Y-type biobased glycolipids, methods of making and using the same

By preparing Y-type bio-based glycolipids and utilizing the etherification reaction of cardiotonic phenol and β-D-glucose pentaacetate to form a bihydrophilic head group with a Y-type structure, the problems of insufficient thermal and solvent stability of cashew phenol glycolipid molecules in self-assembled materials are solved, enabling the application of nanomaterials with higher stability.

CN117886861BActive Publication Date: 2026-07-14NASURFAR BIOMATERIAL TECH (CHANGSHU) CO LTD
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Patent Information

Application Number
CN202311771719.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-12-21
Publication Date
2026-07-14
Estimated Expiration
2043-12-21

AI Technical Summary

Technical Problem

Nanomaterials formed by the self-assembly of cashew glycolipid molecules lack sufficient thermal and solvent stability, failing to meet the requirements of practical applications.

Method used

Using cardiac glycosides and β-D-glucose pentaacetate as raw materials, Y-type bio-based glycolipids were prepared by etherification reaction. The symmetrical bisphenol hydroxyl groups of the glycolipids reacted with β-D-glucose pentaacetate to form a bihydrophilic head group with a Y-type structure, which enhanced the intermolecular hydrogen bonding and thus improved the stability of the self-assembled nanomaterials.

Benefits of technology

This improved the thermal and solvent stability of self-assembled nanomaterials, making them excellent drug carriers and promoting their practical application in the biomedical field.

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Abstract

The application discloses Y-type bio-based glycolipid and a preparation method and application thereof, and the preparation method is as follows: taking strophanthin and beta-D-glucose pentaacetate as raw materials, under the action of a catalyst and molecular sieves in an organic solvent, a preliminary product is obtained through reaction, and then after washing, drying and removal of the organic solvent in vacuum, purification is carried out to obtain the Y-type bio-based glycolipid. The application first takes strophanthin and beta-D-glucose pentaacetate as raw materials, and through etherification reaction, a pure bio-based amphiphilic hydrophilic head group glycolipid with Y-type structure is prepared, the compactness of molecular stacking is effectively improved, the nano aggregate obtained through self-assembly has excellent thermal stability and solvent stability, the problem that a self-assembly drug carrier is applied to a biomolecular engineering field and has poor stability can be solved, and the practical application of the self-assembly material can be promoted.
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