A formulation and method of preparing a lotion of ciclopirox olamine

Abstract

The application provides a cyclopirox olamine lotion formula and a preparation method, relates to the field of antibacterial lotions, and the raw materials of the cyclopirox olamine lotion include cyclopirox olamine, sodium laureth sulfate, cocamidopropyl betaine, cocamide DEA, hexylene glycol, oleyl alcohol, polysorbate, polyquaternium, disodium hydrogen phosphate dodecahydrate, citric acid, essence and water. The preparation method is simple, the prepared cyclopirox olamine lotion can solve the problems of instability, poor adhesive peeling strength and the like of traditional ointments, the foam is more abundant, the drug efficacy is facilitated to play, and the use feeling, such as combing property, cleaning effect, after-washing freshness and dandruff-removing and itching-relieving effect, is better.

Description

Technical Field

[0001] This invention relates to the field of antibacterial detergents, specifically to a formulation and preparation method of a ciclopirox olamine detergent. Background Technology

[0002] Tinea manuum, tinea pedis, tinea corporis, onychomycosis, and fungal vaginitis are skin diseases caused by pathogenic bacteria, fungi, and viruses, and are highly contagious. They are more common in tropical and subtropical regions, and the incidence rate in my country is also quite high, causing great suffering to patients. Ciclopirox olamine is a broad-spectrum antifungal drug against superficial skin fungi, yeasts, and Candida albicans. At a concentration of 4-8 micrograms / ml, it can inhibit the growth of skin fungi and yeasts. It mainly works by altering the integrity of the fungal cell membrane, causing the outflow of intracellular substances and blocking the uptake of protein precursors, leading to fungal cell death. It also has some inhibitory effect on various actinomycetes, Gram-positive and Gram-negative bacteria, as well as mycoplasma, chlamydia, and trichomonas, and has strong penetrability. However, common ointments on the market have drawbacks such as difficulty in fixation, poor tackiness and peel strength, and reliance on adhesive dressings for fixation. A safer and more effective formulation that overcomes these shortcomings is needed. Ciclopirox olamine is a broad-spectrum antibacterial drug that exhibits strong inhibitory effects on fungi at low concentrations and on bacteria at high concentrations. Ciclopirox olamine lotion is a topical liquid preparation that can be applied to the skin. It is applied gently to the skin or soaked in gauze and applied directly. Ciclopirox olamine lotion has local effects such as disinfection, anti-inflammation, antipruritic, astringent, and protective properties, and has good permeability, making it particularly advantageous for treating superficial skin diseases. Existing technologies, such as patent CN201410131720.1, disclose a drug for treating scalp itching and increased dandruff, which consists of the following components by weight: ciclopirox olamine 20-50, sodium dodecyl sulfate 70-90, glycerol 5-20, sodium chloride 20-40, fragrance 0.5-2, sodium benzoate 0.1-1, citric acid as needed, and deionized water added to the appropriate amount. The invention also provides a method for preparing the shampoo, but it does not further examine the antibacterial effect and long-term stability of the drug. The accelerated test only examined the drug's condition for about 10 days, and the long-term stability is still unknown. At the same time, the invention also has the following problems: (1) The formula is too simple and lacks conditioning agents and moisturizers, which are common in shampoos, resulting in poor comfort after use; (2) The patented formula does not contain a pH buffer. The national standard for adult shampoos specifies a pH range of 4.0-9.0 (25°C), which may lead to excessive pH changes during storage; (3) Sodium benzoate is added as a preservative in the formula, while ciclopirox olamine is an antibacterial drug that already has an antibacterial effect and does not need to be added as a preservative. Sodium benzoate itself has potential harm to the human body, including damage to the nervous system and carcinogenicity.

[0003] Given the shortcomings of existing technologies, such as poor adhesiveness and peel strength, and reliance on adhesive dressings for fixation, it is crucial to find a safer and more efficient formulation that can overcome these defects. Summary of the Invention

[0004] This invention addresses the problems existing in the prior art by providing a formulation and preparation method for a ciclopirox olamine lotion, which can solve the problems of instability, poor tack and peel strength of traditional ointments.

