A traditional Chinese medicine composition for treating pharyngitis and its preparation method

Abstract

This invention discloses a traditional Chinese medicine composition for treating pharyngitis and its preparation method, belonging to the field of traditional Chinese medicine technology. The composition, by weight, is made from the following raw materials: 1-18 parts of Astilbe, 1-12 parts of *Trifolium repens*, 1-30 parts of *Solidago virgaurea*, 1-30 parts of Forsythia suspensa, 1-24 parts of Asparagus cochinchinensis, 1-21 parts of Ophiopogon japonicus, 1-30 parts of Scrophularia ningpoensis, 1-30 parts of Chrysanthemum indicum, 1-30 parts of Rehmannia glutinosa, 1-20 parts of Platycodon grandiflorus, and 1-20 parts of Glycyrrhiza uralensis. Astilbe, Trifolium repens, and *Solidago virgaurea* are the principal herbs; Scrophularia ningpoensis, Forsythia suspensa, and Chrysanthemum indicum are the assistant herbs; Rehmannia glutinosa, Ophiopogon japonicus, and Asparagus cochinchinensis are the adjuvant herbs; and Platycodon grandiflorus and Glycyrrhiza uralensis are the guiding herbs. This composition is mainly used to treat sore throat caused by yin deficiency and internal heat, and is suitable for acute pharyngitis, chronic pharyngitis, and tonsillitis. It has the effects of clearing heat and detoxifying, nourishing yin and reducing fire, dispersing nodules and reducing swelling, and clearing the throat.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating pharyngitis and a preparation method thereof. Background Art

[0002] In recent years, with the changes in living environment and lifestyle, the incidence of human respiratory diseases, especially throat diseases, has been increasing year by year. Among them, acute pharyngitis is one of the most common diseases in otolaryngology, and chronic pharyngitis is one of the difficult-to-treat diseases in otolaryngology. Laryngeal obstruction is a pharyngeal disease mainly characterized by sore throat or foreign body sensation discomfort, red and swollen pharynx, or granular protrusions at the bottom of the throat. The "Diagnostic and Therapeutic Criteria for Traditional Chinese Medicine Internal Medicine Syndromes" (ZY / T001.1-94) classifies laryngeal obstruction into acute laryngeal obstruction and chronic laryngeal obstruction. Acute laryngeal obstruction is an acute pharyngeal disease caused by exogenous pathogens invading the pharynx, characterized by sore throat and swelling of the pharyngeal mucosa, that is, acute pharyngitis. Chronic laryngeal obstruction is a chronic pharyngeal disease caused by weakness of the viscera, loss of nourishment of the pharynx, or stagnation of pathogens in the pharynx, characterized by discomfort in the pharynx, swelling or atrophy of the pharyngeal mucosa, that is, chronic pharyngitis. Laryngeal obstruction is classified into exogenous wind-cold attack, exogenous wind-heat invasion, excessive heat in the lung and stomach, yin deficiency of the lung and dryness, deficiency of the lung and spleen qi, and phlegm-heat accumulation according to different syndromes.

[0003] From the perspective of modern medicine, throat diseases are mainly manifested as swelling and pain in the throat and discomfort in breathing obstruction. Modern medicine generally believes that there are various pathogenic bacteria in the oral and throat areas, such as hemolytic streptococcus, etc., which form a dynamic balance with other microbial communities in the body. With the change of the internal microenvironment of the human body, for example, when the body's resistance to diseases decreases or when the voice is used too much or excessively due to various reasons, the natural balance of the original microbial community will be disrupted, and harmful pathogenic bacteria will rapidly multiply abnormally in large numbers, causing serious infections. As a result, typical symptoms such as dryness, pain, and swelling appear in the throat or adjacent areas, and inflammation appears in areas such as the pharyngeal mucosa, submucosa, and lymphoid tissue.

[0004] For the treatment of acute pharyngitis and chronic pharyngitis, Western medicine mainly uses antibacterial, antiviral, and glucocorticoid drugs, such as cephalosporins, penicillins, roxithromycin, etc. However, it is prone to recurrence, and if not cured, it will turn into chronic. Long-term use of drugs is extremely likely to produce drug resistance, and there are also various adverse reactions. At the same time, antibiotics are ineffective in treating sore throats caused by viral infections and will also cause the problem of environmental antibiotic pollution.

