 drop / second;

[0053] Figure 7 In Embodiment 2 of the present invention, the following is utilized Figure 1 Output voltage diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0054] Figure 8 In Embodiment 2 of the present invention, the following is utilized Figure 1 Output current diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0055] Figure 9 The method used in Embodiment 3 of the present invention Figure 1 Output voltage diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0056] Figure 10 The method used in Embodiment 3 of the present invention Figure 1 Output current diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0057] Figure 11 The method used in Embodiment 4 of the present invention Figure 1 Output voltage diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0058] Figure 12 The method used in Embodiment 4 of the present invention Figure 1 Output current diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0059] Figure 13 The method used in Embodiment 5 of the present invention Figure 1 Output voltage diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0060] Figure 14 The method used in Embodiment 5 of the present invention Figure 1 Output current diagrams obtained by detecting kudzu root solutions with different contents of active ingredients using droplet triboelectric nanogenerators;

[0061] Figure 15 The method used in Embodiment 6 of the present invention Figure 1 Output voltage obtained from Astragalus membranaceus solution by detecting droplet triboelectric nanogenerator;

[0062] Figure 16 The method used in Embodiment 6 of the present invention Figure 1 The output current diagram obtained by detecting Astragalus membranaceus solution using a droplet triboelectric nanogenerator. Detailed Implementation

[0063] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0064] Example 1

[0065] Please combine Figures 1-3 This embodiment provides a droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines. The droplet triboelectric nanogenerator includes a support 1, a lower electrode 2, a negative triboelectric layer 3, an upper electrode 4, and an electrical signal detection device 6. It may also include a droplet falling device 5 and a charge storage layer 7.

[0066] Support 1 provides an inclined support surface, the inclination angle of which can be 0 degrees to 90 degrees, preferably 30-60 degrees. In this embodiment, the support surface is at a 45-degree angle to facilitate the sliding of droplets. Support 1 can be made of acrylic sheet, metal sheet, or wood with a thickness of 2-10 mm. In this embodiment, support 1 includes a fixing plate 1-1, a support base 1-2, and a support plate 1-3. Fixing plate 1-1 and support base 1-2 are both made of 5 mm thick acrylic sheet. The position of the triboelectric nanogenerator can be fixed by fixing plate 1-1. Support base 1-2 is a right-angled trapezoidal structure, and its right-angled side is connected to the top surface of the fixing plate by adhesive. In this embodiment, the upper base of support base 1-2 is 30 mm, the lower base is 60 mm, and the right-angled side is 30 mm. The support plate 1-3 is made of 50mm×50mm×3mm acrylic sheet. The support plate 1-3 is connected to the inclined waist of the support base 1-2 by shadowless adhesive. The top surface of the support plate 1-3 is the support surface.

[0067] The lower electrode 2 is used for conductivity. It should be made of a material with excellent conductivity, easy adhesion, and resistance to detachment. It can be made of aluminum foil, copper foil, tin foil, or zinc foil with a thickness of 10–50 μm. The shape of the lower electrode 2 is not limited; it can be rectangular, circular, elliptical, or other geometric shapes. In this embodiment, the lower electrode 2 is a 30 mm × 30 mm × 20 μm square aluminum foil, which is adhered to the support surface using 0.15 μm thick double-sided adhesive.

[0068] The negative triboelectric layer 3 is located above the lower electrode 2. The negative triboelectric layer 3 should be made of a material with a high triboelectric charge density. Based on the sequence of triboelectric charges on the material surface, it can be made of materials such as polystyrene (PS), polyethylene (PE), polypropylene (PP), polyimide (Kapton), polyvinyl chloride (PVC), polydimethylsiloxane (PDMS), polytetrafluoroethylene (PTFE), or fluorinated ethylene propylene copolymer (FEP), and has a thickness of 10–50 μm. The shape of the negative triboelectric layer 3 is not limited and can be rectangular, circular, elliptical, or other geometric shapes. In this embodiment, the negative triboelectric layer 3 uses a 50 mm × 50 mm × 20 μm cube-shaped FEP film. FEP, as an excellent negatively charged triboelectric material, has a high charge density, which can improve the output signal of the triboelectric nanogenerator.

