Extraction method and application of ginseng and fingered citron beauty-activating active ingredients

Abstract

The application discloses an extraction method of ginseng and fingered citron beauty-activating active ingredients and application of the extraction method in preparation of beauty products. The extraction method is as follows: ginseng and fingered citron are dried, crushed and mixed to obtain a ginseng and fingered citron mixture, then a dissolving agent is added for subcritical extraction, the residue is dried after extraction to obtain a residue, and the filtrate obtained by extraction is rotary evaporated to remove organic solvents to obtain beauty-activating active ingredients. The method can simultaneously and efficiently extract beauty-activating active ingredients in ginseng and fingered citron, and the effect is significantly improved compared with a simple water extraction method or an alcohol extraction method, and the method can be used for preparing ginseng and fingered citron compound tablets. The ginseng and fingered citron compound tablets have the advantages of remarkable anti-fatigue effect, no toxic side effect, pure smell, no peculiar smell, and the functions of tonifying kidney and liver, tonifying blood and essence, nourishing yin and tranquilizing the nerves, inhibiting the generation of melanin, removing freckles, reducing wrinkles, activating skin cells, enhancing skin elasticity, and making skin white and smooth.

Description

Technical Field

[0001] This invention relates to the field of food preparation that is both food and medicine, specifically a method for extracting and applying the beauty-enhancing active ingredients of ginseng and bergamot. Background Technology

[0002] The concept of "medicine and food sharing the same origin" is one of the most valuable contributions of traditional Chinese medicine to humanity, and it is the primary criterion for selecting foods in traditional Chinese medicine. Ginseng, known as the "King of Herbs," is renowned for its ability to replenish vital energy, strengthen the spleen and lungs, promote the production of body fluids and quench thirst, calm the mind, and enhance intelligence. Its multifaceted effects have been increasingly confirmed. Regarding its beauty-enhancing properties, ginseng's effectiveness has been proven.

[0003] Ginseng contains ginsenosides, which promote blood circulation, prevent skin aging and wrinkles, increase skin nutrition, and have the effects of nourishing qi, beautifying the complexion, and promoting blood circulation. Its amino acid components can accelerate metabolism, deeply moisturize the skin, prevent dryness and aging, and effectively treat itching and peeling, making facial skin delicate, smooth, and fair. Its active polysaccharides can inhibit melanin production, resulting in white and smooth skin. Therefore, it is widely used in the beauty and cosmetics industry, and can be formulated into cosmetics that remove blemishes, reduce wrinkles, activate skin cells, and enhance skin elasticity. In addition to the above applications, modern medical research has found that American ginseng also has anti-fatigue, anti-aging, anti-shock, cognitive-enhancing, memory-improving, immune-boosting, cardiovascular-improving, and central nervous system-regulating effects.

[0004] It has a significant inhibitory effect on intestinal smooth muscle; it dilates coronary vessels and increases coronary blood flow; at high concentrations, it inhibits myocardial contractility, slows heart rate, lowers blood pressure, and protects against experimental myocardial ischemia; bergamot polysaccharides have a significant promoting effect on multi-linked immune function, promoting the phagocytic function of peritoneal macrophages and significantly counteracting the immunosuppression caused by cyclophosphamide. Bergamot is non-toxic, with a pungent, bitter, and sweet taste; it is warm in nature; it enters the liver, spleen, and stomach meridians, and has multiple medicinal functions including regulating qi and resolving phlegm, relieving nausea and bloating, soothing the liver and strengthening the spleen, and harmonizing the stomach. It has a significant relieving effect on bronchitis and asthma caused by smoking; it also has a more significant effect on indigestion and chest and abdominal distension that easily occur after quitting smoking. The clinical application of bergamot in medicinal pairs and compound prescriptions is mainly used to treat depression, insomnia, stomach diseases, liver diseases, and menstrual disorders.

[0005] Common extraction methods for traditional Chinese medicinal materials include ethanol reflux extraction and decoction with water. Other extraction methods include maceration, reflux extraction, ultrasonic extraction, supercritical fluid extraction, and microwave extraction. In the extraction of total ginsenosides, solvents used include water, methanol, ethanol, and n-butanol. However, methanol has high solubility for various substances, resulting in a higher concentration of impurities in the extract, particularly fat-soluble pigments. This leads to low purity and a darker appearance of the prepared total saponins. Furthermore, solvents like methanol and ethanol, being of medium grade, have low extraction rates for malonyl ginsenosides (which are more polar). Using these solvents results in the loss of some saponins (malonyl saponins), further reducing the total saponin yield. Therefore, breakthroughs in the extraction of traditional Chinese medicinal materials are needed in two main areas: innovative extraction techniques and appropriate solvent selection.

