Sublatus subtilis CCFM1349 and its postbiotic with hair loss prevention and hair care effects

By regulating hair follicle growth and development through Lactobacillus paracasei CCFM1349 and its post-genetic agents, the side effects of existing hair loss treatments have been resolved, achieving the effect of preventing hair loss and protecting hair.

CN117645948BActive Publication Date: 2026-06-19JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JIANGNAN UNIV
Filing Date
2023-11-22
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing hair loss treatments such as minoxidil and finasteride have side effects such as allergic dermatitis and hirsutism, leading to poor patient compliance. There is a need to find substances from natural materials that regulate hair follicle growth and development to reduce side effects.

Method used

Using Lactobacillus paracasei CCFM1349 and its prepared metagenes, hair follicle growth and development were regulated by promoting VEGF expression in dermal papilla cells, inhibiting TGF-β2 expression, upregulating IGF-1 and VEGF levels, downregulating TGF-β1 levels, and promoting Wnt5α and Wnt10b expression.

Benefits of technology

While promoting hair follicle growth and preventing hair loss, it reduces side effects and has a significant effect on preventing hair loss and protecting hair.

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Abstract

This invention discloses a strain of *Lactobacillus paracasei* CCFM1349 and its metagener with anti-hair loss and hair care effects, belonging to the fields of microbial technology and pharmaceutical technology. The *Lactobacillus paracasei* CCFM1349 provided by this invention has anti-hair loss and hair care effects, including: (1) promoting VEGF expression in dermal papilla cells (HDPCs) and inhibiting TGF-β2 expression in dermal papilla cells; (3) upregulating IGF-1 content in mouse skin; (4) upregulating VEGF content in mouse skin; (5) downregulating TGF-β1 content in mouse skin; (6) promoting Wnt5α expression in mouse skin; (7) promoting Wnt10b expression in mouse skin; and (8) promoting hair growth in mice. The *Lactobacillus paracasei* CCFM1349 and its metagener provided by this invention can be used to prepare products for the prevention and / or treatment of hair loss, and have great application prospects.
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