Exosome skin care patch and preparation device and method thereof

Abstract

The invention relates to the technical field of nursing patch preparation, and in particular to an exosome skin care patch and a preparation device and method thereof, comprising a preparation box, a stirring unit, a refrigerator, a conveyor belt and an execution unit; the invention can solve the following problems existing in the prior art in the process of stirring a hydrogel mixture: the hydrogel mixture cannot be poured out for shaping, which requires an increase in workload, and bubbles are easily generated when the hydrogel is poured into a mold, affecting the quality; the hydrogel mixture is not applied to a substrate, which requires further steps, and bubbles are easily generated when the hydrogel mixture is applied at a higher temperature; the invention mixes the hydrogel mixture under a vacuum environment to remove bubbles, and can automatically apply the mixed hydrogel mixture, during which the mixture can be cooled to accelerate the solidification of the hydrogel mixture, and avoid the generation of bubbles in the hydrogel mixture under the condition of increased temperature to affect the quality.

Description

Technical Field

[0001] The present invention relates to the technical field of nursing patch production, and in particular to an exosome skin care patch and a preparation device and method thereof. Background Art

[0002] Exosome skin care patches are an advanced skin care product that utilizes the bioactive properties of exosomes to improve skin condition. In exosome skin care products, exosomes are usually derived from stem cells, which can secrete exosomes rich in growth factors and other beneficial substances.

[0003] Exosome skin care patches are usually prepared using hydrogels or freeze-dried patches. Among them, hydrogels have good biocompatibility and biodegradability, can slowly release exosomes, and are usually used to make wound dressings and skin care patches. When preparing hydrogel patches, it is necessary to prepare an aqueous solution containing exosomes and polymers and stir and mix them within a specific temperature range to ensure that the exosomes are evenly dispersed in the solution. The mixed solution is then poured into a pre-prepared mold, and finally the mold is placed in a refrigerator or constant temperature box to solidify. For the stirring and mixing of the aqueous solution of exosomes and polymers, the temperature range needs to be controlled to simulate physiological conditions to promote material interaction and the stability of the exosomes.

[0004] However, there are usually some problems in the preparation of current skin care patches. With the development of science and technology, technical personnel in related fields have also carried out a lot of optimization on skin care patches to solve some problems that different consumer groups care about. In order to make a more accurate comparison, a Chinese patent with publication number CN118105906A discloses a hydrogel patch preparation device and a preparation method thereof, including a base plate, a fixing frame fixedly connected to the base plate, and a vacuum stirring box fixedly connected to the fixing frame; a feeding mechanism is provided at the upper side of the vacuum stirring box, and the feeding mechanism is used to inject the hydrogel mixture to be stirred into the vacuum stirring box while keeping air from entering the vacuum stirring box; a support frame is fixedly connected to the base plate, and a material return mechanism is provided on the support frame, and the material return mechanism is used to take the stirred hydrogel out of the vacuum stirring box while maintaining vacuum in the vacuum stirring box; a first driving mechanism is provided on the base plate, and the first driving mechanism is used to drive the operation of the material return mechanism.

[0005] When the above-mentioned prior art is in use, the hydrogel mixture is injected into the feeding mechanism, and then the feeding mechanism injects the hydrogel mixture into the vacuum stirring box for stirring while the vacuum stirring box maintains vacuum. When the vacuum stirring box stirs the hydrogel mixture in a relatively vacuum environment, the bubbles in the colloid will be directly discharged, thereby effectively improving the quality of the stirred hydrogel; after the vacuum stirring box completes stirring, the first driving mechanism drives the material return mechanism to take out the stirred hydrogel while ensuring that the vacuum stirring box is relatively vacuum.

[0006] However, the above-mentioned prior art still has some deficiencies in the process of stirring the hydrogel mixture:

[0007] 1. After the hydrogel mixture is stirred, it needs to be poured into a designated mold to cool and set. However, the above-mentioned prior art only achieves stirring of the hydrogel mixture and cannot pour it out to set it. Therefore, the stirred hydrogel mixture needs to be further processed, which increases the workload. In addition, when the hydrogel is poured into the mold, air is easily introduced and bubbles are formed inside, thereby affecting the quality of the hydrogel patch.

[0008] 2. In order to facilitate the use of the skin care patch, during the production process of the skin care patch, the mixed hydrogel mixture needs to be applied to a specified substrate to complete the preparation of the skin care patch. However, the above-mentioned prior art only involves the stirring and mixing of the hydrogel mixture, and does not involve applying the hydrogel mixture to the substrate. Therefore, further steps are required, and it is difficult to ensure that the hydrogel mixture is within the specified temperature range when applying it, which causes the hydrogel mixture to easily generate bubbles when applied at a higher temperature, further affecting the quality of the hydrogel patch.

[0009] Therefore, based on the above-stated viewpoints, there is still room for improvement in the preparation of existing hydrogel patches. Summary of the Invention

[0010] In order to solve the above problems, the present invention adopts the following technical solutions:

[0011] In a first aspect, the present invention provides an exosome skin care patch, comprising a substrate patch, the upper end of which is coated with a hydrogel containing exosomes, and the upper end of the substrate patch is also adhered with a protective patch that is easy to peel off, which surrounds the outside of the hydrogel and is used to prevent water loss in the hydrogel.

