A coating liquid, a preparation method and application thereof, and a hydrophobic and stain-resistant coating and a preparation method thereof

Abstract

The application provides a coating liquid and a preparation method and application thereof, and a hydrophobic and anti-fouling coating and a preparation method thereof, and belongs to the technical field of medical functional materials. The application provides a coating liquid, which comprises the following components in mass content: 20-60% of solvent type polyamide-imide resin; 1-5% of thermoplastic elastomer resin; 1-5% of thermoplastic fluororesin; and the balance of diluent; the thermoplastic elastomer resin comprises maleic anhydride grafted styrene elastomer; and the thermoplastic fluororesin comprises polyperfluoroethylene propylene. The polyperfluoroethylene propylene resin used in the application can provide good hydrophobic and anti-fouling properties, and has thermoplasticity which polytetrafluoroethylene does not have; the maleic anhydride grafted styrene elastomer can improve the toughness of the coating and effectively absorb ultrasonic energy; and the polyamide-imide resin used as the base resin of the coating can provide good chemical stability and heat resistance and certain mechanical strength for the coating, and effectively fix other components of the coating.

Description

Technical Field

[0001] This invention belongs to the field of medical functional materials technology, specifically relating to a coating liquid and its preparation method and application, and a hydrophobic and antifouling coating and its preparation method. Background Technology

[0002] Hydrophobic and antifouling coatings have significant application value in protecting against fouling in daily life, shipping, and medical fields. The hydrophobic and antifouling function is typically achieved by introducing low surface energy fluorine- or silicon-containing materials into the coating. Patent application number CN201710265247.X discloses a fluorine-containing self-cleaning polymer and its application in a hydrophobic and antifouling coating liquid.

[0003] In the medical field, some medical devices encounter more complex contamination environments during use. For example, ultrasonic cutters utilize the cavitation effect of high-energy ultrasound to vaporize water molecules within tissues, break down cells, and cut the tissue. However, the heat energy converted from high-energy ultrasound can also easily cause human cells and tissues to char and adhere to the cutter head, thus hindering its normal use. In addition, the surface cleaning of some medical devices often requires the aid of ultrasonic cleaning processes.

[0004] However, fluorinated hydrophobic and antifouling coatings often have weak internal interactions due to their low surface energy, making them susceptible to damage in high-energy ultrasonic environments. Summary of the Invention

[0005] In view of this, the purpose of this invention is to provide a coating liquid, its preparation method and application, and a hydrophobic and antifouling coating and its preparation method. The hydrophobic and antifouling coating provided by this invention has good hydrophobicity and good antifouling effect on cells and tissues. At the same time, the coating has good strength and good stability in an ultrasonic environment of 20-55 kHz. Applying it to the surface of medical devices can significantly extend the service life of medical devices.

[0006] To achieve the above objectives, the present invention provides the following technical solution:

[0007] This invention provides a coating liquid comprising the following components in mass percentage:

[0008] Solvent-based polyamide-imide resin 20-60%;

[0009] 1-5% thermoplastic elastomer resin;

[0010] 1-5% thermoplastic fluoropolymer;

[0011] The remainder is diluent;

[0012] The thermoplastic elastomer resin includes maleic anhydride-grafted styrene elastomer;

[0013] The thermoplastic fluoropolymer includes perfluoroethylene propylene.

[0014] Preferably, the mass content of polyamide-imide resin in the solvent-based polyamide-imide resin is 20-30%.

[0015] Preferably, the maleic anhydride-grafted styrene elastomer comprises one or more of the following: maleic anhydride-grafted styrene-butadiene-styrene block copolymer, maleic anhydride-grafted styrene-hydrogenated butadiene-styrene block copolymer, and maleic anhydride-grafted styrene-isoprene-styrene block copolymer.

[0016] Preferably, the average particle size of the poly(fluoroethylene propylene) is 1–30 μm.

[0017] Preferably, the diluent includes one or more of N-methylpyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide, and xylene.

[0018] This invention provides a method for preparing the coating liquid described above, comprising the following steps:

[0019] The solvent-based polyamide-imide resin, thermoplastic fluororesin, thermoplastic elastomer resin, and diluent are mixed and ball-milled to obtain the coating liquid.

[0020] The present invention provides the application of the coating liquid described in the above-described scheme or the coating liquid prepared by the above-described method in the protection of the surface of an ultrasonic cutting tool or an ultrasonically cleanable instrument from contamination.

