Electronic devices for realizing biomedical applications of QMR technology

Abstract

An electronic device (1) for biomedical use includes a radio frequency circuit (3) powered by a voltage (21) and at least one electrode (4) connected at an output to the radio frequency circuit (3) and applicable to a part of the human body. The radio frequency circuit (3) is configured to generate a current wave (5) as an output having a fundamental frequency of 2 MHz or higher and distorted due to the presence of at least a second harmonic, wherein a first percentage ratio between the peak amplitude at the second harmonic of the current wave (5) and the peak amplitude at the fundamental frequency of the current wave (5) is included between 20% and 70% when a load of approximately 100 ohms is applied to the electrode (4), and the first percentage ratio is included between 25% and 120% when a load of approximately 830 ohms is applied to the electrode (4).

Description

Technical Field

[0001] This invention relates to an electronic device for realizing the biomedical applications of QMR technology. Background Technology

[0002] As is well known in physiology, electric currents, or more precisely, electric fields, passing through biological tissues can not only generate thermal effects but also alter the distribution of surface charges in cell membranes. This change in charge distribution can induce modifications in membrane proteins, particularly the opening or closing of voltage-dependent ion channels.

[0003] At a certain intensity, an electric current can induce electroporation in the membrane, allowing molecules, even relatively large molecules, to transfer across the membrane itself.

[0004] The effect of electric current on membrane potential may subsequently trigger important biological responses, such as pain control using low-frequency currents, or improvements in nutrition and muscle function.

[0005] In particular, the applicant demonstrated that the application of current waves with a fundamental frequency higher than 2 MHz and distorted due to the presence of harmonics transfers energy to the molecules to which these current waves are applied, and that this energy corresponds to the so-called “molecular resonance” known as quantum molecular resonance (QMR).

[0006] As reported in document EP1087691, this QMR energy is just sufficient to break the intermolecular bonds involved in the passage of current, making it particularly useful in applications such as surgical scalpels. In particular, this molecular resonance advantageously enables the temperature rise of tissues to which such an electric field is applied.

[0007] The QMR scalpel can actually cut the area of ​​interest without producing any rupture, tearing, necrosis, reduction or increase in thickness, alteration of fluid content, or other degenerative effects around the incision.

[0008] Recent studies, such as those by Dal Maschio et al. ( Biophysical effects of high- frequency electric field (4-64 MHz) on muscle fibers in culture (Biophysical effects of high-frequency electric fields (4-64 MHz) on cultured muscle fibers, BAM, 2009) also demonstrated how the effects on QMR-treated cells can depend on the frequency of the current wave within the QMR range and the harmonic spectrum of the same wave.

[0009] Depending on the frequency and harmonic spectrum used, the application of an electric field can actually cause deformation of the plasma membrane, leading to, for example, cell damage or stimulation of the cells being treated.

[0010] In particular, Dal Maschio et al. demonstrated that applying a high-frequency electric field to stress-prone cells (such as muscle cells) would generate a cellular response even if the action potential threshold was not reached, and would induce activation of intracellular signal transduction pathways even if the treated cells did not contract.

[0011] In addition, Ferrari et al. High Frequency Electrotherapy for the Treatment of Meibomian Gland Dysfunction (High-frequency electrotherapy for the treatment of meibomian gland dysfunction, Clinical Science, 2019) showed how applying QMR to patients with meibomian gland dysfunction significantly reduced pathological symptoms and signs, thus hypothesizing its relevant role in the treatment of evaporative dry eye.

[0012] Another unpublished study showed how the application of QMR to glioblastoma cells reduced the mitotic activity, motility, and invasiveness of these tumor cells, and decreased their ability to migrate through the matrix to cause, for example, metastasis.

[0013] Therefore, it is clear from these studies that applying QMR to different types of cells can induce biological responses, even completely different biological responses.

[0014] Moreover, applying QMR to the same type of cells at different frequencies, and most importantly, with different harmonic spectra, can also induce cellular stimulation with biological effects and / or cause activation of completely different cellular pathways, as described by DalMaschio et al.

[0015] This discovery makes it possible to "modulate" cell function to achieve a variety of biologically correct and functional functions.