[0006] Although some research and inventions have been conducted in recent years using ginseng and bergamot as the main medicinal materials to produce beauty products, developing a new method for extracting the effective components of ginseng has become a significant research area. However, the extraction processes are still based on traditional water decoction or ethanol extraction, which do not specifically target and maximize the extraction of the beauty-enhancing components of ginseng and bergamot. For example, most studies have used conventional hydrothermal methods (100℃, atmospheric pressure) to extract water and ethanol extracts of ginseng or bergamot. Therefore, a technological breakthrough in effectively extracting the beauty-enhancing components from a mixture of ginseng and bergamot as the main medicinal materials has become a key challenge.

[0007] However, research shows that the main chemical components of ginseng and bergamot have different chemical properties in terms of their beauty-enhancing effects. When the two are mixed and water / ethanol is used as the solvent, the amount of beauty-enhancing components obtained by hydrothermal extraction cannot be maximized simultaneously. First, the beauty-enhancing active ingredient of ginseng is ginsenoside, which is rich in eighteen kinds of ginsenoside monomers. According to the structural type of ginsenosides, they can be divided into tetracyclic triterpenoids of the dammarane type and pentacyclic triterpenoids of the oleanane type. According to the presence or absence of C6-OH in the four hydroxyl groups of C-3, C-6, C-12, and C-20 on the tetracyclic parent nucleus, they can be divided into protopanaxadiol type and protopanaxtriol type. Chemical components above triol are difficult to dissolve in water. Ginsenoside Ra2 is soluble in methanol, and Rg3 is also insoluble in water, making it difficult to be absorbed by the gastrointestinal mucosa, which seriously limits the function of ginsenoside Rg3 in the human body. The antioxidant and beautifying components in Buddha's Hand are mainly volatile oils, flavonoids, 5,6-dimethoxycoumarin, bucroside and other polyphenols, as well as bergamot lactone, limonene lactone, zanthoxylate, dioamine, hesperidin, trace amounts of coriander glycoside, etc. These components are difficult to dissolve in water.

[0008] Therefore, when using water as the sole solvent, the beautifying components of ginseng (Ginsenosides Ra2 and Rg3) and the volatile oils, flavonoids, 5,6-dimethoxycoumarins, and polyphenols such as bubujin, as well as bergamot lactones, limonols, and zanthoxylins, are difficult to dissolve, especially the volatile oily substances in bergamot. Furthermore, when using ethanol as the extractant, the hydrolysates of ginseng and bergamot cannot dissolve, severely limiting their beautifying effects. Although some inventions use water / ethanol as a mixed solvent for separate extraction, these are currently conducted at a conventional temperature of 100℃ and atmospheric pressure, which still cannot maximize the extraction of beautifying components. There is currently no research on the extraction effect of these two components under subcritical conditions. Therefore, to maximize the extraction of beautifying components from a mixture of these two components, we have, for the first time, utilized a subcritical hydrothermal method (non-supercritical extraction) with a novel dissolving agent to maximize the extraction of the effective beautifying and anti-aging components from ginseng and bergamot, and formulated it into ginseng-bergamot compound tablets. Summary of the Invention

[0009] The purpose of this invention is to overcome the shortcomings of the prior art and provide a method for extracting the beautifying active ingredients of ginseng and Buddha's hand, and its application, so as to at least simultaneously extract the beautifying active ingredients from ginseng and Buddha's hand and prepare ginseng and Buddha's hand compound tablets with beautifying effects.

[0010] The objective of this invention is achieved through the following technical solution:

[0011] A method for extracting the beautifying active ingredients of ginseng and bergamot, characterized by comprising the following steps:

[0012] Ginseng and Buddha's hand are dried, pulverized, and mixed to obtain a ginseng-Buddha's hand mixture. Then, a dissolving agent is added for subcritical extraction. The resulting filter residue is dried to obtain medicinal residue. The filtrate obtained from the extraction is rotary evaporated to remove organic solvents to obtain the beauty active ingredients.

