A PCR reaction device for home testing

Abstract

The application discloses a PCR reaction device for home detection and relates to the technical field of nucleic acid detection boxes. In order to solve the problem that nucleic acid detection kits are prone to loosening and thus causing the detection materials to be damaged and spilled when the nucleic acid detection kits are squeezed during storage and transportation, an inner box cavity is formed in the inner part of an outer box body, an inner box body is slidably arranged in the inner box cavity, a locking block groove is formed in the upper part of the inner box cavity, a locking block is slidably arranged in the locking block groove, the lower end of the locking block extends into the inner box cavity, the lower end surface of the locking block is matched with the inner box body, two iron blocks are symmetrically arranged in the inner part of the locking block, a magnet block positioning end is arranged at one end of the outer box body, the outer box body is a box body with an open side, the inner box body is a box body with an open upper end, magnet block grooves are symmetrically formed in one side of the magnet block positioning end, and magnet blocks are movably arranged in the magnet block grooves.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of nucleic acid detection kits, and particularly relates to a PCR reaction device for home detection. BACKGROUND

[0002] The PCR reaction device for home detection is a device capable of performing PCR, i.e., polymerase chain reaction detection in a home environment. The device realizes the convenience and efficiency of nucleic acid detection by integrating the reagents, amplification equipment and detection device required for PCR. The PCR reaction device for home detection is mainly based on the principle of PCR technology. Through specific temperature cycling, DNA is rapidly amplified outside the organism. This amplification process can greatly improve the detection sensitivity, so that even a small amount of virus can be accurately detected. The device is small in design, easy to carry and store, suitable for home use, and can complete the PCR reaction in a short time and give the detection result. The operation is simple, and people without medical background can easily use it. On the basis of ensuring high detection sensitivity, the accuracy of home detection is realized. Family members can perform nucleic acid detection by themselves without going to the hospital or detection agency.

[0003] Chinese Patent Publication No. CN217997200U discloses a nucleic acid detection kit suitable for home self-detection, comprising: a cover plate, at least four bubble caps are formed on the first surface of the cover plate; the bubble caps are respectively used to accommodate flat sampling swabs, sampling tubes, PCR reaction liquid tubes and PCR reaction tubes; aluminum foil paper is laid on the second surface of the cover plate to seal the bubble caps. The utility model has the advantages of simple structure, low manufacturing cost, easy use, low cost, high reagent stability, realization of the most simplified fluorescent quantitative PCR reagent and consumables, and suitability for home detection.

[0004] The prior art in the above has the following defects: the nucleic acid detection kit stores the sampling swabs, sampling tubes, PCR reaction liquid and other detection settings by aluminum foil paper and bubble caps. Although the kit can keep the detection materials from being contaminated during storage and transportation, the kit is prone to come off when it is squeezed during storage and transportation, thereby causing the detection materials to be spilled and damaged. Therefore, the present application provides a PCR reaction device for home detection to solve the above problems. SUMMARY

[0005] The present application aims to provide a PCR reaction device for home detection to solve the problem that the nucleic acid detection kit is prone to come off when it is squeezed during storage and transportation, thereby causing the detection materials to be spilled and damaged.

[0006] In order to achieve the above object, the present application provides the following technical scheme: a PCR reaction device for home detection, comprising an outer box body, an inner box cavity is formed in the inner part of the outer box body, an inner box body is slidably arranged in the inner box cavity, a locking block slot is formed in the upper part of the inner box cavity, and a locking block is slidably arranged in the inner part of the locking block slot.

[0007] Preferably, two iron blocks are symmetrically arranged in the inner part of the locking block, one end of the outer box body is provided with a magnet block positioning end, the outer box body is a box body with one side open, and the inner box body is a box body with the upper end open.

[0008] Preferably, a magnet block slot is symmetrically formed on one side of the magnet block positioning end, a magnet block is movably mounted in the inner part of the magnet block slot, and the magnet block is magnetically connected with the iron block, compression spring slots are symmetrically formed on the two sides of the upper end of the locking block, compression springs are arranged in the compression spring slots, the upper end of the compression spring is in close contact with the inner wall of the upper end of the locking block slot, and the lower end of the compression spring is in close contact with the inner wall of the compression spring slot.

