A herbicidal composition containing halosulfuron-methyl and its application

Abstract

The present invention discloses a herbicidal composition containing halosulfuron-methyl and its application. The active ingredients are indaziflam and halosulfuron-methyl, and the weight ratio is 3:1 to 1:3. The herbicidal composition of the present invention mixes indaziflam and halosulfuron-methyl in a specific ratio, kills weeds through two different mechanisms, and reduces the speed of weed resistance generation; the interaction type after compounding is additive effect and there is a synergistic effect, the control effect is enhanced, and the application effect is significantly better than the theoretical effect sum of single agents, which can better control the occurrence and harm of dominant weeds and greatly improve the herbicidal activity of the herbicide. The herbicidal spectra of the two herbicides in the herbicidal composition of the present invention are different. The herbicidal composition combines the herbicidal spectra and activities of these two agents, making the herbicidal spectrum of the compound preparation wider and the effective period longer.

Description

Technical Field

[0001] The present invention relates to the technical field of pesticides, and particularly relates to a herbicidal composition containing halosulfuron-methyl and its application. Background Art

[0002] Chemical weed control is one of the main means in agriculture to control weeds. In recent years, due to the large-scale single use of some herbicide varieties, many weeds have developed resistance. At the same time, due to the complex weed community when weeds occur, with multiple types of weeds such as gramineous weeds, sedge weeds, and broad-leaved weeds growing mixedly, a single herbicide variety cannot solve farmland weeds and will show defects and limitations in certain aspects.

[0003] There are a wide variety of weeds with high density and large growth amount in non-agricultural fields such as lawns, ornamental plants, railways, highways, airports, residential areas, ditches, industrial areas, military bases, municipal and government sites, around farm buildings, commercial areas, coniferous forests, etc., as well as in cash crops such as corn, sorghum, soybeans, citrus, grapes, fruit trees, nuts, sugarcane fields, etc. When using a single agent for control, the weed damage cannot be effectively suppressed and reduced, and it is often difficult to control their spreading growth.

[0004] Indaziflam is a triazine herbicide developed by Bayer, with the development code BCS-AA10717. Its IUPAC name: N-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-[(1RS)-1-fluoroethyl]-1,3,5-triazine-2,4-diamine; CAS registry number: 950782-86-2; relative molecular mass 301.37; molecular formula C16H20FN5. The structural formula is as follows:

[0005]

[0006] Indaziflam is a cellulose biosynthesis inhibitor (CBI). After soil application, it is absorbed through the hypocotyl of plants, inhibits the growth of new roots and leaves, causes chlorosis in the stems and leaves, and ultimately leads to the death of weeds. Indaziflam is highly effective, broad-spectrum, and has a long residual effect, with a control effect on gramineous weeds and broad-leaved weeds lasting up to 6 months and being safe for crops.

[0007] In the field of herbicides, in order to expand the weed control spectrum, usually two or more herbicides are compounded. For example, the Chinese patent document "CN110035660B - Herbicidal combination containing flucetosulfuron and indaziflam" discloses the compounding of indaziflam and flucetosulfuron for controlling weeds in sugarcane fields.

[0008] Halosulfuron-methyl, with the common name methyl 3-chloro-5-[[[[(4,6-dimethoxypyrimidin-2-yl)amino]carbonyl]amino]sulfonyl]-1-methyl-1H-pyrazole-4-carboxylate, CAS NO. 100784-20-1, is a sulfonylurea selective systemic herbicide.

[0009] The structural formula of halosulfuron-methyl is as follows:

[0010]

[0011] Halosulfuron-methyl is used to control annual broadleaf weeds and annual / perennial sedges in, for example, corn, sugarcane, rice, sorghum, tree nuts, and turf. Summary of the Invention

[0012] The technical problem to be solved by the present invention is to provide a herbicidal composition containing halosulfuron-methyl with high herbicidal activity, broad herbicidal spectrum, and high safety, and its application.

[0013] The technical solution for achieving the first object of the present invention is a herbicidal composition containing halosulfuron-methyl, with the active ingredients being indaziflam and halosulfuron-methyl.