[0069] The charge storage layer 7 is located between the lower electrode 2 and the negative triboelectric layer 3, and is connected to both the lower electrode 2 and the negative triboelectric layer 3. The shape of the charge storage layer 7 is the same as that of the negative triboelectric layer 3, and its area and thickness are the same as those of the negative triboelectric layer 3, respectively. The charge storage layer 7 determines the amount of charge stored, which will affect the output signal of the triboelectric nanogenerator. The charge storage layer 7 can be a thin film or sheet with a thickness of 10-50 μm made of materials such as polyimide (Kapton), polyvinyl chloride (PVC), polydimethylsiloxane (PDMS), polytetrafluoroethylene (PTFE), or fluorinated ethylene propylene copolymer (FEP). The shape of the charge storage layer 7 is not limited and can be rectangular, circular, elliptical, or other geometric shapes. In this embodiment, the charge storage layer 7 is preferably a 50 mm × 50 mm × 20 μm cube-shaped Kapton film. The Kapton film, as the charge storage layer 7, can retain more triboelectric charge, thereby improving the output signal of the droplet triboelectric nanogenerator.

[0070] The upper electrode 4 is also used for conductivity. It should be made of a material with excellent conductivity, easy adhesion, and resistance to detachment. Materials such as aluminum foil, copper foil, tin foil, or zinc foil with a thickness of 10–50 μm can be selected. The area of ​​the upper electrode 4 is smaller than the area of ​​the negative triboelectric layer 3, and a gap is left between the edge of the upper electrode 4 and the edge of the negative triboelectric layer 3. The shape of the upper electrode 4 is not limited and can be rectangular, circular, elliptical, or other geometric shapes. In this embodiment, the upper electrode 4 is a strip of aluminum foil measuring 15 mm × 2 mm × 20 μm. The upper electrode 4 is adhered to the upper surface of the negative triboelectric layer and close to the bottom of the negative triboelectric layer using double-sided adhesive with a thickness of 0.15 μm. The side edge of the upper electrode 4 is 5 mm from the side edge of the negative triboelectric layer 3, and the top edge of the upper electrode 4 is 30 mm from the top edge of the negative triboelectric layer 3.

[0071] To obtain more accurate monitoring results, when the droplets of natural medicine fall onto the negative triboelectric layer 3 and spread completely, it is necessary to ensure that the droplets are completely located within the negative triboelectric layer 3 and simultaneously contact the negative triboelectric layer 3 and the upper electrode 4.

[0072] The droplet delivery device 5 is used to continuously supply natural drug droplets to the negative triboelectric layer 3. In this embodiment, the droplet delivery device 5 can be an infusion tube. The droplet delivery position provided by the droplet delivery device 5 needs to be adjusted according to the position of the upper electrode 4 to ensure that when the droplet is delivered to the negative triboelectric layer 3 and fully spreads, the droplet is completely located within the negative triboelectric layer 3 and simultaneously contacts the negative triboelectric layer 3 and the upper electrode 4.

[0073] The electrical signal detection device 6 is electrically connected to the upper electrode 4 and the lower electrode 2 via wires. It is used to detect the electrical signal generated when the natural drug droplet falls onto the surface of the negative triboelectric layer 3 and slides on the surface of the negative triboelectric layer 3. The content of the active ingredient in the natural drug is determined based on the electrical signal. In this embodiment, the electrical signal detection device 6 can be an electrometer, and the electrical signal includes voltage and current.

