A sanitary insecticide compound composition and its application

Abstract

The present invention discloses a sanitary insecticide compound composition and its application. The compound insecticide comprises active ingredients A and B, wherein active ingredient A is a piperic acid derivative compound and active ingredient B is an organophosphorus insecticide, wherein the organophosphorus insecticide is any one of dimethoate, fenthion, fenitrothion, and pirimiphos-methyl. The combined weight of active ingredient A and the organophosphorus insecticide accounts for 2% to 50% of the insecticide composition, with a combined weight ratio of 20:1 to 1:10. This binary composition addresses the problem of organophosphorus resistance in sanitary pests, improving control efficacy, reducing application dosage, and reducing irritation, while also prolonging the duration of the effect. Active ingredient A, as a lethal agent, exhibits no cross-resistance with organophosphorus compounds, resulting in a good lethal effect and no repellency to sanitary pests. The compound is widely used in hotels, schools, factories, farms, and other places, and is particularly effective in controlling sanitary pests.

Description

Technical Field

[0001] The present invention relates to a sanitary insecticide compound composition, in particular to a sanitary insecticide composition containing an active component A and an active component B, wherein the active component A is selected from piperic acid derivative compounds, and the active component B is selected from any one of dimethoate, fenthion, fenitrothion and pirimiphos-methyl, and belongs to the technical field of sanitary insecticide. Background Art

[0002] In recent years, residual spraying has faced challenges such as the difficulty in completely eliminating mosquitoes and flies, and the short or no effect of the pesticides. Applicators have resorted to increasing the dosage and frequency of spraying, which has led to significantly increased mosquito and fly resistance, exponentially increased spraying costs, and increased irritation for applicators. Therefore, the market is in urgent need of a new generation of residual spraying agents to address these challenges.

[0003] Chinese invention patent CN112457288 discloses a piperic acid derivative and its applications. Compound I-72, in particular, exhibits contact and stomach toxicity, as well as excellent conductivity, causing pests to become overexcited and convulse, leading to their death. It boasts high efficacy, a broad spectrum, and long-lasting effects, and is used to control a variety of Lepidoptera, Hemiptera, Thysanoptera, and Coleoptera pests. Compound I-72 has a registered formulation, but has not yet been used against sanitary pests. The compound's structural formula is as follows:

[0004]

[0005] For a long time, organophosphorus insecticides have been widely used in the prevention and control of public health pests. The long-term use of these agents inevitably causes health pests such as mosquitoes, flies, and cockroaches to develop resistance to some organophosphorus agents, which greatly reduces the control effect of the agents. Especially in southern China, the resistance is increasing rapidly, which greatly reduces the effectiveness of health pest control.

[0006] To address this dilemma, we considered combining the new piperic acid derivative insecticide compound I-72 with organophosphorus insecticides. On the one hand, the two have different mechanisms of action, and the combination has no cross-resistance, which can solve the problem of resistance of sanitary pests to organophosphorus and reduce the amount of pesticides applied. On the other hand, compound I-72 is less irritating, which improves the safety of pesticide applicators. Furthermore, through research, it was found that combining the two can improve the control effect of sanitary pests, and it is a combination drug application technology with good market prospects. Summary of the Invention

[0007] The technical problem to be solved by the present invention is to provide a sanitary insecticide compound composition and its application in response to the deficiencies in the prior art. The present invention compounds compound I-72 with organophosphorus to obtain a sanitary insecticide composition. The sanitary insecticide compound composition of the present invention has good insecticidal effect, low medication cost, synergistic effect, is not easy to produce drug resistance, and has a long lasting effect.

[0008] In order to achieve the above object, the present invention adopts the following technical solutions:

[0009] The present invention first provides a sanitary insecticide compound composition, wherein the active ingredients are composed of active ingredient A and active ingredient B, the total weight of active ingredient A and active ingredient B accounts for 2% to 50% of the weight of the entire composition, and the balance is auxiliary materials;

[0010] The active ingredient A is a piperic acid derivative compound represented by formula I (referred to as compound I-72);

[0011] The active ingredient B is an organophosphorus insecticide selected from any one of fenthion, fenthion, fenitrothion, and pirimiphos-methyl;

[0012]

[0013] In the above technical solution, the weight ratio of the active ingredient A to the active ingredient B is 20:1 to 1:10, preferably 10:1 to 1:6.

