Equipment for filling medical containers
By designing a modular device that includes a filling unit and a transport unit, and utilizing interchangeable elements to enable flexible container conversion, the problems of high equipment modification costs and long downtime in existing technologies are solved, achieving efficient and low-cost pharmaceutical container filling.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- BAUSCH STROEBEL MASCHINENFABRIK ILSHOFEN GMBH CO KG
- Filing Date
- 2021-12-22
- Publication Date
- 2026-06-30
AI Technical Summary
Existing technologies are difficult to adapt to the filling needs of different types of pharmaceutical containers efficiently and at low cost, and equipment modification is costly and results in long downtime.
An apparatus comprising a filling device, a transport device, a transfer element, and a supply unit was designed. The transfer element enables flexible conversion and unified processing of containers, reducing modification costs. The modular structure is designed to adapt to containers of different sizes.
It achieves high versatility and simple structure of equipment, reduces manufacturing costs and training expenses, reduces equipment modification time, and adapts to different types of pharmaceutical container filling needs.
Smart Images
Figure CN116723984B_ABST
Abstract
Description
Technical Field
[0001] This invention relates to an apparatus for filling different types of pharmaceutical containers, wherein the containers particularly include syringes, vials, and / or cartridges. Vials may also be referred to as "long-necked bottles" or "tubular bottles." Containers may also be referred to as "vessels." The drugs are, in particular, medically effective substances (pharmaceuticals). For filling, the apparatus includes a filling device, which may also be referred to as a "filling machine," and includes a filling station. Summary of the Invention
[0002] The purpose of this invention is to provide a device of the type described at the beginning that has a simple construction.
[0003] According to the present invention, this objective is achieved by an apparatus for filling different types of pharmaceutical containers, wherein the containers particularly include syringes, vials, and / or cartridges, the apparatus comprising:
[0004] - A filling device comprising: particularly a linear transport device, which preferably includes a retaining element for the circulation of the container, movable along the transport direction from the access side to the disengagement side of the transport device; and at least one processing station for the container, the processing station including a filling station arranged at the transport device for filling the container with the drug.
[0005] - Access elements for transferring containers to transport devices and detachment elements for receiving containers from transport devices;
[0006] - A first supply unit for providing containers of a first type to be filled and a second supply unit for supplying containers of a second type to be filled;
[0007] - A junction element, which is arranged on the supply side of the transport device or may be arranged at at least one junction location and preferably at exactly one junction location, can be used to indirectly or directly selectively supply a first type of container of the first supply unit or a second type of container of the second supply unit to the transport device.
[0008] In the device according to the invention, containers can be transferred one by one to the transport device via an access element, and particularly to a circulating holding element. The transport device is preferably designed to be linear. After being filled at the filling station, the containers can be detached from the transport device via a release element. First-type and second-type containers can be supplied via a supply unit, thereby giving the device a high degree of versatility. First-type and second-type containers can be filled using a filling device. In particular, the “type” of container is determined here by the form in which the container is supplied by the respective supply unit. This will be discussed further below. A transfer element is arranged at at least one, and preferably exactly one, transfer location. The first-type or second-type containers can be selectively supplied directly or indirectly to the transport device via the transfer element, depending on the application of the device, and particularly the filling device. This preferably provides a feasible solution for making the device preferably have a simple and / or compact construction. It is particularly advantageous here to construct and / or position the filling device in a manner independent of the supply unit. This advantageously makes the device according to the invention constructed with filling devices of a substantially standardized, for example, modular construction, which are distinguished from each other on the supply side by supply units. This also provides a feasible solution for simple expansion of the device. Beneficially, the use of standardized parts can reduce manufacturing costs and decrease training and maintenance expenses.
[0009] For example, terms such as "above," "over," "below," and "horizontal" refer to the conventional use of the equipment. In particular, at least one rack of the equipment is positioned here on a scaffold surface, such as a workshop or laboratory. The scaffold surface can be considered to be horizontally oriented.
[0010] The equipment preferably includes control devices for operating and / or adjusting the operation of the equipment and the filling device. It is understood that the equipment may have actuators for the corresponding moving parts. These are not described below. Such actuators are known to those skilled in the art.
[0011] Preferably, a linear transport device is provided with a filling device for transporting the container from the inlet element to the outlet element.
[0012] It is understandable that modifications to the equipment may be necessary to selectively supply containers to either the first or second supply unit. However, by using interchange components, modification costs and downtime can be kept to a minimum. Preferably, no modification is required.
[0013] It can be stipulated that, depending on whether the container is supplied from the first supply unit or the second supply unit, different handover elements are positioned at the same handover location.
[0014] It can be specified that the first supply unit or the second supply unit includes a handover element, or that the filling device includes a handover element.
[0015] The junction elements of the equipment for containers, and preferably other transport elements such as transport wheels, unit chains, transport devices, etc., advantageously possess the characteristic that they can cover different specifications. In this context, “specification” is currently understood in particular to mean different styles of containers that differ from one another in their container type (vial, syringe, or cartridge) and / or in their container characteristics (e.g., especially size).
[0016] The device preferably comprises multiple groups of sizable components having corresponding sizable parts, which differ from each other in characteristics specific to the container, to container parts, and / or to processing, particularly the interchange and / or access and / or disengagement elements. This applies accordingly to other interchange elements, which will also be mentioned below. Preferably, the remaining transport elements for the container may also be sizable components. The holding elements of the transport device are preferably sizable components. Accordingly, the holding element carrier of the transport device may be sizable components, each comprising multiple holding elements.
[0017] It can be specified that the transfer element is formed separately from the access element, wherein the container can be transferred from the transfer element indirectly through at least one other transport element or directly to the access element.
[0018] The alternative location may specify that the access element is or constitutes a handover element.
[0019] It is understood that when using standard components, the connecting element can be replaced according to the specifications to be used. However, it is preferable to have exactly one defined connecting position.
[0020] The equipment preferably includes a positioning or positionable frame for the filling device on a mounting surface. Components of the filling device can be arranged and held at the frame. The frame may also be referred to as a base or "platform" and can be positioned on a mounting surface, such as the floor of a laboratory or workshop.
[0021] Access components can be arranged on a rack.
[0022] "Arranged on the rack" can be understood here as "held at the rack" and vice versa.
[0023] It can be stipulated that the handover components are arranged on the rack.
