Self-heating Tibetan medicine foot bath bag containing sophora moorcroftiana seed extract and preparation method of self-heating Tibetan medicine foot bath bag

Abstract

The invention relates to the technical field of lavipeditum bags, and discloses a self-heating Tibetan medicine lavipeditum bag containing sophora moorcroftiana seed extract and a preparation method thereof.The self-heating Tibetan medicine lavipeditum bag comprises a medicine powder bag and an essential oil bag, and the essential oil bag is obtained by sealing and packaging essential oil obtained by conducting carbon dioxide supercritical extraction on raw materials including rhizoma acori calami and pepper; the traditional Chinese medicine powder in the medicine powder bag is obtained by performing reflux extraction on a mixture of raw materials including sophora moorcroftiana seeds, daughter tree seeds, gallnut, halite, wormwood, madder and radix angelicae; a heating component is adhered to the surface of the medicine powder bag. Compared with the prior art that the curative effect of the traditional Chinese medicine is reduced due to compatibility reaction when multiple raw materials are mixed and extracted at high temperature, according to the scheme, the raw materials are separately extracted according to water solubility or water insolubility, essential oil and medicine powder are obtained and separately packaged, and the essential oil and the medicine powder are mixed before being used and then dissolved in water, so that the curative effect of the traditional Chinese medicine is improved. The reduction of the curative effect of the medicine due to compatibility reaction among the raw material components is effectively avoided.

Description

Technical Field

[0001] The invention relates to the technical field of foot bath bags, and in particular to a self-heating Tibetan medicine foot bath bag containing a Sophora japonica seed extract and a preparation method thereof. Background Art

[0002] Sophora moorcroftiana (Benth.) Benth.ex Baker is a small shrub of the genus Sophora in the Leguminosae family. It is mainly distributed in the Yarlung Zangbo River Basin in Tibet, China. It is a unique species distributed in Tibet and has a long history of application in Tibetan medicine. For example, the Jingzhu Materia Medica published the disease of vomiting bile caused by Sophora moorcroftiana seeds, and the Ruyi Baoshu said that "the interpretation of Sophora moorcroftiana seeds is like raw bacon." Rangqiong Dorje said: "The seeds of Sophora moorcroftiana can treat diphtheria." The names of this product include: Angba Qieju, Angba Saiergong, Angba Qietu, etc. The Illustrated Guide says: Sophora moorcroftiana seeds are one of the most effective medicines. They have gray-white thorns all over the body, small leaves, small blue flowers, long fruit pods, and seeds like beans. They taste bitter and have a fragrant smell. They can treat insect diseases and diphtheria. "Chinese National Medicine Annals" Jue Wei Zhe Wu: The seeds are used for diphtheria, jaundice hepatitis, suppurative tonsillitis, and worm diseases "Bu Zang Biao". However, the existing Sophora japonica is mostly decocted and taken orally, and the decoction often takes a long time, which makes it very troublesome to use.

[0003] At present, in order to adapt to the fast pace of work of contemporary young people, foot bath bag related products have come into being. By soaking the feet, blood circulation in the body is increased and the medicine is absorbed into various parts of the body, achieving the conditioning of sub-health status. However, the existing foot bath bags are mostly directly packaged in small segments or powders of medicinal materials. During the decoction or hot water soaking process, the compatibility reaction between the medicinal materials can easily lead to a decrease in the content of markers, resulting in poor treatment effects. In addition, the existing foot bath bags mostly need to be boiled to fully release the efficacy, which is time-consuming and inconvenient.

[0004] In summary, the development of a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract that is easy to use and has good therapeutic effects and a preparation method thereof can not only effectively make up for the shortcomings of the existing technology, but also develop various ways of using Sophora japonica, which plays an important role in expanding the application scope of the Tibetan medicine Sophora japonica. Summary of the invention

[0005] The present invention aims to provide a self-heating Tibetan medicine foot bath bag containing Sophora moracha seed extract and a preparation method thereof, so as to solve the technical problem of the single usage of Sophora moracha seed in the prior art.

[0006] To achieve the above-mentioned purpose, the present invention adopts the following technical scheme: a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract, comprising a medicine powder bag and an essential oil bag, the essential oil bag is obtained by sealing and packaging the essential oils obtained by supercritical extraction of Tibetan calamus and Zanthoxylum bungeanum with carbon dioxide, and the medicine powder in the medicine powder bag is obtained by reflux extraction of a mixture of Sophora japonica seed, Xanthoceras chinensis seed, Galla chinensis, Isatis salt, Artemisia argyi, Rubia cordifolia and Angelica dahurica with raw materials; a heating component is also pasted on the surface of the medicine powder bag.

[0007] The principle of this scheme is:

[0008] A part of the foot bath bag of the present scheme is obtained by mixing and refluxing extraction of Sophora japonica seeds, Phellodendron chinense seeds, Zanthoxylum bungeanum, Gallnut, Salt of Green Salt, Acorus calamus, Artemisia annua, Rubia cordifolia and Angelica dahurica, and then drying to obtain foot bath powder, which is packaged to obtain powder bag, and a heating component is also pasted on the surface of the powder bag; the other part is essential oil obtained by supercritical extraction of Acorus calamus and Zanthoxylum bungeanum, which is filled in a small PE packaging bag, and the two parts are combined to form a Tibetan medicine foot bath bag.