[0021] This invention provides a hydrophobic and antifouling coating, which is obtained by curing a coating liquid; the coating liquid is the coating liquid described in the above scheme or the coating liquid prepared by the preparation method described in the above scheme.

[0022] This invention provides a method for preparing the hydrophobic and antifouling coating described above, comprising the following steps:

[0023] The coating liquid is sprayed onto the surface of the metal substrate and cured to obtain the hydrophobic and antifouling coating.

[0024] Preferably, before spraying, the metal substrate is further subjected to an amination treatment.

[0025] This invention provides a coating liquid comprising the following components by mass: 20-60% solvent-based polyamide-imide resin; 1-5% thermoplastic elastomer resin; 1-5% thermoplastic fluororesin; and the balance being a diluent. The thermoplastic elastomer resin includes maleic anhydride-grafted styrene elastomer; and the thermoplastic fluororesin includes perfluoroethylene propylene. The use of perfluoroethylene propylene resin in this invention provides good hydrophobicity and antifouling properties, and possesses thermoplasticity not found in polytetrafluoroethylene (PTFE). Using maleic anhydride-grafted styrene elastomer as a component of the coating liquid improves its toughness as a coating and effectively absorbs ultrasonic energy. Using solvent-based polyamide-imide resin as a component of the coating liquid, when used as a coating, the polyamide-imide resin serves as the base resin, providing good chemical stability, heat resistance, and a certain mechanical strength to the coating, and effectively fixing other components of the coating. Therefore, the coating provided by the present invention has good hydrophobicity and good anti-fouling effect on cells and tissues. At the same time, the coating has good strength and good stability in an ultrasonic environment of 20-55kHz. Applying it to the surface of medical devices can significantly extend the service life of medical devices.

[0026] Medical device coatings differ significantly from coatings in other fields in that they require strict control over cytotoxicity. Therefore, the coating should contain as few toxic small-molecule catalysts and initiators as possible to prevent their migration into human tissues during use. The hydrophobic and antifouling coating provided by this invention does not contain small-molecule initiators or catalysts. After the added diluent completely evaporates during the gradient thermosetting process, the resulting coating consists only of resin, thus exhibiting excellent biocompatibility.

[0027] Furthermore, in preparing the hydrophobic and antifouling coating, the present invention first performs an amination treatment on the metal substrate, which enables the metal substrate surface to be grafted with amino groups. Then, some of the carboxyl groups of the polyamide imide and maleic anhydride grafted elastomer undergo a condensation reaction with the amino groups on the metal substrate at high temperature (curing), thereby forming a strong bonding force with the metal substrate and effectively improving the interfacial bonding strength between the metal substrate and the coating. Attached Figure Description

[0028] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0029] Figure 1 The water contact angle diagrams are shown for the coatings obtained in Examples 1-3;

[0030] Figure 2Scanning electron microscope images of cell adhesion after 1 hour of contact between the surface of a pure titanium substrate without pretreatment and the surface of a pure titanium substrate with a hydrophobic and antifouling coating in Example 2 and blood cells.

[0031] Figure 3 Optical microscope images of the surface tissue adhesion after cutting tissue of the pure titanium substrate without fluorine resin coating in Comparative Example 1 and the pure titanium substrate with hydrophobic and antifouling coating (containing fluorine resin) obtained in Example 2.

[0032] Figure 4 The ultrasonic scalpel head with no elastomer coating obtained in Comparative Example 2 and the ultrasonic scalpel head with hydrophobic and antifouling coating containing elastomer obtained in Example 3 are shown in the appearance images after being excited by 55kHz ultrasound for 10min.

[0033] Figure 5 The images show tissue adhesion after 200 and 400 ultrasonic cuts of animal muscle tissue at 55 kHz using an uncoated ultrasonic scalpel tip (an ultrasonic scalpel tip made of TC4 titanium alloy without pretreatment) and an ultrasonic scalpel tip with a coating as described in Example 3. Detailed Implementation

[0034] This invention provides a coating liquid comprising the following components in mass percentage:

[0035] Solvent-based polyamide-imide resin 20-60%;

[0036] 1-5% thermoplastic elastomer resin;

[0037] 1-5% thermoplastic fluoropolymer;

[0038] The remainder is diluent;

[0039] The thermoplastic elastomer resin includes maleic anhydride-grafted styrene elastomer;

[0040] The thermoplastic fluoropolymer includes perfluoroethylene propylene.

[0041] Unless otherwise specified, all materials and equipment used in this invention are commercially available.