[0009] Preferably, locking block sliding block slots are symmetrically formed on the two sides of the locking block slot, locking block sliding blocks are symmetrically arranged on the two sides of the upper end of the locking block, and the locking block sliding blocks are slidably connected with the locking block sliding block slots.

[0010] Preferably, a positioning sealing block is arranged at the middle position of the lower end of the locking block, and the positioning sealing block is in close contact with the upper end of the inner box body.

[0011] Preferably, an inner box body edge slot is formed on the outer side of the lower end of the locking block, and a sealing strip is arranged in close contact with the inner wall of the upper end of the inner box body edge slot and the bottom end of the end of the locking block close to the positioning sealing block.

[0012] Preferably, three limiting strips are equidistantly arranged at the lower end of the inner box cavity, three limiting strip slots are formed in the lower end of the inner box body, and the limiting strip slots are slidably connected with the limiting strips.

[0013] Preferably, a sponge supporting block slot is formed in the inner side of the inner box body, a Shanghai sponge supporting block and a lower Shanghai sponge supporting block are placed in the inner part of the sponge supporting block slot, and the Shanghai sponge supporting block is located above the lower Shanghai sponge supporting block.

[0014] Preferably, the Shanghai sponge block is provided with a reagent tube equidistant from the inside of the lower sponge block, the length of the Shanghai sponge block is less than the distance between the limiting rings, and the height of the Shanghai sponge block and the lower sponge block is the same as the height of the upper surface of the limiting ring.

[0015] Preferably, the two sides of one end of the magnet block are symmetrically provided with magnet block limiting blocks, the two sides of the magnet block slot are symmetrically provided with magnet block limiting block slots, and the magnet block limiting block slots are in sliding connection with the magnet block limiting blocks, and the magnet block limiting block slots are L-shaped slots.

[0016] Compared with the prior art, the present application has the following beneficial effects:

[0017] 1. When the present application is used, the locking block is pressed down due to its own gravity and the pressure of the compression spring, at this time the upper edge of the inner box body is clamped inside the inner box body edge groove, at this time the upper edge of the inner box body and the limiting ring are respectively attached to the sealing strip, thereby achieving good sealing of the inner box body, through the sealing and attaching connection relationship, the sealing protection of the inner box body can be improved, effectively preventing the outside material from polluting the reagent tube, through the upper and lower pressing and fixing of the Shanghai sponge block and the lower sponge block, the external pressure and shaking can be greatly buffered, thereby improving the protection effect of the reagent tube, preventing the internal reagent tube from being damaged, and at the same time, due to the fitting relationship between the locking block and the inner box body, the outward sliding of the locking block can be effectively limited, solving the problem that when the nucleic acid detection tool kit is squeezed during storage and transportation, the tool kit is easily loosened, thereby causing the detection materials to be spilled and damaged.

[0018] 2. When the present application is opened, the magnet block in the magnet block slot is taken out, one end of the magnet block is gripped, the magnet block is rotated in the magnet block slot, the magnet block limiting block is slid in the arc-shaped slot of the magnet block limiting block slot, after being rotated to the point where it cannot be rotated, it is pulled outwards, so that the magnet block limiting block is slid out of the vertical slot of the magnet block limiting block, at this time the magnet block is placed at the position of the positioning sticker, the positioning sticker generates an attractive force on the iron block, so that the locking block slides upwards under the limiting of the locking block sliding block slot and the locking block sliding block, thereby releasing the locking of the locking block to the inner box body, at this time the inner box body is pulled outwards, the inner box body slides outwards under the limiting of the limiting strip and the limiting strip slot, after the inner box body is completely taken out, the Shanghai sponge block is taken out, and the reagent tube can be taken out for collection work, the unlocking is achieved by the magnetic attraction of the magnet block, making the unlocking simple and easy to operate, and reducing the time-consuming of disassembling the reagent kit. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 It is a structure diagram of the first working state in the present application;