[0005] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0006] This invention provides a ciclopirox olamine detergent, comprising the following raw materials:

[0007] ciclopirox olamine

[0008] Sodium lauryl ether sulfate

[0009] Cocamidopropyl Betaine

[0010] Cocamide DEA

[0011] Hexanediol

[0012] Oil alcohol

[0013] Polysorbate

[0014] Polyquaternium salt

[0015] Sodium hydrogen phosphate dodecahydrate

[0016] Citric acid

[0017] essence

[0018] water.

[0019] Furthermore, the ciclopirox olamine detergent, by weight percentage, comprises:

[0020]

[0021]

[0022] Preferably, the raw materials, by weight percentage, include:

[0023]

[0024] Furthermore, the polysorbate includes polysorbate 80; the polyquaternium salt includes polyquaternium salt-10.

[0025] Furthermore, the sodium lauryl ether sulfate is 35% sodium lauryl ether sulfate and / or 70% sodium lauryl ether sulfate, and the cocamidopropyl betaine is 35% cocamidopropyl betaine and / or 45% cocamidopropyl betaine (the above percentage content specifically refers to the specifications of the material, i.e., the content of the active ingredient).

[0026] Furthermore, the flavoring includes one or more of the following flavorings from Guangdong Mingkang Flavors & Fragrances Co., Ltd.: MKH01804, MK85153, MKG02097C, and MKG02860.

[0027] The present invention also provides a method for preparing the above-mentioned ciclopirox olamine lotion, comprising the following steps:

[0028] (1) Add polyquaternium salt to water and let it stand;

[0029] (2) After the polyquaternary ammonium salt in step (1) is fully dispersed, add disodium hydrogen phosphate dodecahydrate, heat and keep the temperature constant, and stir until the material is completely dissolved;

[0030] (3) Add sodium lauryl ether sulfate to the solution obtained in step (2) and stir until the material is completely dissolved;

[0031] (4) Add hexanediol to the solution obtained in step (3) and stir until the material is completely dissolved;

[0032] (5) Add cocamidopropyl betaine to the solution obtained in step (4) and stir until the material is completely dissolved;

[0033] (6) Add cocamide DEA to the solution obtained in step (5) and stir until the material is completely dissolved;

[0034] (7) Add polysorbate to the solution obtained in step (6) and stir until the material is completely dissolved;

[0035] (8) Add ciclopirox olamine to the solution obtained in step (7) and stir until the material is completely dissolved;

[0036] (9) Add oleyl alcohol to the solution obtained in step (8) and stir until the material is completely dissolved;

[0037] (10) Cool the solution obtained in step (9), add the fragrance, and stir until the material is completely dissolved;

[0038] (11) Add citric acid to the solution obtained in step (10) and stir until the material is completely dissolved;

[0039] (12) Add water to the final volume; stir until the materials are evenly mixed;

[0040] (13) Adjust the pH and stir well to obtain the final product.

[0041] Further, the heating temperature in step (2) is 55-90℃, preferably 75℃; the cooling temperature in step (10) is room temperature - 50℃, preferably 45℃.

[0042] Further, the citric acid described in step (11) is added until the pH of the solution is not higher than 6.2.

[0043] Further, the pH in step (13) is 5.2-6.2. The pH is adjusted using a 10% sodium hydroxide aqueous solution.

[0044] The technical effects achieved by this invention are:

[0045] The preparation method of this invention is simple, and the ciclopirox olamine lotion prepared can solve the problems of instability, poor tackiness and peel strength of traditional ointments. The order of addition of hexanediol, fragrance, and cocamidopropyl betaine and cocamidopropyl DEA is crucial in this invention, as it will affect the final properties of the product. The product of this invention produces richer foam, which is beneficial for the efficacy of the medicine. At the same time, the user experience is better, with improved combability, cleaning effect, post-wash refreshing feeling, and dandruff and itching relief. Detailed Implementation

[0046] The following specific examples illustrate the implementation of the present invention. Those skilled in the art can easily understand other advantages and effects of the present invention from the content disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and various details in this specification can also be modified or changed based on different viewpoints and applications without departing from the spirit of the present invention.

