A health insecticidal compound composition and application thereof

Abstract

The present application belongs to the field of sanitary insecticide technology, and relates to a sanitary insecticide compound composition and application. The composition is a compound of component A and component B with a mass ratio of 20:1-1:10, wherein component A is a methoxy acrylate compound shown in formula I, and component B is an organic phosphorus insecticide. The binary composition solves the problem of resistance of sanitary pests to organic phosphorus, improves the control effect, reduces the application amount, reduces the stimulation of application, and prolongs the efficacy. The active ingredient A is a lethal agent, has no cross-resistance with organic phosphorus, has good lethal effect, has no repellency to sanitary pests, and is widely applied in hotels, schools, factories, farms and other places, and has special effect on the control of sanitary pests.

Description

TECHNICAL FIELD

[0001] The application belongs to the field of sanitary insecticidal technology, and relates to a sanitary insecticidal compound composition and application. BACKGROUND

[0002] In recent years, in the field of residual spraying and killing, there are some problems such as difficulty in completely killing mosquitoes and flies, short persistence period of pesticides or no persistence, and the like. When applying pesticides, the applicators can only increase the dosage and improve the application frequency, which leads to significant increase of mosquito and fly resistance, multiple increase of application cost, and increase of irritability of pesticides to applicators. Therefore, there is an urgent need for a new generation of residual spraying pesticides to solve these problems in the market.

[0003] Flupyroxystrobin is the first methoxy acrylate insecticide, which is discovered by the British Imperial Chemical Industry Company and developed by its successor company, Syngenta. Flupyroxystrobin is a Qo mitochondrial respiratory inhibitor. Flupyroxystrobin has not been registered for use in sanitary pests, and the structural formula of the compound is as follows:

[0004]

[0005] For a long time, organophosphorus insecticides have been widely used in the prevention and control of public health pests. Long-term use of these pesticides inevitably leads to resistance of sanitary pests such as mosquitoes, flies and cockroaches to some organophosphorus pesticides, which greatly reduces the control effect of the pesticides. In particular, in the southern region of China, the resistance increases rapidly, which greatly reduces the control effect of sanitary pests.

[0006] In view of this dilemma, we consider compounding a new type of piperonyl acid derivative insecticide compound I-72 with an organophosphorus insecticide. On the one hand, the two have different mechanisms of action, and the compound has no cross-resistance, which can solve the problem of resistance of sanitary pests to organophosphorus pesticides and reduce the amount of pesticide application. On the other hand, the compound Flupyroxystrobin has small irritability, which improves the safety of applicators. Furthermore, through research, it is found that the compound can improve the control effect on sanitary pests, and is a compound pesticide technology with good market prospect.

[0007] In recent years, in the field of residual spraying and killing, there are some problems such as difficulty in completely killing mosquitoes and flies, short persistence period of pesticides or no persistence, and the like. When applying pesticides, the applicators can only increase the dosage and improve the application frequency, which leads to significant increase of mosquito and fly resistance, multiple increase of application cost, and increase of irritability of pesticides to applicators. Therefore, there is an urgent need for a new generation of residual spraying pesticides to solve these problems in the market. SUMMARY

[0008] The present application aims to solve the technical problems in the prior art and provides a sanitary insecticidal compound composition and application.

[0009] To achieve the above object, the present application adopts the following technical solutions.

[0010] A sanitary insecticidal compound composition, the composition is a compound of component A and component B with a mass ratio of 20:1-1:10, wherein the component A is a methoxy acrylate compound (Flupyroxystrobin) shown in formula I, and the component B is an organic phosphorus insecticide.

[0011]

[0012] The component B is any one of bisultap, fenthion, fenitrothion, and pirimiphos-methyl. Preferably, the mass ratio of the component A to the component B in the composition is 10:1-1:2.

[0013] More preferably, the weight ratio of the Flupyroxystrobin to the bisultap is preferably 1:1.

[0014] The weight ratio of the Flupyroxystrobin to the fenthion is preferably 2:1.

[0015] The weight ratio of the Flupyroxystrobin to the pirimiphos-methyl is preferably 4:1.

[0016] The weight ratio of the Flupyroxystrobin to the fenitrothion is preferably 2:1.

[0017] An application of the sanitary insecticidal compound composition, the application of the sanitary insecticidal compound composition in preventing and treating sanitary pests.