[0020] Figure 2 It is a structure diagram of the first working state in the present application;

[0021] Figure 3 A local enlarged view of the A area in the present application Figure 1 A local enlarged view of the A area in the present application

[0022] Figure 4 A perspective view of the outer box body in the present application

[0023] Figure 5 A perspective view of the inner box body in the present application

[0024] Figure 6 A perspective view of the magnet block positioning end in the present application

[0025] In the figure: 1, outer box body; 2, inner box body; 3, locking block slot; 4, locking block; 5, iron block; 6, magnet block positioning end; 7, magnet block; 8, lower sponge support block; 9, lower sponge support block; 10, magnet block slot; 11, positioning sealing block; 12, locking block sliding block slot; 13, locking block sliding block; 14, inner box body edge slot; 15, sealing strip; 16, limiting ring; 17, magnet block limiting block; 18, inner box body cavity; 19, limiting strip; 20, positioning sticker; 21, limiting strip slot; 22, sponge support block slot; 23, magnet block limiting block slot; 24, reagent tube; 25, compression spring slot; 26, compression spring. DETAILED DESCRIPTION

[0026] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, not all the embodiments.

[0027] Please refer to Figures 1-6 , the present application provides an embodiment: a PCR reaction device for home detection, comprising an outer box body 1, an inner box body cavity 18 is formed in the inside of the outer box body 1, an inner box body 2 is slidably arranged in the inside of the inner box body cavity 18, a locking block slot 3 is formed in the upper part of the inner box body cavity 18, a locking block 4 is slidably arranged in the inside of the locking block slot 3, the lower end of the locking block 4 extends to the inside of the inner box body cavity 18, and the lower end surface of the locking block 4 is matched with the inner box body 2.

[0028] When in use, the locking block 4 is pressed down by its own gravity and the pressure of the compression spring 26, at this time, the upper edge of the inner box body 2 is clamped inside the inner box body edge groove 14, at this time, the upper edge of the inner box body 2 and the limiting ring 16 are respectively in close contact with the sealing strip 15, thereby achieving good sealing of the inner box body 2. Through the sealing and close contact connection relationship, the sealing protection of the inner box body 2 can be improved, effectively preventing the outside material from polluting the reagent tube 24. Through the upper and lower compression of the upper sponge holder 8 and the lower sponge holder 9, the external pressure and shaking can be greatly buffered, thereby improving the protection effect of the reagent tube 24, preventing the internal reagent tube 24 from being damaged. At the same time, due to the adaptive relationship between the locking block 4 and the inner box body 2, the outward sliding of the locking block 4 can be effectively limited, thereby preventing the reagent box from being easily loosened when the reagent box is squeezed during storage and transportation, thereby causing the detector material to be spilled and damaged.

[0029] Please refer to Figures 1-2 , two iron blocks 5 are symmetrically arranged inside the locking block 4, one end of the outer box body 1 is provided with a magnet block positioning end 6, the outer box body 1 is a box body with one side open, the inner box body 2 is a box body with the upper end open, and the magnet block positioning end 6 is adapted to the inner box body cavity 18.

[0030] When stacking, the magnet block positioning end 6 can be spliced with the magnet block positioning end 6 of the adjacent reagent box, thereby improving the stability of the stacking of the reagent boxes.

[0031] Please refer to Figure 1 , a magnet block groove 10 is symmetrically arranged on one side of the magnet block positioning end 6, a magnet block 7 is movably installed inside the magnet block groove 10, and the magnet block 7 is magnetically connected with the iron block 5. A compression spring groove 25 is symmetrically arranged on both sides of the upper end of the locking block 4, a compression spring 26 is arranged inside the compression spring groove 25, the upper end of the compression spring 26 is in close contact with the inner wall of the upper end of the locking block groove 3, and the lower end of the compression spring 26 is in close contact with the inner wall of the compression spring groove 25.