[0012] In a second aspect, in order to facilitate the production of an exosome skin care patch, the present invention provides a preparation device for producing the above-mentioned exosome skin care patch, the preparation device comprising a preparation box, wherein both ends of the preparation box in the longitudinal direction have a penetrating feeding end and a feeding end, and a stirring unit for uniformly mixing the exosome solution and the hydrogel is installed inside the preparation box, and the stirring unit comprises a vacuum cylinder installed in the middle of the inner wall of the preparation box for applying the hydrogel on the substrate patch, the vacuum cylinder and the top of the preparation box are jointly provided with a feeding port, and a sealing assembly for sealing the feeding port is installed on the top of the vacuum cylinder;

[0013] A refrigerator is installed on the top of the preparation box between its material collection end and the vacuum cylinder. A conveyor belt for transporting substrate patches is also provided on the inner wall of the preparation box, and the conveyor belt is located below the vacuum cylinder. An execution unit for applying a protective patch to the outside of the hydrogel is installed between the conveyor belt and one side of the material collection end of the preparation box.

[0014] As a preferred technical solution of the present invention, the stirring unit also includes a support shaft passing through the inside of the vacuum cylinder, and a plurality of annular stirring racks are evenly arranged on the outer wall of the support shaft. A driving motor connected to the support shaft is installed on the outer wall of the preparation box through a motor seat. An air suction pump and an air delivery pump are provided at the upper end of the preparation box. The air suction pump and the air delivery pump are symmetrically arranged along the feed port, and the ends of the air suction pump and the air delivery pump away from the vacuum cylinder both pass through the preparation box and extend to the outside.

[0015] As a preferred technical solution of the present invention, the sealing assembly includes two baffles symmetrically hinged to the inner wall of the feed port through torsion springs, the opposite sides of the two baffles are clamped to each other, and the inner wall of the feed port is equipped with a limiting block that rests against the upper end of the baffle.

[0016] As a preferred technical solution of the present invention, a through hole is provided at the bottom of the vacuum cylinder, a smearing roller is rotatably arranged inside the through hole, a plurality of glue storage pads are equidistantly arranged on the outer wall of the smearing roller along the axial direction, and the plurality of glue storage pads correspond to the plurality of groove positions on the conveyor belt, a linkage shaft is passed through the middle of the smearing roller, and a power switching assembly is installed between the preparation box, the conveyor belt, the support shaft and the linkage shaft.

[0017] As a preferred technical solution of the present invention, the power switching assembly includes a spline head, and both ends of the linkage shaft are installed with spline heads after passing through the vacuum cylinder. A positioning shaft with the same axis as the linkage shaft is rotatably provided on the preparation box, and the positioning shaft is connected to the support shaft through a belt drive. A receiving groove is provided on the side of the positioning shaft close to the linkage shaft, and a spline sleeve matching the spline head is provided in the receiving groove. A limiting groove parallel to the axis of the receiving groove is provided on the inner wall of the receiving groove, and a connecting block slidably docked in the limiting groove is installed on the outer wall of the spline sleeve;

[0018] A cylinder is provided at one end of the positioning shaft away from the linkage shaft. The cylinder is symmetrically mounted on the outer wall of the preparation box through a bracket. The telescopic end of the cylinder slides through the positioning shaft and is rotationally connected to the spline sleeve.

[0019] As a preferred technical solution of the present invention, the power switching assembly also includes a connecting shaft, multiple connecting shafts are passed through the middle of the conveyor belt, and one of the connecting shafts is located below the positioning shaft. An installation groove is opened inside the preparation box, and a first gear that meshes with each other is jointly sleeved between the positioning shaft and the connecting shaft below it, and the outer diameter and number of teeth of the two first gears are equal.

[0020] As a preferred technical solution of the present invention, the execution unit includes a limit shaft rotatably arranged on the inner wall of the preparation box, the limit shaft is located on the side of the preparation box close to the material taking end, and the limit shaft and the end of the connecting shaft close to the material taking end of the preparation box are jointly sleeved with a second gear, and two supporting plates are symmetrically arranged along the width direction on one side of the material taking end of the preparation box, and the winding roller and the unwinding roller distributed up and down are rotatably installed on the opposite sides of the two supporting plates;

[0021] A patch roll is provided between the winding roller and the unwinding roller, which passes through the preparation box and then bypasses the bottom of the limiting shaft. The patch roll is provided with multiple protective patches corresponding to the substrate patches and groove positions. The limiting shaft and the winding roller are connected by a belt drive.

[0022] In a third aspect, the present invention further provides a method for preparing an exosome skin care patch, comprising the following steps:

[0023] S1: Pouring raw materials: First, pour the hydrogel and the solution containing exosomes into the vacuum cylinder through the feed port;

[0024] S2: stirring and mixing: stirring and mixing the hydrogel mixture under a vacuum environment by a stirring unit to remove bubbles therein;

[0025] S3: Spreading the hydrogel mixture: After the hydrogel mixture is stirred, the hydrogel mixture is spread on the substrate patch at the upper end of the conveyor belt through the stirring unit, and then the inside of the preparation box is cooled by the refrigerator to accelerate the solidification of the hydrogel mixture;

[0026] S4: Applying a protective patch: Applying a protective patch on the upper end of the base patch through the execution unit to complete the production of the exosome skin care patch, and then taking out the prepared exosome skin care patch.