[0024] In a preferred embodiment, it has proven advantageous that the filling device has an inlet element arranged on a frame. The container can be transferred from the inlet element to the receiving element. The container can also be transferred from the receiving element to the inlet element.
[0025] It is advantageous that, on the supply side, only the access element or the access element and other transport elements for the container are arranged on the frame of the filling device, such as the aforementioned inlet element, wherein preferably, in particular exactly one other transport element is arranged on the frame of the filling device.
[0026] The first supply unit and the second supply unit may include separate racks. Alternatively, the first supply unit and the second supply unit may include a common rack.
[0027] The equipment preferably includes a second frame adjacent to the first frame on the supply side, on which transfer elements and parts of one of the supply units, namely the first or second supply unit, are arranged. Containers can be transferred directly or indirectly across the boundary between the frames to a transport element of the filling device via the transfer elements. For example, the transfer elements transfer containers directly to a transport element of the filling device, such as an inlet or outlet element. Alternatively, at least one intermediate transport element can be arranged on the second frame, which itself transfers containers across the boundary to the filling device.
[0028] The racks can be oriented in a way that aligns with each other, especially in that the longitudinal directions of the racks coincide.
[0029] The first and second racks can be positioned, for example, in a manner that is not aligned with each other and oriented at an angle relative to each other. The angle is preferably 90° or substantially 90°. Here, the angle is specifically the angle between the longitudinal directions of the racks.
[0030] The equipment preferably includes a third rack adjacent to the second rack on the supply side, on which parts of corresponding other supply units, i.e., the second or first supply unit, are arranged, wherein containers are transferred directly or indirectly from these other supply units across the boundary between the racks to the transfer element. Containers from the other supply units can thus be supplied to the filling device via the transfer element.
[0031] In a preferred embodiment, the third rack may be oriented at an angle relative to the second rack, not aligned with it. The angle is preferably 90° or substantially 90°. This angle may particularly be the angle between the longitudinal directions of the racks.
[0032] It can be specified that the third rack extends along the boundary between the rack of the filling device and the second rack.
[0033] It can be specified that the third rack is aligned with the rack of the filling device, with the second rack positioned between the third rack and the rack of the filling device.
[0034] The first type of container is preferably a small bottle or a medicine cartridge.
[0035] The first supply unit is advantageously configured to provide a first type of container as bulk goods and includes a transport element or storage element on which the containers positioned can be dispatched. Bulk goods can be understood herein as "bulk goods" consisting of containers. Containers are arranged, for example, on a turntable forming the transport element or storage element. Containers can be dispatched by the turntable and transferred one by one, directly or indirectly, to a transfer element.
[0036] The first supply unit preferably includes at least one of the following features:
[0037] - A cleaning device for containers;
[0038] - A sterilization device for containers;
[0039] - A drying device for containers.
[0040] Preferably, the aforementioned devices are arranged in this order at the supply unit. The output side of the drying device is preferably connected to the transport or storage element of the supply unit.
[0041] The second type of container includes, for example, vials, syringes, or cartridges.
[0042] The second supply unit preferably includes mechanisms for supplying containers received in a common carrier and operating means for removing containers from the common carrier. For example, the containers are received in a carrier commonly referred to as a "nest." The carrier may be arranged in a receiving unit, for example, referred to as a "barrel-shaped storage unit." The receiving unit can be opened to remove the carrier. The containers can be removed from the carrier by the operating means and, for example, transferred to a transport element of the second supply unit to be separated into individual containers, and from this transport element, directly or indirectly supplied to a transfer element.
[0043] Advantageously, the holding element of the transport device has container receiving portions with a pre-given or pre-given spacing between them, and the spacing between the containers can be adjusted in the first and / or second supply units or downstream of the transfer element in the supply direction as the spacing of the container receiving portions. The spacing between the container receiving portions can be referred to as the so-called "machine gap" of the filling device. Advantageously, containers can be fed into the transport device one by one with a spacing ("gap") corresponding to the machine gap. Preferably, the spacing has been adjusted in the first and / or second supply units or alternatively downstream of the transfer element.
[0044] The first type of containers, for example, have been individually distributed by transport or storage elements at the correct spacing (“gap”) in the first supply unit.
[0045] In the second supply unit, it may be specified that the spacing (“nest pitch”) of the containers in the common carrier may be adjusted if necessary before transfer to the handover element. This can preferably be achieved by means of an operating device. How this is achieved is described in the applicant’s unpublished patent application DE 10 2020 134 783.9, the full disclosure of which is incorporated herein by reference.
[0046] Alternatives, for example, can be used, such as the stichverzugsrad.
[0047] At least one processing station preferably has the characteristic that it can process containers having the previously mentioned spacing (“machine spacing”) between their receiving parts without changing the spacing. Multiple processing stations preferably have this characteristic. In this way, a filling device that can be used in a very versatile manner can be constructed.
[0048] At least one processing station preferably includes a first weighing station for weighing the containers before filling. This makes it possible to determine the tare weight of the unfilled containers. The first weighing station is preferably located upstream of the filling station in the transport direction.
[0049] Advantageously, at least one processing station includes a second weighing station for weighing the containers after filling, preferably located downstream of the filling station in the transport direction. The gross weight of the filled containers can be determined using the second weighing station.
[0050] The degree of container filling can be determined by the difference between the gross weight and the tare weight. If the container is underfilled, refilling is preferably performed. This is preferably done at a second weighing station or above.
[0051] The container can preferably be filled during its movement along the transport direction.
[0052] At least one processing station preferably includes a sealing station for sealing the container with a sealing element. For example, depending on the type of container, the sealing element may include a mushroom-shaped plug or a piston-shaped plug. The sealing station is preferably located downstream of a second weighing station (if present) in the transport direction.
[0053] Advantageously, at least one processing station includes an inspection station for checking the presence of sealing elements at the respective container, wherein the inspection station is preferably arranged downstream of the sealing station in the transport direction.
[0054] An advantageous embodiment of the device according to the invention is characterized by 100% inspection during container handling. In particular, it can be specified that the amount of medicine in each container is checked by means of gross weight and tare weight, refilling is performed if necessary, and the presence of sealing elements at the container is checked.