[0032] The positioning sticker 20 generates an attractive force on the iron block 5, so that the locking block 4 slides upward under the limiting of the locking block sliding block groove 12 and the locking block sliding block 13, thereby releasing the locking of the locking block 4 on the inner box body 2. The compression spring 26 in the compression spring groove 25 applies a downward pressure to the locking block 4, thereby increasing the pressure of the locking block 4 on the inner box body 2, thereby improving the sealing effect of the inner box body 2.

[0033] Please refer to Figure 1 and Figure 3The two sides of the locking block slot 3 are symmetrically provided with locking block sliding block slots 12, the two sides of the upper end of the locking block 4 are symmetrically provided with locking block sliding blocks 13, and the locking block sliding blocks 13 are in sliding connection with the locking block sliding block slots 12, and the middle position of the lower end of the locking block 4 is provided with a positioning sealing block 11 which is in abutment with the upper end of the inner box body 2.

[0034] Please refer to Figure 1 and Figure 3 The outer side of the lower end of the locking block 4 is provided with an inner box body edge slot 14, and the inner wall of the upper end of the inner box body edge slot 14 and the bottom end of the end of the locking block 4 close to the positioning sealing block 11 are provided with a sealing strip 15, and the inner box body 2 is fixedly installed with a limiting ring 16, the sealing strip 15 in the inner box body edge slot 14 is in abutment with the upper end of the inner box body 2, and the sealing strip 15 at the bottom end of the end of the locking block 4 close to the positioning sealing block 11 is in abutment with the upper end of the limiting ring 16.

[0035] At this time, the upper edge of the inner box body 2 and the limiting ring 16 are respectively in abutment with the sealing strip 15, thereby realizing good sealing of the inner box body 2, and through the sealing and abutting connection relationship, the sealing protection of the inner box body 2 can be improved, and the pollution of external substances to the reagent tube 24 can be effectively prevented.

[0036] Please refer to Figure 1 and Figure 4 The upper end of the outer box body 1 is symmetrically provided with positioning stickers 20, and the positioning stickers 20 are correspondingly provided with the iron blocks 5.

[0037] Please refer to Figures 4-5 The lower end of the inner box body cavity 18 is fixedly provided with three limiting strips 19 at equal intervals, and the lower end of the inner box body 2 is provided with three limiting strip slots 21 which are in sliding connection with the limiting strips 19.

[0038] When stacking, the magnet block positioning end 6 can be spliced with the magnet block positioning end 6 of the adjacent reagent box, thereby improving the stability of the stacking of the reagent boxes, when opening the reagent box, the magnet block 7 in the magnet block slot 10 is taken out first, one end of the magnet block 7 is gripped, the magnet block 7 is rotated in the magnet block slot 10, the magnet block limiting block 17 is slid in the arc-shaped slot of the magnet block limiting block slot 23, after being rotated to the position where it cannot be rotated, it is pulled outwards, so that the magnet block limiting block 17 slides out of the vertical slot of the magnet block limiting block slot 23, at this time, the magnet block 7 is placed at the position of the positioning sticker 20, the positioning sticker 20 generates an attractive force on the iron block 5, so that the locking block 4 slides upwards under the limiting of the locking block sliding block slot 12 and the locking block sliding block 13, thereby releasing the locking of the inner box body 2 by the locking block 4, at this time, the inner box body 2 is pulled outwards, the inner box body 2 slides outwards under the limiting of the limiting strip 19 and the limiting strip slot 21, after the inner box body 2 is completely taken out, the Shanghai cotton supporting block 8 is taken out, and the reagent tube 24 can be taken out for collection work.

[0039] Please refer to Figure 1 , Figure 2 and Figure 5 , the inner side of the inner box 2 is provided with a sponge supporting block groove 22, the inside of the sponge supporting block groove 22 is placed with a top sponge supporting block 8 and a lower sponge supporting block 9, and the top sponge supporting block 8 is located above the lower sponge supporting block 9, and the top sponge supporting block 8 is arranged in close contact with the lower sponge supporting block 9.

[0040] The upper and lower pressing and fixing of the top sponge supporting block 8 and the lower sponge supporting block 9 can greatly buffer the external pressure and shaking, thereby improving the protection effect of the reagent tube 24, preventing the internal reagent tube 24 from being damaged.