[0014] In the above technical solution, the auxiliary material can be a mixture of any five or more of dispersant, wetting agent, defoaming agent, antifreeze, preservative, disintegrant, thickener, binder, attractant, stabilizer, filler and water in any proportion.

[0015] In the above technical solution, the sanitary insecticide compound composition is in the form of a wettable powder, a water-dispersible granule, a suspension concentrate or a dry suspension concentrate.

[0016] In the above technical solution, the sanitary insecticide composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 5%-10% stabilizer, 5%-15% attractant, and filler is supplemented to 100%.

[0017] In the above technical solution, the sanitary insecticide composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10% disintegrant, 0.1%-1% binder, 5%-10% stabilizer, 5%-15% attractant, and filler is supplemented to 100%.

[0018] In the above technical solution, the sanitary insecticide composition, when in the form of a suspension, comprises the following materials in weight percentage: 2%-50% of active ingredient, 1%-10% of dispersant, 1%-5% of wetting agent, 0.3%-0.5% of preservative, 0.5%-1.5% of thickener, 0.1-0.3% of defoaming agent, 3%-5% of antifreeze, 5%-10% of stabilizer, 5%-15% of attractant, and water is supplemented to 100%.

[0019] In the above scheme, the dispersant is selected from: any one of polycarboxylates (for example, TERSPERSE 2500, produced by Huntsman Corporation of the United States), lignin sulfonates, alkylbenzene sulfonates, naphthalenesulfonic acid formaldehyde condensate salts, alkylphenol polyoxyethylene ethers, fatty alcohol polyoxyethylene ethers, fatty amine polyoxyethylene ethers, fatty acid polyoxyethylene esters, and glycerol fatty acid ester polyoxyethylene ethers, or a mixture of two or more of the above in any proportion.

[0020] In the above scheme, the wetting agent is selected from: alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, alkylbenzene polyoxyethylene ether phosphate, phenylethylphenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (such as TERSPERSE 2425, Huntsman), naphthalene sulfonate (such as NNO), opening powder BX, wetting and penetrating agent F, sodium dodecylbenzene sulfonate, detergent LS, or a mixture of two or more in any proportion.

[0021] In the above solution, the defoaming agent can be any one of polydimethylsiloxane, diethylene glycol ester, tributyl phosphate, and dipalmitoylethylenediamine, or a mixture of two or more of the above in any proportion.

[0022] In the above solution, the antifreeze agent can be any one of ethylene glycol, propylene glycol, glycerol, and urea, or a mixture of two or more of them in any proportion.

[0023] In the above solution, the preservative is selected from potassium sorbate, sodium benzoate, or a mixture of the two in any proportion.

[0024] In the above solution, the disintegrant is selected from: any one of ammonium sulfate, sodium sulfate, sodium bicarbonate, and sodium carbonate, or a mixture of two or more of the above in any proportion.

[0025] In the above solution, the thickener is selected from: any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, and magnesium aluminum silicate, or a mixture of two or more of the above in any proportion.

[0026] In the above technical solution, the stabilizer is selected from the group consisting of: urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethylpiperidinamine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and n-acylated alkylolamines, or a mixture of two or more in any proportion. When added to the composite composition, the stabilizer can achieve a 30-day lethality of greater than 60% on a semi-absorbent or absorbent surface.

[0027] In the above solution, the binder is selected from: any one of dextrin, polyvinyl pyrrolidone, and sodium alginate, or a mixture of two or more of the above in any proportion.

[0028] In the above embodiment, the attractant is selected from any one of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, and milk flavor, or a mixture of two or more in any proportion. When added to the composite composition, the attractant can increase the application area by 20% to 40% of conventional application, with application locations selected from the four corners of indoor walls, or the top or bottom corners.

[0029] In the above solution, the filler is selected from: any one of kaolin, clay, diatomaceous earth, bentonite, white carbon black, attapulgite, corn starch, and light calcium carbonate, or a mixture of two or more of the above in any proportion.

[0030] In the above technical solution, the sanitary insecticide composition, when in the form of wettable powder, water dispersible granules, suspension concentrate, or dry suspension concentrate, can be prepared according to conventional methods or existing methods in the art.

[0031] The present invention also provides an application of the sanitary insecticide compound composition in preventing and controlling sanitary pests in an application field by local application.

[0032] In the above technical solution, the local application method refers to a residual spraying method or a brushing method.

[0033] In the above technical solution, the application fields include hotels, schools, factories, farms and other places.