[0014] Preferably, the weight ratio of indaziflam to halosulfuron-methyl is 3:1 to 1:3.

[0015] More preferably, the weight ratio of indaziflam to halosulfuron-methyl is 1:2 to 2.5.

[0016] Even more preferably, the weight ratio of indaziflam to halosulfuron-methyl is 1:2.5.

[0017] Among them, the active ingredients indaziflam and halosulfuron-methyl account for 5% to 75% of the total weight of the herbicidal composition.

[0018] The dosage form of the herbicidal composition is a suspension concentrate, water dispersible granule, wettable powder, granule, dispersible oil suspension, or microcapsule suspension.

[0019] The technical solution for achieving the second object of the present invention is the application of the above herbicidal composition containing halosulfuron-methyl in controlling gramineous weeds, broadleaf weeds, and cyperaceae weeds in non-agricultural lawns, ornamental lawns, ornamental plants, railways, highways, airports, residential areas, ditches, industrial areas, military bases, municipal and government sites, around farm buildings, commercial areas, coniferous forests, and cash crops such as corn, sorghum, soybeans, citrus, grapes, fruit trees, nuts, and sugarcane fields.

[0020] The weeds include Eleusine indica, Lolium multiflorum, Bidens pilosa, Xanthium sibiricum, Sonchus oleraceus, and Cyperus rotundus.

[0021] The present invention has positive effects:

[0022] (1) The herbicidal composition of the present invention mixes indaziflam and halosulfuron-methyl in a specific ratio, kills weeds through two different mechanisms, and reduces the rate of weed resistance generation; the interaction type after compounding is additive and has a synergistic effect, the control effect is enhanced, and the application effect is significantly better than the sum of the theoretical effects of single agents, and it can better control the occurrence and harm of dominant weeds, greatly improving the herbicidal activity of the herbicide.

[0023] (2) The herbicidal spectra of the two herbicides in the herbicidal composition of the present invention are different, and the herbicidal composition combines the herbicidal spectra and activities of these two agents, making the herbicidal spectrum of the compound preparation wider and the duration of efficacy longer.

[0024] (3) The herbicidal composition of the present invention can significantly improve the control effect on various resistant weeds, delay the generation of weed resistance, and extend the service life of the agent.

[0025] (4) The combined herbicide of the present invention is applied to pre-planting or pre-emergence weeding in sugarcane fields, and can control various gramineous or broad-leaved weeds in sugarcane fields; on the premise of improving the drug efficacy, it has reliable safety for sugarcane and subsequent crops.

[0026] (5) The combined herbicide of the present invention can also be applied to non-agricultural fields such as lawns, ornamental lawns, ornamental plants, railways, highways, airports, residential areas, ditches, industrial areas, military bases, municipal and government sites, around farm buildings, commercial areas, coniferous forests, etc., as well as for weeding in cash crops such as corn, sorghum, soybeans, citrus, grapes, fruit trees, and nut fields, and can control various gramineous weeds, broad-leaved weeds, and Cyperaceae weeds therein. On the premise of improving the drug efficacy, it has reliable safety for crops and subsequent crops. Detailed Embodiments

[0027] The following are some of the multiple possible embodiments of the present invention, aiming to provide a basic understanding of the present invention, and not aiming to identify the key or decisive elements of the present invention or limit the scope to be protected. It is easy to understand that according to the technical solution of the present invention, without changing the essence of the present invention, those of ordinary skill in the art can propose other interchangeable implementation manners. Therefore, the following detailed embodiments are only illustrative descriptions of the technical solution of the present invention, and should not be regarded as the whole of the present invention or regarded as a limitation or restriction of the technical solution of the present invention.

[0028] (Example 1, 42% suspension concentrate)

[0029] 42% suspension of indazine fluazifop-amid and chlorpyrifos sulfamethoxam: indazine fluazifop-amid 12%, chlorpyrifos sulfamethoxam 30%, wetting agent phenethylphenol polyoxyethylene ether 4%, dispersant polycarboxylate 3%, antifreeze agent propylene glycol 4%, rheological agent magnesium aluminum silicate 1%, thickener xanthan gum 0.2%, sodium benzoate 0.2%, water is supplemented to 100%, and the above and following embodiments are all mass percentages.

