Left atrial appendage occluder

Abstract

The present application relates to the technical field of left atrial appendage occlusion by intervention, and discloses a left atrial appendage occlusion device, which comprises an occlusion component and a fixing component, the occlusion component comprises an elastic net-like braided body structure which has a proximal end face and a distal end face, the occlusion component is connected with the fixing component on the side of the distal end face, the occlusion component further comprises a flow blocking film arranged in the elastic net-like braided body structure, the flow blocking film is configured to cover the distal end face or the proximal end face in the radial direction and is fixed along the circumferential direction of the elastic net-like braided body structure, and the flow blocking film is further pulled and limited by a pulling piece leading to the fixing component, so that the occlusion efficiency of the left atrial appendage occlusion device is enhanced.

Description

Technical Field

[0001] This invention relates to the field of interventional left atrial appendage occlusion technology, and particularly to an implantable medical device for left atrial appendage occlusion. Background Technology

[0002] Left atrial appendage occlusion can be used to treat patients with non-valvular atrial fibrillation. Studies have shown that more than 90% of thrombi in the left atrium originate from the left atrial appendage. When atrial fibrillation occurs, the normal rhythm of the left atrium is disrupted, which slows down the blood flow in the left atrium. The blood flow in the left atrial appendage is even slower, causing blood components to stagnate and coagulate, thus forming thrombi. Left atrial appendage occlusion can significantly reduce the chance of atrial fibrillation embolism.

[0003] Left atrial appendage occluders can be implanted via interventional procedures. They are elastically compressed within a sheath, delivered to the atrial appendage via the interventional pathway, and then released. Once deformed, the occluder can be fixed and occlude the left atrial appendage. Left atrial appendage occluders typically have interconnected but relatively independent fixing and occluding components. The fixing component is placed within the atrial appendage cavity to fix the occluder to the left atrial appendage, while the occluding component is positioned at the atrial appendage opening by the fixing component to achieve the occlusion effect. Existing designs of such typical left atrial appendage occluders include those described in Chinese patents CN101795628A (AGA), CN202143640U (Xianjian), CN204814031U (Deno), CN104856741A (Maibo), CN206120393U (Pushi), and CN108472031A (Keyiton). Depending on the requirements, the fixing component and the sealing component can be selected as frames of various shapes such as disc, dish, column, umbrella, trapezoid, etc. The two frames can be an integrated structure (for example, the sealing device disclosed in CN101795628A is an integrated braided wire) or a separate two-component connection structure.

[0004] The fixing component can be a mesh frame structure woven from braided wires or a frame structure with a certain axial length formed by multiple support rods arranged after laser cutting and shaping, to form stable radial support with the inner wall of the atrial appendage for stable positioning. The occlusion component is usually a mesh structure with a relatively small axial length and better flexibility, woven from braided wires, to form a good fit at the atrial appendage opening. The occlusion component usually contains a membrane as a flow-blocking membrane to separate the atrial appendage and left atrial cavity, blocking blood flow.

[0005] The choke membrane within existing occlusion components may change shape or position due to deformation of the occlusion component, potentially leading to reduced occlusion efficiency or incomplete occlusion. For example, the occlusion component may elongate axially due to contraction and pressure from the atrial appendage wall, causing the choke membrane to shift or deviate outward from the atrial appendage, resulting in leakage at the junction of the choke membrane and the atrial appendage opening. Although this leakage may be small and likely to be closed by the recovering occlusion component during atrial appendage diastole.

[0006] Furthermore, it is desirable to achieve immediate closure of the left atrial appendage during the implantation of the left atrial appendage occluder. However, during the implantation procedure, in order to verify the stable fixation of the left atrial appendage occluder in the atrial appendage after release, the occluder is usually pulled outward through the delivery system before the occluder is separated from the delivery system. The occluder is pulled and elongated axially at the proximal end, and there is also a significant axial displacement or offset of the choke membrane, which will result in the atrial appendage not being closed at this time. Summary of the Invention

[0007] The purpose of this invention is to provide an improved left atrial appendage occluder with enhanced closure efficiency.