[0034] In the above technical solution, the sanitary pests refer to one or more of housefly, city fly, big-headed golden fly, silk-tailed green fly, copper green fly, bright green fly, summer toilet fly, original toilet fly, red-headed blowfly, and bedfly.

[0035] In the above technical solution, when the sanitary insecticide compound composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on the surfaces of walls, floors, doors, windows, ceilings and homes in the application area, so that the sanitary pests are knocked down and killed when they come into contact with the surface.

[0036] Compared with the existing technology, it has the following characteristics:

[0037] (1) The present invention has found through experiments that compound I-72 and some organophosphorus insecticides have a synergistic effect when combined. On the one hand, the environmental compatibility is good, which reduces the amount of pesticide used. On the other hand, from the perspective of the mechanism of action, compound I-72 has a different mechanism of action from organophosphorus sanitary insecticides and does not have cross-resistance, which solves the problem of sanitary pests' resistance to organophosphorus and improves the prevention effect. The combination of insecticides with different mechanisms of action can also delay pest resistance, which is beneficial to pest resistance management.

[0038] (2) In order to solve the problems of long-term effectiveness and poor lethality to targets such as houseflies, we solved the problem of long-term effectiveness through formulation technology. By studying the feeding habits of houseflies, we added attractants to increase the licking frequency of houseflies, thereby increasing the amount of medicine ingested by houseflies; adding stabilizers to increase the long-term effectiveness of the composition, the 30-day lethality rate is greater than 60%. DETAILED DESCRIPTION

[0039] The following describes in detail the specific implementation of the technical solution of the present invention, but the present invention is not limited to the following description:

[0040] The preparation methods of the dosage forms in each embodiment of the present invention are as follows:

[0041] The laboratory preparation method of wettable powder is: weigh the active ingredient, wetting agent, dispersant, stabilizer, attractant and filler in proportion, add them into a mixer and mix them evenly, and then grind them into powder using a jet mill to obtain the wettable powder.

[0042] The laboratory preparation method of water-dispersible granules is as follows: weigh the active ingredient, wetting agent, dispersant, attractant, disintegrant, stabilizer and filler in proportion and add them into a mixer to mix evenly, grind them with a jet mill, use the mixer again, add water and binder mixture, extrude granules with a granulator, and dry them by boiling drying to obtain water-dispersible granules.

[0043] The laboratory preparation method of the suspension concentrate is as follows: weigh water, dispersant, wetting agent, antifreeze, thickener, preservative, attractant, defoaming agent, and stabilizer in proportion, mix them evenly, add the active ingredient, shear them with a high-speed shearing machine for 5 minutes, and then transfer them to a sand mill and sand grind them for 2-3 hours to control the particle size D90 to below 5μm to obtain the suspension concentrate.

[0044] The present invention is described below in conjunction with specific embodiments:

[0045] Formulation Example 1: 20% Compound I-72·Temephos Wettable Powder

[0046] Compound I-7210g, dimethoate 10g, sodium dodecylbenzenesulfonate 5g, calcium ligninsulfonate 10g, dimethyl disulfide 15g, urea-formaldehyde resin 5g, and kaolin to 100%.

[0047] Formulation Example 2: 30% Compound I-72·Dimethoate Water Dispersible Granules

[0048] Compound I-7220g, dimethoate 10g, lakai powder BX 0.5g, sodium lauryl sulfate 0.5g, naphthalenesulfonic acid formaldehyde condensate sodium salt 1g, ammonium sulfate 5g, dextrin 1g, polyalkylene glycol 5g, fatty acid dimethyl disulfide 5g, kaolin is made up to 100%.

[0049] Formulation Example 3: 15% Compound I-72·Dimethophos Suspension

[0050] Compound I-725g, dimethoate 10g, sodium hexadecylsulfonate 0.5g, sodium laurylsulfate 0.5g, potassium polycarboxylate 1g, calcium ligninsulfonate 4g, potassium sorbate 0.5g, magnesium aluminum silicate 1g, xanthan gum 0.5g, polydimethylsiloxane 0.3g, propylene glycol 5g, polyacrylic acid 5g, tilapia meal 5g, and water is added to 100%.

[0051] Formulation Example 4: 50% Compound I-72·Dimethophos Water Dispersible Granules

[0052] Compound I-7230g, dimethoate 20g, lakai powder BX 2g, sodium lauryl sulfate 2g, sodium hexadecylbenzenesulfonate 2g, calcium ligninsulfonate 8g, ammonium sulfate 1g, sodium sulfate 3g, polyvinylpyrrolidone 1g, ethylene oxide-propylene oxide block polyether 6g, brown sugar 12g, and kaolin to 100%.