[0047] Before further describing specific embodiments of the present invention, it should be understood that the scope of protection of the present invention is not limited to the specific embodiments described below; it should also be understood that the terminology used in the embodiments of the present invention is for describing specific embodiments and not for limiting the scope of protection of the present invention.

[0048] When numerical ranges are given in the embodiments, it should be understood that, unless otherwise stated in the invention, both endpoints of each numerical range and any value between the two endpoints may be selected. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains.

[0049] It is worth noting that the fragrances used in Examples 1-3 of this invention were all purchased from Guangdong Mingkang Fragrance & Flavor Co., Ltd., and the models were MKH01804, MK85153 and MKG02097C, respectively; the other raw and auxiliary materials were all commercially available products, so their sources are not specifically limited.

[0050] Example 1

[0051] A ciclopirox olamine detergent comprises the following components:

[0052]

[0053]

[0054] The preparation method of the above-mentioned ciclopirox olamine lotion includes the following steps:

[0055] (1) Add 68.97g of purified water to a beaker, then add 0.30g of polyquaternium-10, let stand, and wait for the material to be fully dispersed in the water;

[0056] (2) After the polyquaternium-10 in step (1) is fully dispersed, add 0.66g of disodium hydrogen phosphate dodecahydrate, start heating and keep the temperature constant at 75°C, stir until the material is completely dissolved;

[0057] (3) Add 15.00g of sodium lauryl ether sulfate to the solution obtained in step (2) and stir until the material is completely dissolved;

[0058] (4) Add 0.40g of hexanediol to the solution obtained in step (3) and stir until the material is completely dissolved;

[0059] (5) Add 6.00g of cocamidopropyl betaine to the solution obtained in step (4) and stir until the material is completely dissolved;

[0060] (6) Add 4.50g of cocamide DEA to the solution obtained in step (5) and stir until the material is completely dissolved;

[0061] (7) Add 0.60g of polysorbate 80 to the solution obtained in step (6) and stir until the material is completely dissolved;

[0062] (8) Add 1.50g of ciclopirox olamine to the solution obtained in step (7) and stir until the material is completely dissolved;

[0063] (9) Add 1.10g of oleyl alcohol to the solution obtained in step (8) and stir until the material is completely dissolved;

[0064] (10) Lower the temperature of the solution obtained in step (9) and maintain it at 45°C, add 0.20g of flavoring, stir until the material is completely dissolved;

[0065] (11) Add the prescribed amount of citric acid to the solution obtained in step (10), stir until the material is completely dissolved. Measure the pH value. If the pH value is higher than 6.2, add another 0.77g of citric acid and continue stirring to dissolve until the pH value is no higher than 6.2.

[0066] (12) Use purified water to bring the weight down to 100g, stir until the materials are evenly mixed;

[0067] (13) Adjust the pH value to 5.2-6.2 with 10% sodium hydroxide aqueous solution, stir evenly to obtain intermediate solution.

[0068] Example 2

[0069] A ciclopirox olamine detergent comprises the following components:

[0070]

[0071] The preparation method of the above-mentioned ciclopirox olamine lotion includes the following steps:

[0072] (1) Add 67.95g of purified water to a beaker, then add 0.30g of polyquaternium-10, let stand, and wait for the material to be fully dispersed in the water;

[0073] (2) After the polyquaternium-10 in step (1) is fully dispersed, add 0.60g of disodium hydrogen phosphate dodecahydrate, start heating and keep the temperature constant to 75°C, stir until the material is completely dissolved;

[0074] (3) Add 16.80g of sodium lauryl ether sulfate to the solution obtained in step (2) and stir until the material is completely dissolved;

[0075] (4) Add 0.45g of hexanediol to the solution obtained in step (3) and stir until the material is completely dissolved;

[0076] (5) Add 6.30g of cocamidopropyl betaine to the solution obtained in step (4) and stir until the material is completely dissolved;

[0077] (6) Add 3.70g of cocamide DEA to the solution obtained in step (5) and stir until the material is completely dissolved;

[0078] (7) Add 0.55g of polysorbate 80 to the solution obtained in step (6) and stir until the material is completely dissolved;

[0079] (8) Add 1.50g of ciclopirox olamine to the solution obtained in step (7) and stir until the material is completely dissolved;

[0080] (9) Add 0.95g of oleyl alcohol to the solution obtained in step (8) and stir until the material is completely dissolved;

[0081] (10) Lower the temperature of the solution obtained in step (9) and maintain it at 45°C, add 0.20g of flavoring, stir until the material is completely dissolved;

[0082] (11) Add the prescribed amount of citric acid to the solution obtained in step (10), stir until the material is completely dissolved. Measure the pH value. If the pH value is higher than 6.2, add another 0.70g of citric acid and continue stirring to dissolve until the pH value is no higher than 6.2.

