Device for regulating and controlling balance of two eyes based on single-eye flicker

Abstract

The invention discloses a device for regulating and controlling the balance of two eyes based on single-eye flicker, and the device comprises a split-vision display module which is used for displaying a first visual stimulation and a second visual stimulation to the two eyes of a tested object, the first visual stimulation flickers at a suitable flicker frequency, and an inter-eye balance value corresponding to the suitable flicker frequency is close to 1 compared with a baseline value; the inter-ocular balance value is an inter-ocular contrast ratio when the first visual stimulation and the second visual stimulation are displayed to the tested object and the first visual stimulation flickers at the corresponding flicker frequency, and the probability that the fused perceptual tilt direction sensed by the two eyes of the tested object is consistent with the tilt direction of the first visual stimulation accounts for half; the baseline value is an inter-ocular balance value where neither the first visual stimulus nor the second visual stimulus flickers. According to the method, the original inter-eye imbalance state of the tested object is quantified through a psychophysics method, and then the flicker frequency of visual stimulation watched by the dominant eyes of the tested object is pertinently set, so that inter-eye suppression is regulated and controlled, and personalized regulation and control of the balance of the two eyes of the tested object are realized.

Description

Technical Field

[0001] The present invention relates to the field of visual cognition technology, and in particular to a device for regulating binocular balance based on monocular blinking. Background Art

[0002] Anisometropia, amblyopia, and strabismus are common eye diseases that cause binocular imbalance in patients. Taking amblyopia as an example, amblyopia is a common eye disease in which the best corrected visual acuity of one or both eyes is lower than the normal value for the corresponding age due to abnormal visual experience (such as strabismus, anisometropia, high refractive error, or cataract) during the critical period of visual development. As a major public health issue, the prevalence of amblyopia in children and adolescents can be as high as 3%. If no intervention or treatment is carried out, the consequences will lead to widespread visual dysfunction and even abnormal psychological development, seriously affecting the quality of life of individuals.

[0003] A series of studies have shown that in addition to monocular visual abnormalities, amblyopia also has binocular visual dysfunctions such as reduced stereoscopic vision and binocular imbalance. These binocular visual defects are highly correlated with interocular inhibition, and studies have found that the inhibition of the amblyopic eye on the fellow eye is significantly weaker than the inhibition of the fellow eye on the amblyopic eye. Therefore, reducing interocular inhibition in amblyopic patients can promote binocular balance to a certain extent, thereby improving the binocular visual function of amblyopic patients. Summary of the invention

[0004] The purpose of the present invention is to provide a device for regulating binocular balance based on monocular flicker, quantify the original inter-ocular imbalance state of the subject through psychophysical methods, and then set the flicker frequency of the visual stimulus viewed by the subject's dominant eye in a targeted manner to regulate inter-ocular inhibition and achieve personalized regulation of the subject's binocular balance.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] A device for regulating binocular balance based on monocular blinking, comprising:

[0007] A split-view display module, used for displaying a first visual stimulus and a second visual stimulus to the dominant eye and the non-dominant eye of the subject, respectively, and the first visual stimulus flickers at an appropriate flickering frequency;

[0008] Among them, the inter-ocular balance value corresponding to the appropriate flicker frequency is closer to 1 than the baseline value, the inter-ocular balance value refers to the inter-ocular contrast ratio when the probability that the inclination direction of the fusion perception perceived by both eyes of the subject is consistent with the inclination direction of the first visual stimulus when the first visual stimulus and the second visual stimulus are displayed to the subject and the first visual stimulus flickers at the corresponding flicker frequency is half, the baseline value is the inter-ocular balance value obtained when the first visual stimulus and the second visual stimulus displayed to the subject do not flicker, and the inter-ocular contrast ratio refers to the ratio of the contrast of the first visual stimulus to the contrast of the second visual stimulus.

[0009] Optionally, the dichographic display module is further used to display the first visual stimulus and the second visual stimulus to the dominant eye and the non-dominant eye of the subject, respectively, the first visual stimulus and the second visual stimulus have opposite inclination directions so that the subject can give the inclination direction of binocularly perceived fusion perception, and the flickering frequency of the first visual stimulus is changed, and for the first visual stimulus at any flickering frequency, the first visual stimulus and the second visual stimulus with different inter-eye contrast ratios are displayed to the subject;

[0010] It also includes: an evaluation module, which is used to obtain the inter-ocular balance value at any flicker frequency of the first visual stimulus according to the visual stimulus displayed to the subject and the corresponding obtained tilt direction signal, and select the flicker frequency whose corresponding inter-ocular balance value is closer to 1 than the baseline value from each flicker frequency, and determine the appropriate flicker frequency according to the selected flicker frequency.