[0074] In this embodiment, the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines operates as follows: When the droplet falling device 5 continuously supplies droplets of natural medicine to the negative triboelectric layer 3, the droplets first come into contact with and rub against the negative triboelectric layer 3. Under the influence of gravity and the inclined support surface, the droplets slide and spread along the negative triboelectric layer 3. Upon complete spreading, the droplets simultaneously contact the triboelectric layer 3 and the upper electrode 4. Finally, the droplets pass through the upper electrode 4 and slide down the negative triboelectric layer 3. As the droplets continue to fall, they continuously come into contact with and separate from the negative triboelectric layer 3, causing the induced charge in the negative triboelectric layer 3 to change periodically, generating an AC signal and effectively converting the drug solution into an electrical signal. Natural medicine solutions containing different concentrations of active ingredients can generate different amounts of charge with the negative triboelectric layer 3, resulting in differences in current and voltage signal values. This allows the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines in this embodiment to be used to detect the content of active ingredients in natural medicines.

[0075] The droplet triboelectric nanogenerator used in this embodiment for detecting the content of active ingredients in natural medicines is simple to prepare, low in cost, has good repeatability, requires no external driving energy, has a fast response, high sensitivity, long service life, and stable output, and can achieve rapid response to drug solutions of different concentrations. The droplet triboelectric nanogenerator used in this embodiment for detecting the content of active ingredients in natural medicines can be applied to the content determination of various active ingredients in natural medicines, thus solving the problems of long detection time and high cost in current methods for detecting the content of active ingredients in natural medicines.

[0076] Next, the test conditions for the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines in this embodiment are determined, thereby enabling the determination of the optimal test conditions for the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines, and realizing the detection of the content of active ingredients in natural medicines.

[0077] Taking water droplets as an example, electrical signal tests were conducted on the droplet triboelectric nanogenerator of this embodiment at droplet rates of 1 / 4 drop / second, 1 / 3 drop / second, 1 / 2 drop / second, 1 drop / second, 2 drop / second, 3 drop / second, and 4 drop / second, respectively. The test results are as follows: Figure 4 , Figure 5 As shown. Figure 4 , Figure 5The data showed no significant difference in electrical signals under different drip rates. Considering the time cost and the ease of drip rate control, a drip rate of 1 drop / second was selected.

[0078] When the droplet velocity is 1 drop / second, the droplet triboelectric nanogenerator is connected in series with a resistance box. The resistance box size is adjusted from low to high, according to P=I 2 When P changes significantly, the resistance is increased by an order of magnitude; when P changes slightly, the resistance is increased slowly. The resistance box is adjusted to 1×10⁻⁶ for each change. 5 Ω, 5×10 5 Ω, 8×10 5 Ω, 10×10 5 Ω, 50×10 5 Ω, 80×10 5 Ω, 100×10 5 Ω, 102.5×10 5 Ω, 150×10 5 Ω, 500×10 5 Ω, the output current was measured and the power was calculated. The voltage-power diagram of the droplet triboelectric nanogenerator in this embodiment is shown below. Figure 6 As shown. From Figure 6 As can be seen, the output current gradually increases with the increase of the load resistance, while the power first increases and then decreases; the power is 1429 μW when the load resistance is 10.25 MΩ. This indicates that the droplet triboelectric nanogenerator in this embodiment can convert the potential energy of the water droplet into electrical energy to achieve the output of an electrical signal.