[0008] An embodiment of the left atrial appendage occlusion device of the present invention includes an occlusion component and a fixing component. The occlusion component includes an elastic mesh braided structure having a proximal end face and a distal end face. The occlusion component is connected to the fixing component on the distal end face side. The occlusion component also includes a flow-blocking membrane disposed within the elastic mesh braided structure. The flow-blocking membrane is configured to radially cover the distal end face or the proximal end face and is fixed to the elastic mesh braided structure circumferentially. The flow-blocking membrane is also traction-limited by a traction member leading to the fixing component.

[0009] The fixed component is largely unaffected by the deformation of the sealing component. Therefore, the flow-blocking membrane of the sealing component is restricted by the traction component. The swing or displacement of the flow-blocking membrane towards the proximal end face of the sealing component is limited. Compared with no traction component, the swing amplitude or displacement of the flow-blocking membrane during atrial appendage contraction can be reduced. This is beneficial for the flow-blocking membrane to adhere to the distal end face of the sealing component, thereby improving the dynamic bonding between the flow-blocking membrane and the atrial appendage orifice and reducing leakage.

[0010] In some embodiments, the flow-blocking membrane is traction-limited by the traction member and is substantially not biased toward the proximal end face.

[0011] In some embodiments, when the elastic mesh structure is in a radially compressed state, the flow-blocking membrane is pulled towards the distal end face by the traction member.

[0012] In some embodiments, the elastic mesh structure has a flange connecting the proximal and distal faces, and the flow-blocking membrane is fixedly connected to the flange at its edge or near the edge, or the flow-blocking membrane is fixedly connected to the distal or proximal face near the flange at its edge or near the edge.

[0013] In some embodiments, the flange constitutes the maximum diameter of the sealing component, and the cross-section of the flange in the axial direction is arc-shaped.

[0014] In other embodiments, the diameter of the distal end face is larger than the diameter of the proximal end face, forming the maximum diameter of the sealing component, wherein the diameter of the sealing component tapers towards the proximal end face at the flange.

[0015] In some embodiments, the distance between the proximal and distal surfaces of the sealing component is less than 1 cm.

[0016] Optionally, the flow-blocking membrane and the elastic mesh braided structure are fixedly connected by circumferentially alternating threads, or the flow-blocking membrane and the elastic mesh braided structure are bound together by a plurality of circumferentially distributed binding threads. However, this is not a limitation; those skilled in the art can also choose other thread binding methods or other fixing methods, such as bonding, welding, or clamping.

[0017] In a preferred embodiment, the diameter of the left atrial appendage occluder at the connection between the occlusion component and the fixation component is significantly smaller than the diameter of the occlusion component and the fixation component.

[0018] In some embodiments of the present invention, the blocking component and the fixing component are integrally woven from a plurality of braided filaments, and the connection between the two is a tubular structure formed by the bundled braided filaments. The fixing component includes a frame structure woven from the braided filaments. The blocking component and the fixing component are respectively provided with fixing members at their other ends to bundle and fix the free ends of each braided filament. The end of the traction member that leads to the fixing component is fixed to a fixing member at one end of the fixing component or to the braided filaments of the frame structure.

[0019] In other embodiments of the present invention, the fixing component includes a frame structure woven from a plurality of braided yarns, and a fixing member is provided at the proximal end of the frame structure to gather and fix each braided yarn. The fixing component is connected to the sealing component through the fixing member, and one end of the traction member that leads to the fixing component is fixed to the fixing member or the braided yarn of the frame structure.

[0020] In some embodiments of the present invention, the fixing component includes a frame structure composed of several support rods, each support rod converging at a fixing member at the proximal end of the fixing component, the fixing component being connected to the sealing component through the fixing member, and one end of the traction member leading to the fixing component being fixed to the fixing member or the support rod.

[0021] In some other embodiments of the present invention, the support rods are arranged in a crisscross pattern to form an overlapping portion adjacent to the fixing member, and one end of the traction member that leads to the fixing member is fixed to the overlapping portion.

[0022] In some embodiments, the traction element is a wire.

