Ultrafiltration concentration device for treating vaccine stock solution

Abstract

The invention discloses an ultrafiltration concentration device for vaccine stock solution treatment, and relates to the technical field of vaccine production.The concentration device comprises a concentration barrel and a concentration cover, the concentration cover is meshed with the concentration barrel through threads, a sealing ring is arranged on the concentration cover, a feeding port is formed in the concentration cover, a feeding pipeline is arranged on the feeding port, and a control valve is arranged on the feeding pipeline; an adjusting assembly is arranged in the feeding pipeline, a temperature control layer is arranged in the concentration barrel, a temperature control plate is arranged in the temperature control layer, the temperature control plate is communicated with a temperature control pipeline group through a guide pipe, a concentration layer is arranged in the concentration barrel, a concentration motor is arranged in the concentration barrel, a separator is arranged on the concentration motor, and a water outlet and a discharging opening are formed in the concentration barrel. A drainage pipeline is arranged on the water outlet, a discharging pipeline is arranged on the discharging port, a back flushing assembly is arranged in the discharging pipeline, and the automatic vaccine production and recovery device has the functions of automatic vaccine production and automatic recovery.

Description

Technical Field

[0001] The invention relates to the technical field of vaccine production, in particular to an ultrafiltration concentration device for treating vaccine stock solution. Background Art

[0002] In the vaccine production workshop, the virus must go through six major steps, including cultivation, inactivation, purification, concentration, filling and packaging, before it can finally be actually used by people.

[0003] The concentration process has always been taken very seriously. During the concentration, it is necessary to pay great attention to the degree of concentration and the threatening problems caused by the concentration. The usual solution to this problem is the ultrafiltration concentration process. Usually this process also represents the first step in separating the product from large pieces of debris, while maximizing the product output and quality. In this process, if there is a problem of legacy deterioration, the vaccine concentrate is likely to be contaminated on a large scale, leading to fatal problems in product production. At the same time, the concentration process may also be accompanied by a lot of waste and harm to the surrounding ecology. These problems need to be urgently solved. Summary of the invention

[0004] The object of the present invention is to provide an ultrafiltration concentration device for treating vaccine stock solution to solve the problems raised in the above-mentioned background technology.

[0005] In order to solve the above technical problems, the present invention provides the following technical solution: an ultrafiltration concentration device for processing vaccine stock solution.

[0006] The concentrating device comprises a concentrating barrel and a concentrating cover, the concentrating cover and the concentrating barrel are meshed by threads, a sealing ring is arranged on the concentrating cover, a feed port is arranged on the concentrating cover, a feed pipe is arranged on the feed port, a control valve is arranged on the feed pipe, an adjusting component is arranged in the feed pipe, a temperature control layer is arranged in the concentrating barrel, a temperature control plate is arranged in the temperature control layer, the temperature control plate is connected with the temperature control pipe group through a conduit, a concentrating layer is arranged in the concentrating barrel, a concentrating motor is arranged in the concentrating barrel, a separator is arranged on the concentrating motor, a water outlet and a discharge port are arranged on the concentrating barrel, a drainage pipe is arranged on the water outlet, a discharge pipe is arranged on the discharge port, a backwashing component is arranged in the discharge pipe, and in the concentrating process, the raw material is firstly fed into the concentrating barrel, and then fed into the The concentrated barrel is fully sealed with a concentrated cover, and the sealing valve is used to control the entry of the vaccine concentrate. During the delivery process, the regulating component can fully adjust the fluid pressure in the feed pipe to reduce residue. When the vaccine concentrate enters the concentrated layer, the concentrating motor will drive the separator to rotate, thereby centrifuging the vaccine concentrate. The heavier cell membrane and impurity proteins will be separated to the farthest position and discharged to the drain outlet. These materials are then sent to the drain pipe. The concentrated vaccine concentrate will then be sent to the discharge outlet, and the discharge outlet will then be sent to the discharge pipe. During the transportation process, the backwash component will backwash the inner wall of the discharge pipe to avoid blockage in the discharge pipe.