[0055] The device advantageously includes at least one isolation device that covers at least one frame with a covering element, preferably for providing an atmosphere between the covering element and the frame for protective and / or purifying purposes, and for, for example, applying an atmosphere to a container. For example, the corresponding frame is preferably covered by the isolation device along its entire outer contour in order to provide the atmosphere. The atmosphere includes, for example, a protective gas, such as H₂O₂.
[0056] Advantageously, the filling device includes separate or independent isolation devices. In this way, container filling can be performed in an atmosphere with a protective gas for protective and / or purification purposes. Therefore, the filling device is particularly suitable for filling containers with toxic or highly sensitive pharmaceuticals.
[0057] Instead of isolation devices, a machine protection section in the shape of a cover, for example having glass or plastic sheets, can be provided to cover at least one frame.
[0058] Advantageously, the device includes a first dispensing unit for receiving filled containers and a second dispensing unit for receiving filled containers, as well as other dispensing elements arranged relative to the transport device or at at least one other dispensing location, preferably at exactly one other dispensing location, through which containers can be selectively supplied to the first dispensing unit or the second dispensing unit, either indirectly or directly. This also allows the advantages described at the beginning based on the presence of the dispensing elements to be achieved on the disengagement side of the device. Thus, the device has high versatility. Containers can be selectively supplied to the first dispensing unit or the second dispensing unit via the other dispensing elements.
[0059] Advantageously, both the first and second type of containers can be transferred to the first retrieval unit, depending on which type of container has been supplied.
[0060] Advantageously, both the first and second type of containers can be transferred to the second retrieval unit, depending on which type of container has been supplied.
[0061] It is understood that modifications to the equipment may be necessary to selectively transfer containers to either the first or second retrieval unit. However, by using transfer elements, modification costs and downtime can be kept to a minimum. Preferably, no modification is required.
[0062] It can be stipulated that, depending on whether the container is transferred to the first or the second retrieval unit, different handover elements are positioned at the same handover location.
[0063] It can be specified that the first extraction unit or the second extraction unit includes a transfer element, or that the filling device includes a transfer element.
[0064] As mentioned earlier, other interface elements can be specification components of the corresponding specification component group. Advantageously, the characteristic of other interface elements is that, like the first interface element, they can cover different specifications.
[0065] It can be specified that other transfer elements are formed separately from the disengagement elements, wherein the container can be transferred directly from the disengagement element or indirectly through at least one other transport element to other transfer elements.
[0066] The alternative site may specify that the disconnecting element is another connection element or constitutes another connection element.
[0067] It is understood that when using standard components, other connection elements may be replaced according to the specifications to be used. However, it is preferable to provide exactly one other defined connection position.
[0068] The detachment element can be arranged, for example, on the rack of the filling device.
[0069] It can be stipulated that other handover components are arranged on the frame of the filling device.
[0070] In a preferred embodiment, it has proven advantageous that the filling device has a take-up element arranged on the frame of the filling device. A take-up element can transfer the container to the take-up element. The container can be transferred from the take-up element, for example, directly or indirectly, to other transfer elements.
[0071] It is advantageous that, on the removal side, only the detachment element or the detachment element and other transport elements for the container are arranged on the frame of the filling device, such as the aforementioned lead-out element, wherein preferably, in particular only one other transport element is arranged on the frame of the filling device.
[0072] The second and third racks have already been mentioned. The fourth and fifth racks will be discussed later. It is understood that the terms "second," "third," "fourth," and "fifth" are used only to better understand this explanation and to facilitate clear differentiation of racks. For example, the second and third racks can be omitted. In this case, four or five racks are not necessarily required.
[0073] The first and second retrieval units may include separate racks. Alternatively, the first and second retrieval units may include a common rack.
[0074] The equipment preferably includes a fourth frame on the retrieval side adjacent to the frame of the filling device, on which other transfer elements and parts of one of the retrieval units, namely the first or second retrieval unit, are arranged. Containers can be transferred from the transport elements of the filling device directly or indirectly across the boundary between the frames to other transfer elements. For example, the transport elements of the filling device, such as detachment or lead-out elements, transfer containers directly to other transfer elements. Alternatively, at least one intermediate transport element can be arranged on a second frame, which itself crosses the boundary to receive containers from the filling device.
[0075] The racks can be oriented in a way that aligns with each other, especially in the longitudinal direction of the racks.
[0076] The filling device frame and the fourth frame can, for example, be positioned in a manner that is not aligned with each other and oriented at an angle relative to each other. This angle is preferably 90° or substantially 90°. Here, this angle is particularly the angle between the longitudinal directions of the frames.
[0077] The device preferably includes a fifth rack adjacent to the fourth rack on the retrieval side, on which components of the corresponding other retrieval units, the second retrieval unit, or the first retrieval unit are arranged, wherein the container is transferred directly or indirectly from other transfer elements across the boundary between the racks to the other retrieval units.
[0078] In a preferred embodiment, the fifth rack may be oriented at an angle relative to the fourth rack, not aligned with it. This angle is preferably 90° or substantially 90°. In particular, this angle may be the angle between the longitudinal directions of the racks.
[0079] It can be specified that the fifth rack extends along the boundary between the rack of the filling device and the fourth rack.
[0080] It can be stipulated that the fifth frame is aligned with the frame of the filling device, wherein the fourth frame is arranged between the fifth frame and the frame of the filling device.
[0081] The first extraction unit may preferably include other transport devices, at which at least one additional processing station for further processing of the container is arranged.
[0082] At least one other processing station includes, for example, an inspection station for checking whether the sealing element is correctly positioned at the corresponding container. If it is confirmed that it is not, the container can be removed, for example.
[0083] Alternatively or supplementally, at least one other processing station preferably includes a sealing station for attaching sealing elements to an already sealed container. The sealing station is particularly used here in connection with already sealed vials in order to place the crimp cap onto the container.
[0084] Preferably, the other processing stations are configured as edge-rolling stations for rolling the edge of the rolled-edge cap.
[0085] The equipment preferably includes a first retrieval unit for receiving filled containers and a second retrieval unit for receiving containers, wherein the first retrieval unit includes other transport devices, at which at least one additional processing station for processing containers is arranged, through which containers can be transported to the second retrieval unit. For example, in this type of embodiment, the aforementioned additional transfer elements are not used. Containers can be supplied from the filling device to other transport devices, for example, via at least one transport device, and processed there if necessary. Refer to the preceding description regarding at least one additional processing station. Alternatively, containers can be transported through other transport devices, for example, without further processing. Downstream of the other transport devices, containers processed there can be supplied, for example, to a receiving unit, particularly a warehousing unit. Containers that are only transported can, for example, be supplied to a common vehicle.