[0013] The dissolving agent, by weight, comprises 60-70 parts water, 10-15 parts ethanol, 2-4 parts acetone, 5-8 parts diethyl ether, and 3-5 parts petroleum ether.

[0014] Furthermore, the ginseng and Buddha's hand are dried and then pulverized to 100-200 mesh.

[0015] Furthermore, the weight ratio of the ginseng and bergamot mixture to the dissolving agent is 3-6:50.

[0016] Furthermore, the subcritical extraction is carried out in a subcritical reactor;

[0017] Furthermore, the subcritical extraction temperature is 120-150℃, the pressure is 0.5-3MPa, and the reaction time is 40-50min.

[0018] Furthermore, the ginseng and bergamot active ingredients extracted by the extraction method are used to prepare ginseng and bergamot compound tablets.

[0019] Furthermore, the preparation method of the ginseng and bergamot compound includes the following steps: mixing the medicinal residue and the beauty active ingredients, and then adding pulverized wolfberry, amla, yam, tangerine peel, longan pulp, hawthorn, ginger, black pepper, angelica, kelp and xylitol to obtain the ginseng and bergamot compound.

[0020] Furthermore, by weight, the following ingredients are present: 150 parts of medicinal residue, 15-22.5 parts of beauty-enhancing active ingredients, 150 parts of wolfberry, 80 parts of amla, 80 parts of yam, 30 parts of tangerine peel, 30 parts of longan pulp, 30 parts of hawthorn, 30 parts of ginger, 30 parts of black pepper, 20 parts of angelica dahurica, 20 parts of kelp, and 20 parts of xylitol.

[0021] Furthermore, the wolfberry, amla, yam, tangerine peel, longan pulp, hawthorn, ginger, black pepper, angelica, kelp, and xylitol are pulverized to 100-200 mesh; preferably, they are pulverized to 150 mesh.

[0022] Furthermore, the ginseng and bergamot compound is mixed with sucrose, starch, polyethylene glycol and dextrin and then compressed into tablets to obtain ginseng and bergamot compound tablets.

[0023] Pharmacological description of the ginseng and bergamot compound tablets of this invention:

[0024] A healthy heart leads to a healthy complexion. Therefore, our formula includes ginseng to improve heart function, especially ginseng components Rg1, Rb1, and Rg3. Rg1 has anti-fatigue, anti-aging, anti-cancer, lipid-lowering, memory-enhancing, and immunity-boosting effects. Rb1 has antioxidant, anti-infective, anti-inflammatory, melanoma-treating, melanin-inhibiting (skin whitening) effects, hypertrophic scar remodeling, abdominal aortic aneurysm-reducing effects, and improves vascular permeability and intestinal edema after endotoxemia. Rg3 has anti-tumor, antioxidant, anti-inflammatory, learning-enhancing, anti-photoaging, acute lung injury-improving, melanin-inhibiting (skin whitening) effects, treatment of doxorubicin-induced cardiotoxicity, and reduction of myocardial ischemia / reperfusion injury effects. It is further combined with goji berries (for nourishing yin and blood), longan (for replenishing qi and blood), hawthorn (for clearing turbidity and lowering lipids), jujubes (for nourishing blood and calming the mind), and amla (for beauty, skin care, and cardiovascular protection), among others. This formula nourishes the heart and beautifies the complexion.

[0025] Furthermore, a vigorous heart fire relies on the support of a healthy liver. Therefore, the formulation of the ginseng and bergamot compound tablets of this invention emphasizes both heart yang and liver wood. The liver governs the free flow of qi, promotes upward movement, thrives on smooth flow, stores blood and spirit, harmonizes qi and blood, regulates emotions, coordinates the ascending of spleen and the descending of stomach, and opens the orifice of the eyes. In the formulation of this invention, bergamot contains volatile oil and limonene, which can soothe the liver and regulate qi; wolfberry can nourish the liver and kidneys to treat sallow complexion and premature graying of hair caused by deficiency, and also has antioxidant and anti-aging effects; hawthorn is slightly warm in nature, enters the liver meridian, and has a good regulatory effect on hyperlipidemia; xylitol has excellent effects on inhibiting fatty liver, improving liver function, and treating hepatitis B and cirrhosis.

