Antler-dcb@evsabpcs bone graft material and preparation method

By preparing antler-DCB@EVsABPCs bone graft material, the problems of immune rejection and insufficient bioactivity of existing biomedical materials in bone grafting have been solved, achieving bone regeneration effects with high safety and high repair rate, and promoting the coordinated growth of bone, blood vessels and nerve structures.

CN119405896BActive Publication Date: 2026-01-23FOURTH MILITARY MEDICAL UNIVERSITY
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Patent Information

Application Number
CN202411682134.6
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2024-11-22
Publication Date
2026-01-23
Estimated Expiration
2044-11-22

AI Technical Summary

Technical Problem

Existing biomedical materials suffer from immune rejection and insufficient bioactivity in bone transplantation, resulting in low clinical integration rates in engineered bone transplantation and failing to meet the requirements of high safety, high repair rate, and high bioactivity.

Method used

Deer antler-DCB@EVsABPCs bone graft material was prepared by decellularizing decellularized antler cancellous bone and combining it with ABPCs-EVs and HAMA hydrogel to form antler-DCB@ABPCs-EVs bone graft material. The bioactive molecules of ABPCs-EVs and the stability of HAMA hydrogel were utilized to achieve coordinated growth of bone, blood vessels and nerve structures.

Benefits of technology

Deer antler-DCB@EVsABPCs bone graft material exhibits strong osteogenic, angiogenic, neurogenic, and immunomodulatory capabilities, promoting bone regeneration, providing potential therapeutic interventions, and improving the effectiveness of bone repair.

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Abstract

The application discloses a preparation method of a deer antler-DCB@EVsABPCs bone graft material, and specifically comprises the following steps: step 1, preparing an Antler-DCB support; step 2, preparing a 10% HAMA hydrogel and ABPCs-EVs; step 3, mixing; step 4, taking the Antler-DCB and immersing it into the HAMA hydrogel containing the ABPCs-EVs; and step 5, exposing to 405 nm ultraviolet light for 30 seconds to obtain the bone graft material. The application further discloses the deer antler-DCB@EVsABPCs bone graft material. The deer antler-DCB@EVsABPCs bone graft material and the preparation method thereof disclosed by the application have a strong ability to regulate osteogenesis, angiogenesis, neurogenesis and immune response, thereby providing a potential therapeutic intervention measure for treating serious bone defects.
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