[0009] When using the product of this solution, you need to tear open the essential oil packet first, pour or apply the essential oil on the powder bag, then place the powder bag in an appropriate amount of cold water, and wait for a few minutes to soak your feet. Specifically, after the heating component enters the water, the heating component reacts chemically with water to release heat, the blue salt in the powder bag dissolves, and the heat release is accelerated. The powder quickly dissolves in the water during the heat release process of the heating component, and the feet can be soaked after the water temperature rises to nearly 40°C. In this solution, blue salt is both a medicinal material and can promote the accelerated heat release of the heating component, improve the heating efficiency of the heating component, shorten the waiting time for the user to soak their feet, and is more convenient. At this time, the effective substances of the powder in the foot bath bag have been dissolved, and the heating component has agglomerated, which can be discarded after the foot bath is completed. In order to improve the foot bath experience, the heating component can be directly discarded to avoid the problem of the heating component seeping into the basin and leaving a lot of residue in the basin. Then, during the foot soaking process, the powder and essential oil quickly dissolve into the hot water. After the user opens the pores by soaking their feet in hot water, the alkaloids and flavonoids in the powder enter the user's foot circulation, which can effectively relieve symptoms such as itchy feet, foot odor, and athlete's foot, and promote blood circulation and relieve fatigue. The essential oil can not only give the user a fragrant foot soaking experience, but also promote relaxation and improve the user's nervous state after entering the human body with the medicine.

[0010] The advantages of this solution are:

[0011] 1. Compared with the existing single usage of Sophora japonica which limits its wide application, this solution compounds Sophora japonica with, yellow flower tree seeds, prickly ash, gallnut, salt of green salt, Tibetan calamus, mugwort, madder, and angelica dahurica, and obtains alkaloids and flavonoids-rich medicinal powder through reflux extraction. The medicinal powder is filled into a foot bath bag and dissolved in hot water. After the user uses hot water to soak their feet to open the pores, the alkaloids and flavonoids in the medicinal powder enter the user's foot circulation, effectively relieving symptoms such as itchy feet, foot odor, and athlete's foot, and effectively expanding the application scope of Sophora japonica.

[0012] 2. Compared with the prior art, which easily causes compatibility reactions when mixing multiple raw materials for high-temperature extraction, thereby reducing the efficacy of traditional Chinese medicine, this solution extracts the raw materials separately according to their water solubility or water insolubility, obtains essential oils and medicinal powders and packages them separately, mixes them before use and then dissolves them in water, effectively avoiding compatibility reactions between the raw material components and reducing the efficacy of the medicine.

[0013] 3. This solution can effectively prevent the aroma from escaping due to loose packaging and reduce the effect of aromatherapy by packaging the essential oils and powders separately. On the other hand, packaging the essential oils and powders separately can also prevent the powders and oils from mixing into agglomerates, which can reduce the dissolution effect of the medicinal ingredients in hot water. This can effectively improve the dissolution effect of the medicinal ingredients in the powders and essential oils, and significantly improve the efficacy.

[0014] 4. Compared with the prior art in which all raw materials are packaged into products in the form of medicinal material segments or medicinal material powders, which results in the need to boil or directly soak before use and has a lower efficacy, the present solution forms a foot bath package product by extracting the raw materials in advance and then storing them separately according to their performance. This makes it convenient for users to directly tear open the sealed bag of the essential oil package after getting the foot bath package product of the present solution, mix the raw material extracts in the essential oil package and the powder package with hot water, which is not only convenient to use but also can maximize the efficacy. The applicant has found through long-term experiments that after 21 days of periodic use of the foot bath medicine of the present solution, its complete relief rate for itchy feet, foot odor, and sweaty feet can reach 70%; and after continuing to increase the use time to 28 days, its complete relief rate can be greater than 85%.

[0015] Preferably, the heating component contains the following raw materials in parts by mass: 1 to 3 parts of iron powder, 1 to 2 parts of activated carbon, 0.5 to 1 part of salt and 0.5 to 1 part of vermiculite.

[0016] Beneficial effect: This solution adopts the above-mentioned setting, which makes it easy for the heating component to quickly release heat when it comes into contact with water to heat the foot bath water, thereby being convenient for users.

[0017] Preferably, the extraction raw materials of the medicinal powder are as follows: 1-5 parts of Sophora japonica seeds, 1-5 parts of Atractylodes macrocephala seeds, 1-5 parts of Salt of the Great Blue, 1-5 parts of Gallnut, 1-5 parts of Artemisia annua, 1-5 parts of Rubia cordifolia, and 1-5 parts of Angelica dahurica.

[0018] Beneficial effects: Sophora japonica seeds are used for diphtheria, icteric hepatitis, suppurative tonsillitis.

[0019] "Tibetan Materia Medica" records that the seeds of the yellow flower tree can treat skin diseases and rheumatoid arthritis.

[0020] Daqingyan is salty and cold. It enters the heart, kidney and bladder meridians. It clears away heat, cools blood and improves eyesight. It is used for vomiting blood, hematuria, swollen and painful gums with bleeding, red and swollen eyes, and eye ulcers caused by wind.