[0011] Optionally, the evaluation module is used to obtain the inter-ocular balance value at any flicker frequency of the first visual stimulus according to the visual stimulus displayed to the subject and the corresponding acquired tilt direction signal, including:

[0012] The evaluation module is used to obtain a preset function at the current flicker frequency based on the visual stimulus displayed to the subject and the corresponding tilt direction signal obtained, and obtain the inter-ocular balance value at the current flicker frequency based on the preset function, wherein the preset function describes the probability that the tilt direction given by the subject is consistent with the tilt direction of the first visual stimulus, and the relationship between the inter-ocular contrast ratio of the visual stimulus displayed to the subject.

[0013] Optionally, the evaluation module is used to obtain the probability that the tilt direction given by the subject at each inter-eye contrast ratio is consistent with the tilt direction of the first visual stimulus based on the visual stimulus displayed to the subject and the corresponding tilt direction signal obtained, and use Gaussian distribution cumulative distribution function fitting to obtain the preset function.

[0014] Optionally, the evaluation module is used to select a flicker frequency whose corresponding inter-eye balance value is closer to 1 than the baseline value from various flicker frequencies, and determining the appropriate flicker frequency according to the selected flicker frequency includes:

[0015] The evaluation module is used to select a flicker frequency whose corresponding inter-eye balance value is closer to 1 than the baseline value from various flicker frequencies, and further determine the flicker frequency whose corresponding inter-eye balance value is closest to 1 among the selected flicker frequencies as the appropriate flicker frequency.

[0016] Optionally, the evaluation module is used to select, from each flicker frequency, a flicker frequency whose corresponding inter-eye balance value is closer to 1 than the baseline value, including:

[0017] The evaluation module is used to convert the inter-eye balance value and the baseline value corresponding to each flicker frequency into an absolute logarithmic scale and normalize them, which is expressed as:

[0018] Normalized |logBP|=|logBP|-Baseline|logBP|;

[0019] Where BP represents the inter-eye balance value, Baseline|logBP|=|logBP 0 |, BP 0 represents the baseline value, and the flicker frequency with normalized |logBP|<0 is selected from each flicker frequency.

[0020] Optionally, the dichoptic display module is used to display the first visual stimulus and the second visual stimulus to the dominant eye and the non-dominant eye of the subject respectively, including:

[0021] The dichographic display module is used for displaying the first visual stimulus and the second visual stimulus with different inter-ocular contrast ratios to the subject at any flickering frequency of the first visual stimulus, wherein for any inter-ocular contrast ratio, a visual stimulus configured in a first direction and a visual stimulus configured in a second direction are displayed to the subject, the first direction configuration wherein the first visual stimulus is inclined in a clockwise direction and the second visual stimulus is inclined in a counterclockwise direction, and the second direction configuration wherein the first visual stimulus is inclined in a counterclockwise direction and the second visual stimulus is inclined in a clockwise direction.

[0022] Optionally, the dichographic display module is used to display visual stimulation configured in a first direction to the subject a preset number of times and to display visual stimulation configured in a second direction to the subject a preset number of times for any inter-ocular contrast ratio, so that the subject will give the tilt direction of the fusion perception perceived by both eyes each time the visual stimulation is displayed to the subject.

[0023] Optionally, it also includes: a control module, connected to the split-view display module, for adjusting the flickering frequency of the first visual stimulus.

[0024] Optionally, the flashing mode of the first visual stimulus includes a square wave form, a sine wave form, a sawtooth wave form or a triangle wave form.

[0025] It can be seen from the above technical scheme that the device for regulating binocular balance based on monocular flicker provided by the present invention includes a split-view display module for displaying a first visual stimulus and a second visual stimulus to the dominant eye and the non-dominant eye of the subject, respectively, and the first visual stimulus flickers at an appropriate flicker frequency. Among them, the inter-ocular balance value corresponding to the appropriate flicker frequency is closer to 1 than the baseline value, and the inter-ocular balance value refers to the inter-ocular contrast ratio when the probability that the tilt direction of the fusion perception perceived by the subject's binocular eyes is consistent with the tilt direction of the first visual stimulus when the first visual stimulus and the second visual stimulus are displayed to the subject and flicker at the corresponding flicker frequency accounts for half of the time, and the baseline value is the inter-ocular balance value obtained when the first visual stimulus and the second visual stimulus displayed to the subject do not flicker, and the inter-ocular contrast ratio refers to the ratio of the contrast of the first visual stimulus to the contrast of the second visual stimulus. The device for regulating binocular balance based on monocular flicker of the present invention quantifies the original inter-ocular imbalance state of the subject through a psychophysical method, and then sets the flicker frequency of the visual stimulus viewed by the dominant eye of the subject in a targeted manner to regulate inter-ocular inhibition and realize personalized regulation of binocular balance of the subject. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0027] Figure 1 A schematic diagram of a device for regulating binocular balance based on monocular blinking provided by an embodiment of the present invention;

[0028] Figure 2 This is a schematic diagram of a device for regulating binocular balance based on monocular flickering according to an embodiment of the present invention displaying visual stimulation to a subject;

[0029] Figure 3 It is a preset function diagram obtained by fitting experimental data in a specific example of the present invention;

[0030] FIG4( a ) shows the change of the interocular balance state of a normal person when both eyes receive different visual stimuli in a specific example of the present invention;

[0031] FIG4( b ) shows the change of the inter-ocular balance state of an amblyopic patient when both eyes receive different visual stimuli in a specific example of the present invention;

[0032] Figure 5 The data of changes in interocular balance state under different monocular flicker frequency conditions for patients with different degrees of binocular visual function abnormality in a specific example of the present invention;

[0033] Figure 6 4 are four waveform diagrams of visual stimulus flickering according to an embodiment of the present invention. DETAILED DESCRIPTION

[0034] In order to enable those skilled in the art to better understand the technical solutions in the present invention, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work should fall within the scope of protection of the present invention.