[0086] The second retrieval unit preferably includes: an operating device through which the container can be transferred to a common carrier; and a mechanism for removing the container from the carrier. For example, the container can be reloaded into the carrier from which it was previously retrieved by means of the second supply unit. Preferably, a conveying device is provided by which the carrier can be transported from the second supply unit to the second retrieval unit.
[0087] The spacing between containers can preferably be adjusted from the spacing of the container receiving portions to the spacing between them in a common carrier, either in the first and / or second dispensing unit or upstream of other connecting elements in the dispensing direction. This provides, in particular, the feasibility of adjusting the spacing of containers in the filling device (“machine spacing”) to a different spacing, such as the spacing of containers in a carrier. Here, the carrier is particularly a “nest,” which is then loaded into the nest again at a “nest spacing.” An operating device can be constructed in the second dispensing unit, for example, to adjust the machine spacing to the nest spacing. Alternatively, spacing adjustment wheels can be used, for example.
[0088] Further details regarding preferred designs of the filling device, and in particular its transport device, are described in an unpublished patent application filed by the applicant on the same filing date, entitled "Apparatus and Filling Device for Handling Pharmaceutical Containers." The full disclosure of that patent application is incorporated herein by reference. Attached Figure Description
[0089] The following description of preferred embodiments of the present invention illustrates the invention in more detail by way of the accompanying drawings. In the drawings:
[0090] Figure 1 A schematic diagram of an apparatus for filling a pharmaceutical container according to the present invention is shown, the apparatus including a filling device;
[0091] Figure 2 The diagram schematically shows multiple medical containers (above) received in a common carrier and multiple medical containers (below) held at the transport device of the equipment.
[0092] Figure 3 An enlarged view of the filling device according to detail A is shown in a non-schematic and simplified manner;
[0093] Figure 4 It shows that according to Figure 3 A magnified partial view of detail C in the image;
[0094] Figure 5 It is shown in a non-schematic, simplified diagram. Figure 1 An enlarged view of the extraction unit of the device according to detail B;
[0095] Figure 6 Other embodiments of the device according to the invention are shown in partial view;
[0096] Figure 7 Other embodiments of the device according to the invention are shown in partial views; and
[0097] Figure 8 Other embodiments of the device according to the invention are shown in partial view. Detailed Implementation
[0098] Preferred embodiments of the apparatus for filling pharmaceutical containers according to the present invention are described below with reference to the accompanying drawings. The same reference numerals are used for the same or equivalent features and components.
[0099] First refer to Figures 1 to 5 A first preferred embodiment of the device is discussed. The description of this embodiment applies accordingly to the embodiments described subsequently. The advantages obtainable by using the first described embodiment can also be obtained by the embodiments described subsequently. For this reason, relative to... Figures 1 to 5 The main differences in the implementation methods described below are the main aspects of the implementation methods. In other respects, the descriptions made herein are applicable.
[0100] In this example, pharmaceutical containers specifically include vials (also known as long-necked bottles or tubular bottles), syringes, and / or cartridges. This equipment is used to process containers, particularly to fill them using a filling device.
[0101] Figure 1 An advantageous embodiment of an apparatus for processing container 12 according to the present invention is shown schematically, in a so-called "layout" view. The apparatus is generally labeled with reference numeral 10. Container 12 is... Figure 2 and Figure 4 The view is shown only schematically.
[0102] Device 10 includes, as shown by reference numeral 14, and Figure 3 The filling device is shown in the detailed view. The filling device 14 can also be referred to as a filling machine.
[0103] Furthermore, the device 10 includes a first supply unit 16 and a second supply unit 18 upstream of the filling device 14 in the supply direction of the container 12. The device 10 also includes a first removal unit 20 and a second removal unit 22 downstream of the filling device 14 in the detachment or removal direction of the container 12.
[0104] The device 10 includes a control device 23 for operating and / or regulating the operation of the device 10 and the filling device 14. It is understood that the device 10 has actuators for corresponding moving parts. These are not shown in the figures and are not described. This type of actuator is known to those skilled in the art.
[0105] Supply units 16 and 18 are configured to provide and supply different types of containers 12. Retrieval units 20 and 22 are configured as needed for further processing of the containers 12.
[0106] The “type” of containers 12 is determined here in particular by the form in which they are provided by supply units 16, 18.
[0107] The first supply unit 16 is configured to provide containers 12 as bulk goods (“bulk goods”). In this case, the containers 12 are, for example, vials or cartridges.
[0108] The supply unit 16 includes a transport element 24, which can also be considered a storage element. In this example, the transport element 24 is a turntable 26 on which the container 12 is arranged, for example, upright.
[0109] Containers 12 can be individually distributed by turntable 26 and supplied directly or indirectly to transfer element 28 of device 10. Transfer element 28 is a transport element; here, it is transferred from turntable 26 to transfer element 28 via other transport elements 30.
[0110] Unless otherwise stated below, the transport element of device 10 is a transport wheel.
[0111] The junction element 28 is arranged at one, and in particular exactly one, junction position 32. The junction element 28 is positioned here on the rack 34 of the supply unit 16.
[0112] Accordingly, container 12 is indirectly transferred from turntable 26 to transfer element 28.
[0113] The rack 34, also referred to as a base or "platform," is positioned on a mounting surface 36 in a space such as a laboratory or workshop. It can provide a cleanroom atmosphere or environment.
[0114] Supply unit 16 also includes Figure 1 The element is marked with reference numeral 38 in the accompanying drawings. In the present case, element 38 serves as a substitute for other parts for the supply unit 16. For example, the supply unit 16 preferably includes a cleaning device, a sterilizing device, and / or a drying device for the container 12 in the following order.
[0115] The second supply unit 18 is configured to remove the container 12 (so-called RTU / ready-to-use object) from the common carrier 40. A mechanism 42 (arrow 44) is provided for supplying the carrier 40. The carrier 40 can be removed from a receiving unit (also called a "barrel-shaped storage") not shown in the figure, for example, by means of the mechanism 42.