[0083] (12) Use purified water to bring the weight down to 100g, stir until the materials are evenly mixed;

[0084] (13) Adjust the pH value to 5.2-6.2 with 10% sodium hydroxide aqueous solution, stir evenly to obtain intermediate solution.

[0085] Example 3

[0086] A ciclopirox olamine detergent comprises the following components:

[0087]

[0088] The preparation method of the above-mentioned ciclopirox olamine lotion includes the following steps:

[0089] (1) Add 70.52g of purified water to a beaker, then add 0.30g of polyquaternium-10, let stand, and wait for the material to be fully dispersed in the water;

[0090] (2) After the polyquaternium-10 in step (1) is fully dispersed, add 0.60g of disodium hydrogen phosphate dodecahydrate, start heating and keep the temperature constant to 75°C, stir until the material is completely dissolved;

[0091] (3) Add 13.60g of sodium lauryl ether sulfate to the solution obtained in step (2) and stir until the material is completely dissolved;

[0092] (4) Add 0.38g of hexanediol to the solution obtained in step (3) and stir until the material is completely dissolved;

[0093] (5) Add 5.70g of cocamidopropyl betaine to the solution obtained in step (4) and stir until the material is completely dissolved;

[0094] (6) Add 4.90g of cocamide DEA to the solution obtained in step (5) and stir until the material is completely dissolved;

[0095] (7) Add 0.42g of polysorbate 80 to the solution obtained in step (6) and stir until the material is completely dissolved;

[0096] (8) Add 1.50g of ciclopirox olamine to the solution obtained in step (7) and stir until the material is completely dissolved;

[0097] (9) Add 1.18g of oleyl alcohol to the solution obtained in step (8) and stir until the material is completely dissolved;

[0098] (10) Lower the temperature of the solution obtained in step (9) and maintain it at 45°C, add 0.20g of flavoring, stir until the material is completely dissolved;

[0099] (11) Add the prescribed amount of citric acid to the solution obtained in step (10), stir until the material is completely dissolved. Measure the pH value. If the pH value is higher than 6.2, add another 0.70g of citric acid and continue stirring to dissolve until the pH value is no higher than 6.2.

[0100] (12) Use purified water to bring the weight down to 100g, stir until the materials are evenly mixed;

[0101] (13) Adjust the pH value to 5.2-6.2 with 10% sodium hydroxide aqueous solution, stir evenly to obtain intermediate solution.

[0102] Comparative Example 1

[0103] The only difference from Example 1 is that the ciclopirox olamine detergent contains the following components:

[0104]

[0105]

[0106] The preparation method is the same as in Example 1.

[0107] Comparative Example 2

[0108] The only difference from Example 1 is that the preparation method specifically includes the following steps:

[0109] (1) Add 68.97g of purified water to a beaker, then add 0.30g of polyquaternium-10, let stand, and wait for the material to be fully dispersed in the water;

[0110] (2) After the polyquaternium-10 in step (1) is fully dispersed, add 0.66g of disodium hydrogen phosphate dodecahydrate, start heating and keep the temperature constant at 75°C, stir until the material is completely dissolved;

[0111] (3) Add 15.00g of sodium lauryl ether sulfate to the solution obtained in step (2) and stir until the material is completely dissolved;

[0112] (4) Add 4.50g of cocamide DEA to the solution obtained in step (3) and stir until the material is completely dissolved;

[0113] (5) Add 6.00g of cocamidopropyl betaine to the solution obtained in step (4) and stir until the material is completely dissolved;

[0114] (6) Add 0.60g of polysorbate 80 to the solution obtained in step (5) and stir until the material is completely dissolved;

[0115] (7) Add 1.50g of ciclopirox olamine to the solution obtained in step (6) and stir until the material is completely dissolved;

[0116] (8) Add 0.40g of hexanediol to the solution obtained in step (7) and stir until the material is completely dissolved;

[0117] (9) Add 1.10g of oleyl alcohol to the solution obtained in step (8) and stir until the material is completely dissolved;

[0118] (10) Lower the temperature of the solution obtained in step (9) and maintain it at 45°C. Add 0.20g of flavoring to step (9) and stir until the material is completely dissolved.