[0035] This embodiment provides a device for regulating binocular balance based on monocular blinking, including:

[0036] A split-view display module, used for displaying a first visual stimulus and a second visual stimulus to the dominant eye and the non-dominant eye of the subject, respectively, and the first visual stimulus flickers at an appropriate flickering frequency;

[0037] Among them, the inter-ocular balance value corresponding to the appropriate flicker frequency is closer to 1 than the baseline value, the inter-ocular balance value refers to the inter-ocular contrast ratio when the probability that the inclination direction of the fusion perception perceived by both eyes of the subject is consistent with the inclination direction of the first visual stimulus when the first visual stimulus and the second visual stimulus are displayed to the subject and the first visual stimulus flickers at the corresponding flicker frequency is half, the baseline value is the inter-ocular balance value obtained when the first visual stimulus and the second visual stimulus displayed to the subject do not flicker, and the inter-ocular contrast ratio refers to the ratio of the contrast of the first visual stimulus to the contrast of the second visual stimulus.

[0038] The subject's dominant eye can be understood as the subject's relatively dominant eye, and the subject's non-dominant eye can be understood as the subject's relatively non-dominant eye. The split-view display module displays the first visual stimulus to the subject's dominant eye and displays the second visual stimulus to the subject's non-dominant eye.

[0039] Wherein, the first visual stimulus flickers, and the visual stimulus flickering refers to the visual stimulus appearing and disappearing alternately periodically, and the flickering frequency refers to the number of times the visual stimulus is presented per unit time. The flickering frequency of the visual stimulus can be changed by changing the presentation time of the visual stimulus or the time interval between two adjacent presentations. Wherein, the second visual stimulus displayed by the split-view display module to the non-dominant eye of the subject may not flicker.

[0040] If the subject's binocular imbalance, the subject's baseline value, that is, the interocular balance value when the first visual stimulus and the second visual stimulus displayed to the subject are not flickering, will deviate from 1. Then, if the interocular balance value corresponding to a certain flickering frequency is closer to 1 than the baseline value, it indicates that the first visual stimulus and the second visual stimulus with the flickering frequency and the corresponding interocular contrast ratio are helpful for the subject's binocular balance and have an improving effect on the subject's binocular imbalance. Based on this, the device displays the first visual stimulus and the second visual stimulus to the subject's dominant eye and non-dominant eye respectively through the dichoptic display module, wherein the first visual stimulus displayed to the subject's dominant eye flickers at an appropriate flickering frequency, and visually stimulates the subject's eyes, which can regulate the subject's interocular inhibition, promote binocular balance, and improve the subject's binocular visual function.

[0041] The present embodiment is a device for regulating binocular balance based on monocular flicker. By flickering a first visual stimulus displayed to the dominant eye of a subject, an inter-ocular balance value corresponding to the flicker frequency is obtained for the flicker frequency of the first visual stimulus, thereby quantifying the original inter-ocular imbalance state of the subject, and selecting a flicker frequency whose corresponding inter-ocular balance value is closer to 1 than a baseline value, determining an appropriate flicker frequency, and visually stimulating both eyes of the subject through the first visual stimulus and the second visual stimulus defined by the appropriate flicker frequency, so as to regulate the inter-ocular inhibition.

[0042] The device for regulating binocular balance based on monocular flicker in this embodiment quantifies the original inter-ocular imbalance state of the subject through a psychophysical method, and then specifically sets the flicker frequency of the visual stimulus viewed by the subject's dominant eye to regulate inter-ocular inhibition, thereby achieving personalized regulation of the subject's binocular balance.

[0043] The appropriate flicker frequency for the subject can be determined by performing corresponding tests on the subject. In some embodiments, the subject can be tested using the device for regulating binocular balance based on monocular flicker to determine the appropriate flicker frequency for the subject. Figure 1 , Figure 1 This is a schematic diagram of a device for regulating binocular balance based on monocular flicker provided in this embodiment. The device includes a split-view display module 11 and an evaluation module 12.

[0044] Among them, the dichographic display module 11 is also used to display the first visual stimulus and the second visual stimulus to the dominant eye and the non-dominant eye of the subject respectively, and the inclination directions of the first visual stimulus and the second visual stimulus are opposite so that the subject can give the inclination direction of the fusion perception perceived by both eyes, and the flickering frequency of the first visual stimulus is changed. For the first visual stimulus at any flickering frequency, the first visual stimulus and the second visual stimulus with different inter-eye contrast ratios are displayed to the subject.

