A phospholipid nanomaterial derived from adventitious root extract of jasmonate-induced methyl jasmonate, as well as its preparation method, application, and pharmaceutical composition

By combining the adventitious root extract of the yellow lacquer tree induced by methyl jasmonate with phospholipids to form phospholipid nanomaterials, the problems of stability and poor water solubility of the adventitious root extract of the yellow lacquer tree were solved, and high bioavailability and improved drug delivery efficiency were achieved.

CN118903230BActive Publication Date: 2025-09-23NINGBO INST OF TECH ZHEJIANG UNIV ZHEJIANG
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Patent Information

Application Number
CN202410963426.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-07-18
Publication Date
2025-09-23
Estimated Expiration
2044-07-18

AI Technical Summary

Technical Problem

The stability and water solubility of the adventitious root extract of Psoralea corylifolia are poor, which affects its bioavailability and efficacy.

Method used

The adventitious root extract of the yellow lacquer tree induced by methyl jasmonate is combined with phospholipids to form a phospholipid nanomaterial, and the adventitious root extract of the yellow lacquer tree induced by methyl jasmonate is embedded through hydrogen bonding. The preparation method includes the steps of mixing, water dissolution, compounding, ultrasonic treatment and drying.

Benefits of technology

The stability and water solubility of the adventitious root extract of the yellow lacquer tree induced by methyl jasmonate were improved, its bioavailability and pharmacological activity were enhanced, it showed excellent time stability and thermal stability, and improved drug delivery efficiency.

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Abstract

The present invention provides a methyl jasmonate-induced phospholipid nanomaterial from an extract of the adventitious roots of the Chinese yew vine, as well as a preparation method, application, and pharmaceutical composition thereof, relating to the field of biomedical technology. The methyl jasmonate-induced phospholipid nanomaterial from an extract of the adventitious roots of the Chinese yew vine provided by the present invention comprises an extract of the adventitious roots of the Chinese yew vine induced by the methyl jasmonate and a phospholipid bonded to the surface of the extract of the adventitious roots of the Chinese yew vine induced by the methyl jasmonate. The present invention bonds the extract of the adventitious roots of the Chinese yew vine induced by the methyl jasmonate with the phospholipid, thereby greatly improving the stability, water solubility, bioavailability, and pharmacological activity of the extract of the adventitious roots of the Chinese yew vine induced by the methyl jasmonate, and having excellent anti-inflammatory and anti-tumor activities. The phospholipid has low toxicity, and the methyl jasmonate-induced phospholipid nanomaterial from the adventitious roots of the Chinese yew vine induced by the methyl jasmonate is highly safe. The methyl jasmonate-induced phospholipid nanomaterial from the adventitious roots of the Chinese yew vine induced by the methyl jasmonate is a nanoscale biomaterial that greatly improves the efficiency of drug delivery.
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