[0016] In fact, the applicant has discovered that by appropriately altering the ratio between the harmonics constituting the QMR wave, particularly the distorted sine wave, it is possible to generate specific "cellular codes" to achieve desired functions, such as effective cures for various musculoskeletal pathologies, or to counteract tumors, or even cures for tinnitus, through acting on tissue regeneration of adult stem cells. Appropriately modulated current wave QMR can also be effective in cosmetic medicine (regenerative medicine) or for other types of pathologies that have so far been treated with invasive, inadequate, and non-persistent methods that are merely temporary.

[0017] Therefore, it is necessary to identify those parameters associated with the QMR current, by which different biological effects can be induced depending on the cells or tissues being treated, and thus on the ohmic load applied to the device configured to generate such a QMR current. Summary of the Invention

[0018] Advantageously, the applicant has recently identified the fundamental properties of QMR currents that can modulate some desired biological effects on the treated tissues or cells (even different types of tissues or cells).

[0019] Therefore, based on this information, the object of the present invention is to develop an electronic device adapted to generate multiple currents in the QMR frequency range, and further configured to modulate such currents according to the cells and tissues to be treated and / or the biological effects to be obtained, and thus according to the ohmic load applied to the device configured to generate such currents.

[0020] Another object of the present invention is that the electronic device is configured to modulate the generated current based on biological effects obtained on the same type of cells or tissues and on different types of cells or tissues.

[0021] Another object of the present invention is that the device is configured to generate such an electric current without simultaneously producing a thermal effect on the cells or tissues being treated.

[0022] Furthermore, an object of the present invention is that such a device is configured to modify one or more parameters of the generated current in real time and independently based on the received cellular or tissue response and thus according to the ohmic load applied to the aforementioned electronic device.

[0023] Another objective of this invention is that this device has good safety features.

[0024] The above objectives are achieved by an electronic device for biomedical use as described in this invention.

[0025] In particular, the electronic device for biomedical use according to the invention includes a radio frequency circuit powered by a suitable voltage, preferably a continuous voltage, at least one electrode connected at the output of the radio frequency circuit and applicable to the human body, particularly to the skin or internal tissue, wherein the radio frequency circuit is configured to generate a current wave as output having a fundamental frequency of 2 MHz or higher, preferably 4 MHz, said current wave being distorted due to the presence of at least a second harmonic, and wherein when an ohmic load of approximately 100 ohms is applied to the electrode, the percentage between the peak amplitude of the current wave at the frequency of the second harmonic and the peak amplitude of the current wave at the fundamental frequency (hereinafter defined as the first percentage) is between 20% and 70%, and when an ohmic load of approximately 830 ohms is applied to the electrode, the first percentage includes between 25% and 120%.

[0026] Preferably, the aforementioned current wave has a sinusoidal shape that is at least distorted by the aforementioned second harmonic.

[0027] Depending on the applied load, these specific values ​​of the aforementioned first percentage rate between the peak amplitudes of the current wave and the second harmonic and the fundamental frequency make it possible to advantageously modulate some of the biological effects obtained by applying QMR, and thus to modulate the treatment to be performed on tissues or cells, even different types of tissues or cells.

[0028] In particular, some possible treatments that can be performed using the electronic device of the present invention for the aforementioned biomedical use in realizing the aforementioned QMR relate in a non-exclusive manner to the fields of surgery, ophthalmology, major trauma treatment, cosmetic medicine, physical therapy, tissue regeneration, tinnitus and cancer treatment. Attached Figure Description

[0029] Referring to the accompanying drawings, the above-mentioned objects and advantages, which will be better highlighted during the description of some technical details of the device of the present invention and some application examples of the invention, which are given by way of non-limiting examples, wherein:

[0030] - Figure 1 The structure of the electronic device of the present invention for biomedical use is illustrated schematically;

[0031] - Figure 2 The device of the present invention is schematically depicted, with two monopolar electrodes connected to the device to close the circuit in contact with the human body;

[0032] - Figure 3 The device of the present invention is schematically depicted, with bipolar electrodes connected to the device to close the circuit in contact with the human body;

[0033] - Figure 4 A connection diagram of the measuring instrument and the device of the present invention is depicted so as to measure the peak amplitude of the current wave generated by the device at the fundamental frequency and harmonics. Detailed Implementation

[0034] As described above, generally speaking, according to a preferred embodiment of the present invention, in Figure 1 The electronic device for biomedical use of the present invention, schematically shown and generally indicated by 1, preferably but not necessarily includes a rectifier circuit 2, which is preferably powered by a mains voltage or any other AC voltage source, such that the output voltage 21 at the output of the rectifier circuit 2 is preferably of a continuous type with a predetermined value, preferably including, for example, between 20V and 300V, and even more preferably between 50V and 200V.