[0007] The adjustment component includes multiple pressure-sensitive rings, each of which is arranged in a feed pipe. A flow hole is arranged on the pressure-sensitive ring, and a flow impeller is arranged in the flow hole. The flow impeller is rotatably connected to the pressure-sensitive ring. A lifting column is arranged in the pressure-sensitive ring, and a sliding rod and a lifting spring are arranged in the lifting column. The two ends of the lifting spring respectively resist the lifting column and the sliding rod, and the sliding rod is slidably connected to the inner wall of the lifting column. An elastic switch is arranged in the lifting column. During the transportation of vaccine concentrate, the vaccine concentrate will flow in the discharge pipe and in the pressure-sensitive ring, and drive the flow impeller to rotate. During the rotation, the flow impeller will drive the sliding rod to move in the lifting column. The lifting spring is responsible for timely resetting the sliding rod in the lifting column and continuously triggering the elastic switch. The flow speed of the vaccine concentrate can be known through the triggering frequency of the elastic switch. By utilizing its perception of the flow speed, the pressure and flow rate in the feed pipe can be fully adjusted.

[0008] A boosting ring is arranged in the feed pipe, and a plurality of boosting holes and a plurality of flow holes are arranged on both sides of the boosting ring respectively. An extrusion ring is rotatably connected in the boosting ring, and teeth are arranged on the extrusion ring. An extrusion motor is arranged on the feed pipe, and the teeth on the extrusion ring are meshed with the output end of the extrusion motor. The extrusion motor is electrically connected to the elastic switch through a wire, and an extrusion chute is arranged on the extrusion ring. During the transmission of the vaccine concentrate, the extrusion motor will be affected by the elastic switch. The higher the triggering frequency of the elastic switch, the faster the rotation speed of the extrusion motor, and the faster the flow speed of the vaccine concentrate in the feed pipe, thereby avoiding the accumulation of cell membranes and impurity proteins in the feed pipe for a long time during the feeding of the vaccine concentrate, which will cause pollution to the vaccine concentrate to be concentrated, and the extrusion chute on the extrusion ring will also accelerate the vaccine concentrate.

[0009] The concentrating barrel is provided with a temperature insulation cover, a connecting groove is provided on the temperature insulation cover, a discharge tray and a debris removal tray are provided in the concentrating barrel, the debris removal tray is rotatably connected to the discharge tray, the separator is rotatably connected to the discharge tray, the separator is connected to the feed pipe, a plurality of separation chambers are provided in the separator, the separation chamber is connected to the discharge tray, a discharge groove is provided on the discharge tray, a debris removal hole is provided on the separation chamber, and the debris removal hole is connected to the debris removal tray. During the concentration process, the separation chamber in the separator can be controlled to perform centrifugal separation, and then after centrifugal separation, the vaccine concentrate will be sent to the discharge tray, and then the waste liquid after centrifugation will also be sent to the debris removal tray, the debris removal tray will send out the waste liquid after centrifugation, and the centrifuged waste liquid will be discharged into the drainage pipe.

[0010] A feedback shrapnel net and a feedback switch group are provided in the debris discharge disk, the feedback shrapnel net is rotationally connected to the debris discharge disk, the feedback switch group includes multiple feedback tubes and feedback columns, each feedback column is slidingly connected to the corresponding feedback tube, a feedback resistor is provided in the feedback tube, a sliding sleeve is provided on the feedback column, the sliding sleeve is sleeved on the feedback resistor and slidingly connected to the feedback resistor, a sliding spring is provided in the feedback tube, and the two ends of the sliding spring respectively resist the feedback tube and the sliding sleeve. In the process of discharging, the waste liquid after centrifugation will flow through the feedback shrapnel net. When the concentration of the vaccine stock solution is high, the sliding sleeve will fully move on the feedback resistor under the action of the feedback shrapnel net. At this time, the transmitted current will be large, and it can be directly discharged at this time. When the concentration of the vaccine stock solution is low, the impact on the feedback shrapnel net is small. At this time, the waste liquid after centrifugation is not completely impure protein, etc., and needs to be recycled for the second time. At this time, the waste liquid after centrifugation is sent to the water storage tank and waits for recycling again.

[0011] The discharge tray is connected with the discharge port through a conduit. A collection trough is provided at the bottom of the concentration barrel. The collection trough is connected with the drain port. A booster pump is provided at the drain port. An electric discharge valve is provided on the drain pipe. The electric discharge valve is electrically connected to the feedback resistor through a wire. A recovery pipe is provided on the drain pipe. The waste liquid after centrifugation will enter the collection trough. The booster pump in the collection trough will operate. The booster pump will send the liquid into the near drainage pipe. According to the feedback current change of the feedback resistor, the electric control valve will choose to discharge the waste liquid after centrifugation directly or send it into the water storage tank to reduce waste and reduce the threat of leaked vaccine concentrate to the ecology.