[0079] Triboelectric nanogenerators (TENGs) are devices that convert mechanical energy in the environment into electrical energy by coupling triboelectric and electrostatic induction effects. They have advantages such as being pollution-free, simple in structure, low in cost, and capable of harvesting low-frequency mechanical energy. TENGs have multiple operating modes and can harvest various types of energy from the environment, such as wind energy and water wave energy. In principle, TENGs can be fabricated from any material. Droplet triboelectric nanogenerators (WD-TENGs) utilize the impact of droplets on a solid surface, leveraging triboelectric and electrostatic induction effects. Employing a contact-separation structure design, when a droplet passes through the generator and activates it, a difference in charge is generated between the triboelectric layer material and the upper and lower electrodes, thus outputting electrical energy. When the droplet contacts the water droplet generator interface, the charge changes, causing the triboelectric nanogenerator to generate output voltage and current. Conversely, when the droplet is not falling, no current or voltage is generated. Furthermore, natural medicinal components are soluble in hot water, resulting in high dissolution rates during brewing. Differences in component concentration can cause differences in electrical signals. This embodiment utilizes a droplet triboelectric nanogenerator to detect the content of active ingredients in natural medicines, providing a feasible method for determining the content of active ingredients in natural medicines. This method has advantages such as being green and environmentally friendly, sustainable, low-cost, and small in size, and is of great significance for the development of monitoring the content of limited components in natural medicines.

[0080] Next, taking kudzu root as an example, kudzu root was soaked under different soaking conditions to obtain kudzu root solutions with different contents of effective ingredients, and the performance of the droplet triboelectric nanogenerator used in Example 1 for detecting the content of effective ingredients in natural medicines was explained.

[0081] Example 2

[0082] This embodiment, based on the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines in Embodiment 1, provides a method for detecting the content of active ingredients in natural medicines. Taking kudzu root from the same place of origin as an example, the detection method in this embodiment includes the following steps:

[0083] S1. Twelve portions of kudzu root from the same origin were soaked in twelve portions of water at 100°C. The mass-to-volume ratios of the twelve portions of kudzu root to water were 1:10, 1:15, 1:20, 1:25, 1:30, 1:35, 1:40, 1:45, 1:50, 1:75, 1:100, and 1:150, respectively. The soaking time for each portion was 5 minutes, resulting in twelve natural drug solutions with different contents of active ingredients.

[0084] S2. Using an infusion tube, the 12 portions of natural drug solution obtained in step S1 are continuously dripped into the negative triboelectric layer of the triboelectric nanogenerator in the form of droplets, at a drip rate of 1 drop / second.

[0085] S3. Use an electrometer to test and observe and record the voltage and current data. The test results are shown in [link to test results]. Figure 7 , Figure 8 .

[0086] from Figure 7 , Figure 8 It can be seen that as the mass-to-volume ratio of kudzu root to water decreases, the concentration of the kudzu root solution continuously decreases, while the output voltage and current gradually increase. Furthermore, when the mass-to-volume ratio of kudzu root to water is 1:150, the output voltage reaches 97V, and the output current reaches 25μA. This is because the active ingredient in kudzu root is puerarin, whose molecular formula is C2. 21 H 20 O9 contains 6 hydroxyl groups. When the concentration of puerarin in the kudzu root solution is high, the hydroxyl content is high, which can neutralize more free charges. Therefore, the amount of charge generated by the droplet triboelectric nanogenerator is increased, and the electrical signal decreases, and vice versa.

[0087] This demonstrates that the output electrical signal of the droplet triboelectric nanoengine in Example 1 exhibits a certain regularity and correlation with the concentration of the active ingredient in the drug solution. The concentration of the active ingredient in the drug solution is inversely proportional to the electrical signal; that is, as the concentration of the active ingredient in the drug solution increases, the output current and voltage decrease, and vice versa. Therefore, the droplet triboelectric nanoengine of Example 1 possesses a high electrical response characterizing the concentration of the active ingredient and a large concentration detection range, making it suitable for detecting the content of active ingredients in natural medicines.

[0088] Example 3

[0089] This embodiment, based on the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines in Embodiment 1, provides a method for detecting the content of active ingredients in natural medicines. Taking kudzu root from the same place of origin as an example, the detection method in this embodiment includes the following steps:

[0090] S1. Twelve portions of kudzu root from the same origin were soaked in twelve portions of water at temperatures of 25℃, 50℃, 55℃, 60℃, 65℃, 70℃, 75℃, 80℃, 85℃, 90℃, 95℃, and 100℃, respectively. The mass-to-volume ratio of the kudzu root to the water was 1:40, and the soaking time was 5 minutes for each portion, resulting in twelve natural drug solutions with different contents of active ingredients.