[0035] However, according to a variation of the embodiments of the present invention, it is not excluded that the electronic device 1 for biomedical use is not equipped with a rectifier circuit 2, but can be directly powered by a voltage of a preferred continuous type generated, for example, by a battery.

[0036] Back Figure 1 In the preferred embodiment shown, the device 1 is further equipped with a radio frequency circuit 3 and at least one electrode 4. The rectifier circuit 2 provides the output voltage 21 to the radio frequency circuit 3. The electrode 4 is connected to the radio frequency circuit 3 at the output end and can be applied to the human body, particularly the skin or internal tissue of the person.

[0037] According to an alternative embodiment where rectifier circuit 2 is absent, the aforementioned external voltage (preferably continuous) is placed at the input of RF circuit 3. Regarding electrode 4, it can preferably, but not exclusively, be a unipolar electrode 41, such as an insulated handheld device, needle-shaped, toroidal, or blade-shaped conductive electrode, conductive glove, or any type of electrode, shaped to allow it to contact a part of the human body. In this case, as... Figure 2 As shown, device 1 preferably provides a second return electrode 42 connected to radio frequency circuit 3 to precisely close the circuit defined by the device, thereby allowing current to flow through at least a portion of the human body.

[0038] For example, in a non-limiting manner, the second return electrode 42 may have a flat surface so as to be placed in contact with the individual to be treated, thereby closing the aforementioned circuit through the individual's body.

[0039] However, it is possible to omit the second electrode 42 and achieve circuit closure by grounding.

[0040] Alternatively, such as Figure 3 As shown, the electrode 4 can be a bipolar electrode 43, such as a bipolar conductive clamp, bipolar scissors, or bipolar clip. Each electrode is defined as having two poles that are isolated from each other and is configured to close a circuit that contacts the human body.

[0041] Specifically, regarding the radio frequency circuit 3 according to the invention, it is configured to generate a current wave 5 as an output, the current wave 5 having a fundamental frequency higher than or equal to 2 MHz and being distorted due to the presence of at least a second harmonic.

[0042] Preferably, but not necessarily, this current wave 5 has a sinusoidal shape that is distorted due to the presence of at least the aforementioned second-order harmonics.

[0043] Preferably, the current wave has a frequency as a fundamental frequency, which is between 2 and 64 MHz, specifically between 2 and 16 MHz.

[0044] More preferably, the current wave generated by the radio frequency circuit 3 has a frequency of approximately 4 MHz as the base frequency.

[0045] According to the invention, the radio frequency circuit 3 is configured such that when a load of approximately 100 ohms is applied to the electrode 4, the percentage value (hereinafter defined as the first percentage) between the amplitude of the peak value of the current wave 5 at the second harmonic and the amplitude of the peak value of the current wave 5 at the fundamental frequency is between 20% and 70%, and the same radio frequency circuit 3 is configured such that when a load of approximately 830 ohms is applied to the aforementioned electrode 4, the same first percentage value is included between 25% and 120%.

[0046] In fact, as a result of the experiment, the applicant has found that, depending on the variation in the load applied to the device, within the aforementioned range, appropriate variation in the value of the first percentage rate allows the effect of a particular QMR treatment to be optimized according to the tissue or cells to which the technology is applied.

[0047] Preferably, the amplitude of the aforementioned peak is equal to the value of the voltage Vrms (root mean square) measured at the fundamental frequency and the relative second harmonic.

[0048] According to the invention, preferably but not necessarily, the radio frequency circuit 3 is also configured such that when a load of approximately 430 ohms is applied to the electrode 4, the value of the aforementioned first percentage rate is between 25% and 95%.

[0049] This additional control over the value of the aforementioned first percentage rate advantageously allows for further optimization of the efficacy of the intended QMR treatment.

[0050] Furthermore, preferably but not necessarily, the radio frequency circuit 3 is configured in such a way that the current wave 5 generated by it is also distorted due to the presence of the third harmonic.

[0051] In this case, specifically, the radio frequency circuit 3 is configured such that when a load of approximately 100 ohms is applied to the electrode 4, the percentage between the amplitude of the peak value of the current wave 5 at the third harmonic and the amplitude of the peak value of the current wave at the fundamental frequency is between 2% and 60%, while when a load of approximately 830 ohms is applied to the same electrode 4, this second percentage is between 4% and 120%.