[0012] A storage tank and a water tank are provided at one end of the discharge pipe away from the discharge port, the water tank is connected to the recovery pipe, an ultrafiltration membrane is provided in the water tank, an ultrafiltration pipe network is provided on the upper end of the ultrafiltration membrane, the ultrafiltration pipe network is connected to the recovery pipe, a reflux pipe is provided on the water tank, and the reflux pipe is connected to the feed pipe. The concentrated vaccine stock solution will be fed into the storage pipe, and the discharged liquid after concentration will also be fed into the water storage tank, and the discharged liquid will be fed into the ultrafiltration pipe network, the ultrafiltration pipe network will flow into the ultrafiltration membrane at high speed, thereby completing the ultrafiltration operation, and the ultrafiltered stock solution will be fed into the feed pipe, waiting for centrifugation again.

[0013] The backwashing assembly includes a backwashing pipe and a backwashing pump. The input end of the backwashing pump is connected with the storage tank. The backwashing pipe passes through the wall of the discharge pipe and is connected with the backwashing pump. A backwashing ring is arranged on the backwashing pipe. A plurality of flow holes are arranged on the backwashing ring. The backwashing pipe is provided with threads. The backwashing ring is engaged with the backwashing pipe through the threads. A plurality of backwashing holes are arranged on the backwashing pipe. The direction of the backwashing holes is spiral. When backwashing is performed, the backwashing pump will send the vaccine concentrate that has been transferred to the storage tank into the backwashing pipe, and then the vaccine concentrate will be discharged to the inner wall of the discharge pipe. When the backwashing ring moves on the backwashing pipe, it will also rotate on the backwashing pipe under the restriction of the threads, and the backwashing holes will act on the backwashing ring under the action of the spiral.

[0014] A backwash groove is provided on the recoil ring, a backwash pillar is provided on the recoil ring, a speed-sensitive paddle is provided in the recoil ring, the speed-sensitive paddle is rotatably connected to the recoil ring, a thread is provided on the backwash pillar, the speed-sensitive paddle is connected to the backwash pillar through a spring rod, the spring rod is a telescopic rod with an elastic recovery function, the backwash pillar is engaged with the recoil ring, and during the backwash process, liquid will be sprayed out from the backwash hole and hit the backwash groove on the recoil ring, so that the recoil ring can move on the drainage pipe, and when the recoil ring moves, the relative speed between the recoil ring and the discharged vaccine concentrate increases, so that the speed-sensitive paddle is completely moved and abuts against the spring rod, and under the power transmission of the spring rod, the backwash pillar extends out of the recoil ring, thereby removing the silt materials accumulated in the discharge pipe.

[0015] Compared with the prior art, the beneficial effects achieved by the present invention are: 1. The present invention adopts a structural component with the function of adjusting the transport pressure, which can fully solve the problem of contamination of the unconcentrated vaccine concentrate due to fluid pressure during transportation, and reduce the problem of contamination of the vaccine concentrate by deteriorated proteins and contamination.

