Clindamycin phosphate processing hydrolysis apparatus and method

Abstract

This invention discloses a clindamycin phosphate processing hydrolysis apparatus and method, specifically relating to the field of injection preparation technology. The apparatus includes a support frame with a hydrolysis mixing component mounted on it. The hydrolysis mixing component includes a slide seat mounted on the support frame, slidably connected to the support frame, and a hydrolysis cylinder at the bottom of the slide seat. This invention prevents clindamycin phosphate powder from agglomerating due to friction. The amplitude plate and heating plate generate high-frequency amplitude, facilitating thorough mixing of the clindamycin phosphate powder molecules. Simultaneously, the heating plate controls the temperature during hydrolysis. Compressed airflow is delivered to an aeration pipe, which aerates the powder within the hydrolysis cylinder. Furthermore, the rotating connection disc, filter plate, first stirring blade, and second stirring blade further agitate the powder, effectively preventing clumping of the clindamycin phosphate powder and ensuring hydrolysis quality and effectiveness.

Description

Technical Field

[0001] This invention relates to the field of injection preparation technology, and more specifically, to an apparatus and method for processing and hydrolyzing clindamycin phosphate. Background Technology

[0002] Clindamycin phosphate is an organic compound and also an antibiotic. It is a semi-synthetic derivative of clindamycin. Clindamycin phosphate has no antibacterial activity in vitro, but it rapidly hydrolyzes to clindamycin in the body, thus exhibiting its pharmacological activity. Therefore, its antibacterial spectrum, antibacterial activity, and therapeutic effect are the same as clindamycin, but its lipid solubility and permeability are superior. Clindamycin phosphate itself is inactive in vitro and requires hydrolysis to release clindamycin in order to exert its antibacterial effect. The hydrolysis process is the key step in its transformation from an inactive form to its active form.

[0003] Among them, the patent with announcement number CN219816053U discloses a clindamycin phosphate injection preparation device, which relates to the field of clindamycin phosphate injection preparation technology. It includes a fixed base for supporting the preparation device, a support column is provided on the top of the fixed base near the length direction, a connecting frame is provided on the outer wall of the support column, a processing mechanism is fixedly connected inside the connecting frame, a filtering mechanism is provided on the top of the fixed base and the bottom facing the processing mechanism, a filter plate is movably provided inside the filtering mechanism, an installation mechanism is snapped on the top of the filter plate, a lifting power mechanism is provided on the top of the support column, a stirring mechanism is movably provided inside the processing mechanism, and the lifting power mechanism is movably connected to the stirring mechanism.

[0004] When in use, this structure, through the clindamycin phosphate injection preparation device, facilitates up-and-down stirring, improving stirring efficiency, and the filter screen is easy to clean. However, when the raw materials are hydrolyzed and mixed, the raw materials are prone to clumping, affecting the hydrolysis effect. Summary of the Invention

[0005] In order to overcome the above-mentioned defects of the prior art, the present invention provides a clindamycin phosphate processing hydrolysis apparatus and method, which aims to solve the problems mentioned in the background art.

[0006] The present invention provides the following technical solution: a clindamycin phosphate processing hydrolysis device, including a support frame, on which a hydrolysis mixing component is disposed;

[0007] The hydrolysis mixing assembly includes a slide seat mounted on a support frame, the slide seat being slidably connected to the support frame, and a hydrolysis cylinder being mounted at the bottom of the slide seat;

[0008] The hydrolysis cylinder has a sealing cylinder embedded inside. The surface of the sealing cylinder is fitted with several connecting rings, and each connecting ring is clamped with an elastic support column. Each of the multiple elastic support columns is provided with an amplitude plate, and each connecting ring is provided with a heating plate on its outer side.

[0009] The top of the hydrolysis cylinder is engaged with a limiting cylinder, and a rotating shaft is rotatably connected inside the limiting cylinder. A connecting plate is fixedly installed at the bottom of the rotating shaft. Several filter screens for separation processing are distributed on the connecting plate. Several first stirring blades are distributed at the top of the connecting plate, and several second stirring blades are distributed at the bottom of the connecting plate. A misalignment opening is formed between each pair of adjacent first stirring blades and second stirring blades.