[0052] Still, preferably but not necessarily, when a load of approximately 430 ohms is applied to electrode 4, the value of the second percentage between the amplitude of the peak value of the current wave 5 at the third harmonic and the amplitude of the peak value of the current wave at the fundamental frequency is included between 2% and 90%, more preferably, under the load of said 430 ohms, the second percentage is included between 2% and 70%.

[0053] In the same case, further control of the peak value of the current wave 5 at the third harmonic of the three load values ​​applied to the electrode 4 of device 1 allows for further optimization of the effect of the QMR treatment to be performed.

[0054] More specifically, preferably, the radio frequency circuit 3 is also configured in such a way that the current wave 5 generated by it is also distorted due to the presence of the fourth harmonic.

[0055] In this case, when a load of approximately 100 ohms is applied to electrode 4, the percentage ratio between the peak amplitude of the current wave 5 at the fourth harmonic and the peak amplitude of the current wave at the fundamental frequency is between 0% and 40%, while when a load of approximately 830 ohms is applied to the same electrode 4, the same third percentage ratio is between 0% and 50%.

[0056] Advantageously, and still preferably but not necessarily, when a load of approximately 430 ohms is applied to electrode 4, the aforementioned third ratio includes between 0% and 45%, or even more preferably between 4% and 40%.

[0057] According to a preferred embodiment of the invention described herein, the radio frequency circuit 3 includes an electronic switch 31 powered by the output voltage 21 and driven by a suitable drive circuit 32.

[0058] Furthermore, the radio frequency circuit 3 includes a power transformer 33 connected at its output to the aforementioned electronic switch 31, so as to preferably define a resonant circuit 34 in a frequency band corresponding to the fundamental frequency of the wave generated by the same electronic switch 31.

[0059] However, according to alternative embodiments of the invention, it is not excluded that the radio frequency circuit 3 may include different power electronic components instead of the aforementioned electronic switch 31, as long as it is able to generate a current wave with the above characteristics starting from the aforementioned output voltage 21.

[0060] Furthermore, in the preferred embodiment described herein, the radio frequency circuit 3 may include a broadband filter instead of the aforementioned transformer 33, the broadband filter being suitably configured to allow an output current wave having the aforementioned characteristics to pass through.

[0061] Regarding the configuration of the radio frequency circuit 3, in order to obtain a current wave 5 with the above characteristics at the output, it is preferable to appropriately configure the electrical / electronic components constituting the radio frequency circuit 3, especially the aforementioned power transformer 33, and even more specifically, the number of turns of the primary winding 331 and the secondary winding 332 of the aforementioned transformer 33.

[0062] In an alternative embodiment of the invention, this configuration mode can be achieved by appropriately selecting the control software settings of the aforementioned drive circuit 32 of the electronic switch 31, particularly by appropriately selecting, preferably but not necessarily, the percentage value of the duty cycle of the aforementioned drive circuit.

[0063] More precisely, according to a later embodiment of the invention, the electronic device 1 for biomedical use, when in use, particularly when one or more electrodes 4 are in contact with a part of the human body, is configured to measure the impedance value of said part of the body as seen by said device, particularly by radio frequency circuit 3, and based on the aforementioned impedance value, the device 1 of the invention is configured to preferably, but not necessarily, modify the aforementioned percentage value of the duty cycle in order to generate an electrically distorted current wave 5 having the aforementioned characteristics depending on the impedance under consideration.

[0064] However, it is not excluded that in another embodiment variation, in order to obtain a current wave 5 with the above-described characteristics, an appropriate configuration of the aforementioned electrical / electronic components (especially transformer 33) and duty cycle values ​​is provided.

[0065] Furthermore, the device 1 of the present invention is configured to allow selection of a nominal electrical power value that can be delivered based on the treatment to be performed. In particular, the device 1 is configured to allow selection of the aforementioned nominal electrical power value within a predetermined power range.

[0066] In particular, preferably but not necessarily, at a given coupling impedance value, the power range includes deliverable electrical power between 0 watts and 150 watts.

[0067] At this point, it is necessary to identify a clear measurement protocol that can be used to determine the aforementioned value of the ratio between the amplitude of the peak of various harmonics and the amplitude of the peak at the fundamental frequency.