[0026] The heart fire and the spleen and stomach (the earth element) have a mother-child relationship; a child's illness will affect the mother, and the health of the spleen and stomach is also related to heart health. The spleen and stomach belong to earth, and earth relies on fire for its generation; when earth is abundant, fire is drained. A healthy spleen and stomach result in sufficient central qi. Therefore, beauty formulas must take into account the issue of central qi. The spleen in the body corresponds to the flesh (muscles), its orifice is the mouth, and its manifestation is in the lips. The spleen and stomach transform and transport the essence of water and grains, which is the material basis for physical and mental health. Ginseng in the formula can strengthen the spleen and lungs, greatly replenish vital energy, and regulate the central nervous system; Buddha's hand can harmonize the stomach, relieve pain, and dry dampness and resolve phlegm; yam strengthens the spleen and stomach; tangerine peel regulates qi, strengthens the spleen, harmonizes the stomach, stops vomiting, and dries dampness and resolves phlegm; hawthorn strengthens the stomach and aids digestion; ginger warms the middle jiao, stops vomiting, and relieves cold and dampness in the spleen and stomach; black pepper increases appetite; angelica root moistens the intestines and promotes bowel movements; jujube replenishes the middle jiao and benefits qi; and so on.

[0027] The five internal organs and six bowels are closely interconnected, with yin and yang in harmony and a balance of mutual generation and restraint. The formulation fully embodies systems thinking. It emphasizes the regulation of the heart (small intestine), liver (gallbladder), and spleen (stomach), while also considering the regulation of the lungs (large intestine) and kidneys (bladder). Ginseng in the formula benefits the lungs, Buddha's hand and tangerine peel resolve phlegm, ginger warms the lungs and stops coughs, black pepper eliminates phlegm and detoxifies, kelp moistens the lungs and eliminates phlegm, and white sesame seeds lubricate the intestines, promote bowel movements, delay aging, and lower cholesterol; goji berries and longan pulp benefit the kidneys, and since the liver and kidneys share a common origin, the formula contains many elements that regulate the liver, which are also beneficial to the kidneys. Systemic health leads to physical and mental health. Physical and mental health leads to a beautiful appearance.

[0028] The beneficial effects of this invention are:

[0029] 1. The extraction method of the present invention is different from water extraction or alcohol extraction, and can efficiently extract the beauty-enhancing active ingredients from ginseng and Buddha's hand, which can be used to quickly prepare ginseng and Buddha's hand compound tablets with beauty-enhancing effects.

[0030] 2. The ginseng and bergamot compound tablets of this invention are a food and medicine homology product. The formulation has a clear purpose, focusing on beauty and skin care, emphasizing both physical and mental well-being. It employs a clear distinction between principal and secondary ingredients, cleverly utilizing both medicinal and edible materials, maintaining yin-yang balance, considering the five elements' generating and restraining relationships, and harmonizing the internal organ systems. It highlights both beauty effects and systemic regulation, emphasizing yin-yang balance, organ harmony, and comprehensive improvement of vital energy and spirit. Attached Figure Description

[0031] Figure 1 Analysis of the results of extracting effective beauty ingredients using different solvents R1 and R4 in Comparative Example 1

[0032] Figure 2 This study analyzes the results of extracting effective beauty ingredients using different solvents, R2 and R5, in Comparative Example 2. Detailed Implementation

[0033] The technical solution of the present invention will be further described in detail below with reference to the accompanying drawings, but the scope of protection of the present invention is not limited to the following description.

[0034] Example 1

[0035] 500g of dried ginseng and bergamot were pulverized to 200 mesh (250g each). The ginseng and bergamot mixture was placed in solvent R1 (the weight ratio of the ginseng and bergamot mixture to the solvent was 6:100). Solvent R1 consisted of 60% water, 20% ethanol, 12% acetone, 8% diethyl ether, and 9% petroleum ether. Comparative experiments were conducted using pure ethanol, acetone, diethyl ether, and petroleum ether as individual solvents, as well as traditional extraction methods using water, ethanol, and a water / ethanol mixture as solvents. The mixture was then placed in a subcritical reactor, with the reaction temperature set at 110℃ and the reactor pressure at 3MPa for 45 minutes. After cooling, the mixture was filtered, and the filter residue was dried at 60℃. The filtrate was then evaporated using a rotary evaporator until all organic solvents were completely removed to obtain the active ingredients. The main chemical components were determined by UFLC-MS / MS, as shown in Table 1.