[0010] As can be seen, in the above technical solution, the rotating filter plate easily filters impurities in the powder during hydrolysis, while the first and second stirring blades facilitate thorough mixing of the stock solution and lincomycin phosphate powder for hydrolysis. The amplitude generated by the vibration motor is transmitted to the connecting ring and amplified by the elastic support column, enabling the amplitude plate and heating plate to generate high-frequency amplitude, which facilitates thorough mixing of the stock solution and lincomycin phosphate powder molecules. Simultaneously, the heating plate controls the temperature during hydrolysis, and aeration is achieved within the hydrolysis cylinder via the aeration pipe. Combined with the rotation of the connecting disc, filter plate, first stirring blade, and second stirring blade, this effectively prevents clumping of the stock solution and lincomycin phosphate powder, ensuring the quality of hydrolysis.

[0011] Optionally, in a possible implementation, one end of the sealing cylinder penetrates through the hydrolysis cylinder and extends to the surface of the hydrolysis cylinder. A vibration motor is bolted inside the sealing cylinder, and an air pump is provided on one side of the vibration motor. The air pump is bolted inside the sealing cylinder, and an aeration pipe is provided at the output end of the air pump. The aeration pipe penetrates through the sealing cylinder and extends to the outside of the sealing cylinder. A support base is provided at the top of the hydrolysis cylinder, and a conveying cylinder connected to the hydrolysis cylinder is inserted into the support base. A docking sleeve is rotatably connected to the top of the conveying cylinder, and a feeder is fixedly provided at the top of the docking sleeve. Several dispensing ports are opened through the feeder, and a feed hopper is rotatably connected to the top of the feeder. A valve is embedded in the feed hopper. A drive motor is bolted to the top of the slide block. A pulley is provided at the output end of the drive motor and one end of the top rotating shaft of the limiting cylinder. The two pulleys are located on both sides of the feeder. A belt is driven to the pulleys and the outside of the feeder. A screw drive module for driving the slide block to move up and down is provided on the slide block.

[0012] As can be seen, in the above technical solution, clindamycin phosphate is diverted by a valve, and the pulley drives the spreader to rotate via a belt, so that each dispensing port can rotate. This makes it easier for the clindamycin phosphate after being diverted by the valve to be screened out and conveyed into the conveying cylinder when the dispensing port rotates, thus avoiding the clindamycin phosphate powder from accumulating together due to friction.

[0013] A method using the above-described clindamycin phosphate processing hydrolysis apparatus, characterized by comprising the following steps:

[0014] Step 1: The staff installs the device at the designated location. When processing and hydrolyzing clindamycin phosphate, the original solution is injected into the hydrolysis cylinder, and clindamycin phosphate is injected into the feed hopper at the same time. The clindamycin phosphate is diverted through the valve.

[0015] Step 2: Simultaneously, the drive motor is started. The output end of the drive motor drives the pulley and drives the spreader to rotate via the belt, so that each dispensing port can rotate. This makes it easier for clindamycin phosphate after being diverted by the valve to be screened out and conveyed into the conveying cylinder when the dispensing port rotates, thus preventing clindamycin phosphate powder from accumulating due to friction.

[0016] Step 3: When the lincomycin phosphate powder is conveyed into the conveying cylinder, it is guided into the hydrolysis cylinder for hydrolysis. At the same time, when the belt rotates, it can also drive the shaft to rotate through the pulley at the top of the shaft, which in turn causes the connecting plate and the filter plate to rotate. When the filter plate rotates, it is easy to filter out impurities in the powder during hydrolysis. The first and second stirring blades facilitate the thorough mixing of the original solution and the lincomycin phosphate powder for hydrolysis.

[0017] Step four: When the stock solution and lincomycin phosphate powder are hydrolyzed and mixed in the hydrolysis cylinder, the amplitude generated by the start of the vibration motor is transmitted to the connecting ring and amplified by the elastic support column, so that the amplitude plate and heating plate can generate high frequency amplitude, which makes it easy for the stock solution and lincomycin phosphate powder molecules to be fully mixed together. At the same time, the temperature during hydrolysis can be controlled by the heating plate.