[0119] (11) Add the prescribed amount of citric acid to the solution obtained in step (10), stir until the material is completely dissolved. Measure the pH value. If the pH value is higher than 6.2, add another 0.77g of citric acid and continue stirring to dissolve until the pH value is no higher than 6.2.

[0120] (12) Use purified water to bring the weight down to 100g, stir until the materials are evenly mixed;

[0121] (13) Adjust the pH value to 5.2-6.2 with 10% sodium hydroxide aqueous solution, stir evenly to obtain intermediate solution.

[0122] I. Antibacterial test

[0123] The antibacterial activity of different drugs against Staphylococcus aureus was determined using the broth dilution method recommended by the National Committee for Clinical Laboratory Standards (NCCLs) M7-A6 protocol. Antibacterial assays against Candida albicans and Saccharomyces cerevisiae were performed using a modified microdilution method according to the NCCLs M-27-T protocol.

[0124] 1. Preparation of Culture Medium and Bacterial Suspension: Broth medium, Sabouraud dextrose agar medium, and RPMI-1640 liquid medium were prepared separately and sterilized for later use. Activated Staphylococcus aureus was diluted to a concentration of 10⁻⁶ with physiological saline using the McFarland turbidimetric method. 6 ~10 7 CFU·mL -1 Using the same method, the activated Candida albicans and Saccharomyces cerevisiae were diluted with physiological saline to the same concentration of bacterial suspension for later use.

[0125] 2. Preparation of Drug Stock Solutions This experiment was divided into three groups: the ciclopirox olamine lotion group, the ciclopirox olamine solution group, and the fluconazole dimethyl sulfoxide solution group (Example 1). First, stock solutions with a concentration of 12800 μg / mL were prepared. -1 The solution contained ciclopirox olamine and fluconazole dimethyl sulfoxide. Then, according to the NCCLs protocol, the antifungal stock solution prepared with dimethyl sulfoxide was diluted to a final concentration using RPMI-1640 liquid medium, and the final volume fraction of dimethyl sulfoxide should not exceed 1%. Therefore, it was diluted to 1280 μg / mL using RPMI-1640 liquid medium. -1 The solution was filtered and sterilized before use. Finally, an appropriate amount of ciclopirox olamine lotion was weighed and prepared with sterile water to a concentration of 1280 μg·mL⁻¹. -1 The solution is filtered and sterilized before use.

[0126] 3. Inoculation and Cultivation: A 96-well microplate was used. 20 μL of the prepared ciclopirox olamine lotion stock solution was added to well 1. Then, 180 μL of RPMI-1640 liquid medium was added to well 1. 100 mL of RPMI-1640 liquid medium was added to wells 2-11, and 200 μL of RPMI-1640 liquid medium was added to well 12. 100 μL of the liquid was aspirated from well 1 and added to well 2, and mixed thoroughly. 100 μL was then aspirated from well 3 and so on, until well 10. 100 μL of the liquid was aspirated from well 10 and discarded. After serial dilution, 100 μL of Candida albicans suspension was added to wells 1-11. At this point, wells 1-10 contained ciclopirox olamine at a concentration of 64.000–0.125 μg / mL. -1 Each well contains 200 μL of bacterial suspension and 100 μL of liquid culture medium as a positive control; well 12 contains 200 μL of liquid culture medium as a negative control.