[0016] 2. The present invention adopts a structure capable of identifying the concentration of the vaccine stock solution, which can fully centrifuge the vaccine stock solution, fully concentrate the vaccine stock solution, and automatically adjust the processing sequence according to the concentration of the waste liquid, thereby solving the problem of vaccine stock solution waste caused by incomplete centrifugal separation and reducing the possibility that leakage problems will affect the ecological environment. 3. The present invention adopts a structural component with backwashing function, which can fully backwash the problem of insufficient flow of vaccine concentrate during transportation, reduce the problem of accumulation of vaccine concentrate, and avoid the problem that these impurities will cause pollution and waste of vaccine concentrate. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] The accompanying drawings are used to provide a further understanding of the present invention and constitute a part of the specification. Together with the embodiments of the present invention, they are used to explain the present invention and do not constitute a limitation of the present invention. In the accompanying drawings: Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention; Figure 2 It is a schematic diagram of the internal structure of the concentration barrel of the present invention; Figure 3 yes Figure 2 The structural schematic diagram of A is partially enlarged in the middle; Figure 4 It is a schematic diagram of the structure of the regulating component of the present invention; Figure 5 yes Figure 4 The structural schematic diagram of the partial enlargement of B in the middle; Figure 6 It is a schematic diagram of the internal structure of the water storage tank of the present invention; Figure 7 It is a schematic diagram of the structure of the backwash assembly of the present invention; Figure 8 yes Figure 7 The structural schematic diagram of C is partially enlarged in the middle; Fig. 9 It is a schematic diagram of the pipeline layout structure of the present invention; In the figure: 1. Concentration barrel; 101. Insulation cover; 102. Communication slot; 103. Discharge tray; 104. Discharge tray; 105. Separation chamber; 106. Feedback spring net; 107. Feedback switch group; 108. Feedback pipe; 109. Feedback column; 110. Feedback resistor; 112. Sliding spring; 111. Sliding sleeve; 113. Collecting trough; 114. Booster pump; 115. Electric discharge valve; 2. Concentration cover; 3. Feeding port; 4. Feeding pipeline; 5. Control valve; 6. Adjustment assembly; 601. Pressure-sensitive ring; 602. Circulation fan wheel; 603. Lifting column; 604. Sliding rod; 605. Lifting spring; 606. 06. Elastic switch; 607. Pressurization ring; 608. Extrusion ring; 609. Extrusion motor; 7. Temperature control layer; 8. Temperature control pipeline group; 9. Concentration motor; 10. Separator; 11. Water outlet; 12. Discharge port; 13. Drainage pipeline; 14. Discharge pipeline; 15. Backwash assembly; 1501. Backwash pipe; 1502. Backwash pump; 1503. Backwash ring; 1504. Backwash hole; 1505. Backwash support; 1506. Speed-sensing paddle; 1507. Spring rod; 16. Recovery pipeline; 17. Storage tank; 18. Water storage tank; 19. Ultrafiltration membrane; 20. Ultrafiltration pipeline network; 21. Reflux pipeline. DETAILED DESCRIPTION

[0018] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] The concentrating device comprises a concentrating barrel 1 and a concentrating cover 2, wherein the concentrating cover 2 is engaged with the concentrating barrel 1 through threads, a sealing ring is arranged on the concentrating cover 2, a feed port 3 is arranged on the concentrating cover 2, a feed pipe 4 is arranged on the feed port 3, a control valve 5 is arranged on the feed pipe 4, an adjusting component 6 is arranged in the feed pipe 4, a temperature control layer 7 is arranged in the concentrating barrel 1, a temperature control plate is arranged in the temperature control layer 7, the temperature control plate is connected with the temperature control pipe group 8 through a conduit, a concentrating layer is arranged in the concentrating barrel 1, a concentrating motor 9 is arranged in the concentrating barrel 1, a separator 10 is arranged on the concentrating motor 9, a water outlet 11 and a discharge port 12 are arranged on the concentrating barrel 1, a drainage pipe 13 is arranged on the water outlet 11, a discharge pipe 14 is arranged on the discharge port 12, and a backwashing component 15 is arranged in the discharge pipe 14. During the concentrating process, first The raw materials are fed into the concentration barrel through the feed pipe and then into the concentration barrel. The concentrated cover is fully sealed and the sealing valve is used to control the entry of the vaccine concentrate. During the feeding process, the regulating component can fully adjust the fluid pressure in the feed pipe to reduce the residue. When the vaccine concentrate enters the concentration layer, the concentration motor will drive the separator to rotate, thereby centrifuging the vaccine concentrate. The heavier cell membrane and impurity proteins will be separated to the farthest position and discharged to the drain outlet. These materials are then fed into the drain pipe. The concentrated vaccine concentrate will then be fed into the discharge outlet, and the discharge outlet will then be fed into the discharge pipe. During the transportation process, the backwash component will backwash the inner wall of the discharge pipe to avoid blockage in the discharge pipe.

