A method for optimizing and controlling continuous fermentation processes at different stages based on parameter reuse
By establishing a state space model and designing a state feedback controller during the continuous fermentation process, and using the parameter matrix of the previous stage to optimize the feed substrate concentration in the current stage, the problems of reduced efficiency and quality caused by fermentation model reconstruction were solved, and efficient and stable control of the fermentation process and maximization of economic benefits were achieved.
Patent Information
- Application Number
- CN202411110381.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-14
- Publication Date
- 2025-09-19
- Estimated Expiration
- 2044-08-14
AI Technical Summary
In the prior art, each fermentation process requires the fermentation model to be rebuilt and solved, which leads to the problem of reduced fermentation efficiency and fermentation quality.
By establishing a state space model of the continuous fermentation process and designing a state feedback controller, the comprehensive benefit optimization index of each fermentation stage is determined. The comprehensive benefit optimization index of the current fermentation stage is solved by using the target feed substrate concentration of the previous fermentation stage and the parameter matrix of the long-term comprehensive benefit, and the feed substrate concentration of each fermentation stage is optimized.
The stability of the cell culture state in the fermenter is improved, the fermentation cost is reduced, the fermentation efficiency and quality are improved, and the economic benefits are maximized.