[0127] Saccharomyces cerevisiae and Staphylococcus aureus were inoculated separately according to the above method, with the Staphylococcus aureus culture medium being liquid broth. The antibacterial test of each drug stock solution was performed in triplicate. The inoculated Candida albicans and Saccharomyces cerevisiae 96-well microculture plates were incubated at 35℃ for 2–3 days, while the Staphylococcus aureus culture plates were incubated overnight at 37℃. Candida albicans ATCC10231 was used as the quality control bacterium and fluconazole as the quality control drug in each experiment. The results were stable and met the standard range specified by NCCLs, indicating that the results of this experiment were reliable. The MICs of each drug against the strains are shown in Table 1. It can be seen that the antibacterial effect of the ciclopirox olamine lotion group was better than that of the solution group and the fluconazole dimethyl sulfoxide solution group. The ciclopirox olamine lotion formulation constructed in this invention has a significantly better in vitro antibacterial effect than the original drug solution, improving the antibacterial performance of the drug.

[0128] Table 1 Evaluation of the antibacterial effect of products at different concentrations

[0129]

[0130] Note: + indicates that the growth of the strain was not inhibited; - indicates that the growth of the strain was inhibited.

[0131] Drug concentration 15 mg / mL -1 The antibacterial effects of ciclopirox olamine lotion in each case are evaluated in the following table:

[0132] Table 2 Evaluation of the antibacterial effect of ciclopirox olamine lotion in each case

[0133]

[0134] II. Stability Test

[0135] 1. Accelerated test: Three batches of samples were prepared according to the prescriptions in the above examples and packaged in metal tubes (Shanghai Xinya Pharmaceutical Packaging Materials Factory). The samples were placed at a temperature of 40℃±2℃ and a relative humidity of 75%±5%. Samples were taken at the end of 0, 1, 2, 3 and 6 months respectively, and tested according to the key stability test items.

[0136] 2. Long-term test: Three batches of samples prepared in Example 1 were placed at a temperature of 25℃±2℃ and a relative humidity of 60%±10%, and samples were taken at 3, 6, 9, 12, 18, and 24 months, respectively, and tested according to the key stability observation items. The results show that after 6 months under the above accelerated test conditions, the observed indicators of the samples did not change significantly; after 24 months of long-term testing, the observed indicators of this product also did not change significantly.

[0137] Table 3. Accelerated stability test results of ciclopirox olamine lotion

[0138]

[0139]

[0140] (Note: The experiment was stopped after the sample in Comparative Example 2 in the table showed stratification.)

[0141] Table 4. Long-term stability of ciclopirox olamine lotion in Example 1

[0142]

[0143] Furthermore, according to GB / T 29679-2013 Shampoo and Shampoo Cream, the foam value of transparent shampoo should be ≥100mm (40℃). The results showed that the original product (specifically SEBIPROX 1.5%, shampooing, manufactured by GlaxoSmithKline) had a foam value of 110-120mm (40℃), while the product of this invention had a foam value between 130-160mm. The product in Comparative Example 1 had significantly less foam than that in Example 1, and caused scalp itching after use, as shown in the table below.

[0144] Table 5. Foam value test results for each example product.

[0145] Example Foam value (mm) Example 1 143 Example 2 155 Example 3 132 Comparative Example 1 86 Comparative Example 2 139 SEBIPROX 113

[0146] User experience test of the product of this invention compared to the original product:

[0147] Trial participants: 20 healthy individuals (10 men and 10 women), aged 18-60;

[0148] The combability, gloss, moisturizing effect, softness, cleansing effect, refreshing feeling after washing, dandruff removal and itch relief, and foaming properties of Example 1 and the original product were examined. Each evaluation index had a maximum score of 100 points, and the results are summarized in Table 6.

[0149] Table 6: Trial Experience Testing Results for Each Example Product

[0150] Evaluation indicators Example 1 SEBIPROX Sorting 92.5±6.1*** 78.9±5.9 gloss 93.5±6.5 93.3±4.1 Moisturizing effect 90.4±6.6 90.3±4.8 Softness 93.2±7.2 92.2±5.0 Cleaning effect 94.4±5.4*** 81.2±4.6 refreshing feeling after washing 92.7±6.3*** 83.4±7.9 Removes dandruff and relieves itching 93.6±6.9*** 83.3±9.0 Foaming properties 92.4±10.0*** 71.5±7.6

[0151] Note: ***, P<0.001

[0152] The results are shown in Tables 5-6: The product of this invention produces richer foam, which facilitates full contact between the product and the scalp, enhances the efficacy of the medicine, and provides a better user experience. After use, the product has better combability, cleaning effect, refreshing feeling after washing, and dandruff and itching relief effects.