[0053] Formulation Example 5: 2% Compound I-72·Dimethophos Suspension

[0054] Compound I-721g, dimethoate 1g, sodium lauryl sulfate 0.5g, sodium hexadecylsulfonate 0.5g, potassium polycarboxylate 0.5g, sodium naphthalenesulfonic acid formaldehyde condensate 0.5g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, diethylene glycol ester 0.2g, ethylene glycol 4g, ethyl acrylate 6g, tilapia meal 5g, and water is added to 100%.

[0055] Formulation Example 6: 14% Compound I-72·Fenthion Wettable Powder

[0056] Compound I-7212g, fenthion 2g, sodium lauryl sulfate 2g, lignin sulfonate calcium salt 6g, brown sugar 10g, vinyl acetate 6g, white carbon black 10g, diatomaceous earth is supplemented to 100%.

[0057] Formulation Example 7: 22% Compound I-72·Fenthion Water Dispersible Granules

[0058] Compound I-7220g, fenthion 2g, sodium lauryl sulfate 3g, laka powder BX 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, sodium sulfate 5g, sodium bicarbonate 5g, polyvinylpyrrolidone 0.5g, dextrin 0.5g, tetramethylpiperidinamine 7g, N-methylacetamide 10g, white carbon black 6g, kaolin is made up to 100%.

[0059] Formulation Example 8: 12% Compound I-72·Fenthion Suspension

[0060] Compound I-7210g, fenthion 2g, sodium hexadecylsulfonate 2g, sodium laurylsulfate 1g, potassium polycarboxylate 4g, calcium ligninsulfonate 6g, potassium sorbate 0.5g, xanthan gum 0.5g, tributyl phosphate 0.3g, glycerol 3g, sodium alginate propylene glycol 7g, maltose 15g, and water is added to 100%.

[0061] Formulation Example 9: 15% Compound I-72·Fenthion Suspension

[0062] Compound I-7215g, dimethoate 5g, sodium lauryl sulfate 3g, polyoxyethylene fatty acid ester 1.5g, potassium polycarboxylate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, tributyl phosphate 0.2g, dipalmitoyl ethylenediamine 0.1g, ethylene glycol 4g, methyl ethyl sulfonate 8g, honey 6g, water is supplemented to 100%.

[0063] Formulation Example 10: 18% Compound I-72·Fenthion Wettable Powder

[0064] Compound I-726g, fenthion 12g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate sodium salt 2g, naphthalenesulfonic acid sodium salt 2g, sodium lauryl sulfate 1g, fatty acid dimethyl disulfide ester 5g, n-acylated alkyl alcoholamine 7g, attapulgite 10g, light calcium carbonate is supplemented to 100%.

[0065] Formulation Example 11: 50% Compound I-72·Fenthion Wettable Powder

[0066] Compound I-7225g, fenthion 25g, fatty alcohol polyoxyethylene ether 2g, lignin sulfonate calcium salt 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, phenethylphenol polyoxyethylene ether phosphate 2g, dimethyl disulfide 5g, milk flavor 10g, urea-formaldehyde resin 4g, polyalkylene glycol 4g, white carbon black 3g, diatomaceous earth is supplemented to 100%.

[0067] Formulation Example 12: 24% Compound I-72·Methyl Pirimiphos Wettable Powder

[0068] Compound I-7216g, methyl pirimiphos 8g, sodium lauryl sulfate 0.5g, alkylbenzene polyoxyethylene ether phosphate 0.5g, lignin sulfonate calcium salt 6g, anisaldehyde 10g, N-methylacetamide 5g, n-acylated alkyl alcoholamine 9g, and clay is supplemented to 100%.

[0069] Formulation Example 13: 40% Compound I-72·Methyl Pirimiphos Water Dispersible Granules

[0070] Compound I-7230g, pirimiphos-methyl 10g, detergent LS 3g, sodium lauryl sulfate 2g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, ligninsulfonic acid calcium salt 6g, sodium carbonate 5g, dextrin 1g, sodium alginate propylene glycol 8g, furanone 10g, bentonite 20g, corn starch is supplemented to 100%.