[0021] Gallnut is sour, astringent and cold. It enters the lung, large intestine and kidney meridians. This product is sour and astringent, and can clear away cold. It enters the lung, kidney and large intestine meridians. It is good at astringing the lungs, astringing the intestines, astringing sweat, consolidating essence, stopping bleeding, astringing sores, and reducing fire. It is suitable for a variety of slipping symptoms, especially those with heat. It is mainly used for chronic cough due to lung deficiency, cough with phlegm due to lung heat, chronic diarrhea and dysentery, spontaneous sweating, night sweats, thirst, blood in stool and hemorrhoids, bleeding due to trauma, carbuncle, sore and ulcer, and wet and rotten skin.

[0022] Mugwort tastes pungent and bitter, and is warm in nature. It enters the liver, spleen, and kidney meridians. It warms the meridians and stops bleeding, dispels cold and relieves pain; it is used externally to dispel dampness and relieve itching. It warms the meridians and stops bleeding, dispels cold and relieves pain; it is used externally to dispel dampness and relieve itching. It is used for vomiting blood, epistaxis, metrorrhagia, menorrhagia, fetal bleeding, cold pain in the lower abdomen, irregular menstruation, and infertility due to uterine coldness; it is used externally to treat skin itching. Vinegar and mugwort charcoal warm the meridians and stop bleeding, and is used for bleeding due to deficiency and cold.

[0023] Rubiaceae is bitter and cold in nature. It enters the liver meridian. This product is bitter, dispersing, cold and cooling, and enters the liver meridian. When it is charred, it has a stopping effect, is good at removing blood stasis, cooling blood and stopping bleeding; when it is used raw, it is specialized in cooling and dispersing, is good at activating blood circulation, cooling blood and removing blood stasis and dredges the menstruation. It has the advantages of stopping bleeding without leaving blood stasis, activating blood circulation without causing bleeding, and is suitable for all bleeding, whether it is blood stasis with heat or blood heat with blood stasis, especially for those with blood heat, blood stasis and bleeding.

[0024] Angelica dahurica is pungent and warm in nature. It enters the stomach, large intestine, and lung meridians. It is pungent, warm, and dry, aromatic, and opens the orifices. It mainly enters the Yangming (stomach) meridian and also enters the Taiyin (lung) meridian. It is good at dispersing wind and cold, removing dampness, and opening the nasal orifices and joints. It is also good at relieving pain, releasing wind, and stopping leukorrhea. It can also dissipate lumps and promote the discharge of pus.

[0025] This scheme adopts the above-mentioned setting and combines a variety of medicinal materials to fully exert the effects of each medicinal material and enhance the therapeutic effect of the formula on symptoms such as itchy feet, foot odor, and athlete's foot.

[0026] Preferably, the raw materials for extracting the essential oil are as follows: 1 to 5 parts of Tibetan calamus and 1 to 5 parts of Zanthoxylum bungeanum.

[0027] Beneficial effects: "Chinese Tibetan Medicine" records that Tibetan calamus can be used externally to treat sores, boils, swellings, and skin scabies. "Tibetan Materia Medica" records that the rhizomes of Tibetan calamus are used for miasma, dampness, phlegm, heat, and chest and abdominal distension. Sichuan pepper tastes spicy and sweet, and is slightly warm in nature. It enters the spleen, stomach, and lung meridians. It has the effects of dispelling cold, warming the stomach, and relieving pain. Adding Sichuan pepper to warm water to soak your feet can calm the mind, prevent colds, detoxify and reduce swelling, enhance the body's resistance, and relieve fatigue. This scheme adopts the above settings, which is convenient for the combination of Sichuan pepper and Tibetan calamus to extract essential oils. Soaking feet in hot water with the powder is convenient for the aromatic substances to volatilize, relieve the fatigue of the user, and detoxify and eliminate miasma, further improving the therapeutic effect of the foot bath bag on symptoms such as itchy feet, foot odor, and athlete's foot.

[0028] Preferably, the mass volume ratio of the medicine powder package to the essential oil package is 18-25:1.

[0029] Beneficial effects: This scheme adopts the above-mentioned setting, which is convenient for the powder bag to be combined with the essential oil bag, and the two work together to achieve better therapeutic effects. The applicant found through long-term experiments that if the powder bag is used alone, the complete remission rate is still less than 50% after 21 days of treatment; and if the essential oil bag is used alone for foot soaking, the complete remission rate is still less than 50%. Only when the two are used in combination, the complete remission rate can be higher than 70% after 21 days of foot soaking treatment, and after continuing to increase the use time to 28 days, the complete remission rate can be greater than 85%; and if the dosage of the combined powder bag and the essential oil bag is increased, the therapeutic effect is not significantly increased, and the cost of the foot bath bag will also increase significantly.