[0091] S2. Using an infusion tube, the 12 portions of natural drug solution obtained in step S1 are continuously dripped into the negative triboelectric layer of the triboelectric nanogenerator in the form of droplets, at a drip rate of 1 drop / second.

[0092] S3. Use an electrometer to test and observe and record the voltage and current data. The test results are shown in [link to test results]. Figure 9 , Figure 10 .

[0093] from Figure 9 , Figure 10 It can be seen that as the soaking temperature increases, the concentration of the kudzu root solution continuously increases, while the output voltage and current gradually decrease. When the soaking temperature is 100℃, the output current is 19μA and the output voltage is 72V. This shows that the output electrical signal of the droplet triboelectric nanoengine in Example 1 exhibits a certain regularity and correlation with the concentration of the active ingredient in the drug solution. The concentration of the active ingredient in the drug solution is inversely proportional to the electrical signal; that is, as the concentration of the active ingredient in the drug solution increases, the output current and voltage decrease, and vice versa. This further proves that the droplet triboelectric nanoengine of Example 1 can be used for the detection of the content of active ingredients in natural medicines.

[0094] Example 4

[0095] This embodiment, based on the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines in Embodiment 1, provides a method for detecting the content of active ingredients in natural medicines. Taking kudzu root from the same place of origin as an example, the detection method in this embodiment includes the following steps:

[0096] S1. Soak 12 portions of kudzu root from the same origin in 12 portions of water at 100℃. The mass-to-volume ratio of kudzu root to water was 1:40 for all 12 portions. The soaking times for the 12 portions of kudzu root were 1 min, 2 min, 3 min, 4 min, 5 min, 6 min, 7 min, 8 min, 9 min, 10 min, 15 min, and 20 min, respectively, to obtain 12 natural drug solutions with different contents of active ingredients.

[0097] S2. Using an infusion tube, the 12 portions of natural drug solution obtained in step S1 are continuously dripped into the negative triboelectric layer of the triboelectric nanogenerator in the form of droplets, at a drip rate of 1 drop / second.

[0098] S3. Use an electrometer to test and observe and record the voltage and current data. The test results are shown in [link to test results]. Figure 11 , Figure 12 .

[0099] from Figure 11 , Figure 12 It can be seen that as the soaking time increases, the concentration of the kudzu root solution continuously increases, while the output voltage and current gradually decrease. When the soaking time is 20 minutes, the output current is 16 μA and the output voltage is 57 V. This shows that the output electrical signal of the droplet triboelectric nanoengine in Example 1 exhibits a certain regularity and correlation with the concentration of the active ingredient in the drug solution. The concentration of the active ingredient in the drug solution is inversely proportional to the electrical signal; that is, as the concentration of the active ingredient in the drug solution increases, the output current and voltage decrease, and vice versa. This further proves that the droplet triboelectric nanoengine of Example 1 can be used for the detection of the content of active ingredients in natural medicines.

[0100] Example 5

[0101] This embodiment, based on the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines in Example 1, provides a method for detecting the content of active ingredients in natural medicines. Taking kudzu root from different origins as an example, the detection method in this embodiment includes the following steps:

[0102] S1. Kudzu roots from Hunan, Hubei, Guangxi, Shaanxi, Sichuan, and Anhui were soaked in 6 portions of water at 100℃. The mass-to-volume ratio of kudzu roots to water was 1:40 for all 6 portions, and the soaking time was 5 minutes for all 6 portions, resulting in 6 natural drug solutions with different contents of active ingredients.

[0103] S2. Using an infusion tube, the 6 portions of natural drug solution obtained in step S1 are continuously dripped into the negative triboelectric layer of the triboelectric nanogenerator in the form of droplets, with a dripping rate of 1 drop / second.