[0071] Formulation Example 14: 50% Compound I-72·Methyl Pirimiphos Suspension

[0072] Compound I-7240g, methyl pirimiphos 10g, sodium hexadecylsulfonate 2g, wetting and penetrating agent F2g, glycerol fatty acid ester polyoxyethylene ether 1g, potassium polycarboxylate 4g, lignin sulfonate calcium salt 4g, sodium benzoate 0.3g, magnesium aluminum silicate 0.2g, methyl cellulose 0.3g, tributyl phosphate 0.1g, propylene glycol 5g, sodium alginate propylene glycol 9g, milk flavor 5g, water supplemented to 100%.

[0073] Formulation Example 15: 16% Compound-Methyl Pirimiphos Water Dispersible Granules

[0074] Compound I-728g, pirimiphos-methyl 8g, lakai powder BX 2g, sodium lauryl sulfate 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 4g, ligninsulfonate calcium salt 5g, sodium sulfate 8g, sodium bicarbonate 2g, polyvinylpyrrolidone 0.3g, sodium alginate 0.5g, sodium alginate propylene glycol 9g, anisaldehyde 10g, clay 10g, kaolin is made up to 100%.

[0075] Formulation Example 16: 12% Compound I-72-Methyl Pirimiphos Suspension

[0076] Compound I-724g, methyl pirimiphos 8g, sodium lauryl sulfate 2g, alkylbenzene polyvinyl ether phosphate 2g, fatty amine polyoxyethylene ether 3g, polycarboxylic acid potassium salt 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, hydroxyethyl cellulose 0.3g, xanthan gum 0.2g, polydimethylsiloxane 0.3g, propylene glycol 4g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol ester 5g, honey 5g, water is supplemented to 100%.

[0077] Formulation Example 17: 30% Compound I-72·Pirimiphos-methyl Wettable Powder

[0078] Compound I-7215g, pirimiphos-methyl 15g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, ligninsulfonic acid calcium salt 2g, detergent LS 3g, sodium lauryl sulfate 1g, N-methylacetamide 12g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol ester 5g, and clay is supplemented to 100%.

[0079] Formulation Example 18: 12% Compound I-72·Fenthion Wettable Powder

[0080] Compound I-728g, fenitrothion 4g, sodium lauryl sulfate 2g, detergent LS1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, ligninsulfonic acid calcium salt 5g, N-methylacetamide 8g, furanone 7g, tetramethylpiperidinamine 5g, and clay is supplemented to 100%.

[0081] Formulation Example 19: 30% Compound I-72·Fenitrothion Water Dispersible Granules

[0082] Compound I-7225g, fenitrothion 5g, phenylethylphenol polyoxyethylene ether phosphate 2g, sodium lauryl sulfate 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, ligninsulfonic acid calcium salt 5g, sodium sulfate 3g, sodium alginate 0.5g, tetramethylpiperidinamine 5g, sodium alginate propylene glycol ester 5g, dimethyl disulfide 8g, kaolin is made up to 100%.

[0083] Formulation Example 20: 2% Compound I-72·Methylpirimiphos Wettable Powder

[0084] Compound I-721g, methyl pirimiphos 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 6g, ligninsulfonic acid calcium salt 2g, detergent LS 3g, sodium lauryl sulfate 1g, N-methylacetamide 12g, sodium alginate propylene glycol ester 4g, tetramethylpiperidinamine 4g, clay is supplemented to 100%.

[0085] Formulation Example 21: 16% Compound I-72·Fenthion Suspension Concentrate

[0086] Compound I-728g, fenitrothion 8g, wetting and penetrating agent F 4g, fatty alcohol polyoxyethylene ether 1g, potassium polycarboxylate 4g, lignin sulfonate calcium salt 4g, sodium benzoate 0.5g, methylcellulose 0.5g, polydimethylsiloxane 0.3g, urea 4g, sodium alginate propylene glycol 5g, N-methylacetamide 5g, water is made up to 100%.

[0087] Formulation Example 22: 45% Compound I-72·Fenitrothion Water Dispersible Granules

[0088] Compound I-7230g, fenitrothion 15g, detergent LS 3g, sodium lauryl sulfate 1g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, ligninsulfonic acid calcium salt 6g, sodium sulfate 5g, polyvinyl pyrrolidone 0.1g, sodium alginate propylene glycol ester 5g, dimethyl disulfide 5g, kaolin is made up to 100%.