[0041] Please refer to Figures 1-2 , the inside of the top sponge supporting block 8 and the lower sponge supporting block 9 is provided with a reagent tube 24, the length of the top sponge supporting block 8 is less than the distance between the limiting rings 16, and the height of the top sponge supporting block 8 and the lower sponge supporting block 9 is the same as the height of the upper surface of the limiting ring 16.

[0042] Please refer to Figure 1 , Figure 2 and Figure 6 , the two sides of one end of the magnet block 7 are symmetrically provided with magnet block limiting blocks 17, the two sides of the magnet block slot 10 are symmetrically provided with magnet block limiting block grooves 23, and the magnet block limiting block grooves 23 are in sliding connection with the magnet block limiting blocks 17, and the magnet block limiting block grooves 23 are L-shaped grooves.

[0043] Take out the magnet block 7 in the magnet block slot 10, grip one end of the magnet block 7, rotate the magnet block 7 in the magnet block slot 10, make the magnet block limiting block 17 slide in the arc-shaped groove of the magnet block limiting block groove 23, and after rotating to the position where it cannot be rotated, pull it outwards, so that the magnet block limiting block 17 slides out of the vertical groove of the magnet block limiting block groove 23, thereby taking out the magnet block 7.

[0044] Working principle: when in use, the locking block 4 is pressed down due to its own gravity and the pressure of the compression spring 26, at this time, the upper edge of the inner box body 2 is clamped inside the inner box body edge groove 14, at this time, the upper edge of the inner box body 2 and the limiting ring 16 are respectively attached to the sealing strip 15, thereby achieving good sealing of the inner box body 2, through the sealing and attached connection relationship, the sealing protection of the inner box body 2 can be improved, effectively preventing the outside material from polluting the reagent tube 24, through the upper and lower pressing and fixing of the upper sponge block 8 and the lower sponge block 9, the external pressure and shaking can be greatly buffered, thereby improving the protection effect of the reagent tube 24, preventing the internal reagent tube 24 from being damaged, at the same time, due to the adaptive relationship between the locking block 4 and the inner box body 2, the outward sliding of the locking block 4 can be effectively limited, thereby preventing the reagent box from being easily loosened when the reagent box is squeezed during storage and transportation, causing the detector material to be spilled and damaged, when stacking, the magnet block positioning end 6 can be spliced with the magnet block positioning end 6 of the adjacent reagent box, thereby improving the stability of the stacking of the reagent boxes, when opening the reagent box, the magnet block 7 in the magnet block slot 10 is taken out first, one end of the magnet block 7 is gripped, the magnet block 7 is rotated in the magnet block slot 10, the magnet block limiting block 17 is slid in the arc-shaped slot of the magnet block limiting block slot 23, after being rotated to the point where it cannot be rotated, it is pulled outwards, thereby making the magnet block limiting block 17 slide out of the vertical slot of the magnet block limiting block slot 23, at this time, the magnet block 7 is placed at the position of the positioning sticker 20, the positioning sticker 20 generates an attractive force on the iron block 5, thereby making the locking block 4 slide upwards under the limiting of the locking block sliding block slot 12 and the locking block sliding block 13, thereby releasing the locking of the locking block 4 on the inner box body 2, at this time, the inner box body 2 is pulled outwards, the inner box body 2 slides outwards under the limiting of the limiting strip 19 and the limiting strip slot 21, after the inner box body 2 is completely taken out, the sponge block 8 is taken out, and the reagent tube 24 can be taken out for collection work.

[0045] It is apparent to those skilled in the art that the present application is not limited to the details of the foregoing exemplary embodiments, and that the present application can be implemented in other specific forms without departing from the spirit or essential characteristics of the present application. Therefore, the embodiments should be considered in all respects as illustrative and not restrictive, the scope of the present application being defined by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein. Any reference signs in the claims should not be construed as limiting the claims concerned.