[0020] The adjusting component 6 includes a plurality of pressure-sensitive rings 601, each of which is arranged in the feed pipe 4, and a flow hole is arranged on the pressure-sensitive ring 601, and a flow impeller 602 is arranged in the flow hole, and the flow impeller 602 is rotatably connected with the pressure-sensitive ring 601, and a lifting column 603 is arranged in the pressure-sensitive ring 601, and a sliding rod 604 and a lifting spring 605 are arranged in the lifting column 603, and the two ends of the lifting spring 605 respectively abut against the lifting column 603 and the sliding rod 604, and the sliding rod 604 is slidably connected with the inner wall of the lifting column 603, and a lifting column 603 is arranged in the lifting column 603. There is an elastic switch 606. During the transportation of vaccine concentrate, the vaccine concentrate will flow in the discharge pipe and in the pressure-sensitive ring, and drive the flow impeller to rotate. During the rotation, the flow impeller will drive the sliding rod to move in the lifting column. The lifting spring is responsible for the timely reset of the sliding rod in the lifting column and continuously triggers the elastic switch. The flow speed of the vaccine concentrate can be known through the triggering frequency of the elastic switch. By utilizing its perception of the flow speed, the pressure and flow rate in the feed pipe can be fully adjusted.

[0021] A boost ring 607 is provided in the feed pipe 4, and a plurality of boost holes and a plurality of flow holes are provided on both sides of the boost ring 607 respectively. An extrusion ring 608 is rotatably connected in the boost ring 607, and teeth are provided on the extrusion ring 608. An extrusion motor 609 is provided on the feed pipe 4, and the teeth on the extrusion ring 608 are meshed with the output end of the extrusion motor 609. The extrusion motor 609 is electrically connected to the elastic switch 606 through a wire, and an extrusion chute is provided on the extrusion ring 608. During the transmission of the vaccine concentrate, the extrusion motor will be affected by the elastic switch. The higher the trigger frequency of the elastic switch, the faster the rotation speed of the extrusion motor, and the faster the flow speed of the vaccine concentrate in the feed pipe, thereby avoiding the accumulation of cell membranes and impurity proteins in the feed pipe for a long time during the feeding of the vaccine concentrate, causing pollution to the vaccine concentrate to be concentrated, and the extrusion chute on the extrusion ring will also accelerate the vaccine concentrate.

[0022] The concentration barrel 1 is provided with a temperature insulation cover 101, and a connecting groove 102 is provided on the temperature insulation cover 101. A discharge tray 103 and a debris removal tray 104 are provided in the concentration barrel 1, and the debris removal tray 104 is rotatably connected to the discharge tray 103. The separator 10 is rotatably connected to the discharge tray 103, and the separator 10 is connected to the feed pipe 4. A plurality of separation chambers 105 are provided in the separator 10, and the separation chamber 105 is connected to the discharge tray 103. A discharge groove is provided on the discharge tray 103, and a debris removal hole is provided on the separation chamber 105, and the debris removal hole is connected to the debris removal tray 104. During the concentration process, the separation chamber in the separator can be controlled to perform centrifugal separation. After centrifugal separation, the vaccine concentrate after centrifugation will be sent to the discharge tray, and then the waste liquid after centrifugation will also be sent to the debris removal tray. The debris removal tray will send out the waste liquid after centrifugation, and the waste liquid after centrifugation will be discharged into the drainage pipe.

[0023] A feedback spring web 106 and a feedback switch group 107 are arranged in the debris removal disk 104. The feedback spring web 106 is rotatably connected to the debris removal disk 104. The feedback switch group 107 includes a plurality of feedback tubes 108 and feedback columns 109. Each feedback column 109 is slidably connected to the corresponding feedback tube 108. A feedback resistor 110 is arranged in the feedback tube 108. A sliding sleeve 111 is arranged on the feedback column 109. The sliding sleeve 111 is sleeved on the feedback resistor 110 and slidably connected to the feedback resistor 110. A sliding spring 112 is arranged in the feedback tube 108. The two ends of the sliding spring 112 are respectively connected to the feedback resistor 110. Do not press against the feedback tube 108 and the sliding sleeve 111. During the discharge process, the waste liquid after centrifugation will flow through the feedback shrapnel net. When the concentration of the vaccine stock solution is high, the sliding sleeve will fully move on the feedback resistor under the action of the feedback shrapnel net. At this time, the transmitted current will be large. At this time, you can choose to discharge it directly. When the concentration of the vaccine stock solution is low, the impact on the feedback shrapnel net is small. At this time, the waste liquid after centrifugation is not completely impure protein, etc., and secondary recovery is required. At this time, choose to send the waste liquid after centrifugation into the water storage tank and wait for recovery again.

