An anticancer medicine recipe, and a preparation method and application thereof

Abstract

The application relates to the technical field of medicines, and particularly discloses an anticancer medicine formula, which comprises a main formula and is made of the following components in parts by weight: cotton root 30 parts, radix astragali 30 parts, night door 20 parts, old alkanin 20-25 parts, horseweed 12 parts, silybum 15 parts, angelica 10-12 parts, discodactylus 20 parts, fried licorice 15 parts, cinnabar root 15-20 parts, peach seven 8 parts, snake six valley 10-12 parts, tien lung 6-8 parts, split wood 15 parts, August Zha 20-25 parts, single foot gold 8-10 parts, big belly skin 8-10 parts. The anticancer medicine formula can be used for the treatment of cancer pathogenesis target points and pharmacological pathological sensitivity characteristics, can play a role in broad-spectrum anticancer and prevention and treatment of cancer complications. The formula takes strengthening the body resistance to cancer as a starting point, has neutral medicine properties, is not too cold or too hot, can be tolerated by old people and children, has low toxic and side effects, and has strong disease adaptability. Even if cancer complications, combined diseases and systemic multiple cancer metastases occur, the formula can still be used.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, and in particular to an anticancer drug formula, its preparation method, and its application. Background Technology

[0002] Cancer seriously endangers people's lives and health, causing enormous losses to families and society. Research data shows that in 2020, there were 19.29 million new cancer cases globally, of which 4.57 million were in China, accounting for 23.7% of the global total. The incidence of cancer is constantly rising. Currently, cancer treatments mainly include radiotherapy (radiotherapy), chemotherapy (including targeted drug therapy), surgery, biological immunotherapy (including hematopoietic stem cell transplantation), and traditional Chinese medicine (including ethnic minority therapies). Radiotherapy uses radiation to kill cancer cells and shrink tumors. However, the effects of radiotherapy are limited, confined to the irradiated area, and it damages both cancer cells and normal cells. Chemotherapy uses drugs that can kill cancer cells. The mechanism of action of anticancer drugs is usually to inhibit the growth of cancer cells by interfering with cell division. Most chemotherapy drugs lack specificity, so they also kill normal cells undergoing cell division. Traditional Chinese medicine treatment is characterized by its universality and cost-effectiveness, suitable for cancer patients at all stages and ages. It can reduce the toxic side effects of radiotherapy and chemotherapy and promote patient recovery.

[0003] Current TCM techniques primarily focus on reducing the toxicity and enhancing the efficacy of radiotherapy and chemotherapy, as well as controlling and regulating the condition after tumor surgery. These methods mainly utilize commonly used herbal formulas and acupuncture, which can improve patient symptoms and reduce medical costs. However, their effectiveness in controlling tumor cell metastasis and spread in mid-to-late stage cancers or cancers in critical locations is generally not ideal. Herbal medicines are rich and diverse, capable of meeting the medication needs of different cancer types. Currently, there are not many existing anticancer drug formulas, and developing new anticancer drug formulas plays a positive role and is of great significance in promoting cancer treatment. Summary of the Invention

[0004] To address the above shortcomings, this invention provides an anticancer formula and its preparation method, which can control mid-to-late stage cancer or cancer in important locations, and improve the control effect on some refractory and metastatic cancers. The specific technical solution is as follows:

[0005] An anticancer prescription includes a main prescription, which comprises the following components by weight: 30 parts cotton root, 30 parts astragalus, 20 parts night-blooming jasmine, 20-25 parts geranium, 12 parts horse nut, 15 parts milk thistle, 10-12 parts angelica, 20 parts ginseng, 15 parts prepared licorice root, 15-20 parts cinnabar root, 8 parts peach kernel, 10-12 parts snake berry, 6-8 parts dragon's heartwood, 15 parts septum, 20-25 parts akebia, 8-10 parts single-stranded gold, and 8-10 parts areca peel.