[0018] Step 5: To ensure hydrolysis efficiency and effectiveness, compressed air is pumped into the aeration pipe, which aerates the solution within the hydrolysis cylinder. The solution is then stirred by rotating the connecting disc, filter plate, first stirring blade, and second stirring blade. This effectively prevents clumping of the original solution and lincomycin phosphate powder, ensuring hydrolysis quality.

[0019] The technical effects and advantages of this invention are as follows:

[0020] 1. In this invention, clindamycin phosphate is diverted by valves, and each dispensing port can rotate. This facilitates the screening and conveying of clindamycin phosphate through the rotating dispensing ports after being diverted by the valves into the conveying cylinder, thus preventing clindamycin phosphate powder from accumulating due to friction.

[0021] 2. The amplitude generated by the vibration motor is transmitted to the connecting ring and amplified by the elastic support column, so that the amplitude plate and the heating plate can generate high frequency amplitude, which makes it easy for the original solution and lincomycin phosphate powder molecules to be fully mixed together. At the same time, the heating plate can control the temperature during the hydrolysis process.

[0022] 3. The present invention uses a rotating connecting disc and a filter plate. When the filter plate rotates, it is easy to filter out impurities in the powder during hydrolysis, while the first and second stirring blades facilitate the thorough mixing of the original solution and lincomycin phosphate powder for hydrolysis.

[0023] 4. In order to ensure hydrolysis efficiency and effect, the present invention uses an air pump to deliver compressed air to the aeration pipe, which aerates the hydrolysis cylinder. The aeration is then combined with the rotating of the connecting disc, filter plate, first stirring blade and second stirring blade to stir the mixture. This effectively avoids the clumping of the original solution and lincomycin phosphate powder, thus ensuring the quality of hydrolysis.

[0024] In summary, through the coordinated use of various structures, the clindamycin phosphate ester, after being diverted by the valve, is screened out and conveyed into the conveying cylinder when the feed port rotates. This prevents the clindamycin phosphate ester powder from accumulating due to friction. The amplitude plate and heating plate can generate high-frequency amplitude, which facilitates the thorough mixing of the clindamycin phosphate ester powder molecules. At the same time, the heating plate can control the temperature during hydrolysis. The compressed air is conveyed to the aeration pipe, where it is aerated in the hydrolysis cylinder. In addition, the connecting disc, filter plate, first stirring blade, and second stirring blade rotate to stir the powder, which can effectively prevent the clindamycin phosphate ester powder from clumping together, ensuring the quality and effect of hydrolysis. Attached Figure Description

[0025] To more clearly illustrate the technical solutions in this disclosure, the accompanying drawings used in some embodiments will be briefly described below. Obviously, the drawings described below are only drawings of some embodiments of this disclosure, and those skilled in the art can obtain other drawings based on these drawings. In addition, the drawings described below can be regarded as schematic diagrams and are not intended to limit the actual size of the product, the actual flow of the method, the actual timing of the signals, etc. involved in the embodiments of this disclosure.

[0026] Figure 1 This is a front view of the overall structure of the present invention.

[0027] Figure 2 This is a side view of the overall structure of the present invention.

[0028] Figure 3 This is a perspective view of the hydrolysis cylinder, conveying cylinder, feeder, feed hopper, and valve of the present invention.

[0029] Figure 4 For the present invention Figure 3 Exploded view.

[0030] Figure 5 This is a perspective view of the sealing cylinder, connecting ring, elastic support column, amplitude plate, and heating plate of the present invention.

[0031] Figure 6 This is a perspective view of the slide, limiting cylinder, rotating shaft, connecting plate, and filter screen of the present invention.

[0032] Figure 7 This is a perspective view of the support frame and lead screw drive module of the present invention.

[0033] The attached diagram is labeled as follows: 1. Support frame; 2. Slide seat; 3. Hydrolysis cylinder; 4. Sealing cylinder; 5. Connecting ring; 6. Elastic support column; 7. Amplitude plate; 8. Heating plate; 9. Limiting cylinder; 10. Rotating shaft; 11. Connecting plate; 12. Filter screen plate; 13. First stirring blade; 14. Second stirring blade; 15. Vibration motor; 16. Air pump; 17. Support seat; 18. Conveying cylinder; 19. Connecting sleeve; 20. Dispenser; 21. Distributor port; 22. Feed hopper; 23. Valve; 24. Aeration pipe; 25. Drive motor; 26. Pulley; 27. Belt; 28. Screw drive module. Detailed Implementation