[0027] In summary, this application includes at least one of the following beneficial technical effects:

[0028] First, the present invention extracts the air from the vacuum cylinder, allowing the hydrogel mixture therein to mix in a vacuum environment. As a result, the gas in the hydrogel mixture forms bubbles and diffuses to the outside when the pressure is reduced. The gas in the bubbles is then extracted by an air pump, thereby removing the bubbles in the hydrogel mixture, thereby improving the uniformity and stability of the hydrogel mixture and preventing the bubbles from affecting the quality of the hydrogel mixture.

[0029] 2. The present invention scrapes the hydrogel mixture in the vacuum cylinder by rotating the smear roller and driving the glue pad. When the smear roller drives the glue pad to rotate downward, the hydrogel mixture can be quickly smeared on the substrate patch at the upper end of the conveyor belt, and the smearing can be performed continuously, thereby improving the preparation efficiency of the exosome skin care patch. In addition, the hydrogel mixture can be cooled when smearing, thereby accelerating the solidification of the hydrogel mixture and preventing the hydrogel mixture from generating bubbles when the temperature rises.

[0030] 3. The present invention controls the connection between the spline sleeve and the spline head so that the spline sleeve can drive the spline head, the linkage shaft and the smear roller to rotate as a whole under the action of the positioning shaft, thereby facilitating the smear roller to smear the mixed hydrogel mixture on the substrate patch at the upper end of the conveyor belt, thereby realizing automatic smearing of the hydrogel mixture; at this time, the positioning shaft drives the connecting shaft and the conveyor belt to move in opposite directions through the first gear, and when the smear roller and the conveyor belt move relative to each other, it is always ensured that the multiple glue pads and grooves overlap, so as to ensure the smearing efficiency and smearing accuracy of the hydrogel mixture.

[0031] 4. The present invention can seal the gap between the smear roller and the through hole by abutting each other with the arc-shaped slide plates under the action of the supporting spring, thereby preventing the hydrogel mixture from flowing out during the mixing process, so as to facilitate its sufficient mixing; after the hydrogel mixture is mixed, the spline sleeve and the spline head can be connected by the annular top frame and the top rod to drive the pushing block to cooperate with the force plate to push the two arc-shaped slide plates to both sides, so that the mixed hydrogel mixture can flow out downward, thereby facilitating the smear roller to automatically smear the mixed hydrogel mixture on the substrate patch. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] The present invention will be further described below with reference to the accompanying drawings and examples.

[0033] Figure 1 Schematic diagram of the structure of the hydrogel mixture of the present invention.

[0034] Figure 2 It is a structural schematic diagram of a device for preparing an exosome skin care patch of the present invention.

[0035] Figure 3 It is a schematic diagram of the internal structure between the preparation box and the vacuum cylinder of the present invention.

[0036] Figure 4 This invention Figure 3 A partial enlarged view of point A.

[0037] Figure 5 This invention Figure 3 A partial enlarged view of point B.

[0038] Figure 6 It is a structural schematic diagram of the power switching assembly of the present invention.

[0039] Figure 7 It is a structural diagram of the execution unit of the present invention.

[0040] Figure 8 It is a structural schematic diagram of the control unit of the present invention.

[0041] Figure 9 It is a working state diagram of the control unit of the present invention.

[0042] In the figure, 1. substrate patch; 2. hydrogel; 3. protective patch; 4. preparation box; 5. stirring unit; 51. vacuum cylinder; 511. smear roller; 512. glue storage pad; 513. linkage shaft; 514. power switching assembly; 515. spline head; 516. positioning shaft; 517. storage slot; 518. spline sleeve; 519. limit slot; 520. connecting block; 521. cylinder; 522. connecting shaft; 523. first gear; 53. feed port; 54. sealing assembly; 541. baffle; 542 , limit block; 55, support shaft; 56, stirring frame; 57, drive motor; 58, vacuum pump; 59, air pump; 6, refrigerator; 7, conveyor belt; 8, execution unit; 81, limit shaft; 82, second gear; 83, support plate; 84, winding roller; 85, unwinding roller; 86, patch roll; 9, control unit; 91, arc slide; 92, mounting plate; 93, support spring; 94, force plate; 95, extension rod; 96, pillar; 97, annular top frame; 98, pushing block; 99, top rod. DETAILED DESCRIPTION

[0043] The following is combined with Figures 1-9 The embodiments of the present invention are described in detail.

[0044] The embodiments of the present application disclose an exosome skin care patch and a preparation device and method thereof. It is explained that the present application is mainly used in the production process of the exosome skin care patch. In terms of technical effect, the hydrogel mixture can be mixed in a vacuum environment to remove bubbles in the hydrogel mixture, improve its mixing uniformity and stability, and prevent bubbles from affecting the quality of the hydrogel mixture. The mixed hydrogel mixture is then applied to a substrate patch 1, and then a protective patch 3 is applied to prevent water loss in the hydrogel mixture; in particular, during the process of applying the hydrogel mixture, the substrate patch 1 can be automatically supplied so that the hydrogel mixture can be quickly applied to the substrate patch 1, and continuous application can be performed, thereby improving production efficiency.

[0045] Example 1:

[0046] Reference Figure 1 As shown, in the first aspect, the present invention provides an exosome skin care patch, comprising a substrate patch 1, the upper end of which is coated with a hydrogel 2 containing exosomes, and the upper end of the substrate patch 1 is also adhered with a protective patch 3 that is easy to peel off, and the protective patch 3 surrounds the outside of the hydrogel 2 and is used to prevent water loss in the hydrogel 2.