[0006] Preferably, in the above-mentioned anticancer prescription, the main prescription includes the following components by weight: 30 parts cotton root, 30 parts astragalus, 20 parts night-blooming cereus, 20 parts geranium, 12 parts horse nut, 15 parts milk thistle, 10 parts angelica, 20 parts ginseng, 15 parts prepared licorice, 15 parts cinnabar root, 8 parts peach kernel, 10 parts snake berry, 8 parts dragon fruit, 15 parts septum, 20 parts akebia, 8 parts single-stranded gold, and 8 parts areca peel.

[0007] Preferably, in the above-mentioned anticancer prescription, the main prescription includes the following components by weight: 30 parts cotton root, 30 parts astragalus, 20 parts night-blooming cereus, 25 parts geranium, 12 parts horse nut, 15 parts milk thistle, 10 parts angelica, 20 parts ginseng, 15 parts prepared licorice, 18 parts cinnabar root, 8 parts peach kernel, 12 parts snake berry, 6 parts dragon fruit, 15 parts septum, 25 parts akebia, 8 parts single-stranded gold, and 8 parts areca peel.

[0008] Preferably, in the above-mentioned anticancer prescription, the main prescription also includes: 10 parts of dried ginger.

[0009] Preferably, the above-mentioned anticancer drug formula also includes excipients, which include the following components by weight: 3 parts sodium benzoate and 8-10 parts stevia.

[0010] Preferably, in the above-mentioned anticancer drug formula, the dosage form of the anticancer drug formula is oral liquid, granules, capsules, tablets or pills.

[0011] A method for preparing the above-mentioned anticancer drug formula includes the following steps:

[0012] (1) Mix cotton root, astragalus, night-blooming jasmine, geranium, horse horn, milk thistle, angelica, ginseng, prepared licorice, cinnabar root, peach root, dragon, septum, akebia, single-stranded gold, and areca peel, and extract the extract using conventional extraction methods.

[0013] (2) Use 8 to 10 times the amount of water to decoct the snake six grains, decoct 1 to 3 times, 1 to 2 hours each time, to obtain the decoction;

[0014] (3) Combine the extract and decoction, boil for 20-40 minutes to obtain the anticancer formula. During the research process, the applicant of this invention found that if snake ginseng is processed together with other medicinal materials for a long time (such as decoction), it is easy to reduce the efficacy of other medicinal materials. Processing snake ginseng separately from other medicinal materials is beneficial to improve efficacy and reduce toxicity.

[0015] Preferably, in the preparation method of the above-mentioned anticancer drug formula, in step (1), the conventional extraction method is one of decoction, reflux extraction, and ultrasonic extraction, the extraction solvent is water or ethanol solution, the ethanol solution is an aqueous ethanol solution with a mass fraction of 50~70%, and the extraction is performed no less than once.

[0016] Preferably, the preparation method of the above-mentioned anticancer drug formula includes the following steps:

[0017] (1) Using ethanol solution as solvent, extract cotton root, astragalus, night-blooming jasmine, geranium, horse chestnut, milk thistle, angelica, ginseng, prepared licorice, cinnabar root, peach root, dragon's heartwood, akebia stem, single-stranded gold, and areca peel. The material-to-liquid ratio is 1:10, the reflux extraction temperature is 80-85℃, reflux extraction is performed 1-3 times, each reflux extraction is performed for 0.5-1.5h, concentration is performed, centrifugation and filtration are performed, the concentration ratio is 1.5:1, the concentration temperature is 60-65℃, the centrifugation speed is 10000-20000rpm, and the concentrated solution is obtained.

[0018] (2) Use 8 to 10 times the amount of water to decoct the snake six grains, decoct 1 to 3 times, 1 to 2 hours each time, to obtain the decoction;

[0019] (3) Combine the concentrated liquid and the decoction, boil for 20-40 minutes, add excipients, and prepare according to the prescription amount.

[0020] The above-mentioned anticancer formula is used in the preparation of anticancer drugs.

[0021] The pharmacological effects of each component in the anticancer drug formula of this invention are as follows:

[0022] Cotton root is neutral in nature and sweet and bitter in taste. It enters the spleen and liver meridians. Its functions and indications include: strengthening the body's resistance and fighting cancer, promoting tissue regeneration and eliminating toxins. It is used for various tumors, bleeding and other diseases.