[0116] The container 12 can be removed from the carrier 40 (also referred to as the "nest") by means of the operating device 46 of the supply unit 18. Subsequently, the container 12 can be supplied to the transfer element 28 by at least one other transport element 48, 50. The transport element 48 here is a unit chain 52 for separating the container 12.
[0117] The supply unit 18 also includes a rack 54 separate from the rack 34, which is adjacent to the rack 34 and positioned on the mounting surface 36.
[0118] Depending on whether the container 12 is to be supplied as a batch of goods to the first supply unit 16 or to the filling device 14 via the carrier 40 of the second supply unit 18, the container 12 to be filled is selectively introduced from the supply unit 16 or the supply unit 18 via the transfer element 28. In both cases, the container 12 is transferred to the filling device 14 one by one.
[0119] In this example, the filling device 14 has a frame 56 for positioning on the assembly surface 36, which is adjacent to the frame 34. A transport device 58 is provided for transporting the container 12. The transport device 58 is designed to be linear, wherein the container 12 can move along the transport direction 60.
[0120] To receive the container 12, the transport device 58 includes a holding element 62. The corresponding holding element 62 has a container receiving portion 64.
[0121] For example, it is specified that the transport device 58 has a plurality of retaining element carriers 66, each having a corresponding plurality of retaining elements 62. In this example, each retaining element carrier 66 has six retaining elements 62, but the invention is not limited to this number.
[0122] The filling device 14 is periodic in this example, wherein the number of containers 12 corresponding to the number of holding elements 62 (“points”) can be processed at the processing station 68.
[0123] It can be specified that the filling device 14 is configured to process the container 12 non-periodically.
[0124] The circulating retaining element 62 moves along the transport direction 60 at the transport section 70 of the transport device 58. The containerless retaining element 62 moves against the transport direction 60 at the return section 72.
[0125] The filling device 14 is configured such that, regardless of the type of container 12, the type and size of the container 12 to be processed (within the area of use of the equipment), the spacing 74 between adjacent containers 12 in the filling device 14 is equal. This spacing (“machine clearance”) is defined in the transport device 58 by the spacing between the container receiving sections 64. The processing station 68 also has this constant machine clearance.
[0126] The containers 12 introduced by the first supply unit 16 are distributed by the turntable 26 in such a way that the spacing has been adjusted to the machine spacing.
[0127] When the containers 12 are supplied by the second supply unit 18, the spacing of the containers 12 can preferably have been adjusted to a spacing 74 by means of the operating device 46. If the spacing 76 (“nest pitch”) of the containers 12 in the carrier 40 is different from the spacing 74, the spacing can be adjusted by means of the operating device 46 described in other patent applications of the applicant. In other cases, for example, a pitch variable wheel can be used.
[0128] Beneficially, the spacing of containers 12 at the junction element 28 has been adjusted to the machine spacing.
[0129] Using a constant machine spacing provides the advantage of a simple and compact construction for the equipment 10, especially the filling device 14.
[0130] However, the device 10 may have multiple specification component groups 78, in which the transport elements for the container 12 preferably cover the specification area. Figure 1 Two specification component groups 78 are shown as an example.
[0131] The corresponding specification component group 78 has container-specific, container part-specific, or processing-specific specification components, which can be replaced at the equipment 10 as necessary to enable the processing of the desired container 12. However, in terms of the holding element and holding element carrier of the transport device 58, the specification components of the specification component group 78 are not different, because in the different specification component groups 78, the container receiving part 64 is respectively constructed to ensure a constant machine clearance.
[0132] It is understandable that the transport components of device 10 can also be standard parts.
[0133] Container 12 is transferred from transfer element 28 across boundary 80 between racks 34 and 56 to filling device 14. Container 12 is indirectly transferred from transfer element 28 to transport device 58 via two transport elements: first to introduction element 82, then to receiving element 84. Container 12 is introduced into filling device 14 via introduction element 82. Container 12 is received into transport device 58 via receiving element 84.
[0134] The inlet element 82 and the access element 84 are arranged at and in particular on the rack 56. This has proven to be beneficial for the scalable modular structure of the device 10.
[0135] In the current configuration, rack 34 is aligned with rack 56, with their respective longitudinal directions coinciding.
[0136] The frame 54 is oriented at a preferred angle of 90° relative to the frame 34. The frame 54 is aligned here with the boundary 80 between the frame 34 and the frame 54.
[0137] This type of arrangement of filling device 14 and supply units 16 and 18 enables the construction of device 10 in a way that saves space while having the largest possible edge line so that the corresponding parts can be easily accessed for maintenance purposes.
[0138] Especially from Figure 3 As can be clearly seen, multiple processing stations 68 are arranged at the transport device 58. Referring to the transport direction 60, the processing station 68 includes a first weighing station 86, a filling station 88, a second weighing station 90, a sealing station 92, and an inspection station 94.
[0139] The tare weight of the unfilled container 12 can be determined using the first weighing station 86.
[0140] The container is filled with a drug, particularly a medically effective substance (pharmaceutical), at filling station 88. Filling station 88 includes a filling element (not shown) for engagement with container 12, which is held at operating device 96. A pump mechanism and / or dispensing mechanism 98 is provided for supplying the material.
[0141] Sealing station 92 is used to seal container 12 with sealing elements (e.g., mushroom plugs or piston plugs) not shown in the figure.
[0142] Inspection station 94 is used to inspect whether the sealing element is positioned at the corresponding container 12. Otherwise, container 12 can be removed from device 10.
[0143] The device 10 includes at least one isolation device 102, which includes a covering element 104 for covering at least one rack. For example, the rack is covered from above by means of the covering element 104, which also includes side walls. It is understood that maintenance openings may be provided.
[0144] Advantageously, the filling device 14 has a separate frame 56 and a separate isolation device 102 combined with it. This enables the processing, especially filling, of the container 12 to be performed in an atmosphere with a protective gas for protective and / or purifying purposes. The protective gas is, for example, H2O2. For this reason, the filling device 14 is also particularly suitable for filling the container 12 with toxic or highly sensitive drugs.
[0145] On the release side, the filling device 14 includes a release element 106 for receiving the container 12 from the transport device 58. Furthermore, the filling device 14 includes an outlet element 108 that receives the container 12 from the release element 106.
[0146] The detachment element 106 and the lead-out element 108 are arranged at and on the frame 56.