[0030] Preferably, the present invention also provides a method for preparing a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract, comprising the following steps:

[0031] S1. preparing an essential oil package: crushing and sieving calamus and prickly ash respectively, extracting and purifying them through supercritical carbon dioxide to obtain calamus essential oil, prickly ash essential oil and raw material residue, and packaging the calamus essential oil and prickly ash essential oil in a PE packaging bag to form an essential oil package;

[0032] S2, preparing a powder bag: grinding and sieving raw materials such as Sophora japonica seeds, Psoralea corylifolia seeds, Gallnut, Isatis grandis, Rubia cordifolia, Angelica dahurica, and Artemisia argyi, and mixing them with the raw material residue obtained in S1 to form a mixture, refluxing and extracting the mixture 2-3 times to obtain an extract and a residue; combining the extracts and concentrating to obtain a concentrated extract; drying and grinding the residue and combining it with the concentrated extract, drying to form a powder, packaging the powder with a non-woven fabric and then packaging it with a PE packaging bag to obtain a powder bag;

[0033] S3, preparing a foot bath bag: combining the essential oil bag obtained in S1 and the medicine powder bag obtained in S2 to form a foot bath bag.

[0034] Beneficial effects: This solution adopts the above-mentioned settings, and now extracts essential oils or water from Chinese medicine raw materials according to different properties to obtain essential oil and water extract powders, which effectively improves the effective dissolution of medicinal ingredients in Chinese medicinal materials and improves the efficacy. The essential oils and powders are packaged separately, which is convenient for both to achieve aromatherapy when the user soaks their feet. At the same time, the effective ingredients in the powder can also be quickly dissolved to treat and improve the user's symptoms. It can also effectively avoid the poor dissolution effect of the medicinal ingredients after the two are mixed into a mass, which affects the efficacy of the foot bath bag. In addition, this solution also forms a powder by drying and crushing the extracted drug residues and combining them with the extract. The drug residues not only effectively disperse the extracts to avoid the extracts from agglomerating and being difficult to dissolve; they can also effectively improve the utilization rate of medicinal materials and avoid the waste of effective ingredients in the drug residues.

[0035] Preferably, in S1, the temperature of the supercritical extraction of Acorus calamus is 40-50°C, and the gas flow rate during the supercritical extraction of Acorus calamus is 10-30 L / h. The temperature of the supercritical extraction of Zanthoxylum bungeanum is 40-50°C, and the gas flow rate during the supercritical extraction of Zanthoxylum bungeanum is 10-30 L / h.

[0036] Beneficial effects: This scheme adopts the above-mentioned setting, which is convenient for fully extracting the volatile oils in Tibetan calamus and prickly ash, and improving the utilization rate of the drugs. The applicant has found through long-term experiments that if the extraction pressure is too low, the extraction efficiency will be too low, resulting in a waste of raw materials; if the extraction pressure is too high, the solvent polarity will be too strong, making the extract viscous and turbid; if the extraction temperature is too high, the essential oil substances will volatilize, the CO2 solvent performance will decrease, and the extraction rate will decrease; if the extraction temperature is too low, the extraction will be insufficient.

[0037] Preferably, in S2, the temperature of the reflux extraction is 75-85°C, and the time of the reflux extraction is 1.5-2h.

[0038] Beneficial effects: This scheme adopts the above-mentioned setting, which is convenient for high-efficiency extraction.

[0039] Preferably, the concentration of the extract before mixing with the medicinal residue is to concentrate the extract to a solid content of 15-20%.

[0040] Beneficial effect: This solution adopts the above-mentioned setting, which is convenient for uniformly mixing the dried medicinal residue with the concentrated extract. The applicant has found through long-term experiments that if the extract is too concentrated, the poor fluidity will affect the uniform mixing of the medicinal residue powder and the extract, thereby reducing the dispersibility of the extract; if the extract is too diluted, the product effect will be affected due to the reduced content of the effective ingredients; similarly, if the unconcentrated extract is directly mixed with the medicinal residue powder, the drying rate will be low during the mixing and drying process, the amount of powder obtained will be small, and energy consumption will increase.

[0041] Preferably, in S2, the moisture content of the medicinal powder is less than 5%.

[0042] Beneficial effect: This solution adopts the above-mentioned setting to improve the dispersibility of the powder and avoid agglomeration, which affects the dissolution effect of the powder in water. The applicant found through long-term experiments that if the water content of the powder is too high, it is not only inconvenient for long-term storage of the powder, but also affects the dispersion effect of the extract in the powder and the dissolution effect in water, thereby significantly reducing the efficacy. The applicant also tried to add cyclodextrin to increase the dispersion effect of the powder, but found that the solid powder after the concentrated extract was spray-dried has good dispersibility and is not easy to adhere and agglomerate. DETAILED DESCRIPTION

[0043] The present invention is further described in detail below in conjunction with examples, but the embodiments of the present invention are not limited thereto. Unless otherwise specified, the technical means used in the following examples and experimental examples are conventional means well known to those skilled in the art, and the materials, reagents, etc. used can be obtained from commercial sources.

[0044] Program Overview

[0045] The present invention provides a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract, comprising raw materials in the mass fractions as described in Table 1.