[0023] Night-closing door, neutral in nature and bitter in taste, enters the liver and kidney meridians; functions and indications: tonifies the liver and kidneys, reduces swelling and disperses blood stasis, used for liver and kidney deficiency, lung cancer, nephritis, etc.;

[0024] Astragalus membranaceus (Huang Qi) is sweet and slightly warm in nature; it enters the lung, spleen, liver, and kidney meridians. Its functions and indications include: tonifying qi and strengthening the spleen, consolidating the exterior and stopping sweating, promoting pus drainage from sores, reducing swelling and promoting tissue regeneration; it is used for various diseases caused by qi deficiency.

[0025] Geranium wilfordii Maxim., with a neutral nature, bitter and pungent taste, and attributing to the liver and lung meridians; functions and indications: dispelling wind and dampness, relieving cancer pain; used for tumor arthralgia, traumatic injury;

[0026] Iris lactea Pall. var. chinensis (Fisch.) Koidz., with a warm nature and sweet taste, and attributing to the liver and kidney meridians; functions and indications: detoxifying and killing insects, detumescence and resolving accumulation, used for various tumors;

[0027] Silybum marianum (L.) Gaertn., with a sweet, bitter and cool nature, and attributing to the gallbladder and liver meridians; functions and indications: cooling blood and protecting the liver, detoxifying and anti-cancer, used for various tumors, liver diseases;

[0028] Angelica sinensis (Oliv.) Diels, with a sweet, pungent and warm nature, and attributing to the heart and liver meridians; functions and indications: nourishing blood and promoting granulation, promoting blood circulation to relieve pain, nourishing blood and moistening the skin, dispersing stasis and stagnation, moistening the intestine and relieving constipation, used for various blood deficiency diseases, regulating menstruation, treating disorders of pregnancy and childbirth;

[0029] Spiranthes australis (R. Br.) Lindl., with a neutral nature and sweet taste, and attributing to the liver, lung and kidney meridians; functions and indications: tonifying the lung and nourishing essence, detoxifying and anti-cancer, used for lung cancer, pulmonary tuberculosis, consumptive diseases, etc.;

[0030] Fried Licorice Root, with a neutral nature and sweet taste, and attributing to the spleen and lung meridians; functions and indications: harmonizing various medicines, detoxifying and relieving spasm, used for disharmony between the spleen and stomach, poisoning, etc.;

[0031] Ardisia crenata Sims., with a cool nature and bitter taste, and attributing to the lung and liver meridians; functions and indications: detoxifying and resolving masses, promoting blood circulation and removing stasis, dispelling wind and dampness, used for various tumors, arthralgia syndrome, etc.;

[0032] Sinopodophyllum hexandrum (Royle) Ying, with a warm nature, bitter and pungent taste, and attributing to the liver and lung meridians; functions and indications: promoting blood circulation and removing stasis, treating injuries and anti-cancer, used for traumatic injury, hemoptysis due to lung cancer, etc.;

[0033] Typhonium giganteum Engl., with a warm nature and pungent taste, and attributing to the liver and lung meridians; functions and indications: breaking up accumulation and relieving flatulence, detoxifying and resolving masses, used for tumors of the respiratory and digestive systems;

[0034] Agkistrodon acutus (Guenther), with a cold nature and salty taste, and attributing to the liver and lung meridians. Functions and indications: softening and resolving masses, detoxifying and attacking toxins; used for various tumors, fibrosis diseases;

[0035] Semen Juglandis, with a neutral nature and astringent taste, and attributing to the spleen and kidney meridians; functions and indications: breaking up accumulation and dispersing hardness, tonifying the kidney and astringing essence, used for various kidney deficiency diseases, tumors of the digestive system;

[0036] Fructus Akebiae, with a neutral nature and bitter taste, and attributing to the liver and spleen meridians; functions and indications: regulating qi and harmonizing the stomach, soothing the liver and strengthening the spleen, used for tumors and inflammation of the digestive system;

[0037] Striga asiatica (L.) O. Kuntze, with a cool nature and sweet taste, and attributing to the spleen meridian; functions and indications: clearing heat and detoxifying, resolving accumulation and harmonizing the stomach, used for anorexia due to various reasons, heat stroke, etc.;

[0038] Pericarpium Arecae, with a neutral nature, bitter and pungent taste, and attributing to the liver and spleen meridians; functions and indications: soothing the liver and regulating qi, strengthening the spleen and regulating the stomach, used for various diseases caused by disharmony between the liver and spleen.