[0023] For example, the traction element is a wire with its two ends fixed to the flow-blocking membrane and the fixing component, respectively; or, the traction element is a wire looped between the flow-blocking membrane and the fixing component.

[0024] In a preferred embodiment, the diameter of the traction member is greater than the thickness of the flow-blocking membrane.

[0025] In some embodiments, the traction element may be selected as a metal wire or a polymer wire.

[0026] In some embodiments, the fixing component includes a frame structure and a second membrane fixed to the frame structure, and one end of the traction member that leads to the fixing component is fixed to the second membrane.

[0027] The flow-blocking membrane or the second membrane element can be made of PET or PTFE material, and is particularly preferred to be a spunlace nonwoven fabric made of this material.

[0028] In this embodiment of the invention, the left atrial appendage occluder uses a traction element to limit the flow-blocking membrane within the occlusion component, which can enhance the occlusion efficiency of the left atrial appendage occluder during and after implantation and reduce leakage. Attached Figure Description

[0029] The present invention will now be described in further detail with reference to the accompanying drawings.

[0030] Figure 1 A schematic diagram illustrating the state of a left atrial appendage occluder closing the left atrial appendage orifice in the prior art;

[0031] Figure 2 for Figure 1 A schematic diagram showing the state of the occlusion component of the left atrial appendage occluder under axial stretching and elongation.

[0032] Figure 3 This is a schematic diagram of the occlusion component of a left atrial appendage occlusion device according to an embodiment of the present invention under axial stretching and elongation.

[0033] Figure 4 This is a schematic diagram illustrating the closed state of another type of left atrial appendage occluder in the prior art.

[0034] Figure 5 for Figure 4 A schematic diagram showing the axial elongation of the occlusion component of the left atrial appendage occluder under radial compression.

[0035] Figure 6 This is a schematic diagram of the occlusion component of another embodiment of the left atrial appendage occlusion device of the present invention under radial compression and axial elongation.

[0036] Figure 7 This is a schematic diagram of another embodiment of the left atrial appendage occlusion device of the present invention;

[0037] Figure 8 This is a schematic diagram of another embodiment of the left atrial appendage occlusion device of the present invention.

[0038] The reference numerals in the above figures are explained as follows:

[0039] 1. Sealing component; 11. Proximal face; 12. Distal face; 13. Bleach membrane; 14. Flange; 15. Proximal clamp;

[0040] 2, Fixing component; 21 and 23, Support rods; 231, Overlapping section; 22, Fixing member;

[0041] 3. Traction element; 4. Atrial wall; 5. Embolism. Detailed Implementation

[0042] The present invention will be further described in detail below with reference to the accompanying drawings and specific embodiments, but the present invention is not limited thereto.

[0043] The embodiment of the left atrial appendage occluder of the present invention includes an occlusion component and a fixation component. As an implantable medical device delivered via catheter during interventional procedures, both the occlusion component and the fixation component of the left atrial appendage occluder in this embodiment are elastically compressible so as to be compressed to a smaller diameter and inserted into the delivery catheter, and delivered to the left atrium via the vascular access to perform left atrial appendage occlusion.

[0044] In some embodiments of the present invention, the blocking component includes an elastic mesh braided structure having a proximal end face and a distal end face. The blocking component is connected to a fixing component on the distal end face side. The blocking component also includes a flow-blocking membrane disposed within the elastic mesh braided structure. The flow-blocking membrane is configured to radially cover the distal end face or the proximal end face and is fixed to the elastic mesh braided structure circumferentially. The flow-blocking membrane is also traction-limited by a traction member directed to the fixing component.

[0045] The elastic mesh structure of the sealing component can typically be made of metal wires or polymer wires, and its shape can be disc-shaped, dish-shaped, platform-shaped, etc. Those skilled in the art can choose according to their needs. The preparation method is known in the art. For example, multiple wires mentioned above are woven into a mesh and shaped by mold and heat treatment process. The free ends of the wires can be tied at both ends of the mesh and fixed by clamping or welding to keep the mesh structure stable.

[0046] In this embodiment of the invention, the flow-blocking membrane inside the occlusion component is limited by a traction member to enhance the occlusion efficiency of the left atrial appendage occluder during and after implantation and reduce leakage.