[0018] The composition is suitable for the corresponding area by local application, and the sanitary pests are one or more of housefly, Musca domestica, Chrysomya megacephala, Lucilia cuprina, L. luctuosa, Muscina assimilis, M. metatonia, Calliphora erythrocephala, Phaenicia coeruleocephala, and Fannia scalaris.

[0019] The local application refers to a residual spraying method or a brushing method.

[0020] The application field includes hotels, schools, factories, farms, and the like.

[0021] A sanitary insecticidal compound preparation, the preparation is an active ingredient and an auxiliary material, wherein the active ingredient is the composition, and the active ingredient accounts for 2%-50% of the total weight of the preparation.

[0022] The adjuvant is a dispersant, wetting agent, antifoaming agent, antifreezing agent, preservative, disintegrant, thickening agent, binding agent, phagostimulant, stabilizer, filler, one or several of them in water.

[0023] The formulation dosage form is wettable powder, water dispersible granule or suspension.

[0024] When the dosage form is wettable powder, it comprises the following raw materials in percentage by weight: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 5%-10% stabilizer, 5%-15% phagostimulant, and filler to make up to 100%.

[0025] When the dosage form is water dispersible granule, it comprises the following raw materials in percentage by weight: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 1%-10% disintegrant, 0.1%-1% binding agent, 5%-10% stabilizer, 5%-15% phagostimulant, and filler to make up to 100%.

[0026] When the dosage form is suspension, it comprises the following raw materials in percentage by weight: 2%-50% active ingredient, 1%-10% dispersant, 1%-5% wetting agent, 0.3%-0.5% preservative, 0.5%-1.5% thickening agent, 0.1-0.3% antifoaming agent, 3%-5% antifreezing agent, 5%-10% stabilizer, 5%-15% phagostimulant, and water to make up to 100%.

[0027] The dispersant is selected from any one of the following: polycarboxylate (such as TERSPERSE 2500, Henkel, USA), lignin sulfonate, alkyl benzene sulfonate, naphthalene sulfonate formaldehyde condensate, alkyl phenol polyoxyethylene ether, fatty alcohol polyoxyethylene ether, fatty amine polyoxyethylene ether, fatty acid polyoxyethylene ester, glycerol fatty acid ester polyoxyethylene ether, and a mixture of two or more thereof in any ratio.

[0028] The wetting agent is selected from any one of the following: alkyl phenol polyoxyethylene ether formaldehyde condensate sulfate, alkyl benzene polyoxyethylene ether phosphate, phenylethyl phenol polyoxyethylene ether phosphate, alkyl sulfate, alkyl sulfonate (such as TERSPERSE 2425, Henkel), naphthalene sulfonate (such as NNO), Lai Kao Powder BX, Wetting Penetrant F, sodium dodecyl benzene sulfonate, and Cleaners LS, and a mixture of two or more thereof in any ratio.

[0029] The antifoaming agent can be any one of the following: polydimethylsiloxane, diethylene glycol ester, tributyl phosphate, dipalmitoyl ethylenediamine, and a mixture of two or more thereof in any ratio.

[0030] The antifreeze agent can be any one of ethylene glycol, propylene glycol, glycerol, urea, or a mixture of two or more thereof in any ratio.

[0031] The preservative agent is selected from any one of potassium sorbate, sodium benzoate, or a mixture of two or more thereof in any ratio.

[0032] The disintegrating agent is selected from any one of ammonium sulfate, sodium sulfate, sodium bicarbonate, sodium carbonate, or a mixture of two or more thereof in any ratio.

[0033] The thickening agent is selected from any one of xanthan gum, hydroxyethyl cellulose, methyl cellulose, magnesium aluminum silicate, or a mixture of two or more thereof in any ratio.

[0034] The binding agent is selected from any one of dextrin, polyvinylpyrrolidone, sodium alginate, or a mixture of two or more thereof in any ratio.

[0035] The phagostimulant is selected from any one of anisic aldehyde, N-methyl acetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia powder, maltose, honey, milk flavor, or a mixture of two or more thereof in any ratio. The phagostimulant, when added to the sanitary composition, can make the application area 20% to 40% of the conventional application, and the application position is selected from the corners of the indoor room walls, the top or the bottom corner line.

[0036] The stabilizer is selected from any one of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethylpiperidine amine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and normal acylated alkyl alcohol amine, or a mixture of two or more thereof in any ratio. The stabilizer, when added to the sanitary composition, can make the lethal rate of the half-absorbed surface or the absorbed surface greater than 60% in 30 days.