[0045] The evaluation module 12 is used to obtain the inter-ocular balance value at any flicker frequency of the first visual stimulus according to the visual stimulus displayed to the subject and the corresponding tilt direction signal obtained, and select the flicker frequency whose corresponding inter-ocular balance value is closer to 1 than the baseline value from each flicker frequency, and determine the appropriate flicker frequency according to the selected flicker frequency.

[0046] The dichoptic display module 11 displays a first visual stimulus to the dominant eye of the subject and displays a second visual stimulus to the non-dominant eye of the subject. The first visual stimulus and the second visual stimulus have opposite inclination directions. The subject gives the inclination direction of the fusion perception perceived by both eyes according to the fusion perception perceived by his or her own binocular eyes.

[0047] The first visual stimulus flickers and changes the flickering frequency of the first visual stimulus. For the first visual stimulus at any flickering frequency, the interocular contrast ratio between the first visual stimulus and the second visual stimulus changes. At any interocular contrast ratio, for the first visual stimulus and the second visual stimulus displayed by the split-viewing display module 11 each time, the subject gives feedback on the tilt direction of the fusion perception perceived by his or her binocular eyes.

[0048] The tilt direction signal acquired by the evaluation module 12 indicates the tilt direction of the fusion perception perceived by the subject himself as feedback.

[0049] For the first visual stimulus at any flicker frequency, the evaluation module 12 obtains the inter-ocular balance value at the present flicker frequency according to different inter-ocular contrast ratios of the visual stimulus displayed to the subject and the tilt direction given by the subject in feedback; for each flicker frequency of the first visual stimulus, the evaluation module 12 obtains the corresponding inter-ocular balance value respectively.

[0050] If the subject's binocular imbalance, the subject's baseline value, that is, the interocular balance value when the first visual stimulus and the second visual stimulus displayed to the subject are not flickering, will deviate from 1. Then, if the interocular balance value corresponding to a certain flicker frequency is closer to 1 than the baseline value, it indicates that the first visual stimulus and the second visual stimulus with the flicker frequency and the corresponding interocular contrast ratio are helpful for the subject's binocular balance and have an improving effect on the subject's binocular imbalance. Based on this, the evaluation module 12 selects the flicker frequency whose corresponding interocular balance value is closer to 1 than the baseline value from each flicker frequency, and determines the appropriate flicker frequency according to the selected flicker frequency. Then, according to the first visual stimulus and the second visual stimulus defined by the appropriate flicker frequency and the interocular balance value corresponding to the appropriate flicker frequency, visual stimulation is performed on the subject's eyes, which can regulate the subject's interocular inhibition, promote binocular balance, and improve the subject's binocular visual function.

[0051] The device for regulating binocular balance based on monocular flicker in this embodiment obtains interocular balance values ​​at various flicker frequencies by displaying a first visual stimulus and a second visual stimulus to both eyes of a subject respectively, and changing the flicker frequency of the first visual stimulus displayed to the dominant eye, thereby quantifying the original interocular imbalance state of the subject, and further selecting a flicker frequency whose corresponding interocular balance value is closer to 1 than the baseline value from various flicker frequencies, and determining an appropriate flicker frequency, so as to visually stimulate the dominant eye of the subject through the visual stimulus with the appropriate flicker frequency, so as to regulate its interocular inhibition.

[0052] The evaluation module 12 obtains the inter-ocular balance value at the present flicker frequency according to different inter-ocular contrast ratios of the visual stimulus displayed to the subject and the tilt direction given by the subject through statistical analysis for the first visual stimulus at any flicker frequency. In some embodiments, the evaluation module 12 is used to obtain a preset function at the present flicker frequency according to the visual stimulus displayed to the subject and the corresponding tilt direction signal obtained, and obtain the inter-ocular balance value at the present flicker frequency according to the preset function, wherein the preset function describes the probability that the tilt direction given by the subject is consistent with the tilt direction of the first visual stimulus and the relationship between the inter-ocular contrast ratio of the visual stimulus displayed to the subject. According to the visual stimulus displayed to the subject and the tilt direction given by the subject through statistical analysis, the probability that the tilt direction given by the subject is consistent with the tilt direction of the first visual stimulus under different inter-ocular contrast ratios is obtained; further, the preset function is obtained according to each inter-ocular contrast ratio and the probability corresponding to each inter-ocular contrast ratio. The preset function describes the probability that the tilt direction of the fusion perception perceived by the subject's binocular eyes is consistent with the tilt direction of the first visual stimulus displayed to the subject's dominant eye, and its relationship with the inter-eye contrast ratio of the visual stimulus displayed to the subject. The preset function can be called a psychometric function.

[0053] The preset function may be obtained by fitting according to each inter-eye contrast ratio and the corresponding probability. Optionally, the preset function may be obtained by fitting a Gaussian distribution cumulative distribution function.