[0042] The coating liquid provided by the present invention comprises 20-60% solvent-based polyamide-imide resin, preferably 30-55%, and more preferably 40-50%, by mass content. In the present invention, the mass content of polyamide-imide resin in the solvent-based polyamide-imide resin is preferably 20-30%, and more preferably 22-25%. In the present invention, the solvent in the solvent-based polyamide-imide resin preferably includes N-methylpyrrolidone (NMP), N,N-dimethylformamide (DMF), or N,N-dimethylacetamide (DMAC). The present invention uses solvent-based polyamide-imide resin as a component of the coating liquid. When used as a coating, the polyamide-imide resin serves as the base resin of the coating, providing good chemical stability, heat resistance, and a certain mechanical strength, and effectively fixing other components of the coating.

[0043] The coating liquid provided by the present invention comprises 1-5% thermoplastic elastomer resin, preferably 1.5-3.5%, and more preferably 2-3%, by mass content. In the present invention, the thermoplastic elastomer resin comprises maleic anhydride-grafted styrene elastomer; the maleic anhydride-grafted styrene elastomer preferably comprises one or more of maleic anhydride-grafted styrene-butadiene-styrene block copolymer (MAH-g-SBS), maleic anhydride-grafted styrene-hydrogenated butadiene-styrene block copolymer (MAH-g-SEBS), and maleic anhydride-grafted styrene-isoprene-styrene block copolymer (MAH-g-SIS). In the present invention, the maleic anhydride grafting degree in the maleic anhydride-grafted styrene elastomer is preferably 2-10%, more preferably 5-8%. The present invention uses maleic anhydride-grafted styrene elastomer as a component of the coating liquid, which can improve its toughness as a coating and effectively absorb ultrasonic energy.

[0044] The coating liquid provided by this invention comprises 1-5% thermoplastic fluoropolymer, preferably 1.5-3.5%, by mass content. In this invention, the thermoplastic fluoropolymer comprises perfluoroethylene propylene; the average particle size of the perfluoroethylene propylene is preferably 1-30 μm, more preferably 5-25 μm, and even more preferably 10-20 μm. The perfluoroethylene propylene resin used in this invention provides good hydrophobicity and antifouling properties, and possesses thermoplasticity not found in polytetrafluoroethylene (PTFE).

[0045] The coating liquid provided by this invention includes a balance of diluent. In this invention, the diluent preferably includes one or more of N-methylpyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide, and xylene.

[0046] This invention provides a method for preparing the coating liquid described above, comprising the following steps:

[0047] The solvent-based polyamide-imide resin, thermoplastic fluororesin, thermoplastic elastomer resin, and diluent are mixed and ball-milled to obtain the coating liquid.

[0048] In this invention, the ball milling speed is preferably 400 rpm and the time is preferably 6 hours.

[0049] After the ball milling is completed, the present invention preferably filters the obtained ball milling slurry to obtain the coating liquid.

[0050] In this invention, the filtration is preferably performed using a 1000-mesh filter cloth.

[0051] This invention provides the application of the coating liquid described in the above-described scheme or the coating liquid prepared by the preparation method described in the above-described scheme in the protection of the surface of ultrasonic cutting blades or ultrasonically cleanable instruments from contamination.

[0052] This invention provides a hydrophobic and antifouling coating, which is obtained by curing a coating liquid; the coating liquid is the coating liquid described in the above scheme or the coating liquid prepared by the preparation method described in the above scheme.

[0053] In this invention, the surface water contact angle of the hydrophobic and antifouling coating is preferably 90-130°, and more preferably 100-120°.

[0054] The hydrophobic and antifouling coating provided by this invention has good hydrophobicity and good antifouling effect on cells and tissues. At the same time, the coating has good strength and good stability in an ultrasonic environment of 20-55kHz. Applying it to the surface of medical devices can significantly extend the service life of medical devices.

[0055] Medical device coatings differ significantly from coatings in other fields in that they require strict control over cytotoxicity. Therefore, the coating should contain as few toxic small-molecule catalysts and initiators as possible to prevent their migration into human tissues during use. The hydrophobic and antifouling coating provided by this invention does not contain small-molecule initiators or catalysts. After the added diluent completely evaporates during the gradient thermosetting process, the resulting coating consists only of resin, thus exhibiting excellent biocompatibility.

[0056] This invention provides a method for preparing the hydrophobic and antifouling coating described above, comprising the following steps:

[0057] The coating liquid is sprayed onto the surface of the metal substrate and cured to obtain the hydrophobic and antifouling coating.