[0037] The filler is selected from any one of kaolin, pottery clay, diatomite, bentonite, white carbon black, attapulgite, corn starch, and light calcium carbonate, or a mixture of two or more thereof in any ratio.

[0038] When the dosage form is wettable powder, water dispersible granules, or suspension, it can be prepared according to the conventional method or the existing method in the art.

[0039] When the sanitary insecticidal composition or preparation is used to control sanitary pests, the insecticidal composition or preparation is diluted 100 to 500 times with water, and sprayed on the surfaces of walls, floors, doors, windows, ceilings, and household items in the application field, so that the sanitary pests contact the surfaces to be knocked down and killed.

[0040] Compared with the prior art, the following features are provided:

[0041] (1) The present application finds through experiments that Flupyroxystrobin and part of organic phosphorus insecticides have a synergistic effect, on the one hand, the environmental compatibility is good, and the amount of application is reduced, on the other hand, from the mechanism of action, the mechanism of action of Flupyroxystrobin and organic phosphorus insecticides is different, there is no cross-resistance, the problem of resistance of sanitary pests to organic phosphorus is solved, the prevention effect is improved, and the combination of insecticides with different mechanisms of action can also delay the resistance of pests, which is beneficial to the resistance management of pests, and better quick-acting and persistent effects can be shown on semi-absorbed surfaces or absorbed surfaces.

[0042] (2) Flupyroxystrobin has less irritation, which improves the safety of the application personnel; furthermore, through research, it is found that the combination of the two can improve the control effect on sanitary pests, and it is a combination application technology with good market prospect.

[0043] (3) In view of the problems of poor persistence and poor killing effect of houseflies and other targets, we solve the problem of persistence through formula technology, and through research on the feeding mode of houseflies, add a feeding attractant to increase the licking frequency of houseflies, so as to increase the amount of insecticides ingested by flies. DETAILED DESCRIPTION

[0044] The specific embodiments of the technical scheme of the present application are described in detail below, but the present application is not limited to the following description:

[0045] Application Example 1: Co-toxicity coefficient determination test of Flupyroxystrobin and organic phosphorus Target: housefly (resistant housefly in Yangzhou), adult on the 3rd day to the 4th day after emergence, half male and half female;

[0046] Test method: refer to GB / T26350-2010 'Fly Resistance Detection Method Housefly Bioassay Method' and NY / T1154.7-2006 'Pesticide Indoor Bioassay Test Guidelines Insecticide Part 7: Determination of Synergistic Effect of Mixtures' Test Insect;

[0047] Table 1 Co-toxicity coefficient determination of Flupyroxystrobin and sulfotep (for housefly)

[0048]

[0049]

[0050] As shown in Table 1, the synergistic coefficients of Flupyroxystrobin and phoxim are all greater than 120 when the mixing ratio is 20:1-1:10, and the synergistic effect is obvious, especially when the mixing ratio is 1:1.

[0051] Table 2 Synergistic coefficients of Flupyroxystrobin and phoxim (for Musca domestica)

[0052]

[0053] As shown in Table 2, the synergistic coefficients of Flupyroxystrobin and phoxim are all greater than 120 when the mixing ratio is 20:1-1:10, and the synergistic effect is obvious, especially when the mixing ratio is 2:1.

[0054] Table 3 Optimal synergistic coefficients of Flupyroxystrobin and other organophosphorus (for Musca domestica)

[0055]

[0056] As shown in Table 3, the optimal mixing ratio of Flupyroxystrobin and other organophosphorus is 10:1-1:2, and the synergistic effect is obvious.

[0057] The preparation method of the dosage form in each embodiment of the present application is as follows:

[0058] The laboratory preparation method of the wettable powder is as follows: the effective ingredient, wetting agent, dispersing agent, stabilizer, food attractant, filler are weighed according to the proportion, mixed uniformly in a mixing machine, and then crushed by an air flow crusher to obtain the wettable powder.

[0059] The laboratory preparation method of the water dispersible granule is as follows: the effective ingredient, wetting agent, dispersing agent, food attractant, disintegrating agent, stabilizer, filler are weighed according to the proportion, mixed uniformly in a mixing machine, and then crushed by an air flow crusher, and then mixed again in the mixing machine, and then mixed with water and the binder mixture by using a granulator, and then extruded and granulated, and then dried by boiling drying, to obtain the water dispersible granule.

