A low-residue hydrogen peroxide disinfectant and its preparation method

Abstract

This invention discloses a low-residue hydrogen peroxide disinfectant, composed of the following components by weight percentage: 2.0-8.0% hydrogen peroxide; 0.1-1% formic acid; 0.5-5% acetic acid; 0.05-0.5% acetic acid surfactant; and the balance being purified water. When used for surface disinfection, this hydrogen peroxide disinfectant can kill bacterial spores, achieving a high level of disinfection within 5 minutes. When used for air disinfection, it achieves disinfection within 5 minutes after spraying. The prepared liquid leaves minimal residue, eliminating the need for post-use cleaning. This hydrogen peroxide disinfectant can be used for environmental, equipment, and air disinfection in medical and health institutions, public places, food processing areas, and other areas requiring cleanliness. Furthermore, this invention also discloses a method for preparing the hydrogen peroxide disinfectant.

Description

Technical Field

[0001] This invention relates to the field of chemical disinfection technology for clean environment surfaces and air, specifically to a low-residue hydrogen peroxide disinfectant capable of rapidly killing bacterial spores and its preparation method. Background Technology

[0002] Currently, the main chemical disinfectants used for environmental surface disinfection include alcohol-based disinfectants, chlorine-containing disinfectants, quaternary ammonium salts, and hydrogen peroxide-based disinfectants. Chlorine-containing disinfectants are highly effective, but have a strong chlorine odor, are highly corrosive, and leave significant residues. Quaternary ammonium salt disinfectants are safe, but only achieve low-level disinfection and leave considerable residues. Ethanol disinfectants can achieve medium-level disinfection with no residue, but they are flammable, explosive, and evaporate quickly, requiring high concentrations and sufficient contact time; often, disinfection fails due to insufficient contact time. Finally, hydrogen peroxide disinfectants, whose main component is hydrogen peroxide, are safe and leave no residue, producing only water and oxygen as byproducts, making them an ideal disinfectant.

[0003] However, due to the presence of catalysts in typical contaminated environments, conventional low-concentration hydrogen peroxide disinfectants have poor resistance to interference and their effects are generally not ideal. Furthermore, their effectiveness against bacterial spores is very limited, achieving only low to medium levels of disinfection. To improve sterilization, the concentration of hydrogen peroxide is usually increased; therefore, medical-grade hydrogen peroxide typically contains 3% hydrogen peroxide. At this concentration, hydrogen peroxide has strong oxidizing properties, posing a potential safety hazard. In addition, to enhance the disinfection effect of hydrogen peroxide, other synergistic agents, such as silver ions and other metal ions, are often added. This can cause instability in the hydrogen peroxide solution. To improve the stability of hydrogen peroxide, stabilizers, such as citric acid and phosphates, are added, resulting in complex formulations and high costs. Moreover, although hydrogen peroxide itself leaves no residue, these added synergists and stabilizers can remain on the surface of objects, affecting the safety of disinfected items (especially those requiring high cleanliness) for subsequent use.

[0004] Furthermore, with social development in recent years, low- to medium-level disinfectants that cannot kill bacterial spores are no longer sufficient for surface disinfection in high-risk infection areas. Currently, disinfectants capable of killing bacterial spores mainly include sodium hypochlorite and aldehyde disinfectants. Sodium hypochlorite disinfectants, due to their strong alkaline and oxidizing properties, are highly corrosive to many non-stainless steel metals, thus limiting their application. Glutaraldehyde disinfectants, due to their strong skin and mucous membrane irritation and allergic reactions, are also unsuitable for surface disinfection. At the same time, many medical and health institutions, food processing plants, and pharmaceutical production workshops have high requirements for disinfectant residue levels, and both sodium hypochlorite and aldehyde disinfectants have significant residues, further restricting their application and convenience.

[0005] Due to the above drawbacks, a disinfectant product with low residue that can quickly kill bacterial spores is needed in such scenarios. Summary of the Invention

[0006] To address the shortcomings of the prior art, this invention provides a low-residue hydrogen peroxide disinfectant and its preparation method. This invention can rapidly kill bacterial spores with low residue and exhibits good stability. Furthermore, this invention also provides a method for preparing the aforementioned low-residue hydrogen peroxide disinfectant.

[0007] The present invention provides a hydrogen peroxide disinfectant, which is composed of the following components by weight percentage:

[0008] Hydrogen peroxide 2.0 - 8.0%;

[0009] Formic acid 0.1-1%;

[0010] Acetic acid 0.5-5%;

[0011] Acetyl alcohol surfactant 0.05 - 0.5%;

[0012] The remainder is purified water.

[0013] Furthermore, in the aforementioned hydrogen peroxide disinfectant, the concentration of the hydrogen peroxide raw material can be different, such as 30% or 35%, and the final concentration reaches the pure hydrogen peroxide concentration described in this application.