[0030] Preparation method: put the active ingredient, wetting agent, dispersant, antifreeze agent, rheological agent and water into a stirring tank, stir thoroughly, then pump the material into a sand mill for thorough grinding. After grinding, pump the material into a high-speed shearing machine, add a thickener and sodium benzoate, and perform high-speed shearing. After shearing, the suspension is obtained.

[0031] (Example 2, 70% water dispersible granules)

[0032] 70% indoxazine fluazifop-amid. chlorpyrifos sulfamethoxam water dispersible granules: 20% indoxazine fluazifop-amid, 50% chlorpyrifos sulfamethoxam, 3% polycarboxylate dispersant, 3% sodium lauryl sulfate, 6% naphthalenesulfonate dispersant, 5% disintegrant sodium sulfate, and filler kaolin to make up to 100%.

[0033] Preparation method: After all materials are mixed evenly, they are crushed by a jet mill and mixed evenly again. Then, a certain amount of water is added to knead the mixture, extruded into granules, and dried and sieved to obtain water-dispersible granules.

[0034] (Example 3, 70% wettable powder)

[0035] 70% indoxazine fluazifop-amid. chlorpyrifos methyl wettable powder: 20% indoxazine fluazifop-amid, chlorpyrifos methyl 50%, wetting agent sodium lauryl sulfate 4%, dispersant sodium naphthalenesulfonate formaldehyde condensate 6%, filler diatomaceous earth 5%, and kaolin is made up to 100%.

[0036] Preparation method: The active ingredient and the auxiliary agents are mixed evenly, put into a mechanical crusher for initial crushing, then crushed by a jet mill, and then mixed evenly to obtain a wettable powder.

[0037] (Example 4, 5.6% granules)

[0038] 5.6% indoxazine fluazifop-amid. chlorpyrifos sulfonate granules: 1.6% indoxazine fluazifop-amid, chlorpyrifos sulfonate 4%, wetting agent alkyl succinate sulfonate 0.6%, dispersant alkylphenol polyoxyethylene ether formaldehyde condensate sulfonate 1.0%, colorant basic green (malachite green) 0.1%, filler bentonite is supplemented to 100%.

[0039] Preparation method: After the active ingredient and various auxiliary agents are evenly mixed, a certain amount of water is added to knead the mixture, extrusion granulation is performed, and granules are obtained after drying and sieving.

[0040] (Example 5, 28% Dispersible Oil Suspension)

[0041] 28% Indaziflam + Halosulfuron-methyl Dispersible Oil Suspension: 8% Indaziflam, 20% Halosulfuron-methyl, 3% Phosphate Ester Dispersant, 7% Emulsifier Alkylbenzene Polyoxyethylene Ether, 7% 500# Calcium Salt, 1% Fumed Silica, 1.8% Thickener Organic Bentonite, and the dispersing medium Methyl Oleate is made up to 100%.

[0042] Preparation Method: Put the active ingredients, emulsifier, dispersant, Calcium Dodecylbenzenesulfonate, fumed silica, and dispersing medium into a stirring kettle, stir well, pump it into a high-speed shearer for high-speed shearing, then pump it to a sand mill for sufficient sanding. After passing the sanding test, add the thickener and stir evenly to obtain the dispersible oil suspension.

[0043] (Example 6, 14% Microcapsule Suspension)

[0044] 14% Indaziflam + Halosulfuron-methyl Microcapsule Suspension: 4% Indaziflam, 10% Halosulfuron-methyl, 10% Solvent Cyclohexanone, 6% Solvent Dibutyl Phthalate, 5% Oil-based Capsule Skin 1,6-Hexamethylene Diisocyanate, 3% Water-based Capsule Skin Ethylenediamine, 6% Emulsifier Alkylphenol Formaldehyde Resin Polyoxyethylene Ether, 7% Dispersant EO-PO Block Polyether, 0.2% Thickener Magnesium Aluminum Silicate, and the dispersing medium Water is made up to 100%.