[0005] Traditional Chinese medicine (TCM) has advantages in treating acute and chronic pharyngitis, such as fewer side effects and addressing both the symptoms and the root cause. For example, Chinese patent document CN103041160A discloses a TCM composition for treating acute pharyngitis. The raw materials of this TCM composition include Polygonum cuspidatum, Polygonum cuspidatum, Acorus tatarinowii, Mahonia fortunei, Sterculia lychnophora, Scutellaria baicalensis, Cicadae periostracum, Dioscorea opposita, Aster tataricus, Sophora japonica, Galla chinensis, Gleditsia sinensis, Solidago virgaurea, Indigo naturalis, Ephedra sinica, Panax ginseng, Polygonatum odoratum, Hippophae rhamnoides, Terminalia chebula, Scrophularia ningpoensis, Piper kadsura, Panax japonicus, Lycoperdon perlatum, Adenophora stricta, Dioscorea opposita, Catechu, and Glycyrrhiza uralensis. This composition can not only control the symptoms of acute pharyngitis but also enhance the body's immunity. Chinese patent document CN108815360A discloses a traditional Chinese medicine composition for treating acute tonsillitis and acute pharyngitis in children. This composition is made from the following herbal raw materials in the indicated weight ratios: honeysuckle 105-145 parts, forsythia 105-145 parts, scrophularia 105-145 parts, dandelion 105-145 parts, red peony root 30-70 parts, scutellaria baicalensis 55-95 parts, mulberry leaf 30-70 parts, chrysanthemum 30-70 parts, angelica dahurica 30-70 parts, bitter almond 30-70 parts, burdock seed 30-70 parts, alisma plantago-aquatica 30-70 parts, sterculia lychnophora 30-70 parts, fritillaria thunbergii 30-70 parts, cicada slough 30-70 parts, and oroxylum indicum 30-70 parts. However, the above-mentioned traditional Chinese medicine composition is only used to treat acute pharyngitis and has a complex composition.

[0006] Chinese patent document CN117562947A discloses a traditional Chinese medicine composition for treating acute pharyngitis and acute exacerbations of chronic pharyngitis. This composition consists of the following raw materials in parts by weight: 5-25 parts of Isatis root, 3-21 parts of Arctium fruit, 5-25 parts of Scrophularia root, 3-15 parts of Gardenia fruit, 2-12 parts of Saposhnikovia root, 3-15 parts of Platycodon root, 1-9 parts of Peppermint, 2-12 parts of Cicadae periostracum, 2-15 parts of Licorice root, 2-15 parts of Schizonepeta, and 2-15 parts of Scutellaria root. In this formula, Isatis root, Arctium fruit, and Scrophularia root are the principal herbs; Gardenia fruit and Scutellaria root are the assistant herbs; Schizonepeta, Saposhnikovia root, Peppermint, Cicadae periostracum, and Platycodon root are the adjuvant herbs; and Licorice root is the guiding herb. While this traditional Chinese medicine composition has significant efficacy in treating acute pharyngitis and acute exacerbations of chronic pharyngitis, it is primarily used to treat wind-heat throat obstruction. Summary of the Invention

[0007] To address the issues of tolerance to Western medicine treatments for pharyngitis and the complex composition of traditional Chinese medicine compositions, this invention provides a traditional Chinese medicine composition for treating pharyngitis. This composition is primarily used to treat throat pain caused by yin deficiency and internal heat, and tonsillitis. It is suitable for acute pharyngitis, chronic pharyngitis, and tonsillitis, and has the effects of clearing heat and detoxifying, nourishing yin and reducing fire, dispersing nodules and reducing swelling, and clearing the throat.

[0008] The specific technical solution adopted is as follows:

[0009] A traditional Chinese medicine composition for treating pharyngitis, comprising, by weight, the following raw materials:

[0010] Astilbe 1-18 parts, Trifolium repens 1-12 parts, Solidago virgaurea 1-30 parts, Forsythia suspensa 1-30 parts, Asparagus cochinchinensis 1-24 parts, Ophiopogon japonicus 1-21 parts, Scrophularia ningpoensis 1-30 parts, Chrysanthemum indicum 1-30 parts, Rehmannia glutinosa 1-30 parts, Platycodon grandiflorus 1-20 parts, and Glycyrrhiza uralensis 1-20 parts.