[0068] First, it should be established that an oscilloscope must be used for the measurement, preferably an Agilent Infiniium DS09104A oscilloscope from Keysight Technologies, or an equivalent oscilloscope with the same functions and settings.

[0069] Alternatively, a differential probe S can be used, connected in a concise manner. In particular, the KEYSIGHT N2891A differential probe is preferred. Similarly, in this case, a similar differential probe with equivalent functional characteristics can be used.

[0070] Furthermore, it is conceivable to use an impedance group I with multiple resistors R, which are suitable for operation in the aforementioned frequency range, and can be connected in series, each resistor having a given ohm value.

[0071] In particular, preferably, the following resistor R is recommended to perform the above measurements:

[0072] -- ARCOL, FPA100 100R J, ohm value is 100 ohms;

[0073] -- ARCOL, FPA100 330R J, ohm value is 330 ohms;

[0074] -- ARCOL, FPA 1K J, ohm value 1000 ohms;

[0075] --OHMITE TGHLV500RJE with an ohm value of 500 ohms

[0076] --OHMITE with an ohmic value of 50 ohms, TGHHV50R0JE;

[0077] --OHMITE with an ohmic value of 250 ohms, TGHLV25R0JE.

[0078] However, it is not excluded that different types of resistors and / or different ohmic values ​​of resistors can be used to perform the above measurements, as long as they are suitable for operation within the above frequency range, and the above ohmic values ​​can be defined as the load to be applied to the electrode 4 of device 1.

[0079] Finally, in order to connect the measuring instrument described above with the device 1 of the present invention, it is envisioned to use a 1-meter-long cable C, preferably with a "banana" connector at the end.

[0080] In particular, preferably, the aforementioned cable C can be a flexible polyurethane-coated bipolar cable with copper conductors, each conductor having a diameter of 0.25 mm. 2 The cross-section has a maximum operating voltage of 250 V, a resistance of 100 Ohm / km, and an insulation test voltage of 1500 V.

[0081] In the same situation, as an alternative, the use of a cable equivalent to the one just described cannot be ruled out.

[0082] Regarding measurement settings, such as Figure 4 As schematically observed, cable C will connect to the output connector of device 1 of the present invention, particularly in the case of unipolar operation, to the neutral connector and the phase connector to which the aforementioned electrodes 41 and 42 are typically connected. Cables C should be arranged parallel to each other with a spacing of approximately 0.50 cm.

[0083] In bipolar operating mode, these cables C must be connected to both poles of the bipolar connector of device 1.

[0084] In this case, preferably, the aforementioned cables must be arranged parallel to each other with minimal distance between them, or even more preferably, they should belong to the same ribbon cable.

[0085] The opposite ends of cable C will be connected to impedance group I in order to define the total ohmic value of the load to be applied to the device 1 of the present invention, which is selected from at least the three values ​​indicated above, namely 100 ohms, 830 ohms and 430 ohms.

[0086] The two input terminals S1 and S2 of the differential probe S will be connected between each of the aforementioned cables C and impedance groups I.

[0087] Preferably, this connection is achieved via a three-way adapter A, which is inserted between each of these cables C and impedance group I.

[0088] The differential probe S must be set to attenuation equal to 1 / 100.

[0089] To avoid being affected by the signal under test, the differential probe S must be kept as far away as possible from the measurement cable C.

[0090] The output S3 of the differential probe S must be connected to the input of the oscilloscope O.

[0091] Oscilloscope O must be set to perform FFT (Fast Fourier Transform) analysis on the input current wave 5 and measure the DCV rms value of the signal (i.e., the rms (root mean square) value of the signal without removing continuous components) at the frequencies of the fundamental and second, third and fourth harmonics of the input current wave 5.

[0092] In addition, the following was envisioned:

[0093] - Set the Hanning filter for measuring the peak value of harmonics;

[0094] - The device 1 of the present invention is activated by setting the transmission power value within a range of selectable values ​​in the same device 1;

[0095] - For each of the above ohmic load values, namely 100 Ohms, 830 Ohms and 430 Ohms, obtain the voltage value V rms at the fundamental frequency and harmonics.

[0096] Based on these obtained values, calculate the values ​​of the first percentage rate, the second percentage rate, and the third percentage rate mentioned above for each considered load value.

[0097] First application example

[0098] According to a first application example of the electronic device 1 for biomedical use according to the present invention, which is particularly suitable for use as a scalpel or for treating musculoskeletal diseases, eye diseases, tinnitus, etc., it is configured such that the fundamental frequency of the generated current wave is set to about 4 MHz, and the aforementioned first percentage rate is included between 35% and 65% when a load of about 100 ohms is applied to the electrode 4.