[0060] The laboratory preparation method of the suspension agent is as follows: water, dispersing agent, wetting agent, antifreeze, thickening agent, preservative, food attractant, defoaming agent, stabilizer are weighed according to the proportion, mixed uniformly, and then the original drug is added, and then sheared by a high-speed shearing machine for 5 min, and then transferred to a sand mill for sand milling for 2-3 h, so that the particle size D90 is controlled to be less than 5 μm, to obtain the suspension agent.

[0061] The present application will be described below in combination with specific embodiments:

[0062] Preparation Example 1: 20% Flupyroxystrobin·phoxim wettable powder

[0063] Flupyroxystrobin 10g, phoxim 10g, sodium dodecylbenzenesulfonate 5g, calcium lignin sulfonate 10g, dimethyl disulfide 15g, urea-formaldehyde resin 5g, kaolin to 100%.

[0064] Preparation Example 2: 30% Flupyroxystrobin·phoxim water dispersible granule

[0065] Flupyroxystrobin 20g, phoxim 10g, pull-apart powder BX 0.5g, sodium dodecyl sulfate salt 0.5g, naphthalene sulfonate formaldehyde condensate sodium salt 1g, fatty acid dimethyl disulfide ester 5g, ammonium sulfate 5g, dextrin 0.5g, polyalkylene glycol 5g, kaolin to 100%.

[0066] Preparation Example 3: 15% Flupyroxystrobin·phoxim suspension concentrate

[0067] Flupyroxystrobin 5g, phoxim 10g, calcium alkylsulfonate 0.5g, sodium dodecyl sulfate salt 0.5g, potassium polycarboxylate 1g, calcium lignin sulfonate 4g, potassium sorbate 0.5g, magnesium aluminum silicate 1g, xanthan gum 0.5g, dimethicone 0.3g, propylene glycol 5g, polyacrylic acid 5g, roe fish powder 5g, water to 100%.

[0068] Preparation Example 4: 50% Flupyroxystrobin·phoxim water dispersible granule

[0069] Flupyroxystrobin 30g, phoxim 20g, pull-apart powder BX 2g, sodium dodecyl sulfate salt 2g, calcium alkylbenzenesulfonate 2g, calcium lignin sulfonate 8g, brown sugar 12g, sodium sulfate 3g, ammonium sulfate 1g, polyvinylpyrrolidone 1g, ethylene oxide-propylene oxide block polyether 6g, kaolin to 100%.

[0070] Preparation Example 5: 2% Flupyroxystrobin·phoxim suspension concentrate

[0071] Flupyroxystrobin 1g, phoxim 1g, sodium dodecyl sulfate salt 0.5g, calcium alkylsulfonate 0.5g, potassium polycarboxylate 0.5g, naphthalene sulfonate formaldehyde condensate sodium salt 0.5g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, diethylene glycol ester 0.2g, ethylene glycol 4g, ethyl acrylate 6g, roe fish powder 5g, water to 100%.

[0072] Preparation Example 6: 14% Flupyroxystrobin·Pirimiphos-methyl wettable powder

[0073] Flupyroxystrobin 12g, Pirimiphos-methyl 2g, sodium dodecyl sulfate 2g, calcium lignin sulfonate 6g, brown sugar 10g, white carbon black 10g, vinyl acetate 6g, diatomite to 100%.

[0074] Preparation Example 7: 22% Flupyroxystrobin·Pirimiphos-methyl water dispersible granule

[0075] Flupyroxystrobin 20g, Pirimiphos-methyl 2g, sodium dodecyl sulfate 3g, Laka powder BX 2g, naphthalene sulfonate formaldehyde condensate sodium salt 5g, N-methyl acetamide 10g, sodium sulfate 5g, sodium bicarbonate 5g, polyvinylpyrrolidone 0.5g, dextrin 0.5g, tetramethylpiperidamine 7g, white carbon black 6g, kaolin to 100%.

[0076] Preparation Example 8: 12% Flupyroxystrobin·Pirimiphos-methyl suspension concentrate

[0077] Flupyroxystrobin 10g, Pirimiphos-methyl 2g, calcium alkyl sulfonate 2g, sodium dodecyl sulfate 1g, potassium polycarboxylate 4g, calcium lignin sulfonate 6g, potassium sorbate 0.5g, xanthan gum 0.5g, tributyl phosphate 0.3g, glycerol 3g, sodium alginate propylene glycol ester 7g, maltose 15g, water to 100%.

