Ureteral stent and method of making same

Abstract

To overcome the problems of poor lubrication and easy transport of exogenous contaminants during ureteral stent placement in the human body, the present invention provides a ureteral stent and its preparation method. The ureteral stent includes a stent body and a lubricating and antibacterial coating. The lubricating and antibacterial coating includes a hydrophilic copolymer, an antibacterial agent, and a catalyst. The hydrophilic copolymer includes component A and component B. Component A includes a cross-linked ionic liquid of a high molecular weight polymer, and component B includes a 2-(dimethylamino)methacrylate-maleate-acrylamide copolymer. The ureteral stent provided by the present invention can play a good lubricating role, reducing the frictional resistance of the stent body. The polymerization reaction of component A and component B forms a hydrophilic copolymer with a gel network structure. This hydrophilic copolymer is cross-linked with the antibacterial agent to form a lubricating and antibacterial coating with an antibacterial gel network structure. The formed lubricating and antibacterial coating has good deformation resistance and mechanical properties, and can prevent the adhesion of impurities such as cell clusters, anion and cation clusters, and bacteria / fungi to the ureteral stent, avoiding urinary tract infections caused by stent placement.

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