[0034] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0035] As attached Figure 1 - Figure 7The clindamycin phosphate hydrolysis device shown in the diagram uses a hydrolysis mixing component on the support frame 1. After being diverted by valve 23, the clindamycin phosphate is screened out through the rotating feed port 21 and conveyed into the conveying cylinder 18, preventing the clindamycin phosphate powder from accumulating due to friction. The amplitude plate 7 and heating plate 8 can generate high-frequency amplitude, which facilitates the thorough mixing of the original solution and the clindamycin phosphate powder molecules. At the same time, the heating plate 8 can control the temperature during the hydrolysis process. The compressed air is conveyed to the aeration pipe 24, which aerates the clindamycin phosphate powder in the hydrolysis cylinder 3. The connecting plate 11, filter plate 12, first stirring blade 13, and second stirring blade 14 rotate to stir the clindamycin phosphate powder, effectively preventing the clindamycin phosphate powder from clumping together and ensuring the quality and effect of hydrolysis. The specific structural configuration of the components is as follows.

[0036] The hydrolysis mixing assembly includes a slide 2 mounted on a support frame 1, the slide 2 being slidably connected to the support frame 1, and a hydrolysis cylinder 3 being mounted at the bottom of the slide 2;

[0037] A sealing cylinder 4 is embedded inside the hydrolysis cylinder 3. Several connecting rings 5 ​​are sleeved on the surface of the sealing cylinder 4, and each connecting ring 5 is clamped with an elastic support column 6. Amplitude plates 7 are provided on each of the multiple elastic support columns 6, and a heating plate 8 is provided on the outside of each connecting ring 5.

[0038] The top of the hydrolysis cylinder 3 is snapped into a limiting cylinder 9. A rotating shaft 10 is rotatably connected inside the limiting cylinder 9. A connecting plate 11 is fixedly installed at the bottom of the rotating shaft 10. Several filter screens 12, all used for separation processing, are distributed on the connecting plate 11. Several first stirring blades 13 are distributed at the top of the connecting plate 11, and several second stirring blades 14 are distributed at the bottom of the connecting plate 11. A misalignment opening is formed between each pair of adjacent first stirring blades 13 and second stirring blades 14.

[0039] One end of the sealing cylinder 4 penetrates through the hydrolysis cylinder 3 and extends to the surface of the hydrolysis cylinder 3. A vibration motor 15 is bolted inside the sealing cylinder 4. An air pump 16 is provided on one side of the vibration motor 15 and is bolted inside the sealing cylinder 4. An aeration pipe 24 is provided at the output end of the air pump 16, which penetrates through the sealing cylinder 4 and extends to the outside of the sealing cylinder 4. A support base 17 is provided at the top of the hydrolysis cylinder 3. A conveying cylinder 18 connected to the hydrolysis cylinder 3 is inserted into the support base 17. A docking sleeve 19 is rotatably connected to the top of the conveying cylinder 18, and the top of the docking sleeve 19 is fixed. A feeder 20 is provided, with several feed openings 21 extending through it. A feed hopper 22 is rotatably connected to the top of the feeder 20, and a valve 23 is embedded in the feed hopper 22. A drive motor 25 is bolted to the top of the slide block 2. A pulley 26 is provided at the output end of the drive motor 25 and at one end of the top rotating shaft 10 of the limiting cylinder 9. The two pulleys 26 are located on both sides of the feeder 20. A belt 27 is connected to both the pulleys 26 and the outer side of the feeder 20. A screw drive module 28 is provided on the slide block 2 for driving the slide block 2 to move up and down.

[0040] A method using the above-described clindamycin phosphate processing hydrolysis apparatus includes the following steps:

[0041] Step 1: The staff installs the device at the designated location. When processing and hydrolyzing clindamycin phosphate, the original solution is injected into the hydrolysis cylinder 3, and clindamycin phosphate is injected into the feed hopper 22 at the same time. The clindamycin phosphate is diverted through valve 23.