[0078] Preparation Example 9: 15% Flupyroxystrobin·Pirimiphos-methyl suspension concentrate

[0079] Flupyroxystrobin 15g, Pirimiphos-methyl 5g, sodium dodecyl sulfate 3g, fatty acid polyoxyethylene ester 1.5g, potassium polycarboxylate 4g, naphthalene sulfonate formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, magnesium aluminum silicate 0.7g, xanthan gum 0.3g, tributyl phosphate 0.2g, dipalmitoyl ethylenediamine 0.1g, ethylene glycol 4g, methyl ethyl sulfonate 8g, honey 6g, water to 100%.

[0080] Preparation Example 10: 18% Flupyroxystrobin·Pirimiphos-methyl wettable powder

[0081] Flupyroxystrobin 6g, Phoxim 12g, Naphthalene sulfonate formaldehyde condensate sodium salt 5g, Alkylphenol polyoxyethylene ether formaldehyde condensate sodium sulfate 2g, Naphthalene sulfonate sodium salt 2g, Sodium dodecyl sulfate 1g, Fatty acid dimethyl disulfide ester 5g, Attapulgite 10g, N-acylated alkylol amine 7g, Light calcium carbonate to 100%.

[0082] Preparation Example 11: 50% Flupyroxystrobin·Phoxim wettable powder

[0083] Flupyroxystrobin 25g, Phoxim 25g, Fatty alcohol polyoxyethylene ether 2g, Calcium lignin sulfonate 4g, Naphthalene sulfonate formaldehyde condensate sodium salt 4g, Phenylethyl phenol polyoxyethylene ether phosphate 2g, Dimethyl disulfide 5g, Milk flavor 10g, White carbon black 3g, Urea-formaldehyde resin 4g, Polyalkylene glycol 4g, Diatomite to 100%.

[0084] Preparation Example 12: 24% Flupyroxystrobin·Methrimorphol wettable powder

[0085] Flupyroxystrobin 16g, Methrimorphol 8g, Sodium dodecyl sulfate 0.5g, Alkylbenzene polyoxyethylene ether phosphate 0.5g, Calcium lignin sulfonate 6g, Anisaldehyde 10g, N-methyl acetamide 5g, N-acylated alkylol amine 9g, Pottery clay to 100%.

[0086] Preparation Example 13: 40% Flupyroxystrobin·Methrimorphol water dispersible granule

[0087] Flupyroxystrobin 30g, Methrimorphol 10g, Detergent LS 3g, Sodium dodecyl sulfate 2g, Naphthalene sulfonate formaldehyde condensate sodium salt 4g, Calcium lignin sulfonate 6g, Furanone 10g, Sodium carbonate 5g, Dextrin 1g, Sodium alginate propylene glycol ester 8g, Bentonite 20g, Corn starch to 100%.

[0088] Flupyroxystrobin 40g, Methrimorphol 10g, Calcium alkylsulfonate 2g, Wetting penetrant F2g, Glycerol fatty acid ester polyoxyethylene ether 1g, Potassium polycarboxylate 4g, Calcium lignin sulfonate 4g, Sodium benzoate 0.3g, Magnesium aluminum silicate 0.2g, Carboxymethyl cellulose 0.3g, Tributyl phosphate 0.1g, Propylene glycol 5g, Sodium alginate propylene glycol ester 9g, Milk flavor 5g, Water to 100%.

[0089] Preparation Example 15: 16% compound · milbemectin water dispersible granules

[0090] Flupyroxystrobin 8g, milbemectin 8g, sodium salt of dodecyl sulfate 3g, naphthalene sulfonic acid formaldehyde condensate sodium salt 4g, calcium salt of lignin sulfonic acid 5g, anisaldehyde 10g, sodium sulfate 8g, sodium bicarbonate 2g, polyvinylpyrrolidone 0.3g, sodium alginate 0.5g, sodium alginate propylene glycol ester 9g, clay 10g, kaolin to 100%.

[0091] Preparation Example 16: 12% flupyroxystrobin · milbemectin suspension concentrate

[0092] Flupyroxystrobin 4g, milbemectin 8g, sodium salt of dodecyl sulfate 2g, alkyl benzene polyvinyl ether phosphate 2g, fatty amine polyoxyethylene ether 3g, potassium salt of polycarboxylic acid 4g, naphthalene sulfonic acid formaldehyde condensate sodium salt 3g, potassium sorbate 0.4g, hydroxyethyl cellulose 0.3g, xanthan gum 0.2g, polydimethylsiloxane 0.3g, propylene glycol 4g, tetramethylpiperidine amine 5g, sodium alginate propylene glycol ester 5g, honey 5g, water to 100%.