Claims

1. A PCR reaction device for home testing, comprising an outer box body (1), characterized in that: The inside of the outer box body (1) is provided with an inner box cavity (18), the inside of the inner box cavity (18) is slidably provided with an inner box body (2), the upper portion of the inner box cavity (18) is provided with a locking block slot (3), the inside of the locking block slot (3) is slidably provided with a locking block (4), the lower end of the locking block (4) extends into the inner box cavity (18), and the lower end surface of the locking block (4) is matched with the inner box body (2); The inside of the locking block (4) is symmetrically provided with two iron blocks (5), one end of the outer box body (1) is provided with a magnet block positioning end (6), the outer box body (1) is a box body with one side open, the inner box body (2) is a box body with the upper end open, and the magnet block positioning end (6) is matched with the inner box cavity (18); The upper end of the outer box body (1) is symmetrically provided with a positioning sticker (20), and the positioning sticker (20) is correspondingly provided with the iron block (5); One side of the magnet block positioning end (6) is symmetrically provided with a magnet block slot (10), the inside of the magnet block slot (10) is movably provided with a magnet block (7), and the magnet block (7) is magnetically connected with the iron block (5), the two sides of the upper end of the locking block (4) are symmetrically provided with a compression spring slot (25), the inside of the compression spring slot (25) is provided with a compression spring (26), the upper end of the compression spring (26) is matched with the inner wall of the upper end of the locking block slot (3), and the lower end of the compression spring (26) is matched with the inner wall of the compression spring slot (25); The two sides of one end of the magnet block (7) are symmetrically provided with a magnet block limiting block (17), the two sides of the magnet block slot (10) are symmetrically provided with a magnet block limiting block slot (23), and the magnet block limiting block slot (23) is slidably connected with the magnet block limiting block (17), and the magnet block limiting block slot (23) is an L-shaped slot; When the kit is opened, the magnet block in the magnet block slot is taken out first, and the magnet block is placed at the position of the positioning sticker, so that the locking of the inner box body by the locking block is released.

2. The PCR reaction device for home testing according to claim 1, wherein: The two sides of the locking block slot (3) are symmetrically provided with a locking block sliding block slot (12), the two sides of the upper end of the locking block (4) are symmetrically provided with a locking block sliding block (13), and the locking block sliding block (13) is slidably connected with the locking block sliding block slot (12), and the middle position of the lower end of the locking block (4) is provided with a positioning sealing block (11), and the positioning sealing block (11) is matched with the upper end of the inner box body (2).

3. The PCR reaction device for home testing according to claim 2, wherein: The outer side of the lower end of the locking block (4) is provided with an inner box edge slot (14), and the inner wall of the upper end of the inner box edge slot (14) and the bottom end of the locking block (4) close to the one end of the positioning sealing block (11) are provided with a sealing strip (15), the inside of the inner box body (2) is fixedly provided with a limiting ring (16), the sealing strip (15) in the inner box edge slot (14) is matched with the upper end of the inner box body (2), and the sealing strip (15) at the bottom end of the locking block (4) close to the one end of the positioning sealing block (11) is matched with the upper end of the limiting ring (16).

4. The PCR reaction device for home testing according to claim 1, wherein: The lower end of the inner box cavity (18) is equidistantly and fixedly provided with three limiting strips (19), the lower end of the inner box (2) is provided with three limiting strip grooves (21), and the limiting strip grooves (21) are in sliding connection with the limiting strips (19).

5. The PCR reaction device for home testing according to claim 4, wherein: The inner side of the inner box (2) is provided with a sponge supporting block groove (22), the inside of the sponge supporting block groove (22) is placed with a top sponge supporting block (8) and a lower sponge supporting block (9), the top sponge supporting block (8) is located above the lower sponge supporting block (9), and the top sponge supporting block (8) is attached to the lower sponge supporting block (9).

6. The PCR reaction device for home testing according to claim 5, wherein: The inside of the top sponge supporting block (8) and the lower sponge supporting block (9) is equidistantly provided with a reagent tube (24), the length of the top sponge supporting block (8) is less than the interval between the limiting rings (16), and the height of the top sponge supporting block (8) and the lower sponge supporting block (9) is the same as the height of the upper surface of the limiting ring (16).

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