[0042] Step 2: Simultaneously, the drive motor 25 is started. The output end of the drive motor 25 drives the pulley 26 to drive the spreader 20 to rotate via the belt 27, so that each distribution port 21 can rotate. This makes it easier for the clindamycin phosphate after being diverted by the valve 23 to be screened out and conveyed into the conveying cylinder 18 when the distribution port 21 rotates, thus preventing the clindamycin phosphate powder from accumulating together due to friction.

[0043] Step 3: When the lincomycin phosphate powder is conveyed into the conveying cylinder 18, it is guided into the hydrolysis cylinder 3 for hydrolysis. At the same time, when the belt 27 rotates, it can also drive the rotating shaft 10 to rotate via the pulley 26 at the top of the rotating shaft 10. This causes the connecting plate 11 and the filter plate 12 to rotate. When the filter plate 12 rotates, it is easy to filter out impurities in the powder during hydrolysis. Meanwhile, the first stirring blade 13 and the second stirring blade 14 facilitate the thorough mixing of the original solution and the lincomycin phosphate powder for hydrolysis.

[0044] Step four: When the stock solution and lincomycin phosphate powder are hydrolyzed and mixed in the hydrolysis cylinder 3, the amplitude generated by the vibration motor 15 is transmitted to the connecting ring 5 and amplified by the elastic support column 6, so that the amplitude plate 7 and the heating plate 8 can generate high frequency amplitude, which makes it easy for the stock solution and lincomycin phosphate powder molecules to be fully mixed together. At the same time, the temperature during the hydrolysis can be controlled by the heating plate 8.

[0045] Step 5: To ensure hydrolysis efficiency and effectiveness, compressed air is delivered to the aeration pipe 24 via the air pump 16. The air is then aerated in the hydrolysis cylinder 3 via the aeration pipe 24. In addition, the connecting disc 11, filter plate 12, first stirring blade 13 and second stirring blade 14 rotate to stir the mixture. This effectively prevents the original solution and lincomycin phosphate powder from clumping together, thus ensuring the quality of hydrolysis.

[0046] According to the above structure, during use, the original solution is injected into the hydrolysis cylinder 3, and clindamycin phosphate is injected into the feed hopper 22. The clindamycin phosphate is diverted through valve 23, and each feed port 21 can rotate. The clindamycin phosphate after being diverted by valve 23 is screened out through the rotating feed port 21 and conveyed into the conveying cylinder 18. When the clindamycin phosphate powder is conveyed into the conveying cylinder 18, it is guided into the hydrolysis cylinder 3 for hydrolysis. When the filter plate 12 rotates, it easily filters out impurities in the powder during hydrolysis. The first stirring blade 13 and the second stirring blade 14... This facilitates thorough mixing of the stock solution and lincomycin phosphate powder for hydrolysis. The amplitude generated by the vibration motor 15 is transmitted to the connecting ring 5 and amplified by the elastic support column 6, enabling the amplitude plate 7 and heating plate 8 to generate high-frequency amplitude. At the same time, the heating plate 8 can control the temperature during the hydrolysis process. The compressed air is delivered to the aeration pipe 24 by the air pump 16, and aeration is carried out in the hydrolysis cylinder 3 through the aeration pipe 24. The connecting plate 11, filter plate 12, first stirring blade 13 and second stirring blade 14 rotate to stir the solution, ensuring the quality of hydrolysis.

[0047] Unlike existing technologies, this application discloses a clindamycin phosphate processing and hydrolysis device. Clindamycin phosphate, after being diverted by valve 23, is screened out through the rotating feed inlet 21 and conveyed into the conveying cylinder 18, preventing clindamycin phosphate powder from accumulating due to friction. The amplitude plate 7 and heating plate 8 generate high-frequency amplitude, facilitating thorough mixing of the original solution and lindamycin phosphate powder molecules. Simultaneously, the heating plate 8 controls the temperature during hydrolysis. Compressed airflow is conveyed to the aeration pipe 24, which aerates the solution within the hydrolysis cylinder 3. Furthermore, the rotating connecting disc 11, filter plate 12, first stirring blade 13, and second stirring blade 14 further agitate the solution, effectively preventing clumping of the original solution and lindamycin phosphate powder, ensuring hydrolysis quality and effectiveness.