[0089] Formulation Example 23: 18% Compound I-72·Fenthion Suspension Concentrate

[0090] Compound I-726g, 12g of fenitrothion, 2g of sodium lauryl sulfate, 4g of potassium polycarboxylate, 2g of sodium naphthalenesulfonic acid formaldehyde condensate, 0.5g of potassium sorbate, 1.2g of magnesium aluminum silicate, 0.3g of xanthan gum, 0.3g of diethylene glycol ester, 5g of propylene glycol, 5g of sodium alginate propylene glycol ester, 5g of n-acylated alkyl alcoholamine, 5g of milk flavor, and water is added to 100%.

[0091] Formulation Example 24: 2% Compound I-72·Fenthion Water Dispersible Granules

[0092] Compound I-721g, fenthion 1g, sodium lauryl sulfate 2g, laka powder BX 3g, naphthalenesulfonic acid formaldehyde condensate sodium salt 5g, sodium sulfate 1g, sodium bicarbonate 2g, polyvinylpyrrolidone 0.5g, dextrin 0.5g, n-acylated alkyl alcoholamine 5g, tetramethylpiperidinamine 5g, N-methylacetamide 5g, white carbon black 6g, kaolin is made up to 100%.

[0093] Formulation Example 25: 5% Compound I-72·Dimethoate Suspension

[0094] Compound I-724g, dimethoate 1g, sodium lauryl sulfate 3g, alkylphenol polyoxyethylene ether 1.5g, potassium polycarboxylate 4g, naphthalenesulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, diethylene glycol ester 0.2g, ethylene glycol 2g, propylene glycol 3g, sodium alginate propylene glycol 5g, tilapia meal 6g, water is supplemented to 100%.

[0095] Application Example 1: Determination of the Co-toxicity Coefficient of Compound I-72 and Organophosphorus

[0096] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half male and half female;

[0097] Test method: Refer to GB / T26350-2010 "Methods for detection of insecticide resistance in flies - Housefly bioassay" and NY / T1154.7-2006 "Guidelines for indoor bioassay of pesticides - Insecticides - Part 7: Determination of the combined effects of mixtures" for test insects;

[0098] Table 1 Determination of the co-toxicity coefficient of compound I-72 and temephos (for houseflies)

[0099]

[0100]

[0101] As shown in Table 1, when the compound I-72 and temephos were mixed at a ratio of 10:1 to 1:6, the co-toxicity coefficient against houseflies was greater than 120, indicating a synergistic effect. Especially when the mixing ratio was 1:1, the synergistic effect was most obvious.

[0102] Table 2 Determination of the co-toxicity coefficient of compound I-72 and fenthion (for houseflies)

[0103]

[0104] As shown in Table 2, when the compound I-72 and fenthion were mixed at a ratio of 10:1 to 1:6, the co-toxicity coefficient against houseflies was greater than 120, indicating a synergistic effect. Especially when the ratio was 6:1, the synergistic effect was most obvious.

[0105] Table 3 Optimal co-toxicity coefficient of compound I-72 and other organophosphorus compounds (for houseflies)

[0106]

[0107] As shown in Table 3, the optimal ratios of compound I-72 and other organophosphorus compounds are all in the range of 10:1 to 1:6, showing a significant synergistic effect.

[0108] Application Example 2: Indoor efficacy test for preventing and controlling mosquitoes and flies on three different surfaces

[0109] Test targets: Culex pipiens pallens (a resistant mosquito species native to Yangzhou), female adults that have not fed blood on the 3rd to 5th day after emergence;

[0110] Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half male and half female;

[0111] Test method: Refer to GB / T 13917.1-2009, forced contact method;

[0112] Test surface: glass board, varnished wood board, gypsum board;

[0113] Dosage setting: The total concentration of active ingredients in the formulation examples is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0114] Control sample 1: prepared according to the formulation of Formulation Example 1 without the stabilizer;

[0115] Control sample 2: prepared according to the formulation of Formulation Example 4 without the stabilizer;

[0116] Control sample 3: prepared according to the formulation of Formulation Example 5 without the stabilizer;

[0117] Commercial sample 1: 50% temephos emulsifiable concentrate (Jiangsu Gongcheng Biotechnology Co., Ltd.) diluted to 200 mg / l;

[0118] Commercial sample 2: 500 g / L pirimiphos-methyl emulsifiable concentrate (Syngenta Ltd., UK) diluted to 200 mg / L;

[0119] Test results:

[0120] Table 4: Efficacy test of formulation examples against mosquitoes and flies (glass plate)

[0121]

[0122]