[0104] S3. Use an electrometer to test and observe and record the voltage and current data. The test results are shown in [link to test results]. Figure 12 , Figure 13 .

[0105] from Figure 12 It can be seen that the output voltages of kudzu produced in Hunan, Hubei, Guangxi, Shaanxi, Sichuan, and Anhui are 43V, 46V, 50V, 43V, 39V, and 83V, respectively. From... Figure 13 It can be seen that the output currents of kudzu from Hunan, Hubei, Guangxi, Shaanxi, Sichuan, and Anhui are 11μA, 12μA, 16μA, 11μA, 11μA, and 22μA, respectively. This shows that the output voltage and current of kudzu from different producing areas vary. The lower output voltage and current of kudzu from Sichuan indicate a higher content of active ingredients. The output electrical signal of the droplet triboelectric nanoengine in Example 1 shows a certain regularity and correlation with the concentration of active ingredients in the drug solution. The concentration of active ingredients in the drug solution is inversely proportional to the electrical signal; that is, as the concentration of active ingredients in the drug solution increases, the output current and voltage decrease, and vice versa. This further proves that the droplet triboelectric nanoengine of Example 1 can be used for the detection of the content of active ingredients in natural medicines.

[0106] Next, taking Astragalus membranaceus as an example, the performance of the droplet triboelectric nanogenerator used in Example 1 for detecting the content of active ingredients in natural medicines will be explained.

[0107] Example 6

[0108] This embodiment, based on the droplet triboelectric nanogenerator for detecting the content of active ingredients in natural medicines in Example 1, provides a method for detecting the content of active ingredients in natural medicines. Taking Astragalus membranaceus as an example, the detection method in this embodiment includes the following steps:

[0109] S1. Soak Astragalus membranaceus in water at 100℃, with a mass-to-volume ratio of 1:40 between Astragalus membranaceus and water, for 5 minutes to obtain an Astragalus membranaceus solution.

[0110] S2. Using an infusion tube, the Astragalus solution obtained in step S1 is continuously dripped into the negative triboelectric layer of the droplet triboelectric nanogenerator in the form of droplets, at a drip rate of 1 drop / second.

[0111] S3. Use an electrometer to test and observe and record the voltage and current data. The test results are shown in [link to test results]. Figure 14 , Figure 15 .

[0112] from Figure 14 , Figure 15 As can be seen, the droplet triboelectric nanogenerator of Example 1, used for detecting the content of active ingredients in natural medicines, outputs a voltage of 75V and an output current of 20μA when measuring the Astragalus membranaceus solution. It can stably output an electrical signal with a fast response and high sensitivity, achieving rapid response to the Astragalus membranaceus solution. This further demonstrates that the droplet triboelectric nanogenerator of Example 1 can be used for detecting the content of active ingredients in natural medicines.

[0113] The technical features of the above embodiments can be combined in any way. For the sake of brevity, not all possible combinations of the technical features in the above embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0114] The embodiments described above are merely illustrative of several implementations of the present invention, and while the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the invention patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of the present invention, and these all fall within the protection scope of the present invention. Therefore, the protection scope of this invention patent should be determined by the appended claims.