[0045] Preparation Method: Dissolve the active ingredients in the solvent completely, add the oil-based capsule skin, and stir well to form an oil phase; pour it into the water phase mixed with emulsifier and dispersant, carry out high-speed shearing, then add the water-based capsule skin, stir evenly, then heat up to 70 °C and keep warm for 2 hours for curing to make microcapsules. Finally, add the thickener and stir evenly to obtain the microcapsule suspension.

[0046] (Test Example 1, Indoor Biological Activity Test)

[0047] Test Agents: 75% Halosulfuron-methyl Water Dispersible Granules and Indaziflam Technical.

[0048] Test Targets: Select several representative weeds among Gramineous weeds, Broadleaf weeds, and Cyperaceae weeds, including Eleusine indica, Lolium multiflorum, Bidens pilosa, Xanthium sibiricum, Sonchus oleraceus, and Cyperus rotundus as test weeds. Cyperus rotundus is a perennial weed, and its underground rhizomes are dug from the field for reproduction; the other several weeds are annual weeds, and their seeds are collected from the field for reproduction.

[0049] Formulation design of agents: 75% halosulfuron-methyl water dispersible granules and indaziflam technical were each formulated into solutions of 0.2, 0.5, 1, 3.3, 4, 5, 10 g / ha for standby; indaziflam technical + 75% halosulfuron-methyl water dispersible granules were formulated into solutions of 10 + 0.2 (50:1), 10 + 0.5 (20:1), 10 + 1 (10:1), 10 + 3.3 (3:1), 10 + 4 (2.5:1), 10 + 5 (2:1), 10 + 10 (1:1), 5 + 10 (1:2), 4 + 10 (1:2.5), 3.3 + 10 (1:3), 1 + 10 (1:10), 0.5 + 10 (1:20), 0.2 + 10 (1:50) g / ha for standby.

[0050] Test method:

[0051] For weeds propagated by seeds, a certain amount of soil was filled into a plastic pot with a height of 6 cm and a diameter of 20 cm. 50 seeds of the target weeds to be tested were sown in the plastic pot, covered with about 1 cm thick fine soil. After 24 hours, the soil surface in the plastic pot was evenly sprayed, with about 2.8 mL of liquid medicine sprayed per pot. Each treatment was repeated 4 times, and a treatment without spraying the agent was set as the control. After treatment, the test materials were placed in a greenhouse for cultivation, and the growth of the target weeds was observed regularly. After 20 days, the damage symptoms and growth inhibition of the target were visually observed, and the fresh weight of the above-ground part was weighed. The virulence of the agent on the target weeds was evaluated by the inhibition rate of the target fresh weight.

[0052] For weeds propagated by rhizomes, a certain amount of soil was filled into a plastic pot with a height of 6 cm and a diameter of 20 cm. 20 segments of the collected underground rhizomes (such as the underground rhizomes of Cyperus rotundus) were planted in the plastic pot, covered with about 1 cm thick fine soil. After 24 hours, the soil surface in the plastic pot was evenly sprayed, with about 2.8 mL of liquid medicine sprayed per pot. Each treatment was repeated 4 times, and a treatment without spraying the agent was set as the control. After treatment, the test materials were placed in a greenhouse for cultivation, and the growth of the target weeds was observed regularly. After 20 days, the damage symptoms and growth inhibition of the target were visually observed, and the fresh weight of the above-ground part was weighed. The virulence of the agent on the target weeds was evaluated by the inhibition rate of the target fresh weight.

[0053] Investigation method: After 20 days of the test treatment, the damage symptoms and growth inhibition of the target were visually observed, and the fresh weight of the above-ground part was weighed, and the fresh weight inhibition rate (%) was calculated.