[0123] Table 5: Efficacy test of formulation examples against mosquitoes and flies (varnished wood board)

[0124]

[0125] Table 6: Efficacy test of formulation examples against mosquitoes and flies (gypsum board)

[0126]

[0127]

[0128] The test results show that when the dosage is reduced by half, the difference in efficacy between the drugs can be clearly seen on the glass surface. The efficacy of formulation examples 1, 4, 8, 11, 14, 17, and 20 are all better than commercial samples 1 and 2 (see Table 4);

[0129] The efficacy of the formulation examples decreased on semi-absorbent varnished wood and absorbent gypsum boards, primarily due to partial absorption of the agent by the materials, resulting in a decrease in the surface agent content. However, the efficacy data showed that the formulation examples had good long-lasting efficacy, with a 30-day lethality rate exceeding 75% on varnished wood and over 60% on gypsum, both exceeding those of control samples 1, 2, and 3 and commercial samples 1 and 2 (see Tables 5 and 6).

[0130] Application Example 3: Application of Appetite Inducing Agent in Preparation Example for Pharmacological Efficacy Determination

[0131] Test target: Housefly (Yangzhou local resistant housefly), adults on the 3rd to 4th day after emergence, half male and half female;

[0132] Test method: Use a 1.2m*1.2**1.2m glass box. Dilute the pesticide and soak it with 20cm*20cm filter paper. After drying, spread it flat on the glass box. Place 30 houseflies in the box and observe the maximum residence time and contact frequency of the houseflies on the filter paper surface.

[0133] Test agents: Preparation Example 10, Preparation Example 20,

[0134] Control sample 4: prepared according to the formulation of Preparation Example 10 without the milk flavor.

[0135] Control Sample 5: Prepared according to the formulation of Formulation Example 20 except for N-methylacetamide:

[0136] Dosage setting: The total concentration of active ingredients is diluted to 200 mg / L (usually 400 mg / L in actual use);

[0137] Table 7 Effect of attractants on the efficacy of houseflies

[0138] name Maximum stay Contact frequency (10min) KT50 24-hour mortality rate Preparation Example 10 15s 75 30.6min 86.7％ Control sample 4 7s 22 62.7 minutes 70％ Preparation Example 20 25s 42 18.5min 100％ Control sample 5 8s 30 58.5min 73.3％

[0139] The test results showed that the addition of milk flavor to Formulation Example 10 increased the frequency of housefly contact with the agent, resulting in relatively better efficacy; the addition of N-methylacetamide to Formulation Example 20 increased the residence time of houseflies on the filter paper surface and increased the frequency of houseflies licking, resulting in the houseflies ingesting more agent, and thus the final efficacy was better (see Table 7).

[0140] Application Example 4: Comparative Test on the Efficacy of Houseflies

[0141] Test target: Housefly

[0142] Experimental method: The walls of the farm buildings were selected as the test objects and divided into areas. The pesticide was sprayed on the wall surface, and the fly density reduction rate of each treatment group was recorded after 1 day, 2 days, and 3 days. The area of ​​the farm room was about 50m2, and the area of ​​each wall was about 20m2.

[0143] Test treatment: Preparations 2, 9, 17, and 24 were diluted 100 times and sprayed on the four corners of the wall and the ground, covering 40% of the total area, at a dosage of 20 mg active ingredient / m2;

[0144] Control sample 6: Prepared according to the formulation of Preparation Example 2 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0145] Control sample 7: Prepared according to the formulation of Preparation Example 9 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0146] Control Sample 8: Prepared according to the formulation of Preparation Example 17 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0147] Control Sample 9: Prepared according to the formulation of Preparation Example 24 without the attractant component and diluted 100 times, with a dosage of 20 mg active ingredient / m2;

[0148] When applying the control samples 6, 7, 8, and 9, the pesticide was sprayed on the entire surface of the wall and the ground;

[0149] Table 8: Treatment of Formulation Examples 2, 9, 17, and 24

[0150]

[0151]

[0152] Test results:

[0153] Table 9 Comparative test of the efficacy of formulation examples 2, 9, 17, and 24 against flies

[0154] deal with 1d density decrease rate 2d density decrease rate 3d density reduction rate Preparation Example 2 66.1％ 85.9％ 95.8％ Preparation Example 9 67.3％ 89.9％ 96.7％ Preparation Example 17 68.9％ 89.2％ 94.7％ Preparation Example 24 68.6％ 90.2％ 99.8％ Control sample 6 56.5％ 79.4％ 89.5％ Control sample 7 52.9％ 79.9％ 89.3％ Control sample 8 58.5％ 78.3％ 88.8％ Control sample 9 58.3％ 80.1％ 89.2％