Claims

1. A method for detecting the content of active ingredients in natural medicines using a droplet triboelectric nanoengine, wherein the natural medicines include kudzu root or astragalus root, and the triboelectric nanoengine comprises: Support component (1); The lower electrode (2) is mounted on the support (1); A negative triboelectric layer (3) is installed on the upper surface of the lower electrode (2) and its upper surface is inclined. The negative triboelectric layer (3) is used to carry the dripping natural drug droplets and allow the droplets to spread. The upper electrode (4) is mounted on the upper surface of the negative triboelectric layer (3); An electrical signal detection device (6) is electrically connected to the upper electrode (4) and the lower electrode (2). The electrical signal detection device (6) is used to detect and display the electrical signals generated when the droplet falls onto the surface of the negative triboelectric layer (3) and during the contact and friction process with the negative triboelectric layer (3) during spreading. The content of the effective ingredients in the natural medicine can be determined based on the electrical signal. The magnitude of the output electrical signal and the concentration of the effective ingredients in the drug solution have a certain regularity and correlation. The content of the effective ingredients in the natural medicine can be determined by the output of electrical signals of different magnitudes. The charge storage layer (7) is located between the lower electrode (2) and the negative triboelectric layer (3) and is connected to the lower electrode (2) and the negative triboelectric layer (3). The shape of the charge storage layer (7) is the same as that of the negative triboelectric layer (3), and its area and thickness are the same as those of the negative triboelectric layer (3). The detection method is characterized by the following steps: S1. Soak the natural medicine in water to obtain a natural medicine solution; S2. The natural drug solution obtained in step S1 is continuously dripped onto the negative triboelectric layer (3) in the form of droplets; S3. Observe and record the electrical signal data of the electrical signal detection device (6); if the electrical signal is strong, it is determined that the content of effective ingredients in the natural medicine is low; if the electrical signal is weak, it is determined that the content of effective ingredients in the natural medicine is high.

2. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, In step S1, the mass-to-volume ratio of the natural medicine to water is 1:10~150.

3. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, In step S1, the temperature of the water is 25℃~100℃.

4. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, In step S1, the soaking time is 1 to 20 minutes.

5. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, In step S2, the droplet rate is 1 drop / second.

6. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, In step S3, the electrical signal includes voltage and current.

7. The method for detecting the content of active ingredients in natural medicines using a droplet triboelectric nanoengine according to claim 1, characterized in that, The upper surface of the negative triboelectric layer (3) has an inclination angle of 0 to 90 degrees.

8. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The negative triboelectric layer (3) is a thin film or sheet.

9. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The negative triboelectric layer (3) is made of polystyrene, polyethylene, polypropylene, polyimide, polyvinyl chloride, polydimethylsiloxane, polytetrafluoroethylene or fluorinated ethylene propylene copolymer.

10. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The support member (1) includes: Fixing plate (1-1); Support base (1-2), which is a long strip structure or a right-angled trapezoidal structure and whose bottom is connected to the top surface of the fixing plate (1-1); and The support plate (1-3) is a square structure and is connected to the top of the support base (1-2). The top surface of the support plate (1-3) is inclined.

11. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 10, characterized in that, The support (1) is made of acrylic sheet, metal sheet or wood.

12. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 10, characterized in that, The top surface of the support plate (1-3) has an inclination angle of 0 degrees to 90 degrees.

13. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The lower electrode (2) is made of aluminum foil, copper foil, tin foil or zinc foil.

14. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The upper electrode (4) is made of aluminum foil, copper foil, tin foil or zinc foil.

15. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The area of ​​the upper electrode (4) is smaller than the area of ​​the negative triboelectric layer (3), and there is a gap between the edge of the upper electrode and the edge of the negative triboelectric layer (3).

16. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, When the droplet falls onto the surface of the negative triboelectric layer (3) and spreads completely, the droplet is completely located within the negative triboelectric layer (3) and simultaneously contacts the negative triboelectric layer (3) and the upper electrode (4).

17. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The charge storage layer (7) is a thin film or sheet.

18. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The charge storage layer (7) is made of polyimide, polyvinyl chloride, polydimethylsiloxane, polytetrafluoroethylene or fluorinated ethylene propylene copolymer.

19. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The triboelectric nanoengine also includes: Droplet delivery device (5) is used to continuously supply droplets of natural medicine to the negative triboelectric layer (3).

20. The method for detecting the content of active ingredients in natural medicines using a droplet-triboelectric nanoengine according to claim 1, characterized in that, The electrical signal detection device (6) is an electrometer.

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