[0046] Table 1 Raw materials of the self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract in this scheme

[0047] Name of medicinal material Latin name Raw material dosage / portion Implementation Standards Sophora japonica seeds SOPHORA MOORCROFTIANA 1~5 servings Chinese Pharmacopoeia 2020 Edition Yellowwood Seeds PIPTANTHUS NEPALENSIS 1~5 servings Chinese Pharmacopoeia 2020 Edition Sichuan peppercorn ZANTHOXYLIPERICARPIUM 1~5 servings Chinese Pharmacopoeia 2020 Edition Gallnut GALLA CHINENSIS 1~5 servings Chinese Pharmacopoeia 2020 Edition Blue salt HALITUM 1~5 servings Chinese Pharmacopoeia 2020 Edition Acorus tibetica ACORI CALAMI RHIZOMA 1~5 servings Chinese Pharmacopoeia 2020 Edition Wormwood ARTEMISIAE ARGYI FOLIUM 1~5 servings Chinese Pharmacopoeia 2020 Edition Rubia cordifolia RUBIAE RADIX ET RHIZOMA 1~5 servings Chinese Pharmacopoeia 2020 Edition Angelica dahurica ANGELICAE DAHURICAE RADIX 1~5 servings Chinese Pharmacopoeia 2020 Edition

[0048] The foot bath bag includes a medicine powder bag and an essential oil bag, wherein the essential oil bag is obtained by sealing and packaging the essential oil obtained by supercritical extraction of Tibetan calamus and prickly ash with carbon dioxide, and the medicine powder in the medicine powder bag is obtained by reflux extraction of a mixture of raw materials such as Sophora japonica seeds, yellow flower wood seeds, gallnut, salt of Daqing, wormwood, madder, and angelica. The mass volume ratio of the medicine powder bag and the essential oil bag in this scheme is 18 to 25:1.

[0049] A heating component is also attached to the surface of the powder bag, and the heating component contains the following raw materials by mass: 1-3 parts of iron powder, 1-2 parts of activated carbon, 0.5-1 parts of salt and 0.5-1 parts of vermiculite. As a reference, the raw materials of this scheme include 5 parts of moss locust seeds, 5 parts of yellow flower wood seeds, 5 parts of Tibetan calamus, 5 parts of pepper, 5 parts of Daqing salt, 5 parts of gallnut, 5 parts of wormwood, 5 parts of madder, and 5 parts of angelica.

[0050] The present invention also provides a method for preparing a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract, comprising the following steps:

[0051] S1. Preparing an essential oil package: crushing calamus and Chinese prickly ash through a 20-40 mesh sieve, respectively extracting them through supercritical carbon dioxide to obtain calamus essential oil, Chinese prickly ash essential oil and raw material residue, mixing the calamus essential oil and Chinese prickly ash essential oil in a ratio of 1:2 and filling them into a PE packaging bag to form an essential oil package;

[0052] Among them, the temperature of supercritical extraction of Tibetan calamus is 40-45°C, and the gas flow rate during supercritical extraction of Tibetan calamus is 10-30L / h; the temperature of supercritical extraction of Zanthoxylum bungeanum is 40-45°C, and the gas flow rate during supercritical extraction of Zanthoxylum bungeanum is 10-30L / h.

[0053] S2, preparing a powder bag: grinding raw materials such as Sophora japonica seeds, Rhizoma Cibotii seeds, Gallnut, Salt of Sophora japonica, Rubia cordifolia, Angelica dahurica and Artemisia argyi through a 40-mesh sieve, and mixing them with the raw material residue obtained in S1 to form a mixture, subjecting the mixture to reflux extraction at 70-80° C. for 1.5-2 h, repeating the reflux extraction 2-3 times, and obtaining an extract and a residue; combining the extracts and concentrating them to a solid content of 15% to obtain a concentrated extract; drying and grinding the residue at 60-70° C. and combining and mixing it with the concentrated extract, spray drying it at 90-95° C. to a water content of less than 5% to form a powder, and packaging the powder with a non-woven fabric to obtain a powder bag;

[0054] S3. Prepare a foot bath bag: package the essential oil bag obtained in S1 and the medicine powder bag in S2 in a PE packaging bag at a ratio of 1-5:1-5 to obtain a foot bath bag.

[0055] Experimental Example 1: Essential Oil Extraction Condition Screening

[0056] Extraction rate = raw material essential oil mass / raw material mass * 100%

[0057] (1) The extraction pressure was fixed at 25 MPa, the extraction temperature was fixed at 45°C, the separation kettle pressure was fixed at 6 MPa, and the separation kettle temperature was fixed at 45°C. The results are shown in Table 2.

[0058] Table 2 Effect of extraction time on extraction rate

[0059] Extraction time (minutes) Extraction rate (%) 20 9.2 40 11.8 60 13.7 80 13.9 100 13.6

[0060] The experimental data show that after 60 minutes, the extraction rate of essential oils does not change much, indicating that supercritical CO2 extraction of essential oils is basically completed in about 60 minutes. In actual process production, if the extraction time is further extended, the extraction rate will increase slowly. Long-term extraction not only consumes too much energy but may also cause other components to be extracted. At the same time, considering the time cost and economic cost, 60 minutes is selected as the optimal extraction time.

[0061] (2) The extraction pressure was fixed at 25 MPa, the extraction time was 60 min, the separation kettle pressure was 6 MPa, and the separation kettle temperature was 45 °C. The results are shown in Table 3.