[0054] In some embodiments, the evaluation module 12 is used to select the flicker frequency whose corresponding inter-eye balance value is closer to 1 than the baseline value from each flicker frequency, including: the evaluation module 12 is used to convert the inter-eye balance value and the baseline value corresponding to each flicker frequency into an absolute logarithmic scale and normalize them, which is expressed as:

[0055] Normalized |logBP| = |logBP| - Baseline |logBP|; (1)

[0056] Where BP represents the inter-eye balance value, Baseline|logBP|=|logBP 0 |, BP 0 represents the baseline value, and the flicker frequency with normalized |logBP|<0 is selected from each flicker frequency.

[0057] When normalized |logBP|=0, according to formula (1), |logBP| is equal to Baseline |logBP|, indicating that this flicker frequency has neither improvement nor impact on the original inter-ocular imbalance of the subject. When normalized |logBP|<0, according to formula (1), |logBP| is less than Baseline |logBP|, indicating that the inter-ocular balance value BP corresponding to this flicker frequency is greater than the baseline value BP 0 Closer to 1.

[0058] Optionally, the evaluation module 12 is used to select a flicker frequency whose corresponding inter-ocular balance value is closer to 1 than the baseline value from each flicker frequency, and determining the appropriate flicker frequency according to the selected flicker frequency includes: the evaluation module 12 is used to select a flicker frequency whose corresponding inter-ocular balance value is closer to 1 than the baseline value from each flicker frequency, and further determine the flicker frequency whose corresponding inter-ocular balance value is closest to 1 among the selected flicker frequencies as the appropriate flicker frequency. The closer the inter-ocular balance value corresponding to the flicker frequency is to 1, the better the first visual stimulation and the second visual stimulation having the flicker frequency and the corresponding inter-ocular contrast ratio have an improving effect on the binocular imbalance of the subject, and the better the improvement effect will be.

[0059] Specifically, according to the normalized |logBP| corresponding to each flicker frequency, the flicker frequency with normalized |logBP|<0 can be selected, and the flicker frequency with the largest absolute value of normalized |logBP| can be further selected as the appropriate flicker frequency. The larger the absolute value of the normalized |logBP| corresponding to the flicker frequency, the closer the corresponding inter-eye balance value is to 1 than the baseline value, and the better the effect of improving binocular imbalance. Exemplarily, for an amblyopic patient, the flicker frequencies of the first visual stimulus displayed to the dominant eye include 4Hz, 7Hz, 10Hz, 15Hz and 20Hz, and the corresponding normalized |logBP| values ​​are -0.1, -0.23, -0.37, -0.51 and -0.25, respectively. All five values ​​are less than 0. It is believed that these five flicker frequencies have an improving effect on the binocular balance of amblyopic patients, but 15Hz has the best effect, that is, 15Hz is the most suitable flicker frequency for the patient.

[0060] The device of this embodiment uses a psychophysical paradigm to quantify the binocular balance of the subject under the condition of binocular dichopia. The device adopts a binocular orientation integration paradigm, in which the subject makes a judgment on the presented visual stimulus, and the feedback data of the subject is collected and analyzed, thereby converting the interaction between the eyes into quantifiable data.

[0061] In this embodiment, the specific value of the flicker frequency of the first visual stimulus is not limited, and can be set based on experience in practical applications. The inter-ocular contrast ratio between the first visual stimulus and the second visual stimulus is not limited, and in practical applications, several appropriate inter-ocular contrast ratios can be determined by first conducting a practice test on the subjects.

[0062] In some embodiments, the dichographic display module 11 is used to display the first visual stimulus and the second visual stimulus to the dominant eye and the non-dominant eye of the subject, respectively, including: for the first visual stimulus at any flicker frequency, the first visual stimulus and the second visual stimulus with different inter-eye contrast ratios are displayed to the subject, wherein for any inter-eye contrast ratio, a visual stimulus configured in a first direction and a visual stimulus configured in a second direction are displayed to the subject, the first direction configuration in which the first visual stimulus is tilted in a clockwise direction and the second visual stimulus is tilted in a counterclockwise direction, and the second direction configuration in which the first visual stimulus is tilted in a counterclockwise direction and the second visual stimulus is tilted in a clockwise direction.

[0063] Furthermore, the dichographic display module 11 can be used to display the visual stimulus configured in the first direction to the subject a preset number of times and to display the visual stimulus configured in the second direction to the subject a preset number of times for any inter-ocular contrast ratio, so that the subject will give the inclination direction of the fusion perception perceived by both eyes each time the visual stimulus is displayed to the subject, so that the probability that the inclination direction given by the subject is consistent with the inclination direction of the first visual stimulus at any inter-ocular contrast ratio can be statistically obtained based on the obtained test data from each time.