[0047] The following comparison is based on existing technologies.

[0048] For reference Figure 1 This paper illustrates a left atrial appendage occlusion device, which is implanted in the left atrial appendage to achieve occlusion of the left atrial appendage. It includes an occlusion component 1 and a fixing component connected together. The occlusion component 1 is an elastic mesh structure made of woven metal wires, and is generally disc-shaped. The occlusion component 1 can be placed at the opening of the left atrial appendage to cover or fill it. Figure 1 This illustrates that, in a capping manner, the outer edge of the sealing component 1 can be positioned outside the atrial appendage and attached to the left atrial wall. For ease of distinction, Figure 1 The distal face 12, proximal face 11, and flow-blocking membrane 13 of the occlusion component are shown to be spaced apart. However, those skilled in the art will readily understand that, in order to reduce the impact on the left atrium, the occlusion component 1 typically has a small thickness, and the arcuate flange 14 connecting the distal face 12 and proximal face 11 can be extremely small. For example, both the distal face 12 and proximal face 11 can be selected as a single layer of metal wire, and in an unrestrained state, the flow-blocking membrane can be clamped by the distal face 12 and proximal face 11, thus achieving a close fit between the occlusion component 1 and the edge of the atrial appendage, achieving a good occlusion effect. The fixing component can be a frame structure mainly composed of multiple support rods, for example, 5-30 support rods can be selected. One end of the support rod can be a free end, and the other end is fixed to the fixing member 22 at the center. The support rod forms the outer edge of the frame structure on the free end side, contacting the inner wall of the atrial appendage, and can be provided with radial support force by the pressure of the inner wall of the atrial appendage, so that the fixing component is fixed in the atrial appendage cavity to achieve the positioning of the occlusion component 1. The multiple support rods of the frame structure can be circumferentially fixed or flexibly connected to each other. The fixing member 22 of the fixing component is connected to the distal end face 12 of the sealing component 1. For example, one end of the braided wire constituting the sealing component 1 can be directly fixed by the fixing member 22, or one end of the braided wire constituting the sealing component 1 can be fixed by the distal clamp, and the distal clamp is then fixedly connected to the fixing member 22.

[0049] Further reference Figure 2During the implantation of a left atrial appendage occluder, the fixation component is typically first released from the delivery catheter into the atrial appendage cavity for fixation. Then, the occlusion component is released outward from the delivery catheter to the atrial appendage orifice. To verify the stability of the left atrial appendage occluder in its implantation position, the operator pulls the occluder outward from the atrial appendage orifice. During this process, the occlusion component is axially stretched and elongated. As the occlusion component extends to one side, the choke membrane 13 can also move away from the atrial appendage orifice, causing leakage, for example... Figure 2 The location of embolus 5, as shown, forms a leakage channel. Although large emboli may be blocked by the braided mesh on the distal end and thus not pass through the leakage channel, the leakage of small emboli from the atrial appendage into the patient's systemic bloodstream may increase the potential risk. The delivery system, along with the delivery catheter, typically includes a delivery cable, which is detachably connected to the proximal clamp 15 of the occlusion component for use in the aforementioned traction or retrieval after the release of the left atrial appendage occluder. The detachable connection is usually a threaded connection, but other methods are also possible.

[0050] For comparison, Figure 3 This invention illustrates one embodiment of the left atrial appendage occlusion device, and... Figure 2 Unlike the left atrial appendage occluder shown, this embodiment of the invention includes a traction member 3, whose two ends are respectively fixed to the choke membrane 13 and the support rod 21 of the fixing component. The traction member 3 can usually be selected as a wire. The traction member 3 can usually be fixed at or near the center of the choke membrane 13 and the fixing component. There can be one traction member 3 or multiple traction members 3, for example, two symmetrically arranged along the axial direction, or three equally spaced. Figure 3 When the left atrial appendage occluder is in its unrestrained natural state, the traction member 3 can be in a slightly tensioned state, with the choke membrane 13 always being pulled towards the fixed component. However, it can also be in a more relaxed state, or the choke membrane 13 can be tensioned by moving a certain distance as the occlusion component extends axially.