[0062] Table 3 Effect of extraction temperature on extraction rate

[0063] Extraction temperature (℃) Extraction rate (%) 35 11.2 40 13.1 45 13.7 50 13.8 55 13.5

[0064] Experimental data show that in the supercritical CO2 extraction system, temperature changes have two opposite effects on supercritical CO2 fluid. As the extraction temperature rises, the molecular thermal motion is strengthened, the solute capacity of the supercritical CO2 fluid is improved, and the essential oil in the raw material moves more violently under the influence of temperature and diffuses outward faster, which is conducive to extraction. On the other hand, the increase in temperature causes the density of the CO2 fluid to be smaller, which will cause the essential oil dissolved in it to precipitate, which is not conducive to extraction. In the range of 35-50℃, the increase in temperature is conducive to extraction, and the yield of essential oils gradually increases with temperature. In the range of 50-55℃, the increase in temperature is not conducive to extraction, and the yield decreases. Therefore, 45℃ is selected as the optimal temperature.

[0065] (3) The extraction temperature was fixed at 45°C, the extraction time was 60 min, the separation kettle pressure was 6 MPa, and the separation kettle temperature was 45°C. The results are shown in Table 4.

[0066] Table 4 Effect of extraction pressure on extraction rate

[0067] Extraction pressure (MPa) Extraction rate (%) 10 7.6 15 12.3 20 13.5 25 13.7 30 13

[0068] Experimental data show that the density of supercritical CO2 fluid changes with pressure. Increasing pressure increases density and solute capacity. However, increased pressure places higher demands on equipment safety and stability. Excessive pressure will affect fluidity and needs to be adjusted according to the properties of the extract and the actual production process. In the range of 10 to 25 MPa, the yield of essential oils increases with increasing pressure. In the range of 5 to 30 MPa, due to excessive pressure, the density and viscosity of supercritical CO2 fluid increase, affecting the mass transfer process. Based on the test results and safety principles, 25 MPa was selected as the optimal extraction pressure.

[0069] (4) The extraction pressure was fixed at 25 MPa, the extraction temperature was 50 °C, the extraction time was 60 min, and the separation kettle temperature was 45 °C. The results are shown in Table 5.

[0070] Table 5 Effect of separation kettle pressure on extraction rate

[0071] Separation kettle pressure (MPa) Extraction rate (%) 4 14.2 6 13.9 8 4.3 10 2.6

[0072] Experimental data show that as the pressure of the separation kettle increases, the essential oil extraction rate decreases, and drops rapidly after 6MPa. This is because when the pressure is near the critical point, the CO2 fluid converts between the gaseous state and the supercritical state, and the density, fluidity and other states change dramatically, which makes the solute capacity of supercritical CO2 change greatly. At 4MPa, CO2 exits the supercritical state, the solubility weakens, and a large amount of substances are precipitated, so the extraction rate is the highest, but the extracted water is also precipitated at this time, so that the essential oil contains a small amount of water, and the oil-water separation is not thorough. At 8-10MPa, due to the excessive pressure, the density of supercritical CO2 increases, and the solubility is greatly improved, so less essential oil is precipitated, and the extraction rate is low. Taking all factors into consideration, 6MPa is selected as the optimal separation temperature of separation kettle I.

[0073] (5) The extraction pressure was fixed at 25 MPa, the extraction temperature was 50 °C, the extraction time was 60 min, and the separation kettle pressure was 6 MPa. The results are shown in Table 6.

[0074] Table 6 Effect of separation kettle temperature on extraction rate

[0075] Separation kettle temperature (℃) Extraction rate (%) 30 12.5 35 13.7 40 14.2 45 13.7 50 13

[0076] Experimental data show that when the temperature of the separation kettle is between 30 and 40°C, the yield of essential oil gradually increases, and when it is between 40 and 50°C, the yield decreases as the temperature rises. The yield of essential oil extracted by supercritical CO2 is greatly affected by the temperature of the separation kettle. This is because the separation temperature controls the precipitation of essential oil. Generally speaking, the increase of separation temperature helps to improve the extraction rate. This is because the density of supercritical CO2 decreases and the solubility decreases as the temperature rises, which helps the precipitation of essential oil. However, too high a temperature will cause the essential oil to volatilize, decompose or otherwise react, thereby losing components. Lower temperatures will increase the solubility of supercritical CO2 fluid, making it difficult for the obtained essential oil to precipitate, resulting in a lower extraction rate. The highest extraction rate is obtained at 40°C, but the essential oil obtained at this time contains a small amount of water, and the oil-water separation is not complete. Therefore, 45°C is selected as the optimal separation temperature of the separation kettle.

[0077] Experimental Example 2: Comparison of dissolution rate and therapeutic effect of different packaging methods

[0078] The applicant takes the extracted powder and mixed essential oil obtained in Example 1 as an example to demonstrate the evaluation of the efficacy of different packaging methods on symptoms such as "foot itching, foot odor, and athlete's foot".

[0079] 1. User situation

[0080] The users who come for treatment are those who have symptoms such as itchy feet, foot odor, and athlete's foot.