[0054]

[0055] Evaluation method for joint action: According to the Gowing method (NY / T 1155.7 - 2006) to evaluate the herbicide combination method, the formula is as follows:

[0056] E0﹦X﹢Y–XY / 100.

[0057] Wherein, X is the fresh weight inhibition rate of target weeds when indazine fluazifop-amid is used alone at a certain dose; Y is the fresh weight inhibition rate of target weeds when chlorpyrifos sulfamethoxam is used alone at a certain dose; E0 is the theoretical value of the fresh weight inhibition rate of target weeds when indazine fluazifop-amid and chlorpyrifos sulfamethoxam are mixed; E is the measured value of the fresh weight inhibition rate of target weeds when indazine fluazifop-amid and chlorpyrifos sulfamethoxam are mixed.

[0058] Evaluation criteria: When E–E0>10%, it indicates a synergistic effect; when –10%≤E–E0≤10%, it indicates an additive effect; when E–E0<–10%, it indicates an antagonistic effect.

[0059] Table 1. Indoor toxicity test of each pesticide treatment on Glechoma longituba.

[0060]

[0061] It can be seen from Table 1 that when indoxazine fluazifop + chlorpyrifos methyl are compounded, they have an obvious additive effect on Gnaphalium truncatum in the weight ratio range of 20 to 1:1 to 20, and have a synergistic effect in the weight ratio range of 3:1 to 1:3, among which the synergistic effect is most obvious in the weight ratio of 1:2 to 2.5.

[0062] Table 2. Indoor toxicity test of each pesticide treatment on Lolium multiflorum.

[0063]

[0064] It can be seen from Table 2 that when indoxazine fluazifop + chlorpyrifos methyl are combined, they have an obvious additive effect on multiflora ryegrass in the weight ratio range of 20 to 1:1 to 20, and have a synergistic effect in the weight ratio range of 3:1 to 1:3, among which the synergistic effect is most obvious in the weight ratio of 1:2 to 2.5.

[0065] Table 3. Indoor toxicity test of each agent treatment on Bidens pilosa

[0066]

[0067] It can be seen from Table 3 that when indoxazine fluazifop + chlorpyrifos methyl are compounded, they have an obvious additive effect on Bidens pilosa L. in the weight ratio range of 20-1:1-20, and have a synergistic effect in the weight ratio range of 3:1-1:3, among which the synergistic effect is most obvious at a weight ratio of 1:2-2.5.

[0068] Table 4. Indoor toxicity test of each agent treatment on Xanthium sibiricum

[0069]

[0070] As can be seen from Table 4, when indaziflam and halosulfuron-methyl are compounded, there is an obvious additive effect on Xanthium sibiricum within the weight ratio range of 20 to 1:1 to 20, and a synergistic effect within the weight ratio range of 3:1 to 1:3. Among them, the synergistic effect is most obvious within the weight ratio range of 1:2 to 2.5.

[0071] Table 5. Indoor toxicity determination of each medicament treatment on Sonchus oleraceus

[0072]

[0073] As can be seen from Table 5, when indaziflam and halosulfuron-methyl are compounded, there is an obvious additive effect on Sonchus oleraceus within the weight ratio range of 20 to 1:1 to 20, and a synergistic effect within the weight ratio range of 3:1 to 1:3. Among them, the synergistic effect is most obvious within the weight ratio range of 1:2 to 2.5.

[0074] Table 6. Indoor toxicity determination of each medicament treatment on Cyperus rotundus

[0075]

[0076] As can be seen from Table 6, when indaziflam and halosulfuron-methyl are compounded, there is an obvious additive effect on Cyperus rotundus within the weight ratio range of 20 to 1:1 to 20, and a synergistic effect within the weight ratio range of 3:1 to 1:3. Among them, the synergistic effect is most obvious within the weight ratio range of 1:2 to 2.5.

[0077] In summary, for the example combinations of indaziflam and halosulfuron-methyl, within the weight ratio range of 20 to 1:1 to 20, they have an additive or synergistic effect on the control of weeds such as Eleusine indica, Lolium multiflorum, Bidens pilosa, Xanthium sibiricum, Sonchus oleraceus, and Cyperus rotundus. Within the weight ratio range of 3:1 to 1:3, they have a synergistic effect, and the synergistic effect is most obvious when the weight ratio is 1:2 to 2.5.