[0155] The results shown in Table 9 show that the present invention, by adding an attractant component, has a strong attractant effect, transforming conventional passive control into active attractant attraction. The application area is 20% and 40% of the conventional application area, and the application location is selected at the four corners of the wall. Formulation Examples 2, 9, 17, and 24 have significant fly control effects, with a 1-day density reduction rate exceeding 80% and a 3-day density reduction rate exceeding 94%, all of which are better than the control samples 6, 7, 8, and 9. Formulation Examples 2, 9, 17, and 24 contain an attractant component, and flies are killed by gathering around the attractant component and contacting the drug solution. This shows that the combination of Compound I-72 and an organophosphorus insecticide with an attractant component is more effective in controlling flies than the combination of Compound I-72 and an organophosphorus insecticide without an attractant component, and the dosage is less than that of the combination without an attractant component.

[0156] The above examples are only for illustrating the technical concept and technical features of the present invention and are not intended to limit the scope of protection of the present invention. Any equivalent transformation or modification made based on the essence of the present invention should be included in the scope of protection of the present invention.

Claims

1. A sanitary insecticide compound composition, characterized in that: The active ingredients are composed of active component A and active component B. The total weight of active component A and active component B accounts for 2% to 50% of the weight of the entire composition, and the balance is excipients, which include an attractant. The active component A is a piperic acid derivative compound shown in formula I; The active ingredient B is an organophosphorus insecticide selected from any one of fenthion, fenthion, fenitrothion, and pirimiphos-methyl; The attractant is selected from: any one of anisaldehyde, N-methylacetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia meal, maltose, honey, and milk flavor, or a mixture of two or more of the above in any proportion.

2. The sanitary insecticide compound composition according to claim 1, characterized in that: The compounding weight ratio of the active ingredient A to the active ingredient B is 20:1 to 1:

10.

3. The sanitary insecticide compound composition according to claim 1, characterized in that: The sanitary insecticide composition has the form of wettable powder, water-dispersible granules, and suspension; the excipients are a mixture of any five or more of dispersant, wetting agent, defoamer, antifreeze, preservative, disintegrant, thickener, binder, attractant, stabilizer, filler, and water in any proportion.

4. The sanitary insecticide composite composition according to claim 3, characterized in that: The sanitary insecticide compound composition, when in the form of a wettable powder, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 5%-10% stabilizer, 5%-15% attractant, and filler to make up to 100%.

5. The sanitary insecticide compound composition according to claim 3, characterized in that: The sanitary insecticide compound composition, when in the form of water-dispersible granules, comprises the following raw materials in weight percentage: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10% disintegrant, 0.1%-1% binder, 5%-10% stabilizer, 5%-15% attractant, and filler is supplemented to 100%.

6. The sanitary insecticide composite composition according to claim 3, characterized in that: The sanitary insecticide compound composition, when in the form of a suspension, comprises the following materials in weight percentage: 2%-50% of active ingredient, 1%-10% of dispersant, 1%-5% of wetting agent, 0.3%-0.5% of preservative, 0.5%-1.5% of thickener, 0.1-0.3% of defoaming agent, 3%-5% of antifreeze, 5%-10% of stabilizer, 5%-15% of attractant, and water is added to 100%.

7. The sanitary insecticide composition according to any one of claims 4 to 6, characterized in that: The stabilizer is selected from: any one of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethylpiperidinamine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and n-acylated alkyl alcohol amine, or a mixture of two or more in any proportion.

8. Use of the sanitary insecticide composite composition according to any one of claims 4 to 6 in controlling sanitary pests in an application field by topical application, characterized in that: The local application method refers to a residual spraying method or a brushing method; the application fields include hotels, schools, factories, and farms; the sanitary pests refer to one or more of houseflies, city flies, big-headed golden flies, silk-tailed green flies, copper green flies, bright green flies, summer toilet flies, toilet flies, red-headed blowflies, and bedflies.

9. The use according to claim 8, characterized in that: When the sanitary insecticide compound composition is used to control sanitary pests, the insecticide composition is diluted 100-500 times with water and sprayed on the walls, floors, doors, windows, ceilings and home surfaces in the application area, so that the sanitary pests are knocked down and killed when they come into contact with the surface.

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