[0048] The above description is merely a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A device for processing hydrolysis of clindamycin phosphate, comprising a support frame (1), characterized in that: The support frame (1) is provided with a hydrolysis mixing component; The hydrolysis mixing assembly includes a slide (2) mounted on a support frame (1), and a hydrolysis cylinder (3) is mounted at the bottom of the slide (2). The hydrolysis cylinder (3) has a sealing cylinder (4) embedded inside. The surface of the sealing cylinder (4) is fitted with several connecting rings (5), and each connecting ring (5) is clamped with an elastic support column (6). Each of the elastic support columns (6) is provided with an amplitude plate (7), and each connecting ring (5) is provided with a heating plate (8) on its outer side. The sealing cylinder (4) is fitted with a vibration motor (15) by bolts. An air pump (16) is provided on one side of the vibration motor (15). An aeration pipe (24) is provided at the output end of the air pump (16). The aeration pipe (24) passes through the sealing cylinder (4) and extends to the outer side of the sealing cylinder (4). The top of the hydrolysis cylinder (3) is fitted with a limiting cylinder (9), and a rotating shaft (10) is rotatably connected inside the limiting cylinder (9). A connecting plate (11) is fixedly provided at the bottom of the rotating shaft (10). The connecting disc (11) has several filter plates (12) for separation processing. The top of the connecting disc (11) has several first stirring blades (13), and the bottom of the connecting disc (11) has several second stirring blades (14). A misalignment opening is formed between each pair of adjacent first stirring blades (13) and second stirring blades (14).

2. The clindamycin phosphate processing hydrolysis apparatus according to claim 1, characterized in that: The top of the hydrolysis cylinder (3) is provided with a support base (17), and a conveying cylinder (18) is inserted into the support base (17). The top of the conveying cylinder (18) is rotatably connected to a docking sleeve (19).

3. The clindamycin phosphate processing hydrolysis apparatus according to claim 2, characterized in that: The top of the docking sleeve (19) is fixedly provided with a feeder (20), and the feeder (20) has several feed openings (21) through it.

4. The clindamycin phosphate processing hydrolysis apparatus according to claim 3, characterized in that: The top of the feeder (20) is rotatably connected to a feed hopper (22), and a valve (23) is embedded in the feed hopper (22).

5. The clindamycin phosphate processing hydrolysis apparatus according to claim 4, characterized in that: The top of the slide (2) is provided with a drive motor (25), and the output end of the drive motor (25) and one end of the top rotating shaft (10) of the limiting cylinder (9) are both provided with pulleys (26).

6. The clindamycin phosphate processing hydrolysis apparatus according to claim 5, characterized in that: Both the pulley (26) and the spreader (20) are connected to a belt (27) on the outside. The slide (2) is provided with a screw drive module (28) for driving the slide (2) to move up and down.

7. A method using the clindamycin phosphate processing hydrolysis apparatus of claim 6, characterized in that: Includes the following steps, Step 1: Inject the original solution into the hydrolysis cylinder (3) and at the same time inject clindamycin phosphate into the feed hopper (22). The clindamycin phosphate is diverted through the valve (23). Step 2: Each feed port (21) can rotate, so that the clindamycin phosphate after being diverted by the valve (23) can be screened out and conveyed into the conveying cylinder (18) when the feed port (21) rotates. Step 3: When clindamycin phosphate powder is conveyed into the conveying cylinder (18), it is guided into the hydrolysis cylinder (3) for hydrolysis. When the filter screen plate (12) rotates, it is easy to filter the impurities in the powder during hydrolysis. The first stirring blade (13) and the second stirring blade (14) facilitate the full mixing of the original solution and clindamycin phosphate powder for hydrolysis. Step 4: The amplitude generated by the start of the vibration motor (15) is transmitted to the connecting ring (5) and amplified by the elastic support column (6), so that the amplitude plate (7) and the heating plate (8) can generate high frequency amplitude, and the temperature during the evolution and hydrolysis can be controlled by the heating plate (8). Step 5: The compressed air is delivered to the aeration pipe (24) by the air pump (16), and aeration is carried out in the hydrolysis cylinder (3) through the aeration pipe (24). Then, the connecting plate (11), filter screen plate (12), first stirring blade (13) and second stirring blade (14) are rotated to stir the hydrolysis to ensure the quality of hydrolysis.

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