[0011] Preferably, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 6-9 parts of Astilbe, 3-6 parts of Trifoliate Orange, 9-15 parts of Solidago Flos, 6-15 parts of Forsythia, 6-12 parts of Asparagus Root, 6-12 parts of Ophiopogon Root, 9-15 parts of Scrophularia Root, 9-15 parts of Chrysanthemum indicum, 10-15 parts of Rehmannia Root, 3-10 parts of Platycodon Root, and 2-10 parts of Licorice Root.

[0012] More preferably, the traditional Chinese medicine composition is made from the following raw materials in parts by weight: 6 parts of Astilbe, 6 parts of Trifoliate Orange, 15 parts of Solidago virgaurea, 10 parts of Forsythia, 10 parts of Asparagus, 10 parts of Ophiopogon japonicus, 15 parts of Scrophularia ningpoensis, 10 parts of Chrysanthemum indicum, 10 parts of Rehmannia glutinosa, 6 parts of Platycodon grandiflorus, and 6 parts of Glycyrrhiza uralensis.

[0013] The traditional Chinese medicine composition provided by this invention is mainly used to treat sore throat caused by yin deficiency and internal heat, and sore throat caused by tonsillitis. It is suitable for acute pharyngitis, chronic pharyngitis and tonsillitis, and has the effects of clearing heat and detoxifying, nourishing yin and reducing fire, dispersing nodules and reducing swelling, and clearing the throat. Among them, Astilbe, Trifolium repens, and Solidago virgaurea are the principal herbs for clearing phlegm and relieving sore throat, detoxifying and reducing swelling; Scrophularia and Forsythia clear heat, nourish yin and disperse nodules, and Chrysanthemum indicum dispels wind and clears heat, clears fire and detoxifies, and assists the principal herbs in clearing the throat, and are the assistant herbs; Rehmannia glutinosa, Ophiopogon japonicus, and Asparagus cochinchinensis nourish yin and moisten dryness, clear the lungs and reduce fire, and have the purpose of "strengthening the water element to control the fire element", and are the adjuvant herbs; Platycodon grandiflorus and Glycyrrhiza uralensis are famous for sore throat, which can promote lung function, clear phlegm, relieve sore throat and stop itching, promote blood circulation and disperse nodules. Platycodon grandiflorus also has the effect of guiding the medicine upward, and Glycyrrhiza uralensis harmonizes the other herbs, and is the guiding herb. The formula combines dispelling pathogens with strengthening the body's foundation, nourishing the yin of the lungs and stomach, clearing the fire of the liver and lungs, and removing stagnant toxins, so that dryness is moistened, swelling is reduced, and itching and pain are relieved.

[0014] The present invention also provides a method for preparing the aforementioned traditional Chinese medicine composition, comprising the following steps:

[0015] Take the following herbs according to the selected weight proportions: Asparagus cochinchinensis, Trifolium repens, Solidago virgaurea, Forsythia suspensa, Asparagus cochinchinensis, Ophiopogon japonicus, Scrophularia ningpoensis, Chrysanthemum indicum, Rehmannia glutinosa, Platycodon grandiflorus, and Glycyrrhiza uralensis. Add water and decoct. After decoction, filter and combine the filtrates. Concentrate the filtrates to obtain the final product.

[0016] Optionally, add 5-8 times the total weight of the raw medicinal materials to the decoction.

[0017] Furthermore, the herbs are decocted three times with water. The ratio of the total weight of the raw materials to the amount of water added during the three decoctions is 1:8, 1:8, and 1:5, respectively.

[0018] Preferably, the filtrate is concentrated at ≤80℃ until the density is 1.0-1.8 g / mL.

[0019] The present invention also provides a traditional Chinese medicine compound preparation, comprising the aforementioned traditional Chinese medicine composition.

[0020] Optionally, the traditional Chinese medicine compound preparation may also include pharmaceutically acceptable excipients, and the dosage form of the traditional Chinese medicine compound preparation may include decoction, tablet, capsule, powder, granule, pill, oral liquid or syrup.

[0021] The present invention also provides the application of the aforementioned traditional Chinese medicine composition or the aforementioned traditional Chinese medicine compound preparation in the preparation of throat-clearing and throat-soothing medicines.