[0039] Compared with the prior art, the beneficial effects of the present invention are:

[0040] 1. The anticancer formula of this invention, based on the pharmacological and pathological sensitivity of tumor cells and their pathogenesis, including metastasis and spread, uses natural medicinal herbs such as cotton root, night-blooming cereus, Panax ginseng, and Geranium wilfordii as principal herbs to enhance immunity and provide broad-spectrum anticancer and anti-metastasis effects. Herbs such as septum spp., Akebia quinata, Astragalus membranaceus, and Angelica sinensis are assistant herbs to regulate qi and strengthen the spleen, enhancing the effects of the principal herbs. Herbs such as Artemisia capillaris, Prunus armeniaca, Cinnamomum cassia, Silybum marianum, Gynostemma pentaphyllum, and Gynostemma pentaphyllum are adjuvant herbs to target tumors in the liver, gallbladder, lungs, and pancreas. Herbs such as Areca peel, Desmodium styracifolium, and Glycyrrhiza uralensis are guiding herbs to harmonize the spleen and stomach, reduce drug toxicity, and ensure the medication reaches the peritoneum and pleura. Through the combination of principal, assistant, adjuvant, and guiding herbs, and the application of specific drugs for specific diseases, this formula targets the pathogenesis mechanisms and pharmacological and pathological sensitivity characteristics of cancer, achieving effects such as anticancer metastasis and spread, broad-spectrum anticancer activity, and prevention of cancer complications.

[0041] 2. The anticancer formula of the present invention is based on supporting the body's resistance to cancer. The medicinal properties are mild and moderate, neither too cold nor too hot, and can be tolerated by the elderly and children, with low toxicity and side effects.

[0042] 3. The anticancer formula of this invention has the advantage of strong adaptability to various conditions. Generally, if patients with mid-to-late stage cancer undergo surgery, radiotherapy, chemotherapy, or biological immunotherapy, it is essential to ensure that the patient's condition is relatively stable and free from various complications, comorbidities, and multiple metastases. If complications such as pneumonia, tuberculosis, coronary heart disease, cerebral infarction, or cerebral hemorrhage occur, both the doctor and the patient may discontinue or refuse the aforementioned modern medical treatments for the sake of medical safety. If a patient has multiple metastases, experimental biological immunotherapy can only be administered in the absence of complications and comorbidities. This invention can serve as a basic medication for various solid cancers and their complications, comorbidities, and multiple metastases, with minimal impact on comorbidities and treatment measures for them. Attached Figure Description

[0043] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0044] Figure 1 This is a tongue image of the patient in Case 1 before taking the medication, as shown in Example 5 of the efficacy of the present invention;

[0045] Figure 2 The image shows the tongue of the patient in Case 1 after taking the medication, as shown in Example 5 of the efficacy of this invention. Detailed Implementation

[0046] The specific embodiments of the present invention are described in detail below, but it should be understood that the scope of protection of the present invention is not limited to the specific embodiments. Unless otherwise defined, all technical terms used below have the same meaning as commonly understood by those skilled in the art. The technical terms used herein are for the purpose of describing specific embodiments only and are not intended to limit the scope of protection of the present invention. Unless otherwise specifically stated, all raw materials, reagents, instruments, and equipment used in the present invention are commercially available or can be prepared by existing methods. Example 1

[0047] An anticancer prescription includes a main prescription, which is made from the following components in parts by weight: 30 parts cotton root, 30 parts astragalus, 20 parts night-blooming jasmine, 20 parts geranium, 12 parts horse nut, 15 parts milk thistle, 12 parts angelica, 20 parts ginseng, 15 parts prepared licorice root, 15 parts cinnabar root, 8 parts peach kernel, 10 parts snake berry, 8 parts dragon fruit, 15 parts septum, 20 parts akebia, 8 parts single-stranded gold, and 8 parts areca peel.