[0064] The inclination angle value of the first visual stimulus and the inclination angle value of the second visual stimulus may be equal. In this embodiment, the inclination angle value of the first visual stimulus is not limited, and the inclination angle value of the second visual stimulus is not limited. The first visual stimulus and the second visual stimulus may be grating patterns, respectively. For example, reference may be made to Figure 2 , Figure 2 This is a schematic diagram of an embodiment of a device for regulating binocular balance based on monocular flickering displaying visual stimulation to a subject. As shown in the figure, the grating displayed to the subject's dominant eye is tilted counterclockwise by θ relative to the horizontal direction, expressed as tilt-θ, and the contrast is δ*C, where C represents a fixed contrast; the grating displayed to the subject's non-dominant eye is tilted clockwise by θ relative to the horizontal direction, expressed as tilt θ, and the contrast is C.

[0065] Furthermore, the device may further include a control module 13 connected to the split-view display module 11, for adjusting the flickering frequency of the first visual stimulus. The flickering mode of the first visual stimulus includes but is not limited to a square wave form, a sine wave form, a sawtooth wave form or a triangle wave form, which can be referred to in Figure 6 , Figure 6 Four waveform diagrams of visual stimulus flickering in one embodiment. The control module 13 can use a periodic wave signal to adjust the flickering frequency, and the periodic wave signal includes but is not limited to a square wave, a sine wave, a sawtooth wave or a triangle wave. The control module 13 can be a computer-built device, for example, a flickering sight mark in the form of a square wave, a sine wave, a sawtooth wave or a triangle wave can be edited by running a program. The running program is, for example, Matlab or PsychToolBox or other programming software. The control module 13 can also be an external device, such as glasses or a flickering light source that flickers at different frequencies. Please refer to Figure 2 As shown, the flashing frequency of the sight mark grating is controlled by a square wave, and the frequency of the square wave corresponds to the flashing frequency of the sight mark grating. For example, if the flashing frequency is 10 Hz, that is, 1000 ms / 10=100 ms, the sight mark grating appears and disappears alternately every 100 ms.

[0066] After determining the appropriate flicker frequency for the subject, the subject's eyes can be regulated according to the appropriate flicker frequency and the first visual stimulus and the second visual stimulus defined by the interocular balance value corresponding to the appropriate flicker frequency, so as to regulate the interocular inhibition of the subject and improve the binocular imbalance. When regulating the subject's eyes, the interocular contrast ratio of the first visual stimulus and the second visual stimulus displayed to the subject's eyes is the interocular balance value corresponding to the appropriate flicker frequency.

[0067] The dichographic display module 11 uses binocular dichographic equipment, including but not limited to dichographic mirrors, head-mounted binocular displays, VR glasses, polarized light displays, flickering dichographic display screens or naked-eye 3D display screens, to present different visual stimuli to the two eyes of the subject. The evaluation module 12 can be performed on a computer equipped with a pre-made program, such as Matlab, PsychToolBox or other programming software, and the computer is connected to the binocular dichographic equipment. In a specific example, the display screen resolution of the dichographic display module 11 is 1600×900 and the refresh rate is 60Hz; before the test, the display screen needs to be gamma corrected using a brightness meter.

[0068] For example, in a specific example, a sinusoidal grating with the same spatial frequency and size is presented to the left eye and the right eye of the subject through the split-view display module 11, and the two sinusoidal gratings have equal but opposite orientations with respect to the tilt angle value, that is, the two sinusoidal gratings deviate clockwise and counterclockwise from the horizontal orientation by θ, respectively, and the orientation difference between the two sinusoidal gratings is 2θ. When the stimulus input to the eyes of the subject is integrated in the visual cortex, the subject will perceive a single integrated grating. The orientation of the grating is affected by the proportion of binocular input information in the visual cortex, which is between -θ and +θ. During the measurement, the subject can report the direction of the grating orientation (i.e., deviate clockwise or counterclockwise relative to the horizontal orientation) by the left and right keys of the keyboard according to the instruction. When binocular input is unbalanced in integration, the integrated grating orientation perceived by the subject will be biased towards the orientation of the grating viewed by the relatively stronger eye; when binocular input reaches a balanced state in integration, the integrated grating orientation perceived by the subject is 0 (i.e., the grating is perceived to be in a horizontal orientation).

[0069] For example, when θ=7.1°, the size of the grating is presented in two cycles, and the spatial frequency is 0.5c / deg. The flickering frequency can be changed by changing the presentation time of the grating, such as 10Hz, which is 1000ms / 10=100ms, that is, the grating appears and disappears alternately every 100ms.

[0070] The steps of using the device to detect the subject may include the following:

[0071] 1) The subjects undergo binocular vision and refraction examinations, and the dominant eye and non-dominant eye of the subjects are determined.

[0072] Alternatively, ocular dominance may be determined by a hole-in-the-hand test.

[0073] 2) Practice trials were conducted before the formal experiment. Each trial had a calibration phase and a test phase. In the calibration phase, the fixation target appeared first. The subjects were required to align the binocular cross and dot by moving the arrow keys to ensure that the images were correctly fused. Then the visual stimulus was presented, which was a sinusoidal grating stimulus tilted relative to the horizontal direction. The subjects were required to indicate whether the perceived fusion grating was tilted clockwise or counterclockwise and give a response through the keyboard. Seven appropriate interocular contrast ratios for the subjects were selected based on the practice trial data.