[0051] Another example of a left atrial appendage occluder in the prior art, see [link to previous text]. Figure 4 and Figure 5 ,and Figure 1 and Figure 2 The example shown differs; its sealing component 1 is frustum-shaped, with a trapezoidal axial cross-section. The diameter of the distal end face 11 is larger than the diameter of the proximal end face 12, and the flange 14 gradually transitions between the two end faces. This differs from the aforementioned disc-shaped sealing component 1. Figure 4 and Figure 5 The frustum-shaped occlusion component 1 shown may have a slightly larger thickness, and in some cases may preferably be at least partially inserted into the atrial appendage cavity. (Reference) Figure 5The occlusion component 1 may be radially compressed and axially elongated during atrial appendage contraction, which may cause the flow-blocking membrane 13 inside the occlusion component 1 to shift or be biased towards the proximal end face 11. The contact between the flow-blocking membrane 13 and the edge of the atrial appendage may have an enlarged gap, resulting in a leakage channel at the location of the embolus 5.

[0052] For comparison, Figure 6 This invention illustrates an embodiment of the left atrial appendage occlusion device, relative to... Figure 4 The difference in the left atrial appendage occlusion device shown is that a traction element 3 is provided between the flow-blocking membrane 13 and the support rod 21 of the fixing component. Figure 6 The traction member 3 is shown to pull the choke membrane 13 toward the distal end face 12. The choke membrane 13, which is biased toward the inner side of the auricle, at least reduces the size of the leakage channel, especially the portion of the choke membrane that extends axially after being biased.

[0053] In a preferred embodiment of the present invention, the traction member 3 is fixed to one end of the fixing member, which can be fixed to a position slightly away from the fixing member 22 on the support rod or braided wire constituting the fixing member, for example... Figure 6 As shown. The fixing component is compressed by the inner wall of the auricle. The portion of the support rod or braid slightly further from the fixing member 22 is more prone to deformation than the portion closer to the root of the support rod or braid. For example... Figure 6 The support rod 21 shown is pressed inward toward the fixed component, thereby providing additional power for the traction member 3 to actively pull the flow-restricting membrane 13.

[0054] In some other embodiments of the present invention, reference is made to Figure 7 Multiple support rods 23 of the fixed component are arranged in a crisscross pattern to form an overlapping portion 231 adjacent to the fixed component 22. One end of the traction member 3 leading to the fixed component 2 is fixed to the overlapping portion 231. The traction member 3 can be a single wire looped between the flow-blocking membrane 13 and the overlapping portion 231 of the fixed component 2.

[0055] In some other embodiments of the present invention, reference may be made to Figure 8 Both the blocking component 1 and the fixing component 2 can be constructed from braided yarns. They can be separately braided and then connected at the fixing member 22. In the figure, the free ends of the braided yarns of the fixing component 2 are fixed to the fixing member 22, while the distal end is open. However, those skilled in the art can also choose the fixing component 2 to be a closed structure similar to the blocking component 1, where both ends are fixed by the fixing member. Figure 8 The flange 14 of the blocking component 1 shown is unevenly tapered and can be provided with two flow-blocking membranes 131 and 132. The traction member 3 can be provided as the gathering portion of the braided filaments connected to the flow-blocking membrane 131 and the fixing component 2. An additional traction member can also be provided between the flow-blocking membrane 132 and the fixing component 2.

[0056] In some embodiments of the present invention, the sealing component 1 and the fixing component 2 can be integrally woven from several braided filaments, without having Figure 8 The fixing member 22 shown between the two components has a tubular structure formed by the bundled braided yarns at the connection point. The fixing component includes a frame structure woven from the braided yarns. At their respective other ends, the occlusion component and the fixing component each have a fixing member that bundles and fixes the free ends of the braided yarns. One end of the traction member leading to the fixing component is fixed to the braided yarns of the fixing member or the frame structure at one end of the fixing component. In a preferred embodiment of the integrated structure, the diameter of the left atrial appendage occluder at the connection point between the occlusion component and the fixing component is significantly smaller than the diameters of the occlusion component and the fixing component. This significantly reduces the deformation of the fixing component caused by the deformation of the occlusion component, thus weakening the transmission of tension in the integrated structure between the two components.