[0081] There were 122 users in total, including 67 males and 55 females. There were 34 male users and 27 female users in the experimental group, and 33 male users and 28 female users in the control group.

[0082] 2. Inclusion criteria

[0083] 122 users voluntarily joined the trial; the local skin was intact and undamaged; there were no abnormalities in blood routine, liver function, kidney function, and coagulation mechanism, and there was no history of drug allergy.

[0084] 3. Exclusion criteria

[0085] Not meeting the inclusion criteria; difficult to communicate with users; pregnant women, breastfeeding women; uncooperative patients.

[0086] 4. Treatment

[0087] Experimental group 1: The extracted powder obtained in Example 1 and the mixed essential oil were packaged in a mass ratio of 20:1 to obtain a foot bath bag. When used, the essential oil bag was torn open, the essential oil was poured on the surface of the powder bag, and the powder bag was placed in 3L, 45°C water, and after standing for 2 to 10 minutes, the user performed foot bath treatment once a day for 2 consecutive weeks.

[0088] Experimental group 2: The difference between this experimental group and Example 1 is that this experimental group also includes a heating component. When using, tear open the essential oil bag, apply the essential oil on the surface of the powder bag, place the powder bag in 3L of room temperature water, let it stand for 2 to 10 minutes, and then the user performs foot soaking treatment once a day for 2 consecutive weeks.

[0089] Comparative group 1: The Chinese medicine powder and essential oil in Experimental Example 1 were mixed in a mass-volume ratio of 20:1, and then packaged with non-woven fabric to form a foot bath bag. When used, the foot bath bag (packaged with non-woven fabric) was placed in 3L, 45°C water, and allowed to stand for 2 to 10 minutes. The user then performed foot bath treatment once a day for 2 consecutive weeks.

[0090] Comparative group 2: After the Chinese medicine powder and essential oil in Experimental Example 1 were mixed at a mass volume ratio of 20:1, they were sealed in a PE sealed bag to form a foot bath bag. When used, after tearing open the sealed bag, the foot bath bag (PE sealed bag packaged) was placed in 3L, 45℃ water, and after standing for 2 to 10 minutes, the user performed foot bath treatment once a day for 2 consecutive weeks.

[0091] Comparative group 3: The extracted powder obtained in Example 1 was packaged with non-woven fabric to obtain a foot bath bag. When used, the foot bath bag was placed in 5L of 45°C hot water, left to stand for 2 to 10 minutes, and then the user performed foot bath treatment once a day for 2 consecutive weeks.

[0092] Comparative group 4: The essential oil obtained in Example 1 was packaged in a PE packaging bag to obtain a foot bath bag. When used, the foot bath bag was torn open and placed in 5L, 45°C hot water, and after standing for 2 to 10 minutes, the user performed foot bath treatment once a day for 2 consecutive weeks.

[0093] Comparative group 5: The Chinese medicine powder and essential oil in Experimental Example 1 were mixed in a mass-volume ratio of 30:1 and packaged with non-woven fabric to form a foot bath bag. When used, the foot bath bag (packaged with non-woven fabric) was placed in 3L, 45°C hot water, and allowed to stand for 2 to 10 minutes. The user then soaked his feet once a day for 2 consecutive weeks.

[0094] Comparative group 6: The Chinese medicine powder and essential oil in Experimental Example 1 were mixed in a mass-volume ratio of 15:1 and packaged with non-woven fabric to form a foot bath bag. When used, the foot bath bag (packaged with non-woven fabric) was placed in 3L, 45°C hot water, and allowed to stand for 2 to 10 minutes. The user then performed foot bath treatment once a day for 2 consecutive weeks.

[0095] 5. Efficacy evaluation indicators

[0096] (1) The results of drug dissolution rates of the foot bath bags in the experimental group and the control group after different soaking times are shown in Table 7, where the drug dissolution rates are calculated as follows:

[0097] Dissolution rate = m total amount of flavonoids and alkaloids in hot water / M total amount of flavonoids and alkaloids in powder * 100%;

[0098] (2) The efficacy evaluation method is shown in Table 8, and the efficacy of the experimental group and the control group is shown in Table 9.

[0099] Table 7 Dissolution effect of active ingredients in the experimental group and the control group

[0100] Group 2min 4min 6min 8min 10min Experimental Group 1 20％ 24％ 38％ 57％ 69％ Experimental Group 2 26％ 33％ 42％ 65％ 72％ Comparison group 1 14％ 19％ 30％ 45％ 50％ Comparison group 2 19％ 22％ 40％ 55％ 63％ Comparison group 3 18％ 22％ 35％ 54％ 60％ Comparison group 4 15％ 20％ 28％ 42％ 51％ Comparison group 5 22％ 26％ 31％ 46％ 51％ Comparison group 6 20％ 25％ 36％ 54％ 66％

[0101] Table 8 Evaluation of therapeutic efficacy

[0102]

[0103] Table 9 Efficacy of experimental group and control group

[0104]

[0105]

[0106] Experimental data show that this solution not only effectively improves the efficiency and effect of drug dissolution by packaging the extracted powder and essential oil separately, but also significantly reduces the volatilization rate of the essential oil after sealing, making it easier to perform aromatherapy of essential oil thermal volatilization while soaking your feet, thereby improving the therapeutic effect. Specifically, the effective rate in both experimental group 1 and experimental group 2 was as high as 100%, and the proportion of users who were completely relieved (i.e., the complete remission rate) was as high as 70%.