[0036] Table 1

[0037]

[0038] The results showed that the extracts obtained using the method described in this study were significantly higher than those obtained using traditional decoction methods and other solvent extraction methods. The extracts of various beauty-enhancing components using this method were 30%-40% higher than those obtained using traditional methods, especially the main beauty-enhancing components Ra2, Rg1, Rb1, and Rg3 in ginseng, and bergamot volatile oil, bergamot hesperidin, and trace amounts of bergamot corianderin, which were 40%-50% higher.

[0039] Example 2

[0040] 500g of dried ginseng and bergamot were pulverized to 200 mesh (250g each). The ginseng and bergamot mixture was placed in solvent R2 (the weight ratio of the ginseng and bergamot mixture to the solvent was 8:100). Solvent R2 consisted of 65% water, 15% ethanol, 5% acetone, 10% diethyl ether, and 12% petroleum ether. Comparative experiments were conducted using pure ethanol, acetone, diethyl ether, and petroleum ether as individual solvents, as well as traditional extraction methods using water, ethanol, and a water / ethanol mixture as solvents. The mixture was then placed in a subcritical reactor, with the reaction temperature set at 115℃ and the reactor pressure at 2MPa for 45 minutes. After cooling, the mixture was filtered, and the filter residue was dried at 60℃. The filtrate was then evaporated using a rotary evaporator until all organic solvents were completely removed to obtain the active ingredients. The main chemical components were determined by UFLC-MS / MS, as shown in Table 2.

[0041] Table 2

[0042]

[0043]

[0044] The results showed that the extracts obtained using the method described in this study were significantly higher than those obtained using traditional decoction methods and other solvent extraction methods. The extracts of various beauty-enhancing components using this method were 30%-40% higher than those obtained using traditional methods, especially the main beauty-enhancing components Ra2, Rg1, Rb1, and Rg3 in ginseng, and bergamot volatile oil, bergamot hesperidin, and trace amounts of bergamot corianderin, which were 40%-50% higher.

[0045] Example 3

[0046] 500g of dried ginseng and Buddha's hand citron were pulverized to 200 mesh (250g each). The ginseng and Buddha's hand citron mixture was placed in solvent R3 (the weight ratio of the ginseng and Buddha's hand citron mixture to the solvent was 10:100). Solvent R3 consisted of 60-70% water, 15% ethanol, 8% acetone, 8% diethyl ether, and 6% petroleum ether. Comparative experiments were conducted using pure ethanol, acetone, diethyl ether, and petroleum ether as individual solvents, as well as traditional extraction methods using water, ethanol, and water / ethanol as solvents. The mixture was then placed in a subcritical reactor, with the reaction temperature set at 130℃ and the reactor pressure at 1 MPa for 45 minutes. After cooling, the mixture was filtered, and the filter residue was dried at 60℃. The filtrate was then evaporated using a rotary evaporator until all organic solvents were completely removed to obtain the active ingredients. The main chemical components were determined by UFLC-MS / MS, as shown in Table 3.

[0047] Table 3

[0048]

[0049]

[0050] The results showed that the extracts obtained using the method described in this study were significantly higher than those obtained using traditional decoction methods and other solvent extraction methods. The extracts of various beauty-enhancing components obtained using this method were 30-40% higher than those obtained using traditional methods, especially the main beauty-enhancing components Ra2, Rg1, Rb1, and Rg3 in ginseng, as well as bergamot volatile oil, bergamot hesperidin, and trace amounts of bergamot corianderin, which were 30-40% higher.

[0051] Comparative Example 1

[0052] 500g of dried ginseng and bergamot were pulverized to 200 mesh (250g each). The ginseng and bergamot mixture was placed in solvent R4 (the weight ratio of the ginseng and bergamot mixture to the solvent was 6:100). The concentration range of solvent R4, which exceeded the range of this scheme, was 40% water, 30% ethanol, 20% acetone, 18% diethyl ether, and 12% petroleum ether. A new solvent R1 from this scheme was used as a control experiment. The mixture was then placed in a subcritical reactor, and the reaction temperature was set at 120℃ and the reactor pressure at 2 MPa for 45 minutes. After cooling, the mixture was filtered, and the filter residue was dried at 60℃. The filtrate was evaporated using a rotary evaporator until all organic solvents were completely removed to obtain the active ingredients. The main chemical components were determined by UFLC-MS / MS as shown in Table 4. Figure 1 As shown:

[0053] Table 4

[0054]

[0055]

[0056] The results showed that when the concentration of each solvent exceeded that of the proposed solution, the concentration of each component decreased. In particular, the main beauty-enhancing components of ginseng, Ra2, Rg1, Rb1, and Rg3, as well as bergamot volatile oil, bergamot hesperidin, and trace amounts of bergamot coriander glycoside, were all 30-40% lower than those in the proposed solution.