[0058] In this invention, the process of spraying preferably includes amylating the metal substrate.

[0059] In this invention, the amination treatment preferably includes: sandblasting the metal substrate, then immersing the sandblasted metal substrate in an aminosilane coupling agent solution, and then baking it.

[0060] In this invention, the metal substrate preferably includes a stainless steel substrate, a titanium alloy substrate, or a pure titanium substrate. In this invention, the sandblasting abrasive is preferably 200-400 mesh corundum, more preferably 250-350 mesh. This invention does not have any particular requirements for the sandblasting; methods well known in the art can be used.

[0061] After the sandblasting is completed, the present invention preferably cleans and dries the sandblasted metal substrate with anhydrous ethanol.

[0062] In this invention, the aminosilane coupling agent solution is preferably obtained by dissolving an aminosilane coupling agent in a methanol-water solution; the aminosilane coupling agent preferably includes KH540 or KH550. In this invention, the mass content of the aminosilane coupling agent in the aminosilane coupling agent solution is preferably 2-10%, more preferably 5-8%; the mass ratio of methanol to water in the methanol-water solution is preferably (15-20):(1-3), more preferably (16-18):(1.5-2.5). In this invention, the soaking time is preferably 0.5-2 hours, more preferably 0.8-1.5 hours. In this invention, the baking temperature is preferably 120°C; the baking time is preferably 0.5-2 hours, more preferably 0.8-1.5 hours.

[0063] The present invention enables the aminosilane coupling agent to fully bond with the metal substrate through baking, and causes the solvent (methanol-water) to evaporate.

[0064] This invention employs sandblasting of a metal substrate and uses an aminosilane coupling agent to amination the surface of the metal substrate, thereby enabling the grafting of amino groups onto the surface of the metal substrate.

[0065] In this invention, the curing preferably includes: heating from 60°C to 300°C; the heating rate is preferably 20-40°C / h, more preferably 25-35°C / h; and the heating is preferably uniform.

[0066] This invention sprays a coating liquid onto the surface of an aminated metal substrate, which allows some of the carboxyl groups of the polyamide-imide and maleic anhydride-grafted elastomer to undergo a condensation reaction with the amino groups on the metal substrate at high temperature (curing), thereby forming a strong bond with the metal substrate and effectively improving the interfacial bonding strength between the metal substrate and the coating.

[0067] To further illustrate the present invention, the following detailed description, in conjunction with the accompanying drawings and embodiments, provides a coating liquid, its preparation method, its application, and the coating and its preparation method, but these descriptions should not be construed as limiting the scope of protection of the present invention.

[0068] Example 1

[0069] Substrate pretreatment: The 316L stainless steel substrate was sandblasted with 200-mesh corundum and then cleaned and dried with anhydrous ethanol. Then, 0.5g of silane coupling agent KH540, 17g of methanol, and 2g of deionized water were mixed to obtain a mixed solution. The sandblasted 316L stainless steel substrate was immersed in the obtained mixed solution for 0.5h, then removed and baked at 120℃ for 0.5h to allow KH540 to fully bond with the surface of the 316L stainless steel substrate and to allow the solvents methanol and water to fully evaporate, resulting in an amination-treated stainless steel substrate.

[0070] Preparation of hydrophobic and antifouling coating liquid: Poly(fluoroethylene propylene) and MAH-g-SBS were thoroughly dried to remove surface moisture; then 12g of solvent-based polyamide-imide resin (solvent DMF, resin mass fraction 30%), 0.6g of MAH-g-SBS, 0.66g of poly(fluoroethylene propylene) micro powder and 9g of DMAc were mixed and ball-milled at 400rpm for 6h. The coating liquid was then obtained by filtration through a 1000-mesh filter cloth.

[0071] Preparation of hydrophobic and antifouling coating: The coating liquid is applied to the surface of the aminated stainless steel substrate by spraying. After gradient heating and curing, the temperature is cooled to room temperature in the oven. The curing temperature is uniformly increased from 60°C to 300°C at a rate of 40°C / h to obtain the hydrophobic and antifouling coating.

[0072] Example 2

[0073] Substrate pretreatment: The pure titanium substrate was sandblasted with 280-mesh corundum and then cleaned and dried with anhydrous ethanol. Then, 1g of silane coupling agent KH540, 17g of methanol and 2g of deionized water were mixed into a solution, and the sandblasted pure titanium was immersed in the mixed solution for 0.5h. Then it was taken out and baked at 120℃ for 0.5h to obtain an aminated pure titanium substrate.