[0024] The discharge tray 103 is connected with the discharge port 12 through a conduit, a collecting trough 113 is provided at the bottom of the concentration barrel 1, the collecting trough 113 is connected with the drain port, a booster pump 114 is provided at the drain port, an electric discharge valve 115 is provided on the drain pipe 13, the electric discharge valve 115 is electrically connected with the feedback resistor 110 through a wire, a recovery pipe 16 is provided on the drain pipe 13, the waste liquid after centrifugation will enter the collecting trough, the booster pump in the collecting trough will operate, and the booster pump will send the liquid into the near drain pipe, according to the feedback current change of the feedback resistor, the electric control valve will choose to discharge the waste liquid after centrifugation directly or send it into the water storage tank to reduce waste and reduce the threat of leaked vaccine concentrate to the ecology.

[0025] A storage tank 17 and a water storage tank 18 are provided at one end of the discharge pipe 14 away from the discharge port 12. The water storage tank 18 is connected to the recovery pipe 16. An ultrafiltration membrane 19 is provided in the water storage tank 18. An ultrafiltration pipe network 20 is provided on the upper end of the ultrafiltration membrane 19. The ultrafiltration pipe network 20 is connected to the recovery pipe 16. A reflux pipe 21 is provided on the water storage tank 18, and the reflux pipe 21 is connected to the feed pipe 4. The concentrated vaccine stock solution will be fed into the storage pipe, and the liquid discharged after concentration will also be fed into the water storage tank, and the discharged liquid will be fed into the ultrafiltration pipe network. The ultrafiltration pipe network will flow into the ultrafiltration membrane at high speed, thereby completing the ultrafiltration operation, and the ultrafiltered stock solution will be fed into the feed pipe, waiting for centrifugation again.

[0026] The backwash assembly 15 includes a backwash pipe 1501 and a backwash pump 1502. The input end of the backwash pump 1502 is connected to the storage tank 17. The backwash pipe 1501 passes through the wall of the discharge pipe 14 and is connected to the backwash pump 1502. The backwash pipe 1501 is provided with a backwash ring 1503. The backwash ring 1503 is provided with a plurality of flow holes. The backwash pipe 1501 is provided with a thread. The backwash ring 1503 is engaged with the backwash pipe 1501 through the thread. A plurality of backwash holes 1504 are arranged on the backwash tube, and the direction of the backwash holes 1504 is spiral. When backwashing is performed, the backwash pump will send the vaccine concentrate that has been transferred to the storage tank into the backwash tube, and then the vaccine concentrate will be discharged to the inner wall of the discharge pipe. When the backwash ring moves on the backwash tube, it will also rotate on the backwash tube under the restriction of the thread, and the backwash holes will act on the backwash ring under the action of the spiral.

[0027] The recoil ring 1503 is provided with a backwash groove, the recoil ring 1503 is provided with a backwash support 1505, a speed-sensing paddle 1506 is provided inside the recoil ring 1503, the speed-sensing paddle 1506 is rotatably connected to the recoil ring 1503, the backwash support 1505 is provided with a thread, the speed-sensing paddle 1506 is connected to the backwash support 1505 via a spring rod 1507, the spring rod 1507 is a telescopic rod with an elastic recovery function, the backwash support 1505 is meshed with the recoil ring 1503, During the backwashing process, liquid will spray out from the backwashing hole and hit the backwashing groove on the backwashing ring, so that the backwashing ring can move on the drainage pipe. When the backwashing ring moves, the relative speed between the backwashing ring and the discharged vaccine concentrate increases, so that the speed-sensitive paddle is completely moved and rests on the spring rod. Under the power transmission of the spring rod, the backwashing support extends out of the backwashing ring, thereby removing the silt accumulated in the discharge pipe.