[0078] (Test Example 2. Field efficacy test)

[0079] Tested medicaments: 6 binary compound combinations in Examples 1 to 6.

[0080] Control medicaments: Indaziflam technical, 75% halosulfuron-methyl water dispersible granules.

[0081] Tested crops: Sugarcane.

[0082] Weed control targets: Annual broadleaf weeds, Gramineae (Eleusine indica, Lolium multiflorum, Bidens pilosa, Xanthium sibiricum, Sonchus oleraceus) and Cyperus rotundus of Cyperaceae.

[0083] Test method: Before the emergence of sugarcane seedlings after sowing, according to the plot area, weigh each pesticide, dilute it with water, and evenly spray it with a knapsack sprayer. When spraying, pay attention to evenly spraying the liquid medicine into the test plot to prevent over-spraying and missed spraying; Example 4 is a granule, and when applying the medicine, mix it with 20 kg of fine soil per mu and evenly broadcast it.

[0084] Within 1 - 15 days after application, observe the emergence and growth of crops to investigate whether the pesticides have phytotoxicity to the crops.

[0085] Observe the death of weeds 20 days and 40 days after application, count the number of weed plants or fresh weight, and compare the herbicidal activities of each pesticide.

[0086] The pesticide application examples of the present invention are shown in Table 7 (20 days after application) and Tables 8 and 9 (40 days after application).

[0087] Table 7. Results of field efficacy trials (plant control efficacy 20 days after application)

[0088]

[0089] Table 8. Results of field efficacy experiments (plant control efficacy 40 days after application)

[0090]

[0091] Table 9. Results of field efficacy experiments (fresh weight control efficacy 40 days after application)

[0092]

[0093] The results of field trials show that when indaziflam and halosulfuron-methyl are mixed and applied at a weight ratio of 1:2.5, it has obvious effects of expanding the herbicidal spectrum, improving the herbicidal activity, and enhancing the herbicidal effect, showing a significant synergistic effect.

[0094] Observation at 7 days, 10 days, 15 days, and 20 days after application showed that no adverse phenomena such as yellow leaves, albinism, contact spots, growth cessation, and dead seedlings were observed in the emerged sugarcane in the treatment areas of each example combination and the control pesticide treatment area. The germination and growth were normal, and the growth of sugarcane was consistent with that in the blank control area, with no obvious difference, indicating that each example combination is safe for the growth of sugarcane at this dosage.

Claims

1. A herbicidal composition containing halosulfuron-methyl, characterized in that: The active ingredients are indaziflam and halosulfuron-methyl, and the weight ratio of indaziflam to halosulfuron-methyl is 3:1 to 1:

3.

2. The herbicidal composition containing halosulfuron-methyl according to claim 1, characterized in that: The weight ratio of indaziflam to halosulfuron-methyl is 1:2 to 2.

5.

3. The herbicidal composition containing halosulfuron-methyl according to claim 2, characterized in that: The weight ratio of indaziflam to halosulfuron-methyl is 1:2.

5.

4. The herbicidal composition containing halosulfuron-methyl according to any one of claims 1 to 3, characterized in that: The active ingredients indaziflam and halosulfuron-methyl account for 5% to 75% of the total weight of the herbicidal composition.

5. The herbicidal composition containing halosulfuron-methyl according to any one of claims 1 to 3, characterized in that: The dosage form of the herbicidal composition is suspension concentrate, water dispersible granules, wettable powder, granule, dispersible oil suspension or microcapsule suspension.

6. Use of the herbicidal composition containing halosulfuron-methyl according to claim 1 in controlling gramineous weeds, broadleaf weeds and cyperaceous weeds, wherein the weeds are Eleusine indica, Lolium multiflorum, Bidens pilosa, Xanthium sibiricum, Sonchus oleraceus and Cyperus rotundus.

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