[0022] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0023] (1) In the traditional Chinese medicine composition formula provided by this invention, Astilbe, Trifolium repens, and Solidago virgaurea are used as principal herbs to dispel phlegm, soothe the throat, detoxify, and reduce swelling; Scrophularia ningpoensis and Forsythia suspensa are used to clear heat, nourish yin, and dissipate nodules; Chrysanthemum indicum is used to dispel wind, clear heat, and detoxify, assisting the principal herbs in clearing the throat, and are used as assistant herbs; Rehmannia glutinosa, Ophiopogon japonicus, and Asparagus cochinchinensis are used to nourish yin, moisten dryness, clear the lungs, and reduce fire, with the aim of "strengthening the water element to control the fire element", and are used as adjuvant herbs; Platycodon grandiflorus and Glycyrrhiza uralensis are used in a famous formula for sore throat, which promotes lung function, dispels phlegm, soothes the throat, relieves itching, invigorates blood, and dissipates nodules. Platycodon grandiflorus also has the effect of guiding the medicine upwards, and Glycyrrhiza uralensis harmonizes the other herbs, and is used as the guiding herb. The whole formula combines dispelling pathogens with strengthening the body's foundation, nourishing the yin of the lungs and stomach, clearing the fire of the liver and lungs, and removing the pathogenic factors of blood stasis and toxins, so that dryness is moistened, swelling is reduced, and itching and pain are relieved.

[0024] (2) The synergistic effect of the 11 medicinal materials in the traditional Chinese medicine composition of the present invention, as shown in animal experiments, can improve the congestion and swelling of the pharynx, reduce pharyngeal secretions, reduce the expression of proteins related to the PI3K / AKT signaling pathway, and relieve pharyngitis symptoms. Attached Figure Description

[0025] Figure 1 Optical images of the pharyngeal appearance of rats in each group are shown. A is the normal control group, B is the model control group, C is the Puji Lan oral liquid group, and D is the traditional Chinese medicine combination group.

[0026] Figure 2 The images show histopathological sections of the pharyngeal tissue of rats in each group. A represents the normal control group, B represents the model control group, C represents the Pu Di Lan oral liquid group, and D represents the traditional Chinese medicine combination group.

[0027] Figure 3 The statistical results of protein expression levels related to the PI3K / AKT signaling pathway in the pharyngeal mucosa of each group of rats are shown. △ indicates that the expression level is significantly different from that of the normal control group (p<0.05), and * indicates that the expression level is significantly different from that of the model control group (p<0.05). Detailed Implementation

[0028] The present invention will be further illustrated below with reference to the embodiments and accompanying drawings. It should be understood that these embodiments are for illustrative purposes only and are not intended to limit the scope of the invention. Operating methods not specifically specified in the following embodiments are generally performed under conventional conditions or as recommended by the manufacturer.

[0029] Example 1

[0030] Take 6 parts of Asparagus cochinchinensis, 6 parts of Clematis armandii, 15 parts of Solidago virgaurea, 10 parts of Forsythia suspensa, 10 parts of Asparagus cochinchinensis, 10 parts of Ophiopogon japonicus, 15 parts of Scrophularia ningpoensis, 10 parts of Chrysanthemum indicum, 10 parts of Rehmannia glutinosa, 6 parts of Platycodon grandiflorus, and 6 parts of Glycyrrhiza uralensis. Add water and decoct 3 times. The ratio of the total weight of raw materials to the amount of water added during the 3 decoctions is 1:8, 1:8, and 1:5, respectively. Each decoction is 1 hour. After decoction, filter and collect the filtrates obtained after each decoction. Combine the filtrates and concentrate them at 80°C to 557 mL. Concentrate to a density of 1.76 g / mL to obtain the Chinese herbal composition.

[0031] Example 2

[0032] Take 8 parts of Asparagus cochinchinensis, 5 parts of Clematis armandii, 15 parts of Solidago virgaurea, 12 parts of Forsythia suspensa, 8 parts of Asparagus cochinchinensis, 12 parts of Ophiopogon japonicus, 15 parts of Scrophularia ningpoensis, 12 parts of Chrysanthemum indicum, 10 parts of Rehmannia glutinosa, 6 parts of Platycodon grandiflorus, and 6 parts of Glycyrrhiza uralensis. Add water and decoct 3 times. The ratio of the total weight of raw materials to the amount of water added during the 3 decoctions is 1:8, 1:8, and 1:5, respectively. Each decoction is 1 hour. After decoction, filter and collect the filtrates obtained after each decoction. Combine the filtrates and concentrate them at 75°C to a density of 1.6 g / mL to obtain the Chinese herbal composition.