[0028] Working principle of the present invention: Fig. 9, where D represents the controller of the water storage tank, which controls the water content and temperature in the water storage tank, E represents the temperature and humidity control of the material storage tank, F represents the refrigerant supply in the concentration tank, and the temperature of the concentration tank needs to be controlled during concentration. The temperature of the refrigerant is -5°C, and G represents the temperature of the refrigerant after the work is completed. Its temperature should be 0°C. If there is a change, the speed of the refrigerant supply needs to be adjusted. H represents the supply of the vaccine stock solution. During the concentration process, the raw materials are first fed into the concentration barrel 1, and then fed into the concentration barrel 1 through the feed pipe 4. The vaccine stock solution will It flows in the discharge pipe 4 and flows in the pressure-sensitive ring 601, thereby sensing the flow speed of the liquid. By sensing the trigger frequency of the elastic switch 606, the extrusion speed of the extrusion motor 609 will also change accordingly, and it is fully sealed through the concentration cover 2, and the sealing valve is used to control whether the vaccine stock solution is passed in. During the feeding process, when the vaccine stock solution enters the concentration layer, the concentration motor 9 will drive the separator 10 to rotate, and the separation chamber in the separator 10 can be controlled to perform centrifugal separation, and the centrifuged vaccine stock solution is fed to the discharge tray 103. At the same time, the temperature control pipeline group 8 and the temperature control layer 7 are used to ensure the separation temperature. Subsequently, the waste liquid after centrifugation will also be sent to the impurity discharge plate 104, and the impurity discharge plate 104 will send out the waste liquid after centrifugation. The waste liquid after centrifugation will be discharged into the drainage pipe 13, and the booster pump 114 in the collection tank 113 will be operated. The booster pump 114 will send the liquid into the near drainage pipe 13. According to the feedback current change of the feedback resistor 110, the electric control valve 115 will select the processing technology, and the discharged liquid will be sent to the ultrafiltration pipeline network 20, and the ultrafiltration pipeline network 20 will be sent to the ultrafiltration membrane 1 9 flows at high speed to complete the ultrafiltration operation, and the concentrated vaccine concentrate will be sent to the discharge port 12, and then the discharge port 12 will be sent to the discharge pipe 14. During the transportation process, the backwash component 15 will backwash the inner wall of the discharge pipe 14, and the backwash pump 1502 will send the vaccine concentrate that has been transferred to the storage tank 17 into the backwash pipe 1501, and then the vaccine concentrate will be discharged to the inner wall of the discharge pipe 14, and the backwash ring 1503 will move on the backwash pipe and can also rotate to avoid blockage in the discharge pipe 14.

[0029] It should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device.

[0030] Finally, it should be noted that the above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art can still modify the technical solutions described in the aforementioned embodiments or replace some of the technical features therein by equivalents. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An ultrafiltration concentration device for treating vaccine stock solution, characterized in that: The concentrating device comprises a concentrating barrel (1) and a concentrating cover (2), wherein the concentrating cover (2) is threadedly engaged with the concentrating barrel (1), a sealing ring is provided on the concentrating cover (2), a feed port (3) is provided on the feed port (3), a feed pipe (4) is provided on the feed pipe (4), a control valve (5) is provided on the feed pipe (4), an adjusting component (6) is provided in the feed pipe (4), a temperature control layer (7) is provided in the concentrating barrel (1), a temperature control plate is provided in the temperature control layer (7), and the concentrating barrel (1) is provided with a temperature control layer (7). The temperature control plate is connected to the temperature control pipe group (8) through a conduit, a concentration layer is arranged in the concentration barrel (1), a concentration motor (9) is arranged in the concentration barrel (1), a separator (10) is arranged on the concentration motor (9), a water outlet (11) and a discharge port (12) are arranged on the concentration barrel (1), a drainage pipe (13) is arranged on the water outlet (11), a discharge pipe (14) is arranged on the discharge port (12), and a backwashing component (15) is arranged in the discharge pipe (14); The adjustment component (6) comprises a plurality of pressure-sensitive rings (601), each of the pressure-sensitive rings (601) being arranged in a feed pipe (4), the pressure-sensitive ring (601) being provided with a circulation hole, the circulation hole being provided with a circulation impeller (602), the circulation impeller (602) being rotatably connected to the pressure-sensitive ring (601), the pressure-sensitive ring (601) being provided with a lifting column (603), the lifting column (603) being provided with a sliding rod (604) and a lifting spring (605), the two ends of the lifting spring (605) respectively abutting against the lifting column (603) and the sliding rod (604), the sliding rod (604) being slidably connected to the inner wall of the lifting column (603), and the lifting column (603) being provided with an elastic switch (606).

2. The ultrafiltration concentration device for treating vaccine stock solution according to claim 1, characterized in that: A boost ring (607) is arranged in the feed pipe (4), and a plurality of boost holes and a plurality of flow holes are arranged on both sides of the boost ring (607). An extrusion ring (608) is rotatably connected in the boost ring (607), and teeth are arranged on the extrusion ring (608). An extrusion motor (609) is arranged on the feed pipe (4), and the teeth on the extrusion ring (608) mesh with the output end of the extrusion motor (609). The extrusion motor (609) is electrically connected to the elastic switch (606) via a wire, and an extrusion chute is provided on the extrusion ring (608).