[0047] Reference Figure 2 and Figure 3 As shown, in the second aspect, in order to facilitate the production of the exosome skin care patch, the present invention provides a preparation device for producing the above-mentioned exosome skin care patch, the preparation device includes a preparation box 4, and the two ends of the preparation box 4 in the length direction have a penetrating feeding end and a feeding end, and a stirring unit 5 is installed inside the preparation box 4, and the stirring unit 5 includes a vacuum cylinder 51 installed in the middle of the inner wall of the preparation box 4, and the vacuum cylinder 51 and the top of the preparation box 4 are jointly provided with a feeding port 53, and a sealing assembly 54 for sealing the feeding port 53 is installed on the top of the vacuum cylinder 51; between the vacuum cylinder 51 and the feeding end of the preparation box 4 is a curing zone for cooling the hydrogel mixture;

[0048] Furthermore, in this embodiment, a refrigerator 6 is installed on the top of the preparation box 4 between its material collection end and the vacuum cylinder 51, and a conveyor belt 7 for transporting the substrate patch 1 is also provided on the inner wall of the preparation box 4, and the conveyor belt 7 is located below the vacuum cylinder 51, and an execution unit 8 for applying the protective patch 3 is installed between the conveyor belt 7 and one side of the material collection end of the preparation box 4; in this embodiment, a plurality of grooves for placing the substrate patch 1 are evenly opened on the outer wall of the conveyor belt 7, and a suction cup (not shown in the figure) is provided in the groove for limiting and fixing the substrate patch 1.

[0049] During the specific implementation process, the hydrogel 2 and the solution containing exosomes are first poured into the vacuum cylinder 51 through the feed port 53, and then the hydrogel mixture is stirred by the stirring unit 5. During this period, the air inside the vacuum cylinder 51 can be discharged, so that the hydrogel mixture is mixed under a vacuum environment, so as to remove the bubbles therein and improve the uniformity and stability of the hydrogel mixture; after the hydrogel mixture is stirred, the conveyor belt 7 is controlled to run, and at the feeding end, the substrate patch 1 is placed in the groove at the upper end of the conveyor belt 7 in turn and limited by the action of the suction cup. When the conveyor belt 7 transports the substrate patch 1 to the bottom of the vacuum cylinder 51, the hydrogel mixture is intermittently discharged downward through the vacuum cylinder 51 and smeared on the substrate patch 1 at the upper end of the conveyor belt 7.

[0050] Then the conveyor belt 7 transports the substrate patch 1 coated with the hydrogel mixture to the side of the material collection end. When the hydrogel mixture is transported to the curing area, the inside of the preparation box 4 is cooled by the refrigerator 6, thereby accelerating the curing of the hydrogel mixture and preventing the hydrogel mixture from generating bubbles when the temperature rises. Then the conveyor belt 7 transports the substrate patch 1 to the material collection end and applies the protective patch 3 on the upper end of the substrate patch 1 through the execution unit 8, thereby completing the production of the exosome skin care patch, and then taking the prepared exosome skin care patch out of the groove from the material collection end.

[0051] It should be noted that the sealing assembly 54 can automatically seal the feed port 53 to ensure the sealing of the vacuum cylinder 51, prevent external air from entering the vacuum cylinder 51 and affecting the internal air pressure, thereby ensuring that bubbles in the hydrogel mixture are completely removed, thereby improving the quality of the hydrogel mixture.

[0052] Continue to refer to Figure 2 and Figure 3 As shown, in order to ensure the mixing uniformity between the hydrogel 2 and the exosome solution in the hydrogel mixture, it is necessary to stir it. Based on this, in this embodiment, the stirring unit 5 also includes a support shaft 55 passing through the inside of the vacuum cylinder 51, and the outer wall of the support shaft 55 is evenly provided with a plurality of annularly distributed stirring racks 56. The outer wall of the preparation box 4 is equipped with a driving motor 57 connected to the support shaft 55 through a motor seat. The upper end of the preparation box 4 is provided with an air extraction pump 58 and an air delivery pump 59. The air extraction pump 58 and the air delivery pump 59 are symmetrically arranged along the feed port 53, and the ends of the air extraction pump 58 and the air delivery pump 59 away from the vacuum cylinder 51 pass through the preparation box 4 and extend to the outside.

[0053] During the specific implementation process, after the hydrogel 2 and the exosome solution are poured into the vacuum cylinder 51, the drive motor 57 is started, and the drive motor 57 drives the support frame and the multiple stirring frames 56 to rotate synchronously as a whole. At the same time, the vacuum pump 58 is started, and the vacuum pump 58 discharges the air inside the vacuum cylinder 51, so that the vacuum cylinder 51 is a vacuum environment, so that the gas in the hydrogel mixture will form bubbles and diffuse to the outside when the pressure is reduced. The gas in the bubbles is then extracted by the vacuum pump 58, thereby removing the bubbles in the hydrogel mixture, thereby improving the uniformity and stability of the hydrogel mixture and preventing the bubbles from affecting the quality of the hydrogel mixture.

[0054] After the hydrogel mixture is mixed, the air pump 59 is started, and the air pump 59 slowly injects external air into the vacuum cylinder 51 to gradually restore the air pressure inside the vacuum cylinder 51, so that the hydrogel mixture is no longer in a vacuum environment and can flow downward, so that the hydrogel mixture can be applied to the substrate patch 1.