[0074] Preparation of hydrophobic and antifouling coating liquid: Poly(fluoroethylene propylene) and MAH-g-SBS were thoroughly dried to remove surface moisture beforehand; then 12g of solvent-based polyamide-imide resin (solvent DMF, resin mass fraction 25%), 0.6g of MAH-g-SBS, 9g of NMP and 9g of xylene were mixed and then mixed with 0.36g of poly(fluoroethylene propylene). The mixture was ball-milled at 400rpm for 6h and filtered through a 1000-mesh filter cloth to obtain the coating liquid.

[0075] Preparation of hydrophobic and antifouling coating: The coating liquid is applied to the surface of an aminated pure titanium substrate by spraying. After gradient heating and curing, the substrate is cooled to room temperature in the furnace. The temperature is then uniformly increased from 60°C to 300°C at a rate of 20°C / h to obtain the hydrophobic and antifouling coating.

[0076] Example 3

[0077] Substrate pretreatment: The ultrasonic cutter head made of TC4 titanium alloy was sandblasted with 200-mesh corundum and then cleaned and dried with anhydrous ethanol. Then, 1g of silane coupling agent KH540, 17g of methanol and 2g of deionized water were mixed into a solution, and the sandblasted cutter head was immersed in the mixed solution for 1 hour. Then, it was taken out and baked at 120℃ for 2 hours to obtain an amination titanium alloy cutter head.

[0078] Preparation of hydrophobic and antifouling coating liquid: Poly(fluoroethylene propylene) and MAH-g-SBS were thoroughly dried to remove surface moisture; then 12g of solvent-based polyamide-imide resin (solvent DMF, resin mass fraction 20%), 0.6g of MAH-g-SEBS, 9g of NMP and 9g of xylene were premixed and mixed with 0.36g of poly(fluoroethylene propylene), ball-milled at 400rpm for 6h, and filtered through a 1000-mesh filter cloth to obtain the coating liquid.

[0079] Preparation of hydrophobic and antifouling coating: The coating liquid is applied to the surface of the aminated titanium alloy cutting head by spraying. After gradient heating and curing, the temperature is lowered to room temperature in the furnace. The temperature is then uniformly increased from 60°C to 300°C at a heating rate of 20°C / h to obtain the hydrophobic and antifouling coating.

[0080] Comparative Example 1

[0081] The preparation steps are the same as in Example 2, except that the coating liquid does not contain polytetrafluoroethylene propylene.

[0082] Comparative Example 2

[0083] The preparation steps are the same as in Example 3, except that the coating liquid does not contain MAH-g-SEBS elastomer.

[0084] Performance testing

[0085] The coatings obtained in Examples 1-3 were subjected to wetting performance tests, and the test results are as follows: Figure 1 As shown. The static water contact angles of the coatings obtained in Examples 1 to 3 are 130°, 90°, and 103°, respectively, indicating that they have good hydrophobicity.

[0086] Figure 2Scanning electron microscopy (SEM) images of cell adhesion after 1 hour of contact between the surfaces of untreated pure titanium substrates and the pure titanium substrate with a hydrophobic and antifouling coating (Example 2). It can be seen that the surface of the pure titanium substrate has a large number of red blood cells, while the surface of the pure titanium substrate with the hydrophobic and antifouling coating has almost no blood cell adhesion. This indicates that the hydrophobic and antifouling coating prepared in this invention has a good antifouling effect on cells, and at the same time, the coating has good strength.

[0087] Figure 3 Optical microscope images of the surface tissue adhesion after cutting tissue of the pure titanium substrate without fluorine resin coating in Comparative Example 1 and the pure titanium substrate with hydrophobic and antifouling coating (fluorine resin) obtained in Example 2.

[0088] After heating the fluorine-free coating to 100°C and cutting animal muscle tissue 10 times, tissue adhesion was still observed after ultrasonic cleaning at 40 kHz for 10 minutes. However, after heating the hydrophobic and antifouling coating containing fluorine resin to 100°C and cutting tissue 10 times, no tissue adhesion was observed on the surface after ultrasonic cleaning at 40 kHz for 10 minutes. This demonstrates that the addition of fluorine resin can significantly improve the antifouling properties of the coating.

[0089] Figure 4 The images show the appearance of the ultrasonic scalpel head with no elastomer coating obtained in Comparative Example 2 and the ultrasonic scalpel head with an elastomer-containing hydrophobic and antifouling coating obtained in Example 3 after being excited by 55 kHz ultrasound for 10 min.