[0147] On the retrieval side, another transfer element 110 is provided at the device 10. The transfer element 110 is arranged at the transfer position, and in particular at exactly one transfer position 112. The transfer element 110 is here arranged at and on the rack 114 of the first retrieval unit 20 adjacent to the rack 56.
[0148] In this example, rack 114 is arranged in a manner aligned with rack 56, wherein their longitudinal directions coincide.
[0149] The lead-out element 108 crosses the boundary 116 between the rack 56 and the rack 114 to transfer the container 12 to the transfer element 110.
[0150] The container 12 processed by the filling device 14 can be selectively transferred to the extraction unit 20 or extraction unit 22 for further processing via the transfer element 110. Depending on the type of further processing desired, the first or second type of container 12 can be transferred to the extraction unit 20 or extraction unit 22.
[0151] As from Figure 1 and Figure 5 As can be clearly seen, the first extraction unit 20 includes other transport devices 118 of the equipment 10. The transport device 118 is preferably constructed in a manner corresponding to the transport device 58, and preferably has the same machine spacing.
[0152] Starting from the transfer element 110, the container 12 can be supplied to the transport device 118. This is done indirectly here through a plurality of transport elements 120, the number of which is exemplary and not limiting.
[0153] Other processing stations 68 are arranged at the transport device 118. Referring to the transport direction 60, an inspection station 122 is arranged first at the transport device 118, followed by a sealing station 124, and then a hemming station 126.
[0154] Inspection station 122 can be used to check whether the sealing element is correctly positioned at container 12. If it is not confirmed, the corresponding container 12 can be removed.
[0155] Sealing station 124 is used for final sealing of containers 12, especially small bottles, with crimp caps, particularly those already sealed with sealing elements. For this purpose, crimp caps are placed onto existing sealing elements via sealing station 124.
[0156] The rolled edge cap can be rolled at the rolled edge station 126.
[0157] The container 12, which is further processed at the retrieval unit 20, can be detached, for example, by the transport element 128 shown exemplarily, and supplied, for example, to the receiving unit 130. This can be referred to as "warehousing".
[0158] The retrieval unit 22 has a separate frame 132. Frame 132 is adjacent to frame 114 and oriented at a preferred angle of 90° relative to frame 114. Frame 132 is aligned with the boundary 116 between frame 56 and frame 114. This arrangement also allows for a compact construction with the largest possible edge line on the detachment side of device 10, ensuring good accessibility to the components of retrieval units 20, 22.
[0159] Advantageously, the filling device 14 can be accessed from both sides: between the supply unit 18 and the dispensing unit 22, and from the opposite side. Therefore, the filling device 14 is also characterized by its exceptional ease of maintenance.
[0160] Starting from the transfer element 110, the container 12 is selectively and indirectly supplied to the dispensing unit 22 as previously described. For this purpose, for example, a transport element 134 is provided for transferring the container 12 across the boundary between the rack 114 and the rack 132.
[0161] In terms of functionality, the take-out unit 22 is designed to correspond at least partially to the second supply unit 18 and includes, for example, transport elements 136, 138 on the input side, wherein the transport elements may be the unit chain 140.
[0162] The container 12 can be transported into the carrier 40 by means of other operating devices 142. Preferably, the previously emptied carrier 40 is supplied by a supply unit via a conveying device 144 (arrow 146).
[0163] When the container 12 is placed into the carrier 40, the spacing 74 is readjusted to the nest spacing with a spacing 76 by means of the operating device 142.
[0164] A mechanism 148 (arrow 150) is provided for transporting the filling carrier 40 away.
[0165] Figures 6 to 8 To correspond to Figure 1 The layout view shows a partial view of a preferred embodiment of the device according to the invention. Figure 6 Only the filling device 14 and the supply units 16 and 18 are shown here. Figure 7 and Figure 8 Only the filling device 14 and the extraction units 20 and 22 are shown in the image.
[0166] This is understandable, for example, it can be based on Figure 1 and / or Figure 6 The device is implemented at the output side of the device. Figure 7 and Figure 8 The variant shown is illustrated. It can be implemented in a corresponding manner according to... Figure 1 , Figure 7 and / or Figure 8 Implemented at the input side of the device in the equipment according to Figure 6 A variant of the scheme.
[0167] According to Figure 6In device 152, frame 54 and frame 56 are aligned, with their longitudinal directions coinciding. Frame 34 is arranged between frame 54 and frame 56, and is adjacent to both frame 54 and 56 respectively. Frame 34 is preferably oriented at an angle of 90° relative to the respective frames 54 and 56.
[0168] The transfer element 28 is arranged on the frame 34. Container 12 can be selectively supplied from supply unit 16 or supply unit 18 indirectly to inlet element 82 via transport element 154 via transfer element 28. Container 12 is supplied from supply unit 18 to transfer element 28 via transport element 156.
[0169] It is understood that only two transport elements 154 and 156 are shown as examples. Their number is not limited.
[0170] According to Figure 7 In device 158, frame 132 is aligned with frame 56 when they coincide in the corresponding longitudinal directions. Frame 114 is arranged between frame 56 and frame 132, oriented at an angle preferably 90° relative to frames 56 and 132, and adjacent to frames 56 and 132.
[0171] The transfer element 110 is arranged on the frame 114. The container 12 is supplied from the lead-out element 108 via the transport element 160. The container 12 is transferred to the retrieval unit 20 via the transport element 162, and to the retrieval unit 22 via the transport element 164.
[0172] In this case, it is understandable that the number of transport elements 160, 162, and 164 is also unlimited.
[0173] According to Figure 8 In device 166, frame 132 and frame 114 are aligned with each other. They are oriented at an angle relative to frame 56, wherein the angle is preferably 90°.
[0174] Unlike the previous devices 10, 152 and 158, device 160 does not have a transfer element through which the container 12 is selectively supplied to the first extraction unit 20 or the second extraction unit 22.
[0175] Alternatively, the container 12, drawn out by the lead-out element 108, is connected to the transport device 118 via the transport element 168. This also applies to the container 12 to be transported to the carrier 40. Accordingly, these containers 12 are transported through the transport device 58 to the second extraction unit 22, such that they pass through a portion of the extraction unit 20.
[0176] exist Figure 8Three transport elements 168 are shown, exemplarily and not limitingly, from the lead-out element 108 to the connection to the transport device 118. One of them is arranged on a separate rack 170, and may alternatively be arranged on rack 56 or rack 114.