3. The ultrafiltration concentration device for treating vaccine stock solution according to claim 1, characterized in that: The concentration barrel (1) is provided with a heat-insulating cover (101), and a connecting groove (102) is provided on the heat-insulating cover (101). A discharge tray (103) and a debris removal tray (104) are provided in the concentration barrel (1), and the debris removal tray (104) is rotatably connected to the discharge tray (103). The separator (10) is rotatably connected to the discharge tray (103), and the separator (10) is connected to the feed pipe (4). A plurality of separation chambers (105) are provided in the separator (10), and the separation chambers (105) are connected to the discharge tray (103). A discharge groove is provided on the discharge tray (103), and debris removal holes are provided on the separation chamber (105), and the debris removal holes are connected to the debris removal tray (104).

4. The ultrafiltration concentration device for treating vaccine stock solution according to claim 3, characterized in that: A feedback spring web (106) and a feedback switch group (107) are arranged in the debris removal disc (104); the feedback spring web (106) is rotatably connected to the debris removal disc (104); the feedback switch group (107) comprises a plurality of feedback tubes (108) and feedback columns (109); each feedback column (109) is slidably connected to a corresponding feedback tube (108); a feedback resistor (110) is arranged in the feedback tube (108); a sliding sleeve (111) is arranged on the feedback column (109); the sliding sleeve (111) is sleeved on the feedback resistor (110) and is slidably connected to the feedback resistor (110); a sliding spring (112) is arranged in the feedback tube (108); two ends of the sliding spring (112) respectively abut against the feedback tube (108) and the sliding sleeve (111).

5. The ultrafiltration concentration device for treating vaccine stock solution according to claim 4, characterized in that: The discharge tray (103) is connected to the discharge port (12) via a conduit; a collecting trough (113) is provided at the bottom end of the concentration barrel (1); the collecting trough (113) is connected to a drain port; a booster pump (114) is provided at the drain port; an electric discharge valve (115) is provided on the drain pipe (13); the electric discharge valve (115) is electrically connected to a feedback resistor (110) via a wire; and a recovery pipe (16) is provided on the drain pipe (13).

6. The ultrafiltration concentration device for treating vaccine stock solution according to claim 5, characterized in that: A material storage tank (17) and a water storage tank (18) are provided at one end of the discharge pipe (14) away from the discharge port (12); the water storage tank (18) is in communication with the recovery pipe (16); an ultrafiltration membrane (19) is provided in the water storage tank (18); an ultrafiltration pipe network (20) is provided at the upper end of the ultrafiltration membrane (19); the ultrafiltration pipe network (20) is in communication with the recovery pipe (16); a reflux pipe (21) is provided on the water storage tank (18); and the reflux pipe (21) is in communication with the feed pipe (4).

7. The ultrafiltration concentration device for treating vaccine stock solution according to claim 6, characterized in that: The backwash component (15) comprises a backwash pipe (1501) and a backwash pump (1502), the input end of the backwash pump (1502) being connected to the storage tank (17), the backwash pipe (1501) passing through the wall of the discharge pipe (14) and being connected to the backwash pump (1502), the backwash pipe (1501) being provided with a backwash ring (1503), the backwash ring (1503) being provided with a plurality of flow holes, the backwash pipe (1501) being provided with threads, the backwash ring (1503) being meshed with the backwash pipe (1501) via the threads, the backwash pipe (1501) being provided with a plurality of backwash holes (1504), the direction of the backwash holes (1504) being spiral.

8. The ultrafiltration concentration device for treating vaccine stock solution according to claim 7, characterized in that: The recoil ring (1503) is provided with a backwash groove, the recoil ring (1503) is provided with a backwash support (1505), a speed-sensing paddle (1506) is provided inside the recoil ring (1503), the speed-sensing paddle (1506) is rotatably connected to the recoil ring (1503), the backwash support (1505) is provided with a thread, the speed-sensing paddle (1506) is connected to the backwash support (1505) via a spring rod (1507), the spring rod (1507) is a telescopic rod with an elastic restoring function, and the backwash support (1505) is meshed with the recoil ring (1503).

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