[0048] This embodiment also provides a method for preparing an oral anticancer drug, comprising the following steps:

[0049] (1) The cotton root, astragalus, night-blooming jasmine, geranium, horse chestnut, milk thistle, angelica, ginseng, prepared licorice, cinnabar root, peach root, dragon's heart, septum, akebia, single-stranded gold, and areca peel were extracted by reflux with a 65% ethanol aqueous solution. The material-liquid ratio was 1:10, the reflux extraction temperature was 80-85℃, and the reflux extraction was performed twice, each time for 1.5h. Then, the extract was concentrated, centrifuged and filtered. The concentration ratio was 1.5:1, the concentration temperature was 65℃, and a tubular centrifuge was used with a peristaltic pump with a feed speed of 19-21Hz. The extract was centrifuged and filtered at a speed of 15000rpm / min to obtain the concentrate.

[0050] (2) Use 8 times the amount of water to decoct the snake six grains twice, each time for 1.5 hours, to obtain the decoction;

[0051] (3) Combine the concentrated liquid and the decoction, boil for 30 minutes, add 3 parts sodium benzoate and 8 parts stevia, stir evenly, cool and fill to obtain oral liquid. Example 2

[0052] An anticancer prescription includes a main prescription, which is made from the following components in parts by weight: 30g of cotton root, 30g of astragalus, 20g of night-blooming cereus, 20g of geranium, 12g of horse chestnut, 15g of milk thistle, 10g of angelica sinensis, 20g of ginseng, 15g of prepared licorice root, 15g of cinnabar root, 8g of peach kernel, 10g of snake stalk, 8g of dragon's heartwood, 15g of septum var. spinosa, 20g of akebia quinata, 8g of stagnation bark, and 8g of areca peel.

[0053] This embodiment also provides a method for preparing an oral anticancer drug, comprising the following steps:

[0054] (1) Use 800g of water to decoct cotton root, astragalus, night-blooming jasmine, geranium, horse horn, milk thistle, angelica, ginseng, prepared licorice, cinnabar root, peach root, dragon, septum, akebia, single-stem wood, scutellaria, and areca peel for half an hour to obtain a decoction.

[0055] (2) Use 100g of water to decoct snake six grains for 1 hour to obtain a separate decoction;

[0056] (3) Combine the decoction and the other decoction, boil for 30 minutes, stir well, and obtain oral liquid. Example 3

[0057] An anticancer prescription includes a main prescription, which is made from the following components in parts by weight: 30g cotton root, 30g astragalus, 20g night-blooming cereus, 25g geranium, 12g horse chestnut, 15g milk thistle, 10g angelica, 20g ginseng, 15g prepared licorice root, 18g cinnabar root, 8g peach kernel, 12g snake stalk, 6g dragon's heartwood, 15g septum, 8g areca peel, 25g akebia stem, 8g single-stranded gold, and 10g dried ginger.

[0058] This embodiment also provides a method for preparing an anticancer drug formula, including the following steps:

[0059] (1) The following ingredients were decocted in 800g of water: cotton root, astragalus, night-blooming jasmine, geranium, horse chestnut, milk thistle, angelica, ginseng, prepared licorice, cinnabar root, peach root, dragon's heartwood, akebia stem, septum, single-stranded gold, areca peel, and dried ginger for 0.5h to obtain the decoction.

[0060] (2) Use 100g of water to decoct snake six grains for 1 hour to obtain a separate decoction;

[0061] (3) Combine the water decoction and the other decoction, boil for 30 minutes, stir well, and obtain the oral preparation.

[0062] Example 1

[0063] This example provides statistical results of the clinical application of the cancer treatment prescription in Example 2 of the present invention.