[0057] Comparative Example 2

[0058] 500g of dried ginseng and bergamot were pulverized to 200 mesh (250g each). The ginseng and bergamot mixture was placed in solvent R5 (the weight ratio of the ginseng and bergamot mixture to the solvent was 6:100). The concentration range of solvent R5 was lower than that of this scheme, which included 80% water, 8% ethanol, 6% acetone, 5% diethyl ether, and 5% petroleum ether. A new solvent R2 from this scheme was used as a control experiment. The mixture was then placed in a subcritical reactor, and the reaction temperature was set at 118℃ and the reactor pressure at 3MPa. The reaction was carried out for 45 minutes. After cooling, the mixture was filtered, and the filter residue was dried at 60℃. The filtrate was evaporated using a rotary evaporator until all organic solvents were completely removed to obtain the active ingredients. The main chemical components were determined by UFLC-MS / MS as shown in Table 5. Figure 2 As shown:

[0059] Table 5

[0060]

[0061]

[0062] The results showed that when the concentration of each solvent exceeded the concentration of the proposed solution, the concentration of each component decreased. In particular, the main beauty-enhancing components of ginseng, Ra2, Rg1, Rb1, and Rg3, as well as bergamot volatile oil, bergamot hesperidin, and trace amounts of bergamot coriander glycoside, were all 40-50% lower than those in the proposed solution.

[0063] The above description is merely a preferred embodiment of the present invention. It should be understood that the present invention is not limited to the forms disclosed herein and should not be construed as excluding other embodiments. It can be used in various other combinations, modifications, and environments, and can be altered within the scope of the concept described herein through the above teachings or related technologies or knowledge. Modifications and variations made by those skilled in the art that do not depart from the spirit and scope of the present invention should be within the protection scope of the appended claims.

Claims

1. A method for extracting the beautifying active ingredients of ginseng and bergamot, characterized in that, Includes the following steps: Ginseng and Buddha's hand are dried, pulverized, and mixed in a weight ratio of 1:1 to obtain a ginseng-Buddha's hand mixture. Then, a dissolving agent is added for subcritical extraction. The filter residue obtained after extraction is dried to obtain medicinal residue. The filtrate obtained after extraction is rotary evaporated to remove organic solvents to obtain the beauty active ingredients. The dissolving agent, by weight, comprises 60-70 parts water, 10-15 parts ethanol, 2-4 parts acetone, 5-8 parts diethyl ether, and 3-5 parts petroleum ether; The weight ratio of the ginseng and bergamot mixture to the dissolving agent is 3-6:50; The subcritical extraction temperature is 120-150℃ and the pressure is 0.5-3MPa.

2. The extraction method according to claim 1, characterized in that: The ginseng and Buddha's hand are dried and then pulverized to 100-200 mesh.

3. The application of the extraction method as described in any one of claims 1-2, characterized in that: The ginseng and bergamot active ingredients extracted by the extraction method are used to prepare ginseng and bergamot compound tablets.

4. The application according to claim 3, characterized in that: The preparation method of ginseng and bergamot compound includes the following steps: 150 parts of the medicinal residue and 15-22.5 parts of the beauty active ingredient are mixed, and then 150 parts of crushed wolfberry, 80 parts of amla, 80 parts of yam, 30 parts of tangerine peel, 30 parts of longan pulp, 30 parts of hawthorn, 30 parts of ginger, 30 parts of black pepper, 20 parts of angelica, 20 parts of kelp and 20 parts of xylitol are added to obtain ginseng and bergamot compound.

5. The application according to claim 4, characterized in that: The ingredients, including wolfberry, amla, yam, tangerine peel, longan pulp, hawthorn, ginger, black pepper, angelica, kelp, and xylitol, are ground to 150 mesh.

6. The application according to claim 4, characterized in that: The ginseng and bergamot compound is mixed with sucrose, starch, polyethylene glycol and dextrin, and then compressed into tablets to obtain the ginseng and bergamot compound tablets.

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