[0090] As can be seen from the figure, the coating without elastomers showed significant large-scale peeling after ultrasonication, while the hydrophobic and antifouling coating with elastomers did not peel off, proving that the addition of elastomers can significantly improve the stability of the coating in the ultrasonic environment.

[0091] Figure 5 The images show tissue adhesion after 200 and 400 ultrasonic cuts of animal muscle tissue at 55 kHz using an uncoated ultrasonic scalpel tip (an ultrasonic scalpel tip made of TC4 titanium alloy without pretreatment) and an ultrasonic scalpel tip with a coating as described in Example 3.

[0092] Uncoated ultrasonic scalpels showed a large amount of tissue adhesion marks on their surface after 200 ultrasonic cuts. Ultrasonic scalpels with hydrophobic and antifouling coatings showed no obvious tissue adhesion after 200 and 400 ultrasonic cuts, and their surfaces remained smooth. This proves that the coating can significantly improve the anti-biological tissue contamination properties of ultrasonic scalpels.

[0093] The coating obtained in Example 2 was subjected to MTT cytotoxicity testing. The test method followed GB / T16886.5-2017. The blank control group was MEM medium containing 10% fetal bovine serum, the positive control was DMSO, and the 100% sample test solution was prepared by mixing the coating and the medium at a 3cm depth. 2The test solutions were prepared by diluting 1 mL of the extracted solution with culture medium. 50%, 25%, and 12.5% ​​sample solutions were prepared from 100% test solution with a specific ratio. The negative control was a high-density polyethylene extract. Grading from 0 to 4 represents cell response from none to severe.

[0094] Table 1. MTT cytotoxicity test results of the coating in Example 2.

[0095]

[0096] As shown in Table 1, the cell grading of the test solution for the hydrophobic and antifouling coating was 0, proving that it has no cytotoxicity.

[0097] Although the above embodiments have provided a detailed description of the present invention, they are only some embodiments of the present invention, and not all embodiments. People can obtain other embodiments based on these embodiments without creative effort, and these embodiments all fall within the protection scope of the present invention.

Claims

1. A coating liquid, characterized in that, The components include the following mass content: The solvent-based polyamide-imide resin comprises 20-60% by mass, wherein the polyamide-imide resin in the solvent-based polyamide-imide resin comprises 20-30% by mass. 1-5% thermoplastic elastomer resin; 1-5% thermoplastic fluoropolymer; The remainder is diluent; The thermoplastic elastomer resin includes maleic anhydride-grafted styrene elastomer; The thermoplastic fluoropolymer includes perfluoroethylene propylene.

2. The coating liquid according to claim 1, characterized in that, The maleic anhydride-grafted styrene elastomer includes one or more of the following: maleic anhydride-grafted styrene-butadiene-styrene block copolymer, maleic anhydride-grafted styrene-hydrogenated butadiene-styrene block copolymer, and maleic anhydride-grafted styrene-isoprene-styrene block copolymer.

3. The coating liquid according to claim 1, characterized in that, The average particle size of the poly(fluoroethylene propylene) is 1~30μm.

4. The coating liquid according to any one of claims 1 to 3, characterized in that, The diluent includes one or more of N-methylpyrrolidone, N,N-dimethylformamide, N,N-dimethylacetamide, and xylene.

5. The method for preparing the coating liquid according to any one of claims 1 to 4, characterized in that, Includes the following steps: The solvent-based polyamide-imide resin, thermoplastic fluororesin, thermoplastic elastomer resin, and diluent are mixed and ball-milled to obtain the coating liquid.

6. The application of the coating liquid according to any one of claims 1 to 4 or the coating liquid prepared by the preparation method of claim 5 in the protection of the surface of an ultrasonic cutting blade or an ultrasonically cleanable instrument from contamination.

7. A hydrophobic and antifouling coating, characterized in that, It is obtained by curing a coating liquid; the coating liquid is the coating liquid according to any one of claims 1 to 4 or the coating liquid prepared by the preparation method according to claim 5.

8. The method for preparing the hydrophobic and antifouling coating according to claim 7, characterized in that, Includes the following steps: The coating liquid is sprayed onto the surface of the metal substrate and cured to obtain the hydrophobic and antifouling coating.

9. The preparation method according to claim 8, characterized in that, Before spraying, the metal substrate is subjected to an amination treatment.

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