[0064] (I) Clinical data of patients with various solid tumors

[0065] 1. Source of cases

[0066] From July 2022 to June 2023, 17 patients with various solid tumors who visited the Department of Pharmacy at Guangxi Nationalities Hospital were included. The patients were aged between 45 and 75 years old, and the diameter of the in situ carcinomas was greater than 2 cm. Among them, there were 4 cases of lung adenocarcinoma, 4 cases of hepatocellular carcinoma, 2 cases of small cell lung carcinoma, 2 cases of gastric adenocarcinoma, 2 cases of prostate cancer, 1 case of pancreatic cancer, 1 case of non-invasive lobular carcinoma of the breast, and 1 case of colon adenocarcinoma. Serious complications such as tumor lysis syndrome, superior vena cava syndrome, malignant hypercalcemia, and hyperviscosity syndrome were excluded.

[0067] 2. Treatment methods

[0068] The prescription for treating cancer in Example 2 of this invention is decocted in water and taken orally, one dose per day, three times a day.

[0069] 3. Results

[0070] After taking 60 doses of the cancer treatment prescription in Example 2 of this invention, the diameter of the in situ carcinoma in 17 patients decreased by more than 8 mm (the tumor diameter did not change or increased when no drugs were used).

[0071] Example 2

[0072] This example provides statistical results of the clinical application of the cancer treatment prescription in Example 2 of the present invention.

[0073] (I) Clinical data of patients with metastasis and invasion of various solid tumors

[0074] 1. Source of cases

[0075] From January 2023 to November 2023, 12 patients with various solid cancers, aged 45-75 years, visited the Department of Pharmacy at Guangxi Nationalities Hospital. All patients had metastatic or invasive lesions. Among them, there were 2 cases of lung adenocarcinoma, 1 case of small cell lung cancer, 3 cases of hepatocellular carcinoma, 2 cases of gastric adenocarcinoma, 2 cases of colonic adenocarcinoma, 1 case of pancreatic cancer, and 1 case of mixed pathological type cancer. Serious complications such as tumor lysis syndrome, superior vena cava syndrome, malignant hypercalcemia, and hyperviscosity syndrome were excluded.

[0076] 2. Treatment methods

[0077] The prescription for treating cancer in Example 2 of this invention is decocted in water and taken orally, one dose per day, three times a day.

[0078] 3. Results

[0079] After taking 60 doses of the cancer treatment formula in Example 2 of this invention, the metastatic and invasive lesions in 11 patients shrank or disappeared (without any medication, the metastatic and invasive lesions increased and spread). One patient withdrew from the observation due to severe exogenous infection during the period.

[0080] Example 3

[0081] This example provides statistical results of the clinical application of the cancer treatment prescription in Example 2 of the present invention.

[0082] (I) Clinical data of patients after surgery for various solid cancers

[0083] 1. Source of cases

[0084] From May 2022 to April 2023, 26 patients with various solid cancers who had undergone radical tumor resection surgery were included in this study at Guangxi Ruikang Hospital. The patients were aged between 38 and 60 years. Among them, there were 7 cases of breast cancer, 4 cases of choriocarcinoma, 5 cases of endometrial cancer, 5 cases of ovarian cancer, 2 cases of clear cell renal cell carcinoma, and 3 cases of bladder cancer. Serious complications such as tumor lysis syndrome, superior vena cava syndrome, malignant hypercalcemia, and hyperviscosity syndrome were excluded.

[0085] 2. Treatment methods

[0086] The prescription for treating cancer in Example 2 of this invention is decocted in water and taken orally, one dose per day, three times a day.

[0087] 3. Results

[0088] After taking 90 doses of the cancer treatment prescription in Example 2 of this invention, none of the 26 patients experienced tumor recurrence or metastasis within 10 months.

[0089] Example of effect 4

[0090] This example provides statistical results of the clinical application of the cancer treatment prescription in Example 2 of the present invention.

