Cis-platinum dendritic lipopeptide nano-drug as well as preparation method and application thereof
By forming a coordination structure with polycarboxylic lipopeptide with cisplatin and combining with auxiliary lipid preparation, the problems of low drug loading and poor stability of cisplatin liposomes were solved, efficient cisplatin delivery and immune activation were achieved, and the therapeutic effect and safety were significantly improved.
CN119633129APending Publication Date: 2025-03-18CHINA PHARM UNIV
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Patent Information
- Application Number
- CN202411808687.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-10
- Publication Date
- 2025-03-18
AI Technical Summary
Technical Problem
The existing cisplatin liposomes have low drug loading, easy leakage and poor stability during the preparation process, which limits their application in the treatment of cancer.
Method used
The coordinate structure of [COO-Pt] is used to form a polycarboxylic lipopeptide and cisplatin, and combined with auxiliary lipid preparation, to form a cisplatin lipopeptide nanodrug with high stability and high drug loading.
Benefits of technology
It improves the drug loading and stability of cisplatin, enhances its distribution and release in tumor tissues, reduces leakage in the systemic circulation, improves efficacy and improves safety, and enhances immune activation capabilities.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention discloses a cis-platinum dendritic lipopeptide nano-drug and a preparation method and application thereof.The cis-platinum dendritic lipopeptide nano-drug is prepared by blending polycarboxylic dendritic lipopeptide, lecithin and other auxiliary lipids, a cis-platinum drug is entrapped in the cis-platinum dendritic lipopeptide nano-drug, and by means of the structure of the polycarboxylic dendritic lipopeptide and the performance of acid response, the cis-platinum dendritic lipopeptide nano-drug is prepared. The cisplatin lipid nano-drug has the advantages that high drug loading property and tumor microenvironment controlled release property of the cisplatin lipid nano-drug are realized, the immune activation ability of cisplatin can be enhanced, the ability of cisplatin to promote maturation of dendritic cells, infiltration of cytotoxic T cells in tumors and inhibition of infiltration of regulatory T cells in tumors in tumor microenvironment is improved, and an extremely strong tumor inhibition effect is realized; in addition, the compound can achieve a synergistic interaction effect when being combined with chemotherapeutic drugs, and has a great application prospect in the anti-tumor aspect.
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