[0014] Furthermore, in the aforementioned hydrogen peroxide disinfectant, the alkynyl surfactant is preferably one or a mixture of several of the following: methylbutynol, methylpentynol, 3,5-dimethyl-1-hexyn-3-ol, 2,5-dimethyl-3-hexyn-2,5-diol, and 2,4,7,9-tetramethyl-5-decyn-4,7-diol polyoxyethylene ether.

[0015] The present invention provides a method for preparing hydrogen peroxide disinfectant, comprising the following steps: adding purified water, formic acid, acetic acid, alkynol surfactant and hydrogen peroxide in sequence by weight percentage to a mixing container, stirring evenly to obtain hydrogen peroxide disinfectant.

[0016] Compared with existing technologies, this invention has the following advantages: Formic acid and acetic acid are used as a synergist in this invention. Since most common pathogenic microorganisms produce catalase during metabolism, they can avoid being attacked by oxygen free radicals generated by hydrogen peroxide, thus achieving a state of resistance to disinfectants. Existing experiments have shown that catalase cannot act on peroxycarboxylic acids; therefore, peroxycarboxylic acids can carry oxygen free radicals into the pathogenic microorganisms to produce a killing effect. In our research, we unexpectedly discovered that adding formic acid to the hydrogen peroxide-acetic acid system rapidly generates peroxycarboxylic acids, which have strong osmotic properties. Therefore, in the presence of formic acid, the bactericidal effect of hydrogen peroxide will be significantly enhanced. At the end of the disinfectant's action, formic acid is oxidized and decomposed into carbon dioxide and water, while hydrogen peroxide is decomposed into oxygen and water. Acetic acid itself is volatile; therefore, this system can achieve disinfection without residue.

[0017] This invention also incorporates a volatile alkynyl alcohol surfactant, which has rapid wetting and dispersing properties, helping the disinfectant reach even the smallest depressions on the surface, allowing the disinfectant to contact pathogens in hard-to-reach areas, thus achieving a comprehensive and thorough disinfection effect. Simultaneously, this surfactant has a certain degree of volatility at room temperature, evaporating into the air when sprayed or wiped onto the surface and being discharged into the environment through the airflow system, thus leaving no residue after disinfection. The hydrogen peroxide disinfectant of this invention can kill bacterial spores. Microbiological tests show that a 2%-8% concentration of hydrogen peroxide disinfectant can achieve a high level of disinfection within 5 minutes.

[0018] The hydrogen peroxide disinfectant of this invention can be used for air disinfection, spraying for 10 minutes at a dosage of 5 mL / m³. 3 After spraying, leave it for 5 minutes to achieve a kill log of >4.00 against Staphylococcus aureus.

[0019] The hydrogen peroxide disinfectant of this invention exhibits a degradation rate of less than 2% after 180 days of storage at 40°C, demonstrating good stability and the ability to be stably stored at room temperature for more than 36 months. Detailed Implementation

[0020] The present invention provides a hydrogen peroxide disinfectant, which is composed of the following components by weight percentage:

[0021] Hydrogen peroxide 2.0 - 8.0%;

[0022] Formic acid 0.1-1%;

[0023] Acetic acid 0.5-5%;

[0024] Acetyl alcohol surfactant 0.05 - 0.5%;

[0025] The remainder is purified water.

[0026] Furthermore, in the aforementioned hydrogen peroxide disinfectant, the concentration of the hydrogen peroxide raw material can be different, such as 30% or 35%, and the final concentration is the concentration of pure hydrogen peroxide.

[0027] Furthermore, in the aforementioned hydrogen peroxide disinfectant, the alkynyl surfactant is preferably one or a mixture of several of the following: methylbutynol, methylpentynol, 3,5-dimethyl-1-hexyn-3-ol, 2,5-dimethyl-3-hexyn-2,5-diol, and 2,4,7,9-tetramethyl-5-decyn-4,7-diol polyoxyethylene ether.

[0028] In this invention, the purified water is purified water prepared according to the requirements of the Chinese Pharmacopoeia.

[0029] The present invention provides a method for preparing hydrogen peroxide disinfectant, comprising the following steps: adding purified water, formic acid, acetic acid, alkynol surfactant and hydrogen peroxide in sequence according to the weight percentage in a mixing container, stirring evenly to obtain hydrogen peroxide disinfectant.

[0030] The present invention will be further illustrated below with reference to specific embodiments. These embodiments should be understood as illustrative only and not as limiting the scope of protection of the present invention. After reading the description of the present invention, those skilled in the art can make various alterations or modifications to the present invention, and these equivalent changes and modifications also fall within the scope defined by the claims of the present invention.