[0091] (I) Clinical data of lung cancer patients

[0092] 1. Source of cases

[0093] Thirteen lung cancer patients aged 55-70 years who visited Guangxi Ruikang Hospital between January and September 2023 were included in this study. Among them, there were 7 cases of lung adenocarcinoma, 2 cases of small cell lung cancer, 2 cases of large cell lung cancer, and 2 cases of squamous cell lung cancer. All patients presented with symptoms of chest pain and hemoptysis. Serious tumor complications and diseases with similar symptoms, such as pulmonary tuberculosis, pulmonary embolism, coronary heart disease, tumor lysis syndrome, superior vena cava syndrome, malignant hypercalcemia, and hyperviscosity syndrome, were excluded.

[0094] 2. Treatment methods

[0095] The prescription for treating cancer in Example 2 of this invention is decocted in water and taken orally (orally), one dose per day, three times a day.

[0096] 3. Results

[0097] After taking 15 doses of the drug composition for treating cancer in Example 2 of this invention, the symptoms of chest pain and blood in sputum disappeared in 8 patients, the symptoms of chest pain and blood in sputum were reduced in 4 patients, and the symptoms of blood in sputum disappeared and chest pain was reduced in 1 patient.

[0098] Example 5

[0099] This example provides individual clinical cases of the application of the anticancer formula of the present invention.

[0100] Case 1:

[0101] Ms. Xia, female, 65 years old, presented in June 2023 after being diagnosed with lung adenocarcinoma for over a month. CT scan showed multiple high-density lesions in the lower lobe of the right lung, the largest measuring 6cm*4.3cm, accompanied by multiple metastatic invasive nodules and concurrent lung inflammation. Pathology: Lung mucinous adenocarcinoma. Symptoms included cough, sputum production, and excessive sweating. Due to concurrent pneumonia, the patient was unable to undergo chemotherapy or other treatments. She was prescribed a decoction of Astragalus membranaceus 30g, Aconitum carmichaelii 10g, Zingiber officinale 10g, Ostrea gigas 15g, Glycyrrhiza uralensis 10g, and Pueraria lobata 15g for two months (one dose daily, three times a day), but her condition did not improve significantly. She was then given the decoction of the regimen described in Example 2 for another two months (one dose daily, three times a day). The frequency of cough and sputum production decreased, and a follow-up CT scan showed shrinkage of the lesions, a reduction in the number of metastatic invasive nodules, and absorption of the pneumonia. Tongue images of the patient before and after medication were shown in Case 1. Figure 1 and Figure 2 The tongue appearance changed significantly; after taking the medicine in Example 2, the tongue coating became thinner and the black coating almost disappeared.

[0102] Case 2:

[0103] Mr. Xuan, male, 57 years old, presented in August 2023 after being diagnosed with lung adenocarcinoma two weeks prior. A CT scan revealed a mass in the right hilum, metastatic lymph nodes in the mediastinum, right hilum, and adrenal glands, and an old lacunar infarction. Pathology confirmed lung adenocarcinoma. Symptoms included cough, wheezing, general weakness, and bilateral lower extremity edema. Due to the concurrent cerebral infarction, chemotherapy was not an option. He was prescribed a formula of "Astragalus membranaceus 30g, Aconitum carmichaelii 15g, Zingiber officinale 15g, Phaseolus angularis 20g, Glycyrrhiza uralensis 10g, Amomum villosum 15g, Rheum palmatum 6g" for one week (one dose daily, three times a day). This reduced the lower extremity edema. He then followed the regimen in Example 2 for two weeks (one dose daily, three times a day), resulting in significant improvement in several symptoms. He continued the treatment with Example 2 for two months. A follow-up CT scan showed a reduction in metastatic lesions, and no enlargement or new thrombi were observed at the site of the cerebral infarction.

[0104] Case 3:

[0105] Mr. Lu, male, 70 years old, sought medical attention in June 2023, 6 years after surgery for liver cancer. He was diagnosed with liver cancer 6 years prior; CT scan showed scattered high-density shadows in the liver area, and pathology revealed mixed carcinoma (cholangiocarcinoma and hepatocellular carcinoma). After surgery, he received targeted therapy with erlotinib and other drugs, but his condition recurred, and he experienced adverse drug reactions, including weight loss, fatigue, hypochondriac pain, poor appetite, and lower extremity rashes. The patient discontinued targeted therapy and took a decoction of the main formula from Example 3 (modified from the main formula in Example 2) orally for 2 months (one dose daily, 3 times per dose). His symptoms significantly improved, and no adverse reactions occurred.