[0057] In this embodiment of the invention, the flow-blocking membrane 13 is preferably circumferentially fixed to the flange 14 of the sealing component 1 at its edge or near the edge. However, in some cases, it can also be fixed to the distal end face 12 or proximal end face 11 of the sealing component 1 near the flange 14, so that the flow-blocking membrane 13 is configured to radially cover the distal end face or proximal end face. The flow-blocking membrane and the elastic mesh braided structure of the sealing component are fixedly connected by circumferentially alternating threads, or the flow-blocking membrane and the elastic mesh braided structure are fixedly bound together by a plurality of circumferentially distributed binding threads; both are well-known techniques in the art. However, those skilled in the art can also choose other thread binding methods or other fixing methods, such as bonding, welding, or clamping.

[0058] In this embodiment of the invention, the flow-blocking membrane of the occlusion component is restricted by the traction member, and the swing or displacement of the flow-blocking membrane towards the proximal side of the occlusion component is limited. Compared with the absence of a traction member, the swing amplitude or displacement of the flow-blocking membrane during atrial appendage contraction can be reduced, which is conducive to the flow-blocking membrane adhering to the distal side of the occlusion component, thereby improving the dynamic bonding between the flow-blocking membrane and the atrial appendage orifice and reducing leakage.

[0059] The traction limiting effect of the traction component on the choke membrane can be based on the traction of the traction component itself, or it can be achieved by the traction component being tensioned between the fixing component and the choke membrane, resulting in the fixing component exerting traction on the choke membrane. During or in the implantation process of the left atrial appendage occluder, the fixing component is fixed within the atrial appendage cavity. When the choke membrane swings or shifts towards the proximal end face of the occlusion component, it can be limited by the traction of the fixed component.

[0060] Particularly advantageously, one end of the traction element is fixed to the fixation component. At the implantation site, the fixation component is already positioned within the atrial appendage and remains essentially unaffected by deformation of the occlusion component. Therefore, it can be assumed that the change in the relative distance between the fixation component and the choke membrane is determined solely by the displacement or bias of the choke membrane. When the choke membrane shifts or biases outward from the atrial appendage, the fixation component, through the traction element, can pull and restrict the choke membrane from moving away. In some embodiments, the choke membrane is pulled and biased towards the distal side by the traction element. This can be advantageous, as the choke membrane biased towards the distal side can provide additional axial occlusion, thereby reducing leakage caused by choke membrane displacement.

[0061] In some embodiments of the present invention, the distance between the proximal and distal surfaces of the sealing component is less than 1 cm or less than 0.5 cm.

[0062] In some embodiments, the fixing component includes a frame structure and a second diaphragm fixed to the frame structure, with one end of the traction member leading to the fixing component fixed to the second diaphragm. The second diaphragm may be used to achieve additional occlusion, or primarily to wrap around the frame structure to reduce friction or damage to the inner wall of the atrial appendage.

[0063] The flow-blocking membrane or the second membrane element can be made of PET (polyester) or PTFE (polytetrafluoroethylene), with spunlace nonwoven fabric made of such material being particularly preferred. The thickness of the flow-blocking membrane or the second membrane element is usually small. In some embodiments, the diameter of the traction member can be larger than the thickness of the flow-blocking membrane or the second membrane element to enhance the traction effect.

[0064] The present invention has been illustrated above, but should not be construed as limiting the present invention.

Claims

1. A left atrial appendage occlusion device, comprising an occlusion component and a fixation component, wherein the occlusion component comprises an elastic mesh braided structure having a proximal end face and a distal end face, the occlusion component being connected to the fixation component on the distal end face side, characterized in that, The occlusion component also includes a flow-blocking membrane disposed within the elastic mesh braided structure. The flow-blocking membrane is configured to radially cover the distal or proximal end face and be fixed to the elastic mesh braided structure circumferentially. The flow-blocking membrane is also traction-limited by a traction member directed to the fixing component, which can reduce the leakage channel caused by the gap between the flow-blocking membrane and the pericardial rim.