[0055] Reference Figure 4 As shown, in order to prevent external air from entering from the feed port 53 and affecting the sealing of the vacuum cylinder 51 after the hydrogel 2 and the exosome solution are poured into the vacuum cylinder 51 from the feed port 53, the feed port 53 needs to be sealed. Based on this, a sealing assembly 54 is provided in this embodiment. Specifically, the sealing assembly 54 includes two baffles 541 symmetrically hinged to the inner wall of the feed port 53 by a torsion spring. The opposite sides of the two baffles 541 are clamped to each other, and the inner wall of the feed port 53 is installed with a limiting block 542 that rests on the upper end of the baffle 541; the torsion spring always applies a torsional force with an upward rotation to the baffle 541, so that the baffle 541 rests on the bottom of the limiting block 542 under the action of the torsion spring. At this time, the opposite sides of the two baffles 541 are clamped to form a seal for the feed port 53 to prevent affecting the vacuum environment inside the vacuum cylinder 51.

[0056] Reference Figure 3 and Figure 5 As shown, in order to facilitate the smearing of the hydrogel mixture mixed in the vacuum cylinder 51 onto the substrate patch 1, in this embodiment, a through hole is opened at the bottom of the vacuum cylinder 51, and a smearing roller 511 is rotatably arranged inside the through hole. A plurality of glue storage pads 512 are equidistantly arranged on the outer wall of the smearing roller 511 along the axial direction, and the plurality of glue storage pads 512 correspond to the plurality of groove positions on the conveyor belt 7. A linkage shaft 513 is passed through the middle of the smearing roller 511, and a power switching component 514 is installed between the preparation box 4, the conveyor belt 7, the support shaft 55 and the linkage shaft 513.

[0057] In the specific implementation process, the power switching component 514 can make the hydrogel mixture in the vacuum cylinder 51 be mixed so that the glue pad 512 on the outer wall of the smear roller 511 is arranged upward, so that the through hole is closed by the smear roller 511 (in Figure 5 ), which facilitates the thorough mixing of the hydrogel mixture; after the mixing is completed, the power switching component 514 controls the linkage shaft 513 to drive the smear roller 511 to rotate, so that the smear roller 511 drives the glue pad 512 to rotate upward to scrape the hydrogel mixture in the vacuum cylinder 51, and then the smear roller 511 drives the glue pad 512 to rotate downward and smear the hydrogel mixture on the upper end of the substrate patch 1 at the upper end of the conveyor belt 7, so as to facilitate the rapid smearing of the hydrogel mixture on the substrate patch 1, and can be applied continuously, thereby improving the preparation efficiency of the exosome skin care patch.

[0058] Reference Figure 5 and Figure 6 As shown, in order to facilitate the thorough mixing of the hydrogel mixture and the automatic application of the mixed hydrogel mixture on the substrate patch 1, it is necessary to control the rotation state of the linkage shaft 513. Based on this, in this embodiment, the power switching component 514 includes a spline head 515. Both ends of the linkage shaft 513 are installed with a spline head 515 after passing through the vacuum cylinder 51. A positioning shaft 516 with the same axis as the linkage shaft 513 is rotatably provided on the preparation box 4. The positioning shaft 516 is connected to the support shaft 55 through a belt drive, and the positioning shaft 516 is close to the linkage shaft. A receiving groove 517 is provided on one side of 513, and a spline sleeve 518 that cooperates with the spline head 515 is provided in the receiving groove 517. A limiting groove 519 parallel to its axis is provided on the inner wall of the receiving groove 517, and a connecting block 520 that slides and docks in the limiting groove 519 is installed on the outer wall of the spline sleeve 518. Through the cooperation between the connecting block 520 and the limiting groove 519, the rotation direction between the positioning shaft 516 and the spline sleeve 518 can be locked, so that when the positioning shaft 516 rotates, it can drive the spline sleeve 518 to rotate synchronously.

[0059] Furthermore, in this embodiment, a cylinder 521 is provided at the end of the positioning shaft 516 away from the linkage shaft 513. The cylinder 521 is symmetrically installed on the outer wall of the preparation box 4 through a bracket. The telescopic end of the cylinder 521 slides through the positioning shaft 516 and is rotatably connected to the spline sleeve 518.

[0060] In the initial state, the spline sleeve 518 is retracted into the receiving groove 517 and does not contact the spline head 515. When the support shaft 55 rotates, it drives the positioning shaft 516 to rotate, and the positioning shaft 516 does not drive the spline head 515 to rotate through the spline sleeve 518. At this time, the coating roller 511 is in a stationary state and the through hole is closed, so that the support shaft 55 drives the stirring frame 56 to fully stir and mix the hydrogel mixture in the vacuum cylinder 51.

[0061] During the specific implementation process, after the hydrogel mixture is mixed, the cylinder 521 is started, and the cylinder 521 drives the spline sleeve 518 to move to the side close to the linkage shaft 513 and is sleeved on the outer wall of the spline head 515. At this time, the spline sleeve 518 drives the spline head 515, the linkage shaft 513 and the smearing roller 511 to rotate as a whole under the action of the positioning shaft 516, so that the rotating smearing roller 511 can smear the mixed hydrogel mixture on the substrate patch 1 at the upper end of the conveyor belt 7, thereby realizing automatic smearing of the hydrogel mixture.