[0107] If the powder is mixed with essential oil and then packaged, whether it is non-woven packaging or PE packaging bag sealed packaging, the dissolution rate and dissolution effect of the drug are greatly reduced, especially, the comparison group 2 seals the powder essential oil mixture in a PE packaging bag, causing it to be placed in hot water, the mixture adheres to the inner side of the packaging bag, causing its dissolution effect to be greatly reduced, and after the mixture is manually turned out, it will dissolve in hot water and the residual particles will not dissolve, reducing the efficacy and causing the user to feel slag when soaking their feet, and the experience is poor. When comparative example 1 is packaged with non-woven fabric, although the dissolution effect of the powder is less affected, however, because the essential oil escapes significantly during packaging and storage, the foot bath bag basically does not have the effect of aromatherapy, resulting in a significant reduction in its overall efficacy, and the expected effect cannot be achieved.

[0108] The above is only an embodiment of the present invention, and the common knowledge such as the known specific technical solutions and / or characteristics in the solution is not described in detail here. It should be pointed out that for those skilled in the art, without departing from the technical solution of the present invention, several modifications and improvements can be made, which should also be regarded as the protection scope of the present invention, and these will not affect the effect of the implementation of the present invention and the practicality of the patent. The scope of protection required by this application shall be based on the content of its claims, and the specific implementation methods and other records in the specification can be used to interpret the content of the claims.

Claims

1. A self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract, characterized in that: The invention comprises a medicine powder bag and an essential oil bag. The essential oil bag is obtained by sealing and packaging essential oils obtained by supercritical extraction of Tibetan calamus and Sichuan pepper respectively through carbon dioxide; the medicine powder in the medicine powder bag is obtained by reflux extraction of a mixture of raw materials including Sophora japonica seeds, Rhizoma Cibotii seeds, Chinese gallnut, salt of sallow, mugwort, madder and angelica dahurica; a heating component is also attached to the surface of the medicine powder bag.

2. The self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 1, characterized in that: The heating component comprises the following raw materials in parts by mass: 1 to 3 parts of iron powder, 1 to 2 parts of activated carbon, 0.5 to 1 part of salt and 0.5 to 1 part of vermiculite.

3. The self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 1, characterized in that: The extraction raw materials of the medicinal powder are as follows: 1-5 parts of Sophora japonica seeds, 1-5 parts of Phellodendron chinense seeds, 1-5 parts of Salt of Sophora japonica, 1-5 parts of Galla chinensis, 1-5 parts of Artemisia argyi, 1-5 parts of Rubia cordifolia and 1-5 parts of Angelica dahurica.

4. The self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 1, characterized in that: The extraction raw materials of the essential oil are as follows: 1-5 parts of Tibetan calamus and 1-5 parts of Zanthoxylum bungeanum.

5. The self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 1, characterized in that: The mass volume ratio of the medicine powder package to the essential oil package is 18-25:

1.

6. The method for preparing a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to any one of claims 1 to 5, characterized in that: The steps include: S1. preparing an essential oil package: crushing and sieving Tibetan calamus and Chinese prickly ash respectively, and then extracting them through supercritical carbon dioxide to obtain Tibetan calamus essential oil, Chinese prickly ash essential oil and raw material residue, and packaging the Tibetan calamus essential oil and Chinese prickly ash essential oil in a PE packaging bag to form an essential oil package; S2, preparing a powder bag: grinding and sieving raw materials such as Sophora japonica seeds, Psoralea corylifolia seeds, Gallnut, Salt of Great Blue, Rubia cordifolia, Angelica dahurica and Artemisia argyi, and mixing them with the raw material residue obtained in S1 to form a mixture, refluxing and extracting the mixture 2 to 3 times to obtain an extract and a residue; combining the extracts and concentrating them to obtain a concentrated extract; The residue is dried and crushed, combined with the concentrated extract, and dried to form a powder, and the powder is packaged with a non-woven fabric to obtain a powder bag; S3. Prepare a foot bath bag: package the essential oil bag obtained in S1 and the medicine powder bag in S2 in a PE packaging bag to obtain a foot bath bag.

7. The method for preparing a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 6, characterized in that: In S1, the supercritical extraction of Tibetan calamus is carried out at a temperature of 40-50°C, a pressure of 30-40 MPa, and a time of 60-100 min; the supercritical extraction of Zanthoxylum bungeanum is carried out at a temperature of 40-50°C, a pressure of 30-35 MPa, and a time of 60-100 min.

8. The method for preparing a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 6, characterized in that: In S2, the temperature of the reflux extraction is 75°C, and the time of the reflux extraction is 1.5 hours.

9. The method for preparing a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 6, characterized in that: The concentration of the extract before mixing with the medicinal residue is to concentrate the extract to a solid content of about 15%.

10. The method for preparing a self-heating Tibetan medicine foot bath bag containing Sophora japonica seed extract according to claim 6, characterized in that: In S2, the moisture content of the medicine powder is less than 5%.

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