[0033] Example 3

[0034] Take 9 parts of Asparagus cochinchinensis, 6 parts of Clematis armandii, 12 parts of Solidago virgaurea, 10 parts of Forsythia suspensa, 10 parts of Asparagus cochinchinensis, 10 parts of Ophiopogon japonicus, 12 parts of Scrophularia ningpoensis, 12 parts of Chrysanthemum indicum, 12 parts of Rehmannia glutinosa, 6 parts of Platycodon grandiflorus, and 6 parts of Glycyrrhiza uralensis. Add water and decoct 3 times. The ratio of the total weight of raw materials to the amount of water added during the 3 decoctions is 1:8, 1:8, and 1:5, respectively. Each decoction is 1 hour. After decoction, filter and collect the filtrates obtained after each decoction. Combine the filtrates and concentrate them at 80°C to a density of 1.7 g / mL to obtain the Chinese herbal composition.

[0035] Sample Analysis

[0036] (1) Grouping of animals

[0037] After acclimatization, 40 rats were randomly divided into 4 groups according to their body weight: normal control group, model control group, Pu Di Lan oral liquid group, and the traditional Chinese medicine composition group of Example 1 (Qing Yan Li Hou Fang group).

[0038] (2) Modeling and drug administration

[0039] Each treatment group was administered the corresponding dose by gavage once daily for 7 consecutive days. On the 5th day of administration, except for the normal control group, rats in the other groups were induced to develop a model using 18% ammonia water. Modeling method: 18% ammonia water was sprayed into the pharynx of the rats using a throat applicator. On the 1st day, it was sprayed twice a day, once in the morning and once in the afternoon, twice a day. On the 2nd and 3rd days, it was sprayed twice a day, twice a day.

[0040] (3) Indicator detection (3.1) Observation of general physical signs

[0041] Regular observation of the general physical condition of rats revealed that after modeling, rats in the model control group exhibited symptoms such as increased oral secretions and dry hair.

[0042] (3.2) Pharyngeal appearance

[0043] After the last administration, rats were anesthetized with urethane, and the pharyngeal condition was observed using a laryngoscope. Pharyngeal condition scoring criteria: 0 points: moist and glossy pharyngeal tissue surface, no secretions, no congestion, swelling, or other pathological phenomena; 1 point: poor pharyngeal tissue luster, small amount of secretions, and slight acute congestion; 2 points: poor pharyngeal tissue color, increased secretions, accompanied by acute, mild swelling; 3 points: poor pharyngeal tissue color, significantly increased secretions, and obvious acute congestion and swelling.

[0044] The results showed that the pharynx of rats in the normal control group was shiny, without secretions, congestion, or swelling. In the model control group, rats showed a large amount of secretions in their pharynx, accompanied by acute congestion and swelling. The pharyngeal secretions of rats treated with Puji Lan oral liquid and Qingyan Lihou formula were significantly reduced, and the congestion and swelling were significantly improved. Optical images of the pharyngeal appearance of rats in each group are shown below. Figure 1 As shown in AD.

[0045] The results of the pharyngeal tissue appearance scores of each group of rats are shown in Table 1. It can be seen that the pharyngeal appearance score of the model control group was significantly higher than that of the normal control group (p<0.01). Compared with the model control group, the appearance scores of the pharyngeal tissue of rats were significantly reduced by both Puji Lan oral liquid and Qingyan Lihou formula (p<0.05, p<0.01).

[0046] Table 1. Apparent scores of pharyngeal tissue in rats of each group (mean ± standard deviation). )

[0047]

[0048] Note: Compared with the normal control group, △△ p<0.01; compared with the model control group: * p<0.05, **p<0.01; the dosage of Pudilan oral liquid and Qingyanlihou formula is calculated based on the amount of medicinal slices.

[0049] (3.3) Histopathological observation of the pharynx

[0050] After the last administration, the rats were anesthetized and sacrificed by cervical dislocation of the abdominal aorta. The trachea and esophagus were immediately cut at the level of the cricoid cartilage. The soft tissue was separated from the posterior pharyngeal wall upwards to the level of the palatine velum and then cut. Pharyngeal mucosal tissue was collected, fixed in 4% neutral formaldehyde solution, and then routinely dehydrated, embedded in paraffin, sectioned, stained with hematoxylin and eosin (HE), and the histopathological state of the pharyngeal tissue was observed under an optical microscope.