[0062] Reference Figure 5 As shown, in order to ensure that the smear roller 511 corresponds to the groove at the upper end of the conveyor belt 7 when it rotates, it is necessary to ensure that the smear roller 511 and the conveyor belt 7 rotate relative to each other and ensure that the movement speed is equal. Based on this, in this embodiment, the power switching component 514 also includes a connecting shaft 522, and a plurality of connecting shafts 522 are passed through the middle of the conveyor belt 7, and one of the connecting shafts 522 is located below the positioning shaft 516. An installation groove is provided inside the preparation box 4, and a meshing first gear 523 is commonly provided between the positioning shaft 516 and the connecting shaft 522 below it, and the outer diameter and number of teeth of the two first gears 523 are equal.

[0063] During the specific implementation process, the two first gears 523 with equal outer diameters and numbers of teeth can ensure that the rotation directions of the positioning shaft 516 and the connecting shaft 522 are opposite and the rotation speeds are equal. Therefore, when the positioning shaft 516 drives the linkage shaft 513 and the smear roller 511 to rotate through the cooperation between the spline sleeve 518 and the spline head 515, the connecting shaft 522 drives the conveyor belt 7 to rotate synchronously, so that when the glue pad 512 on the outer wall of the smear roller 511 rotates to the bottom, the substrate patch 1 in the groove at the upper end of the conveyor belt 7 moves to the bottom of the glue pad 512 and overlaps, and when the smear roller 511 and the conveyor belt 7 move relative to each other, it is always ensured that multiple glue pads 512 and the groove overlap, so that the hydrogel mixture can be automatically applied to the substrate patch 1, thereby ensuring the smearing efficiency and accuracy of the hydrogel mixture.

[0064] Reference Figure 7 As shown, in order to facilitate the automatic application of the protective patch 3 on the upper end of the substrate patch 1 coated with the hydrogel mixture, a corresponding execution unit 8 is also provided in this embodiment. Specifically, the execution unit 8 includes a limit shaft 81 rotatably arranged on the inner wall of the preparation box 4, and the limit shaft 81 is located on the side of the preparation box 4 close to the material taking end, and the limit shaft 81 and the end of the connecting shaft 522 close to the material taking end of the preparation box 4 are jointly sleeved with a second gear 82. Two support plates 83 are symmetrically arranged along the width direction on one side of the material taking end of the preparation box 4, and the two support plates 83 are rotatably installed on the opposite sides with a winding roller 84 and a unwinding roller 85 distributed up and down.

[0065] Furthermore, in this embodiment, a patch roll 86 is provided between the winding roller 84 and the unwinding roller 85, which passes through the preparation box 4 and bypasses the bottom of the limiting shaft 81. The patch roll 86 is provided with a plurality of protective patches 3 corresponding to the substrate patch 1 and the groove position. The limiting shaft 81 and the winding roller 84 are connected by a belt drive.

[0066] During the specific implementation process, when the conveyor belt 7 drives the connecting shaft 522 to rotate counterclockwise while transporting the substrate patch 1, the connecting shaft 522 drives the limiting shaft 81 to rotate clockwise through the second gear 82, and the limiting shaft 81 drives the winding roller 84 to rotate clockwise synchronously, so that the limiting shaft 81 automatically applies the protective patch 3 on the outer wall of the patch roll 86 to the upper end of the substrate patch 1. The cooperation between the substrate patch 1 and the protective patch 3 can prevent the loss of water in the hydrogel mixture.

[0067] Example 2:

[0068] Reference Figure 8 and Figure 9 As shown, on the basis of Example 1, in order to prevent the hydrogel mixture from seeping into the gap between the smear roller 511 and the through hole and flowing downward when stirring and mixing, the smear roller 511 and the through hole need to be sealed. Based on this, a corresponding control unit 9 is also provided in this embodiment. Specifically, the control unit 9 includes a curved slide 91 slidably arranged on the inner bottom wall of the vacuum cylinder 51, and a recess is provided at the lower end of the curved slide 91 to make way for the smear roller 511, and two mounting plates 92 are symmetrically arranged on the inner bottom wall of the vacuum cylinder 51 along the smear roller 511. A plurality of support springs 93 are equidistantly installed on opposite sides of the mounting plate 92 and the curved slide 91 along the length direction. The support springs 93 always apply a supporting force to the curved slide 91, so that the two curved slides 91 abut against each other in the initial state and seal the gap between the smear roller 511 and the through hole, thereby preventing the hydrogel mixture from flowing out during the mixing process.

[0069] Furthermore, in this embodiment, both side walls of the arc-shaped slide 91 in the length direction are installed with force plates 94, and the ends of the two force plates 94 on the same side of the two arc-shaped slides 91 are inclined away from one side, and two guide sliding holes connected to the receiving groove 517 are symmetrically provided on the upper and lower sides of the positioning shaft 516, and two extension rods 95 slidably docked in the guide sliding holes are symmetrically provided on the upper and lower sides of the outer wall of the spline sleeve 518. The two extension rods 95 are installed with an annular top frame 97 on the side close to the vacuum cylinder 51 through the support 96, and the inner bottom wall of the vacuum cylinder 51 is symmetrically provided with two placement grooves along the axial direction, and a pushing block 98 is slidably provided in the placement groove. The pushing block 98 is located between the two force plates 94, and the pushing block 98 has an inclined surface parallel to the inclined side of the force plate 94. The end of the pushing block 98 away from the force plate 94 is installed with a push rod 99 that slides through the vacuum cylinder 51, and the push rod 99 slides in conflict with the annular top frame 97.