[0177] On the disengagement side of the transport device 118, the container 12 is transferred to the operating device 142 via multiple transport elements 172. In this case, the last transport element 172 is again the unit chain 140.
[0178] One of the transport elements 172 forms a transfer element 174 in this case. The transfer element 174 at the transfer position 176 is located on the frame 132 here for disengaging from the container 12, which is being transferred to the receiving unit 130, via other transport elements 178.
[0179] It is understood that the number of transport elements 172 and 178 is not limiting for the present invention.
[0180] The structure and working principle of sealing stations 92 and / or 124 are preferably the same as those described in the applicant's unpublished patent application DE 10 2020 134 792.8. The full disclosure of that patent application is contained in this patent application.
[0181] List of reference numerals
[0182] 10 Equipment
[0183] 12 containers
[0184] 14 Filling device
[0185] Supply Units 16 and 18
[0186] Units 20 and 22 are retrieved.
[0187] 23 Control device
[0188] 24 Transport Components
[0189] 26 turntables
[0190] 28. Interchange Components
[0191] 30 Transport Components
[0192] 32. Handover location
[0193] 34 racks
[0194] 36 Architectural Surfaces
[0195] 38 components
[0196] 40 vehicles
[0197] 42 institutions
[0198] 44 arrows
[0199] 46 Operating device
[0200] 48, 50 Transport Components
[0201] 52-unit chain
[0202] Racks 54 and 56
[0203] 58. Transport equipment
[0204] 60. Transportation direction
[0205] 62 Holding element
[0206] 64 Container Receiving Section
[0207] 66 Holding element carrier
[0208] 68 processing station
[0209] 70 Transportation Section
[0210] 72 Return Section
[0211] 74, 76 spacing
[0212] 78 Specification Components
[0213] 80 Boundary
[0214] 82. Introduction of components
[0215] 84 Access Components
[0216] Weighing stations 86 and 90
[0217] 88 Filling Station
[0218] 92 Sealing Station
[0219] 94 Inspection Station
[0220] 96 Operating Device
[0221] 98. Pump mechanism and / or metering mechanism
[0222] 102 Isolation Device
[0223] 104 Covering Element
[0224] 106 Detachable Component
[0225] 108 Lead-out components
[0226] 110 Interchange Components
[0227] 112 Handover Location
[0228] 114 racks
[0229] 116 Boundary
[0230] 118 Transport Equipment
[0231] 120 Transport Components
[0232] 122 Inspection Station
[0233] 124 Sealing Station
[0234] 126 Curled Edge Station
[0235] 128 Transport Components
[0236] 130 Reception Unit
[0237] 132 racks
[0238] Transport elements 134, 136, and 138
[0239] 140 unit chain
[0240] 142 Operating device
[0241] 144 Conveying device
[0242] 146 arrows
[0243] 148 institutions
[0244] 150 arrows
[0245] Equipment 152, 158, 166
[0246] Transport elements 154, 156, 160, 162, 164, 168
[0247] 170 racks
[0248] 172 Transport Components
[0249] 174 Interchange Components
[0250] 176 Handover Location
[0251] 178. Transport components.
Claims
1. An apparatus for filling different types of medical containers (12), said apparatus (10; 152; 158; 166) comprising: - A filling device (14) comprising: a transport device (58) including a holding element (62) for the medicine container (12) movable from the access side to the disengagement side of the transport device (58) along the transport direction (60); and at least one processing station (68) for the medicine container (12) including a filling station (88) disposed at the transport device (58) for filling the medicine container (12) with a drug. - An access element (84) for transferring the medical container (12) to the transport device (58) and a disengagement element (106) for receiving the medical container (12) from the transport device (58). - A first supply unit (16) for providing a first type of container (12) to be filled and a second supply unit (18) for providing a second type of container (12) to be filled. - A junction element (28) that can be arranged at at least one junction position (32) on the supply side relative to the transport device (58) can be used to indirectly or directly selectively supply the first type container (12) of the first supply unit (16) or the second type container (12) of the second supply unit (18) to the transport device (58). The first supply unit (16) is configured to provide the first type of container (12) as a bulk cargo and includes a transport element (24) or a storage element thereon, on which the first type of container (12) can be dispensed by the transport element or the storage element. The second supply unit (18) includes a mechanism (42) for supplying a second type of container (12) received in a common carrier (40) and an operating device (46) for removing the second type of container (12) from the common carrier (40).
2. The device according to claim 1, characterized in that, The medical container (12) includes a syringe, vial, and / or cartridge.
3. The device according to claim 1, characterized in that, The transport device (58) is linear and / or includes the cyclic holding element.
4. The device according to claim 1, characterized in that, The transfer element (28) can be arranged at exactly one transfer position (32) on the supply side relative to the transport device (58).
5. The device according to any one of claims 1 to 4, characterized in that, Applicable to one of the following features: - The transfer element (28) is formed separately from the access element (84), wherein the medical container (12) can be transferred from the transfer element (28) to the access element (84) indirectly via at least one other transport element (48) or directly. - The access element (84) is the handover element (28).
6. The device according to any one of claims 1 to 4, characterized in that, Applicable to one of the following features: - The transfer element (28) is formed separately from the access element (84), wherein the medical container (12) can be transferred from the transfer element (28) to the access element (84) indirectly via at least one other transport element (48) or directly. - The access element (84) constitutes the handover element (28).
7. The device according to any one of claims 1 to 4, characterized in that, The device (10; 152; 158; 166) includes a frame (56) of the filling device (14) that can be positioned on the building surface (36).
8. The device according to claim 7, characterized in that, On the supply side, the access element (84) and other transport elements for the medical container (12) or only the access element (84) are arranged on the frame (56) of the filling device (14).
9. The device according to claim 8, characterized in that, On the supply side, the access element (84) and exactly one other transport element (48) for the medical container (12) are arranged on the frame (56) of the filling device (14).
10. The device according to claim 7, characterized in that, The device (10; 152; 158; 166) includes a second rack (34) adjacent to the rack (56) on the supply side, on which the transfer element (28) and parts of one of the supply units (16, 18), namely the first supply unit (16) or the second supply unit (18), are arranged, wherein the medical container (12) can be transferred to the transport element of the filling device (14) directly or indirectly across the boundary (80) between the rack (56) and the second rack (34) via the transfer element (28).