[0074] Optionally, the selected inter-ocular contrast ratio is between 0 and 2.

[0075] 3) The formal experiment used the fixed stimulus method for a total of 140 trials (2 direction configurations × 7 interocular contrast ratios × 10 repetitions), and based on the test data, the Gaussian distribution cumulative distribution function was used to fit the psychometric function. Specifically based on the test data, the probability that the tilt direction of the subject's fusion perception is consistent with the tilt direction of the grating displayed to its dominant eye was calculated, and it was plotted against the interocular contrast ratio, and fitted to obtain a preset function representing the relationship between the two. According to the preset function, the interocular contrast ratio at which the probability that the tilt direction of the fusion perception is consistent with the tilt direction of the grating displayed to its dominant eye is 50% was determined as the interocular balance value (Balance Point, BP).

[0076] 4) After obtaining the baseline value of the subject in the non-flicker state, the flicker frequency is changed by adjusting the grating presentation time, thereby obtaining the BP value at different flicker frequencies. Figure 3 , Figure 3 It is a preset function diagram obtained by fitting experimental data in a specific example. The preset function is fitted according to the probability data corresponding to the seven inter-eye contrast ratios, and the inter-eye contrast ratio with a probability of 50% is taken as the inter-eye balance value.

[0077] In another specific example, it was verified that the visual stimulation determined by the present device improves the inter-ocular imbalance of amblyopic patients, and there are personalized differences among different individuals.

[0078] Seven normal people and seven amblyopic patients were selected as verification subjects. Previous research theory supported that amblyopic patients have significant inter-eye imbalance. The verification process was approved, and all subjects voluntarily participated and signed informed consent.

[0079] Five flicker frequency conditions were selected during the verification process, namely 4Hz, 7Hz, 10Hz, 15Hz and 20Hz. With flicker frequency as the horizontal axis and normalized |logBP| value as the vertical axis, the average results of the two groups of subjects are shown in Figure 4(a) and Figure 4(b). Figure 4(a) shows the change of interocular balance state of normal people when their eyes receive different visual stimuli in a specific example, and Figure 4(b) shows the change of interocular balance state of amblyopic patients when their eyes receive different visual stimuli in a specific example. As shown in the figure, mixed repeated measures ANOVA showed that there were significant differences in eye (F=84.631, P<0.001), flicker frequency (F=71.128, P<0.001), between groups (F=47.036, P<0.001), and the interaction between eyes and groups (F=25.586, P<0.001). Paired comparisons showed that the normalized |logBP| values ​​when flicker was applied to the amblyopic eye of amblyopic patients were similar to those when flicker was applied to the non-dominant eye of normal subjects (P=0.481). However, when flicker was applied to the relative healthy eye of amblyopic patients, the normalized |logBP| was significantly lower than the normalized |logBP| values ​​observed when flicker was applied to the dominant eye of normal subjects (P<0.001). Where F represents the variance value and P represents the statistical probability value.

[0080] And you can refer to Figure 5 , Figure 5 The data of changes in interocular balance state of patients with different degrees of binocular vision abnormality under different monocular flicker frequencies in a specific example. From the individual data of 7 amblyopic patients, it can be seen that there are significant individual differences in the optimal normalized |logBP| value (i.e., the lowest point). This shows that when flicker is applied to the relatively healthy eye of amblyopic patients, the interocular imbalance of amblyopic patients can be significantly improved, and the optimal frequency of monocular flicker has individual differences.

[0081] The advantages of this scheme are: 1. The original inter-ocular imbalance state of individuals with binocular vision abnormalities such as amblyopia is quantified through psychophysical methods; 2. By changing the flicker frequency of visual stimulation presented to one eye (such as the relatively healthy eye), the improvement of the individual's inter-ocular balance under different flicker frequencies is obtained, thereby realizing personalized regulation of the individual's binocular balance.

[0082] The above is a detailed introduction to the device for regulating binocular balance based on monocular blinking provided by the present invention. Specific examples are used herein to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

Claims

1. A device for regulating binocular balance based on monocular blinking, It is characterized in that include: A split-view display module, used for displaying a first visual stimulus and a second visual stimulus to the dominant eye and the non-dominant eye of the subject, respectively, and the first visual stimulus flickers at an appropriate flickering frequency; Among them, the inter-ocular balance value corresponding to the appropriate flicker frequency is closer to 1 than the baseline value, the inter-ocular balance value refers to the inter-ocular contrast ratio when the probability that the inclination direction of the fusion perception perceived by both eyes of the subject is consistent with the inclination direction of the first visual stimulus when the first visual stimulus and the second visual stimulus are displayed to the subject and the first visual stimulus flickers at the corresponding flicker frequency is half, the baseline value is the inter-ocular balance value obtained when the first visual stimulus and the second visual stimulus displayed to the subject do not flicker, and the inter-ocular contrast ratio refers to the ratio of the contrast of the first visual stimulus to the contrast of the second visual stimulus.