[0031] Example 1

[0032] In a mixing container, 86.3 kg of purified water, 0.7 kg of formic acid, 4.0 kg of acetic acid, 0.1 kg of methylbutynol, 0.3 kg of 3,5-dimethyl-1-hexyn-3-ol and 8.6 kg of 35% hydrogen peroxide were added in sequence and stirred evenly to obtain the hydrogen peroxide disinfectant sample of Example 1.

[0033] Example 2

[0034] In a mixing container, 84.5 kg of purified water, 0.2 kg of formic acid, 3.0 kg of acetic acid, 0.2 kg of methylpentynol, 0.3 kg of 3,5-dimethyl-1-hexyn-3-ol and 11.8 kg of 35% hydrogen peroxide were added in sequence and stirred evenly to obtain the hydrogen peroxide disinfectant sample of Example 2.

[0035] Example 3

[0036] In a mixing container, 81 kg of purified water, 0.1 kg of formic acid, 1.0 kg of acetic acid, 0.4 kg of 2,4,7,9-tetramethyl-5-decyn-4,7-diol polyoxyethylene ether and 17.5 kg of 30% hydrogen peroxide were added in sequence and stirred evenly to obtain the hydrogen peroxide disinfectant sample of Example 3.

[0037] Experimental Example 1—Determination of Non-volatile Matter in Low-Residue High-Level Hydrogen Peroxide Disinfectant

[0038] In a 100 mL evaporating dish, weigh approximately 50 g of the example sample, accurate to 0.01 g, and evaporate it to dryness in a water bath. Then, dry the residue in an oven at 105-110 °C until weighed, and then cool it in a desiccator. Weigh it accurately to determine the proportion of non-volatile matter. The results are shown in Table 1.

[0039] Table 1. Test data on non-volatile matter of low residual hydrogen peroxide disinfectant

[0040]

[0041] Conclusion: The hydrogen peroxide disinfectant prepared in Examples 1-3 of the present invention has extremely low residue, with the proportion of non-volatile residue reaching less than one ten-thousandth, which basically meets the cleanliness requirements.

[0042] Test Example 2—Test of the bactericidal ability of a low-residue, high-level hydrogen peroxide disinfectant

[0043] The sterilization test was conducted according to the relevant provisions of the "Disinfection Technical Specifications" (2002 edition), and the test results are shown in Table 2:

[0044] Table 2. Tests on the bactericidal ability of low-residue hydrogen peroxide disinfectants

[0045]

[0046]

[0047] Conclusion: The hydrogen peroxide disinfectant prepared in Examples 1-3 of this invention can achieve a high level of disinfection within 5 minutes. After the air spray disinfection is completed according to the prescribed dosage, it can achieve the air disinfection effect within 5 minutes.

[0048] Experimental Example 3—Accelerated Stability Test of Hydrogen Peroxide Disinfectant

[0049] The test was conducted according to GB / T 38499-2020, "Stability Evaluation Method for Disinfectants", and the test results are shown in Table 3.

[0050] Table 3. Accelerated stability test data of hydrogen peroxide disinfectant (based on hydrogen peroxide)

[0051]

[0052] Conclusion: The hydrogen peroxide disinfectant prepared in Examples 1-3 of the present invention showed a decrease rate of <2% after being stored at 40°C for 180 days, indicating good stability and a shelf life of up to 36 months.

[0053] The above tests demonstrate that the hydrogen peroxide disinfectant of this invention can kill bacterial spores when used for environmental surface disinfection, achieving a high level of disinfection effect within 5 minutes; when used for air disinfection, it achieves disinfection effect within 5 minutes after spraying; the prepared liquid has good stability and a shelf life of over 36 months. It can be used for environmental, equipment, and air disinfection in medical and health institutions, public places, food processing sites, and other high-risk infection areas, and is particularly suitable for the disinfection of the aforementioned environmental surfaces and air requiring cleanliness.

Claims

1. A low-residue hydrogen peroxide disinfectant, characterized in that, It consists of the following components by weight percentage: Hydrogen peroxide 2.0 - 8.0%; Formic acid 0.1-1%; Acetic acid 0.5-5%; Acetyl alcohol surfactant 0.05 - 0.5%; The remainder is purified water; The alkynol surfactant is one or a mixture of several of the following: methylbutynol, methylpentynol, 3,5-dimethyl-1-hexyn-3-ol, 2,5-dimethyl-3-hexyn-2,5-diol, and 2,4,7,9-tetramethyl-5-decyn-4,7-diol polyoxyethylene ether.

2. A method for preparing a low-residue hydrogen peroxide disinfectant as described in claim 1, characterized in that, Includes the following steps: Purified water, formic acid, acetic acid, alkynol surfactant, and hydrogen peroxide are added sequentially to a mixing container by weight percentage, and stirred until homogeneous to obtain hydrogen peroxide disinfectant.

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