[0153] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, and is not intended to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions made by those skilled in the art to the technical solution of the present invention do not depart from the essence and scope of the technical solution of the present invention.

Claims

1. A ciclopirox olamine detergent, characterized in that: Raw materials, by weight percentage, include: The ciclopirox olamine detergent is prepared by the following steps: (1) Add polyquaternium salt to water and let it stand; (2) After the polyquaternary ammonium salt in step (1) is fully dispersed, add disodium hydrogen phosphate dodecahydrate, heat and keep the temperature constant, and stir until the material is completely dissolved; (3) Add sodium lauryl ether sulfate to the solution obtained in step (2) and stir until the material is completely dissolved; (4) Add hexanediol to the solution obtained in step (3) and stir until the material is completely dissolved; (5) Add cocamidopropyl betaine to the solution obtained in step (4) and stir until the material is completely dissolved; (6) Add cocamide DEA to the solution obtained in step (5) and stir until the material is completely dissolved; (7) Add polysorbate to the solution obtained in step (6) and stir until the material is completely dissolved; (8) Add ciclopirox olamine to the solution obtained in step (7) and stir until the material is completely dissolved; (9) Add oleyl alcohol to the solution obtained in step (8) and stir until the material is completely dissolved; (10) Cool the solution obtained in step (9), add the fragrance, and stir until the material is completely dissolved; (11) Add citric acid to the solution obtained in step (10) and stir until the material is completely dissolved; (12) Add water to make up the volume; stir until the materials are evenly mixed; (13) Adjust the pH and stir well to obtain the final product.

2. The ciclopirox olamine detergent according to claim 1, characterized in that: Raw materials, by weight percentage, include: 。 3. The ciclopirox olamine detergent according to claim 1, characterized in that: The polysorbate includes polysorbate 80; the polyquaternium salt includes polyquaternium salt-10.

4. The ciclopirox olamine detergent according to claim 1, characterized in that: The sodium lauryl ether sulfate is 35% sodium lauryl ether sulfate and / or 70% sodium lauryl ether sulfate, and the cocamidopropyl betaine is 35% cocamidopropyl betaine and / or 45% cocamidopropyl betaine.

5. The method for preparing the ciclopirox olamine lotion according to any one of claims 1-4, characterized in that: Prepared by the following steps: (1) Add polyquaternium salt to water and let it stand; (2) After the polyquaternary ammonium salt in step (1) is fully dispersed, add disodium hydrogen phosphate dodecahydrate, heat and keep the temperature constant, and stir until the material is completely dissolved; (3) Add sodium lauryl ether sulfate to the solution obtained in step (2) and stir until the material is completely dissolved; (4) Add hexanediol to the solution obtained in step (3) and stir until the material is completely dissolved; (5) Add cocamidopropyl betaine to the solution obtained in step (4) and stir until the material is completely dissolved; (6) Add cocamide DEA to the solution obtained in step (5) and stir until the material is completely dissolved; (7) Add polysorbate to the solution obtained in step (6) and stir until the material is completely dissolved; (8) Add ciclopirox olamine to the solution obtained in step (7) and stir until the material is completely dissolved; (9) Add oleyl alcohol to the solution obtained in step (8) and stir until the material is completely dissolved; (10) Cool the solution obtained in step (9), add the fragrance, and stir until the material is completely dissolved; (11) Add citric acid to the solution obtained in step (10) and stir until the material is completely dissolved; (12) Add water to make up the volume; stir until the materials are evenly mixed; (13) Adjust the pH and stir well to obtain the final product.

6. The preparation method according to claim 5, characterized in that: The heating temperature in step (2) is 55~90℃; the cooling temperature in step (10) is room temperature~50℃.

7. The preparation method according to claim 5, characterized in that: The citric acid described in step (11) is added until the pH of the solution is no higher than 6.

2.

8. The preparation method according to claim 5, characterized in that: The pH value mentioned in step (13) is 5.2-6.2.

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