2. The device for regulating binocular balance based on monocular blinking according to claim 1, It is characterized in that The dichoptic display module is further used to display the first visual stimulus and the second visual stimulus to the dominant eye and the non-dominant eye of the subject, respectively, the first visual stimulus and the second visual stimulus have opposite inclination directions so that the subject can give the inclination direction of binocularly perceived fusion perception, and the flickering frequency of the first visual stimulus is changed, and for the first visual stimulus at any flickering frequency, the first visual stimulus and the second visual stimulus with different inter-eye contrast ratios are displayed to the subject; It also includes: an evaluation module, which is used to obtain the inter-ocular balance value at any flicker frequency of the first visual stimulus according to the visual stimulus displayed to the subject and the corresponding obtained tilt direction signal, and select the flicker frequency whose corresponding inter-ocular balance value is closer to 1 than the baseline value from each flicker frequency, and determine the appropriate flicker frequency according to the selected flicker frequency.

3. The device for regulating binocular balance based on monocular blinking according to claim 2, It is characterized in that The evaluation module is used to obtain the inter-ocular balance value at any flicker frequency of the first visual stimulus according to the visual stimulus displayed to the subject and the corresponding acquired tilt direction signal, including: The evaluation module is used to obtain a preset function at the current flicker frequency based on the visual stimulus displayed to the subject and the corresponding tilt direction signal obtained, and obtain the inter-ocular balance value at the current flicker frequency based on the preset function, wherein the preset function describes the probability that the tilt direction given by the subject is consistent with the tilt direction of the first visual stimulus, and the relationship between the inter-ocular contrast ratio of the visual stimulus displayed to the subject.

4. The device for regulating binocular balance based on monocular blinking according to claim 3, It is characterized in that The evaluation module is used to obtain the probability that the tilt direction given by the subject is consistent with the tilt direction of the first visual stimulus at each inter-eye contrast ratio based on the visual stimulus displayed to the subject and the corresponding tilt direction signal obtained, and to obtain the preset function using Gaussian distribution cumulative distribution function fitting.

5. The device for regulating binocular balance based on monocular blinking according to claim 2, It is characterized in that The evaluation module is used to select a flicker frequency whose corresponding inter-eye balance value is closer to 1 than the baseline value from various flicker frequencies, and the appropriate flicker frequency is determined according to the selected flicker frequency, including: The evaluation module is used to select a flicker frequency whose corresponding inter-eye balance value is closer to 1 than the baseline value from various flicker frequencies, and further determine the flicker frequency whose corresponding inter-eye balance value is closest to 1 among the selected flicker frequencies as the appropriate flicker frequency.

6. The device for regulating binocular balance based on monocular blinking according to claim 2, It is characterized in that The evaluation module is used to select a flicker frequency whose corresponding inter-eye balance value is closer to 1 than the baseline value from each flicker frequency, including: The evaluation module is used to convert the inter-eye balance value and the baseline value corresponding to each flicker frequency into an absolute logarithmic scale and normalize them, which is expressed as: Normalized |logBP|=|logBP|-Baseline|logBP|; Where BP represents the inter-eye balance value, Baseline|logBP|=|logBP 0 |, BP 0 represents the baseline value, and the flicker frequency with normalized |logBP|<0 is selected from each flicker frequency.

7. The device for regulating binocular balance based on monocular blinking according to claim 2, It is characterized in that The dichoptic display module is used to display the first visual stimulus and the second visual stimulus to the dominant eye and the non-dominant eye of the subject respectively, and includes: The dichographic display module is used for displaying the first visual stimulus and the second visual stimulus with different inter-ocular contrast ratios to the subject at any flickering frequency of the first visual stimulus, wherein for any inter-ocular contrast ratio, a visual stimulus configured in a first direction and a visual stimulus configured in a second direction are displayed to the subject, the first direction configuration wherein the first visual stimulus is inclined in a clockwise direction and the second visual stimulus is inclined in a counterclockwise direction, and the second direction configuration wherein the first visual stimulus is inclined in a counterclockwise direction and the second visual stimulus is inclined in a clockwise direction.

8. The device for regulating binocular balance based on monocular blinking according to claim 7, It is characterized in that The dichographic display module is used for displaying visual stimulation configured in a first direction to the subject a preset number of times and displaying visual stimulation configured in a second direction to the subject a preset number of times for any inter-ocular contrast ratio, so that the subject will give the tilt direction of the fusion perception perceived by both eyes each time the visual stimulation is displayed to the subject.

9. The device for regulating binocular balance based on monocular blinking according to any one of claims 1 to 8, It is characterized in that Also includes: A control module is connected to the split-view display module and is used to adjust the flickering frequency of the first visual stimulus.

10. The device for regulating binocular balance based on monocular blinking according to any one of claims 1 to 8, It is characterized in that The flashing mode of the first visual stimulus includes a square wave form, a sine wave form, a sawtooth wave form or a triangle wave form.

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