[0106] The foregoing description of specific exemplary embodiments of the invention is for illustrative and explanatory purposes. These descriptions are not intended to limit the invention to the precise forms disclosed, and it will be apparent that many changes and variations can be made in accordance with the foregoing teachings. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application, thereby enabling those skilled in the art to implement and utilize various different exemplary embodiments of the invention, as well as various different choices and variations. The scope of the invention is intended to be defined by the claims and their equivalents.

Claims

1. An anticancer drug composition, characterized in that, The product includes raw materials of traditional Chinese medicine, which comprise the following components by weight: 30 parts cotton root, 30 parts astragalus, 20 parts night-blooming jasmine, 20-25 parts geranium, 12 parts horse nut, 15 parts milk thistle, 10-12 parts angelica, 20 parts ginseng, 15 parts prepared licorice root, 15-20 parts cinnabar root, 8 parts peach kernel, 10-12 parts snake berry, 6-8 parts dragon fruit, 15 parts septum, 20-25 parts akebia, 8-10 parts single-stranded gold, and 8-10 parts areca peel.

2. The anticancer drug composition according to claim 1, characterized in that, The Chinese medicinal materials include the following components by weight: 30 parts cotton root, 30 parts astragalus, 20 parts night-blooming cereus, 20 parts geranium, 12 parts horse nut, 15 parts milk thistle, 10 parts angelica, 20 parts ginseng, 15 parts prepared licorice root, 15 parts cinnabar root, 8 parts peach kernel, 10 parts snake berry, 8 parts dragon, 15 parts septum, 20 parts akebia, 8 parts single-stranded gold, and 8 parts areca peel.

3. The anticancer drug composition according to claim 1, characterized in that, The Chinese medicinal materials include the following components by weight: 30 parts cotton root, 30 parts astragalus, 20 parts night-blooming cereus, 25 parts geranium, 12 parts horse nut, 15 parts milk thistle, 10 parts angelica, 20 parts ginseng, 15 parts prepared licorice root, 18 parts cinnabar root, 8 parts peach kernel, 12 parts snake berry, 6 parts dragon fruit, 15 parts septum, 25 parts akebia, 8 parts single-stranded gold, and 8 parts areca peel.

4. The anticancer drug composition according to claim 3, characterized in that, The raw materials for traditional Chinese medicine also include: 10 parts of dried ginger.

5. The anticancer drug composition according to claim 1, characterized in that, It also includes excipients, which include the following components by weight: 3 parts sodium benzoate and 8-10 parts stevia.

6. The anticancer drug composition according to claim 1, characterized in that, The dosage form of the anticancer drug composition is oral liquid, granules, capsules, tablets or pills.

7. A method for preparing an anticancer drug composition according to any one of claims 1 to 3, characterized in that, Includes the following steps: (1) Mix cotton root, astragalus, night-blooming jasmine, geranium, horse horn, milk thistle, angelica, ginseng, prepared licorice, cinnabar root, peach root, dragon, septum, akebia, single-stranded gold, and areca peel, and extract the extract using conventional extraction methods. (2) Use 8 to 10 times the amount of water to decoct the snake six grains, decoct 1 to 3 times, 1 to 2 hours each time, to obtain the decoction; (3) Combine the extract and decoction, boil for 20-40 minutes to obtain the anticancer formula.

8. The method for preparing the anticancer drug composition according to claim 7, characterized in that, In step (1), the conventional extraction method is one of decoction, reflux extraction, or ultrasonic extraction. The extraction solvent is water or ethanol solution, and the ethanol solution is an aqueous ethanol solution with a mass fraction of 50-70%. The extraction is performed at least once.

9. The use of the anticancer drug composition according to any one of claims 1 to 4 in the preparation of an anticancer drug.

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