[0099] Furthermore, when a load of approximately 830 ohms is applied to electrode 4, this first percentage rate is included between 70% and 120%. More precisely, preferably but not necessarily, for a load of 830 ohms, this first percentage rate is included between approximately 75% and 100%.

[0100] Furthermore, preferably, when a load of approximately 430 ohms is applied to the electrode 4, the first percentage rate is between 70% and 90%, and in particular, the first percentage rate is between 75% and 85%.

[0101] Again, preferably, according to the first application example, when a load of approximately 100 ohms is applied to electrode 4, the second percentage rate includes between 15% and 50%, and when a load of approximately 830 ohms is applied to electrode 4, the second percentage rate includes between 60% and 120%.

[0102] Preferably, but not necessarily, when a load of approximately 430 ohms is applied to electrode 4, the second percentage rate is between 45% and 70%.

[0103] Furthermore, preferably but not necessarily, when a load of approximately 100 ohms is applied to electrode 4, the third percentage rate is included between 8% and 35%, and when a load of approximately 830 ohms is applied to the same electrode 4, the third percentage rate is included between 10% and 50%.

[0104] Furthermore, it is still preferred, but not mandatory, that when a load of approximately 430 ohms is applied to electrode 4, the aforementioned third ratio includes between 10% and 45%, or even more preferably between 15% and 40%.

[0105] In addition to depending on the inherent characteristics just described, the type of treatment using the device 1 of the present invention according to the foregoing first application example also depends on the type of electrode 4 selected to be connected to the same device 1.

[0106] Second application example

[0107] A second application example of the electronic device 1 of the present invention for biomedical use is particularly applicable to cosmetic treatments, but also to musculoskeletal disorders and inflammatory-degenerative disorders. It is configured such that the fundamental frequency of the generated current wave is set to approximately 4 MHz, and the aforementioned first percentage rate is included between 15% and 45% when a load of approximately 100 ohms is applied to electrode 4.

[0108] Furthermore, when a load of approximately 830 ohms is applied to electrode 4, this first percentage rate is included between 25% and 50%. More precisely, preferably but not necessarily, for a load of 830 ohms, this first percentage rate is included between 30% and 45%.

[0109] Furthermore, preferably, when a load of approximately 430 ohms is applied to the electrode 4, the first percentage rate is included between 25% and 45%, and in particular, the first percentage rate is included between 28% and 40%.

[0110] Again, preferably, according to the second application example, when a load of approximately 100 ohms is applied to electrode 4, the second percentage rate is included between 1% and 10%, and when a load of approximately 830 ohms is applied to electrode 4, the second percentage rate is included between 1% and 15%.

[0111] Preferably, but not necessarily, when a load of approximately 430 ohms is applied to electrode 4, the second percentage rate is included between 1% and 15%.

[0112] Furthermore, preferably but not necessarily, when a load of approximately 100 ohms is applied to electrode 4, the third percentage rate is included between 0% and 5%, and when a load of approximately 830 ohms is applied to the same electrode 4, the third percentage rate is included between 0% and 5%.

[0113] Furthermore, it is still preferred, but not mandatory, that when a load of approximately 430 ohms is applied to electrode 4, the aforementioned third ratio is between 0% and 5%.

[0114] In addition to depending on the inherent characteristics just described, the type of treatment using the device 1 of the present invention according to the foregoing second application example also depends on the type of electrode 4 selected to be connected to the same device 1.

[0115] Therefore, based on the foregoing, the biomedical electronic device 1 of the present invention achieves all the intended objectives.

[0116] Specifically, the objective of developing an electronic device adapted to generate multiple currents in the QMR frequency range has been achieved, and it is also configured to modulate these currents according to the cells and tissues to be treated and / or the biological effects to be obtained, and thus according to the ohmic load applied to the device configured to generate such currents.

[0117] It also achieves the goal of creating a device that is configured to generate such an electric current without producing a thermal effect on the cells or tissues being treated.

[0118] Another objective is to achieve a device configured to modify one or more parameters of the generated current in real time and independently based on the received cellular or tissue response and therefore depending on the ohmic load applied to the aforementioned electronic device.

[0119] It also achieved the goal of creating equipment with good safety features.