2. The left atrial appendage occlusion device according to claim 1, characterized in that: The flow-blocking membrane is traction-limited by the traction member and is not substantially biased towards the proximal end face.

3. The left atrial appendage occlusion device according to claim 1, characterized in that: When the elastic mesh structure is in a radially compressed state, the flow-blocking membrane is pulled towards the distal end face by the traction member.

4. The left atrial appendage occlusion device according to claim 1, characterized in that: The elastic mesh structure has a flange connecting the proximal and distal faces, and the flow-blocking membrane is fixedly connected to the flange at its edge or near the edge, or the flow-blocking membrane is fixedly connected to the distal or proximal face near the flange at its edge or near the edge.

5. The left atrial appendage occlusion device according to claim 4, characterized in that: The flange constitutes the maximum diameter of the sealing component, and the cross-section of the flange in the axial direction is arc-shaped.

6. The left atrial appendage occlusion device according to claim 4, characterized in that: The diameter of the distal end face is larger than the diameter of the proximal end face, and constitutes the maximum diameter of the sealing component. The diameter of the sealing component gradually decreases from the flange towards the proximal end face.

7. The left atrial appendage occlusion device according to claim 1 or 4, characterized in that: The distance between the proximal and distal surfaces of the sealing component is less than 1 cm.

8. The left atrial appendage occlusion device according to claim 1 or 4, characterized in that: The flow-blocking membrane and the elastic mesh braided structure are fixedly connected by circumferentially alternating threads, or the flow-blocking membrane and the elastic mesh braided structure are fixedly bound together by multiple circumferentially distributed binding threads.

9. The left atrial appendage occlusion device according to claim 1, characterized in that: The diameter of the connection between the occlusion component and the fixation component of the left atrial appendage occluder is significantly smaller than the diameter of the occlusion component and the fixation component.

10. The left atrial appendage occlusion device according to claim 9, characterized in that: The blocking component and the fixing component are integrally woven from several braided filaments, and the connection between the two is a tubular structure formed by the bundled braided filaments. The fixing component includes a frame structure woven from the braided filaments. The blocking component and the fixing component are respectively provided with fixing members at their other ends to bundle and fix the free ends of each braided filament. The end of the traction member that leads to the fixing component is fixed to the fixing member at one end of the fixing component or the braided filament of the frame structure.

11. The left atrial appendage occlusion device according to claim 1, characterized in that: The fixing component includes a frame structure woven from several braided yarns. The near end of the frame structure is provided with a fixing member that gathers and fixes each braided yarn. The fixing component is connected to the sealing component through the fixing member. One end of the traction member that leads to the fixing component is fixed to the fixing member or the braided yarn of the frame structure.

12. The left atrial appendage occlusion device according to claim 1, characterized in that: The fixing component includes a frame structure composed of several support rods. The support rods converge at the proximal end of the fixing component to a fixing member. The fixing component is connected to the sealing component through the fixing member. One end of the traction member that leads to the fixing component is fixed to the fixing member or the support rod.

13. The left atrial appendage occlusion device according to claim 12, characterized in that: The support rods are arranged in a crisscross pattern to form an overlapping portion adjacent to the fixed component, and one end of the traction member that leads to the fixed component is fixed to the overlapping portion.

14. The left atrial appendage occlusion device according to claim 1, characterized in that: The traction component is a wire.

15. The left atrial appendage occlusion device according to claim 14, characterized in that: The traction component is a wire, with its two ends fixed to the flow-blocking membrane and the fixing component, respectively; or, the traction component is a wire looped between the flow-blocking membrane and the fixing component.

16. The left atrial appendage occlusion device according to claim 14, characterized in that: The diameter of the traction component is greater than the thickness of the flow-blocking membrane.

17. The left atrial appendage occlusion device according to claim 14, characterized in that: The traction component is made of metal wire or polymer wire.

18. The left atrial appendage occlusion device according to claim 1, characterized in that: The fixing component includes a frame structure and a second membrane fixed to the frame structure, and one end of the traction member that leads to the fixing component is fixed to the second membrane.

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