11. The device according to claim 10, characterized in that, The device (10; 152; 158; 166) includes a third rack (54) adjacent to the second rack (34) on the supply side, on which the components of the corresponding other supply units (16, 18), namely the second supply unit (18) or the first supply unit (16), are arranged, wherein the medical container (12) is transferred directly or indirectly to the transfer element (28) by the other supply unit (18) across the boundary (80) between the second rack (34) and the third rack (54).
12. The device according to any one of claims 1 to 4, characterized in that, The first supply unit (16) includes at least one of the following features: - A cleaning device for the medical container (12); - Sterilization device for the medical container (12); - A drying device for the medical container (12).
13. The device according to claim 7, characterized in that, The holding element (62) of the transport device (58) has a container receiving portion (64) with a pre-given spacing (74) between them, and the spacing between the medical containers (12) can be adjusted to the spacing (74) of the container receiving portion (64) in the first supply unit (16) and / or the second supply unit (18) or in the supply direction downstream of the transfer element (28).
14. The device according to any one of claims 1 to 4, characterized in that, At least one of the processing stations (68) at the transport device (58) includes at least one of the following features: - A first weighing station (86) for weighing the medical container (12) before filling; - A second weighing station (90) for weighing the medicine container (12) after filling; - Sealing station (92) for sealing the medical container (12) with sealing elements; - Inspection station (94) for checking whether a sealing element is present at the corresponding medical container (12).
15. The device according to any one of claims 1 to 4, characterized in that, The device (10; 152; 158; 166) includes at least one isolation device (102) covering at least one rack (34, 54, 56, 114, 132) with a covering element (104).
16. The device according to claim 15, characterized in that, The device (10; 152; 158; 166) includes at least one isolation device (102) covering at least one rack (34, 54, 56, 114, 132) with a covering element (104) for providing an atmosphere for protection and / or purification purposes between the covering element (104) and the at least one rack (34, 54, 56, 114, 132).
17. The device according to claim 15, characterized in that, The device (10; 152; 158; 166) includes at least one isolation device (102) covering at least one frame (34, 54, 56, 114, 132) with a covering element (104) for applying an atmosphere to the medical container (12).
18. The device according to any one of claims 1 to 4, characterized in that, The filling device (14) includes a separate isolation device (102).
19. The device according to claim 13, characterized in that, The device (10; 152; 158; 166) includes a first extraction unit (20) for receiving a filled medical container (12) and a second extraction unit (22) for receiving a filled medical container (12), and other transfer elements (110) that can be arranged at at least one other transfer location (112) relative to the transport device (58), through which the medical container (12) can be selectively supplied indirectly or directly to the first extraction unit (20) or the second extraction unit (22).
20. The device according to claim 19, characterized in that, The other handover elements can be arranged at exactly one other handover position (112) relative to the transport device (58).
21. The device according to claim 19, characterized in that, Applicable to one of the following features: - The other transfer element (110) is formed separately from the detachment element (106), wherein the medical container (12) can be transferred directly from the detachment element (106) or indirectly through at least one other transport element to the other transfer element (110). - The disconnecting element (106) is the other connecting element (110).
22. The device according to claim 19, characterized in that, Applicable to one of the following features: - The other transfer element (110) is formed separately from the detachment element (106), wherein the medical container (12) can be transferred directly from the detachment element (106) or indirectly through at least one other transport element to the other transfer element (110). - The disconnecting element (106) constitutes the other connecting element.
23. The device according to claim 7, characterized in that, The release element (106) is arranged on the frame (56) of the filling device (14).
24. The device according to claim 7, characterized in that, On the removal side, only the release element (106) or the release element (106) and other transport elements for the medical container (12) are arranged on the frame (56) of the filling device (14).
25. The device according to claim 24, characterized in that, On the removal side, the release element (106) and exactly one other transport element for the medical container (12) are arranged on the frame (56) of the filling device (14).
26. The device according to claim 19, characterized in that, The device (10; 152; 158; 166) includes a fourth frame (114) on the retrieval side adjacent to the frame (56) of the filling device (14), on which the other transfer elements (110) and parts of one of the retrieval units (20, 22), namely the first retrieval unit (20) or the second retrieval unit (22), are arranged, wherein the medical container (12) can be transferred from the transport element of the filling device (14) directly or indirectly across the boundary (116) between the frame (56) and the fourth frame (114) to the other transfer elements (110).
27. The device according to claim 26, characterized in that, The device (10; 152; 158; 166) includes a fifth frame (132) adjacent to the fourth frame (114) on the retrieval side, on which the components of the corresponding other retrieval units (20, 22), namely the second retrieval unit (22) or the first retrieval unit (20), are arranged, wherein the medical container (12) is transferred directly or indirectly from the other transfer element (110) across the boundary between the fourth frame (114) and the fifth frame (132) to the other retrieval unit (22).
28. The device according to claim 19, characterized in that, The first extraction unit (20) includes other transport devices (118), at which at least one other processing station (68) for processing the medical container (12) is arranged.
29. The device according to claim 28, characterized in that, At least one other processing station (68) includes: an inspection station (122) for checking whether the sealing element is correctly positioned at the corresponding medical container (12); a sealing station (124) for installing the sealing element onto the already sealed medical container (12); and / or a crimping station (126) for crimping the crimped cap.
30. The device according to any one of claims 1 to 4, characterized in that, The device (10; 152; 158; 166) includes a first extraction unit (20) for receiving a filled medical container (12) and a second extraction unit (22) for receiving a filled medical container (12), and the first extraction unit (20) includes other transport devices (118) at which at least one other processing station (68) for processing the medical container (12) is arranged, wherein the medical container (12) can be transported through the other transport devices (118) to the second extraction unit (22).
31. The device according to claim 19, characterized in that, The second removal unit (22) includes: an operating device (142) through which the medical container (12) can be transferred to a common carrier (40); and a mechanism (148) for removing the container (40).
32. The device according to claim 19, characterized in that, The spacing between the medical containers (12) in the first dispensing unit (20) and / or the second dispensing unit (22) or in the dispensing direction upstream of the other junction element (110) can be adjusted from the spacing (74) of the container receiving part (64) to the spacing between them in the common carrier (40).