[0051] HE results ( Figure 2 The results of the AD study showed that in the normal control group, the pharyngeal tissue of rats had clear structures in all layers, intact mucosal epithelium, no epithelial hyperplasia, normal glands, and no inflammatory cell infiltration. In the model control group, the pharyngeal tissue of rats had damaged mucosal epithelium, significant epithelial hyperplasia, most damaged glands, and inflammatory cell infiltration. In the Pu Di Lan oral liquid group, the epidermal tissue showed slight hyperplasia, the glands were basically normal, and a small amount of inflammatory cell infiltration was present. In the Qing Yan Li Hou Fang group, the pharyngeal tissue had clear and intact structures in all layers, slight epidermal hyperplasia, the glands were basically normal, and a small amount of inflammatory cell infiltration was present.

[0052] (3.4) Expression of proteins related to the PI3K / AKT signaling pathway

[0053] The expression levels of proteins related to the PI3K / AKT signaling pathway in the pharyngeal mucosa of rats in each group were measured using a fully automated protein quantification instrument. The results are as follows: Figure 3 As shown, the relative expression levels of PI3K, p-PI3K, p-p65, AKT, and p-AKT proteins in the pharyngeal mucosa of rats in the model control group were significantly increased (p<0.05, p<0.01), while the throat-clearing and throat-soothing group significantly reduced the relative expression levels of PI3K, p-PI3K, p-p65, AKT, and p-AKT proteins (p<0.05).

[0054] The embodiments described above provide a detailed explanation of the technical solutions of the present invention. It should be understood that the above descriptions are merely specific embodiments of the present invention and are not intended to limit the present invention. Any modifications, additions, or similar substitutions made within the scope of the principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating pharyngitis, characterized in that, The product is made from the following raw materials in parts by weight: 6 parts Astilbe, 6 parts Trifolium repens, 15 parts Solidago virgaurea, 10 parts Forsythia suspensa, 10 parts Asparagus cochinchinensis, 10 parts Ophiopogon japonicus, 15 parts Scrophularia ningpoensis, 10 parts Chrysanthemum indicum, 10 parts Rehmannia glutinosa, 6 parts Platycodon grandiflorus and 6 parts Glycyrrhiza uralensis. The aforementioned traditional Chinese medicine composition is mainly used to treat sore throat caused by yin deficiency and internal heat, and sore throat caused by tonsillitis. It is suitable for acute pharyngitis, chronic pharyngitis and tonsillitis. It can improve the congestion and swelling of the pharynx, reduce pharyngeal secretions, reduce the expression of proteins related to the PI3K / AKT signaling pathway, and relieve pharyngitis symptoms.

2. The method for preparing the traditional Chinese medicine composition according to claim 1, characterized in that, The process includes the following steps: Take the following herbs according to the selected weight proportions: Asparagus cochinchinensis, Trifolium repens, Solidago virgaurea, Forsythia suspensa, Asparagus cochinchinensis, Ophiopogon japonicus, Scrophularia ningpoensis, Chrysanthemum indicum, Rehmannia glutinosa, Platycodon grandiflorus, and Glycyrrhiza uralensis. Add water and decoct them. After decoction, filter the mixture, combine the filtrates, and concentrate the filtrates to obtain the final product.

3. The method for preparing the traditional Chinese medicine composition according to claim 2, characterized in that, Add 5-8 times the total weight of the raw medicinal materials to water and decoct.

4. The method for preparing the traditional Chinese medicine composition according to claim 2, characterized in that, The filtrate was concentrated at ≤80℃ until the density was 1.0-1.8 g / mL.

5. A traditional Chinese medicine compound preparation, characterized in that, Includes the traditional Chinese medicine composition according to claim 1.

6. The traditional Chinese medicine compound preparation according to claim 5, characterized in that, The traditional Chinese medicine compound preparations also include pharmaceutically acceptable excipients, and the dosage forms of the traditional Chinese medicine compound preparations include decoctions, tablets, capsules, powders, granules, pills, oral liquids, or syrups.

7. The use of the traditional Chinese medicine composition according to claim 1 or the traditional Chinese medicine compound preparation according to claim 5 or 6 in the preparation of throat-clearing and throat-soothing medicines.

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