[0070] During the specific implementation process, after the hydrogel mixture is mixed, it needs to be smeared on the substrate patch 1. When the cylinder 521 drives the spline sleeve 518 to move to the side close to the linkage shaft 513 and engages with the spline head 515, the spline sleeve 518 drives the extension rod 95, the support 96 and the annular top frame 97 to move as a whole. The annular top frame 97 applies pressure to the pushing block 98 through the top rod 99, so that the pushing block 98 pushes the two arc-shaped slides 91 to both sides through the force plate 94, so that the hydrogel mixture in the vacuum cylinder 51 passes through the gap between the two arc-shaped slides 91 and flows downward into the smearing roller 511, so that the mixed hydrogel mixture can be automatically smeared on the substrate patch 1 through the smearing roller 511.

[0071] In a third aspect, the present invention further provides a method for preparing an exosome skin care patch, comprising the following steps:

[0072] S1: Pouring raw materials: First, the hydrogel 2 and the solution containing exosomes are poured into the vacuum cylinder 51 through the feed port 53. Then, the opposite sides of the two baffles 541 are clamped together to form a seal on the feed port 53 to prevent affecting the vacuum environment inside the vacuum cylinder 51.

[0073] S2: Stirring and mixing: Start the drive motor 57, which drives the support frame and the multiple stirring frames 56 to rotate synchronously as a whole. At the same time, start the vacuum pump 58, which exhausts the air inside the vacuum cylinder 51, so that the vacuum cylinder 51 is in a vacuum environment. As a result, the gas in the hydrogel mixture forms bubbles and diffuses to the outside when the pressure is reduced. The gas in the bubbles is then extracted by the vacuum pump 58, thereby removing the bubbles in the hydrogel mixture, thereby improving the uniformity and stability of the hydrogel mixture and preventing the bubbles from affecting the quality of the hydrogel mixture.

[0074] S3: Spreading the hydrogel mixture: After the hydrogel mixture is stirred, the cylinder 521 is started, and the cylinder 521 drives the spline sleeve 518 to be sleeved on the outer wall of the spline head 515. At this time, the spline sleeve 518 drives the spline head 515, the linkage shaft 513 and the smearing roller 511 to rotate as a whole under the action of the positioning shaft 516, so that the rotating smearing roller 511 can scrape the hydrogel mixture in the vacuum cylinder 51 through the glue pad 512. Then the smearing roller 511 drives the glue pad 512 to rotate downward and smear the hydrogel mixture on the upper end of the substrate patch 1 at the upper end of the conveyor belt 7, thereby realizing automatic spreading of the hydrogel mixture.

[0075] During this period, the first gear 523 can ensure that the rotation directions of the positioning shaft 516 and the connecting shaft 522 are opposite and the rotation speeds are equal, so that when the glue pad 512 on the outer wall of the coating roller 511 rotates to the bottom, the substrate patch 1 in the groove at the upper end of the conveyor belt 7 moves to the bottom of the glue pad 512 and overlaps with it, thereby ensuring the coating efficiency and coating accuracy of the hydrogel mixture.

[0076] Then the conveyor belt 7 transports the substrate patch 1 coated with the hydrogel mixture to the material removal end. When the hydrogel mixture is transported to the curing area, the refrigerator 6 cools the inside of the preparation box 4 to accelerate the curing of the hydrogel mixture.

[0077] S4: Applying the protective patch: When the conveyor belt 7 drives the connecting shaft 522 to rotate counterclockwise during the process of transporting the substrate patch 1, the connecting shaft 522 drives the limiting shaft 81 to rotate clockwise through the second gear 82, and the limiting shaft 81 drives the winding roller 84 to rotate clockwise synchronously, so that the limiting shaft 81 automatically applies the protective patch 3 on the outer wall of the patch roll 86 to the upper end of the substrate patch 1. The cooperation between the substrate patch 1 and the protective patch 3 can prevent the loss of water in the hydrogel mixture.

[0078] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention.

[0079] In addition, it should be understood that although this specification is described in terms of implementation methods, not every implementation method contains only one independent technical solution. This narrative method of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other implementation methods that can be understood by those skilled in the art.