[0120] Advantageously, the specific values ​​of the aforementioned first, second, and third percentage rates advantageously allow modulation of some biological effects obtained by applying QMR, and thus modulate the treatment intended for tissues or cells (even different types of tissues or cells).

Claims

1. An electronic device for biomedical use, comprising: - Radio frequency circuit (3) that can be powered by voltage (21); - At least one electrode (4), said at least one electrode is connected to the radio frequency circuit (3) at the output end and can be applied to a part of the human body; The radio frequency circuit (3) is configured to generate a current wave (5) as an output, the current wave (5) having a fundamental frequency higher than or equal to 2 MHz and being distorted due to the presence of at least the second harmonic. The first percentage ratio between the peak amplitude of the current wave (5) at the second harmonic and the peak amplitude of the current wave (5) at the fundamental frequency is between 20% and 70% when a load of 100 ohms is applied to the at least one electrode (4), and between 25% and 120% when a load of 830 ohms is applied to the at least one electrode (4).

2. The device (1) as claimed in claim 1, characterized in that, The current wave (5) has a distorted sinusoidal shape.

3. The device (1) as described in any one of the preceding claims, characterized in that, When a load of 100 ohms is applied to the at least one electrode (4), the first percentage rate is between 35% and 65%, and when a load of 830 ohms is applied to the at least one electrode (4), the first percentage rate is between 70% and 120%.

4. The device (1) as claimed in claim 1, characterized in that, When a 430-ohm load is applied to the at least one electrode (4), the first percentage ratio between the peak amplitude of the current wave (5) at the second harmonic and the peak amplitude of the current wave (5) at the fundamental frequency is between 70% and 90%.

5. The device (1) as claimed in claim 4, characterized in that, When a load of 430 ohms is applied to the at least one electrode (4), the first percentage rate is between 75% and 85%.

6. The device (1) as claimed in claim 1, characterized in that, The current wave (5) is also distorted due to the presence of the third harmonic, wherein when a 100-ohm load is applied to the at least one electrode (4), the second percentage ratio between the amplitude of the current wave (5) at the third harmonic and the peak amplitude of the current wave (5) at the fundamental frequency is between 2% and 60%, and when an 830-ohm load is applied to the electrode (4), the second percentage ratio is between 4% and 120%.

7. The device (1) as claimed in claim 6, characterized in that, When a load of 100 ohms is applied to the at least one electrode (4), the second percentage rate is between 15% and 50%, and when a load of 830 ohms is applied to the at least one electrode (4), the second percentage rate is between 60% and 120%.

8. The device (1) as claimed in any one of claims 6 or 7, characterized in that, When a 430-ohm load is applied to the at least one electrode (4), the second percentage between the peak amplitude of the current wave (5) at the third harmonic and the peak amplitude of the current wave (5) at the fundamental frequency is between 45% and 70%.

9. The device (1) as claimed in claim 1, characterized in that, The current wave (5) is also distorted due to the presence of the fourth harmonic, wherein when a 100-ohm load is applied to the at least one electrode (4), the third percentage ratio between the peak amplitude of the current wave (5) at the fourth harmonic and the peak amplitude of the current wave (5) at the fundamental frequency is between 0% and 40%, and when an 830-ohm load is applied to the electrode (4), the third percentage ratio is between 0% and 50%.

10. The device (1) as claimed in claim 9, characterized in that, When a load of 100 ohms is applied to the at least one electrode (4), the third percentage rate is between 8% and 35%, and when a load of 830 ohms is applied to the at least one electrode (4), the third percentage rate is between 10% and 50%.

11. The device (1) as claimed in any one of claims 9 or 10, characterized in that, When a 430-ohm load is applied to the at least one electrode (4), the third percentage between the peak amplitude of the current wave (5) at the fourth harmonic and the peak amplitude of the current wave (5) at the fundamental frequency is between 10% and 45%.

12. The device (1) as claimed in claim 11, characterized in that, When a load of 430 ohms is applied to the at least one electrode (4), the third percentage rate is between 15% and 40%.

13. The device (1) as claimed in claim 1, characterized in that, The current wave (5) shows a fundamental frequency between 2 and 64 MHz.

14. The device (1) as claimed in claim 13, characterized in that, The current wave (5) shows a fundamental frequency between 2 and 16 MHz.

15. The device (1) as claimed in claim 14, characterized in that, The current wave (5) shows a fundamental frequency of 4 MHz.

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