Claims

1. A device for preparing an exosome skin care patch, used for preparing an exosome skin care patch, characterized in that: The exosome skin care patch comprises a base patch (1), the upper end of the base patch (1) is coated with a hydrogel (2) containing exosomes, and the upper end of the base patch (1) is also attached with a protective patch (3) that is easy to peel off, the protective patch (3) surrounds the outside of the hydrogel (2) and is used to prevent the loss of water in the hydrogel (2); The preparation device of the exosome skin care patch comprises a preparation box (4), wherein the two ends of the preparation box (4) in the length direction are provided with a feeding end and a feeding end penetrating therethrough, and a stirring unit (5) for uniformly mixing the exosome solution and the hydrogel (2) is installed inside the preparation box (4), and the stirring unit (5) comprises a vacuum cylinder (51) installed at the middle of the inner wall of the preparation box (4) for applying the hydrogel (2) on the substrate patch (1), and the vacuum cylinder (51) and the top of the preparation box (4) are jointly provided with a feeding port (53), and a sealing component (54) for sealing the feeding port (53) is installed at the top of the vacuum cylinder (51); A refrigerator (6) is installed at the top of the preparation box (4) between its material taking end and the vacuum cylinder (51); a conveyor belt (7) for conveying the substrate patch (1) is also arranged on the inner wall of the preparation box (4); the conveyor belt (7) is located below the vacuum cylinder (51); and an execution unit (8) for applying a protective patch (3) to the outside of the hydrogel (2) is installed between the conveyor belt (7) and one side of the material taking end of the preparation box (4); The stirring unit (5) further comprises a support shaft (55) which is inserted into the interior of the vacuum cylinder (51); the outer wall of the support shaft (55) is evenly provided with a plurality of annularly distributed stirring racks (56); the outer wall of the preparation box (4) is provided with a driving motor (57) which is connected to the support shaft (55) via a motor seat; an air extraction pump (58) and an air delivery pump (59) are provided at the upper end of the preparation box (4); the air extraction pump (58) and the air delivery pump (59) are symmetrically arranged along the feed port (53); and the ends of the air extraction pump (58) and the air delivery pump (59) which are away from the vacuum cylinder (51) both pass through the preparation box (4) and extend to the outside; The bottom of the vacuum cylinder (51) is provided with a through hole, a coating roller (511) is rotatably arranged inside the through hole, a plurality of glue storage pads (512) are equidistantly arranged on the outer wall of the coating roller (511) along the axial direction, the plurality of glue storage pads (512) correspond to the positions of the plurality of grooves on the conveyor belt (7), a linkage shaft (513) is passed through the middle of the coating roller (511), and a power switching assembly (514) is installed between the preparation box (4), the conveyor belt (7), the support shaft (55) and the linkage shaft (513); The power switching assembly (514) comprises a spline head (515), and both ends of the linkage shaft (513) are installed with the spline heads (515) after passing through the vacuum cylinder (51), and a positioning shaft (516) coaxial with the linkage shaft (513) is rotatably arranged on the preparation box (4), and the positioning shaft (516) is connected to the support shaft (55) through a belt drive, and a storage groove (517) is provided on the side of the positioning shaft (516) close to the linkage shaft (513), and a spline sleeve (518) matching with the spline head (515) is provided in the storage groove (517), and a limiting groove (519) parallel to the axis of the storage groove (517) is provided on the inner wall of the storage groove (517), and a connecting block (520) slidably docked in the limiting groove (519) is installed on the outer wall of the spline sleeve (518); A cylinder (521) is provided at one end of the positioning shaft (516) away from the linkage shaft (513). The cylinder (521) is symmetrically mounted on the outer wall of the preparation box (4) through a bracket. The telescopic end of the cylinder (521) slides through the positioning shaft (516) and is rotationally connected to the spline sleeve (518). The power switching assembly (514) further comprises a connecting shaft (522), a plurality of connecting shafts (522) are provided through the middle of the conveyor belt (7), and one of the connecting shafts (522) is located below the positioning shaft (516), a mounting groove is provided inside the preparation box (4), and a meshing first gear (523) is provided between the positioning shaft (516) and the connecting shaft (522) below it, and the outer diameter and number of teeth of the two first gears (523) are equal.

2. The device for preparing an exosome skin care patch according to claim 1, characterized in that: The sealing assembly (54) comprises two baffles (541) symmetrically hinged to the inner wall of the feed port (53) via torsion springs, the opposite sides of the two baffles (541) are mutually clamped, and a limiting clamping block (542) is installed on the inner wall of the feed port (53) and abuts against the upper end of the baffle (541).

3. The device for preparing an exosome skin care patch according to claim 1, characterized in that: The execution unit (8) comprises a limit shaft (81) rotatably arranged on the inner wall of the preparation box (4), the limit shaft (81) being located on a side of the preparation box (4) close to the material taking end, and the limit shaft (81) and an end of a connecting shaft (522) close to the material taking end of the preparation box (4) are jointly sleeved with a second gear (82), one side of the material taking end of the preparation box (4) is symmetrically provided with two supporting plates (83) along the width direction, and opposite sides of the two supporting plates (83) are rotatably installed with a winding roller (84) and an unwinding roller (85) distributed up and down; A patch roll (86) is arranged between the winding roll (84) and the unwinding roll (85), which passes through the preparation box (4) and then bypasses the bottom of the limiting shaft (81). A plurality of protective patches (3) corresponding to the base material patch (1) and the groove position are arranged on the patch roll (86). The limiting shaft (81) and the winding roll (84) are connected by a belt drive.

4. A method for preparing an exosome skin care patch, comprising a preparation device for an exosome skin care patch according to any one of claims 1 to 3, characterized in that: The preparation method comprises the following steps: S1: Pouring raw materials: firstly, pouring the hydrogel (2) raw material and the solution containing exosomes into the vacuum cylinder (51) through the feed port (53); S2: stirring and mixing: stirring and mixing the hydrogel (2) mixture under a vacuum environment by means of a stirring unit (5) so as to remove bubbles therein; S3: Spreading the hydrogel mixture: After the hydrogel (2) mixture is stirred, the hydrogel (2) mixture is spread on the substrate patch (1) at the upper end of the conveyor belt (7) by the stirring unit (5), and then the inside of the preparation box (4) is cooled by the refrigerator (6) to accelerate the solidification of the hydrogel (2) mixture; S4: Applying the protective patch: Applying the protective patch (3) on the upper end of the base patch (1) through the execution unit (8), thereby completing the preparation of the exosome skin care patch, and then taking out the prepared exosome skin care patch.

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