[0093] Preparation Example 17: 30% flupyroxystrobin · milbemectin wettable powder

[0094] Flupyroxystrobin 15g, milbemectin 15g, naphthalene sulfonic acid formaldehyde condensate sodium salt 6g, calcium salt of lignin sulfonic acid 2g, detergent LS 3g, sodium salt of dodecyl sulfate 1g, N-methyl acetamide 12g, tetramethylpiperidine amine 5g, sodium alginate propylene glycol ester 5g, clay to 100%.

[0095] Preparation Example 18: 12% flupyroxystrobin · sumithrin wettable powder

[0096] Flupyroxystrobin 8g, sumithrin 4g, sodium salt of dodecyl sulfate 2g, detergent LS 1g, naphthalene sulfonic acid formaldehyde condensate sodium salt 5g, calcium salt of lignin sulfonic acid 5g, N-methyl acetamide 8g, furanone 7g, tetramethylpiperidine amine 5g, clay to 100%.

[0097] Preparation Example 19: 30% flupyroxystrobin · sumithrin water dispersible granules

[0098] Flupyroxystrobin 25 g, phenthoate 5 g, benzyl alcohol polyoxyethylene ether 2 g, sodium dodecyl sulfate 3 g, naphthalene sulfonate formaldehyde condensate sodium salt 3 g, calcium lignin sulfonate 5 g, dimethyl disulfide 8 g, sodium sulfate 3 g, sodium alginate 0.5 g, tetramethyl piperidinamine 5 g, sodium alginate propylene glycol ester 5 g, kaolin to 100%.

[0099] Preparation Example 20: 2% Flupyroxystrobin·milbemectin wettable powder

[0100] Flupyroxystrobin 1 g, milbemectin 1 g, naphthalene sulfonate formaldehyde condensate sodium salt 6 g, calcium lignin sulfonate 2 g, detergent LS 3 g, sodium dodecyl sulfate 1 g, N-methyl acetamide 12 g, sodium alginate propylene glycol ester 4 g, tetramethyl piperidinamine 4 g, clay to 100%.

[0101] Preparation Example 21: 16% Flupyroxystrobin·phenthoate suspension

[0102] Flupyroxystrobin 8 g, phenthoate 8 g, wetting penetrant F 4 g, fatty alcohol polyoxyethylene ether 1 g, potassium polycarboxylate 4 g, calcium lignin sulfonate 4 g, sodium benzoate 0.5 g, methyl cellulose 0.5 g, polydimethylsiloxane 0.3 g, urea 4 g, sodium alginate propylene glycol ester 5 g, N-methyl acetamide 5 g, water to 100%.

[0103] Preparation Example 22: 45% Flupyroxystrobin·phenthoate water dispersible granules

[0104] Flupyroxystrobin 30 g, phenthoate 15 g, detergent LS 3 g, sodium dodecyl sulfate 1 g, naphthalene sulfonate formaldehyde condensate sodium salt 3 g, calcium lignin sulfonate 6 g, dimethyl disulfide 5 g, sodium sulfate 5 g, polyvinylpyrrolidone 0.1 g, sodium alginate propylene glycol ester 5 g, kaolin to 100%.

[0105] Preparation Example 23: 18% Flupyroxystrobin·phenthoate suspension

[0106] Flupyroxystrobin 6 g, phenthoate 12 g, sodium dodecyl sulfate 2 g, potassium polycarboxylate 4 g, naphthalene sulfonate formaldehyde condensate sodium salt 2 g, potassium sorbate 0.5 g, magnesium aluminum silicate 1.2 g, xanthan gum 0.3 g, diethylene glycol ester 0.3 g, propylene glycol 5 g, sodium alginate propylene glycol ester 5 g, n-acylated alkyl alcohol amine 5 g, milk flavor 5 g, water to 100%.

[0107] Preparation Example 24: 2% Flupyroxystrobin·Fenthion Water Dispersible Granules

[0108] Flupyroxystrobin 1 g, Fenthion 1 g, sodium dodecyl sulfate 2 g, Laka powder BX 3 g, naphthalene sulfonate formaldehyde condensate sodium salt 5 g, N-methyl acetamide 5 g, sodium sulfate 1 g, sodium bicarbonate 2 g, polyvinylpyrrolidone 0.5 g, dextrin 0.5 g, n-acylated alkylol amine 5 g, tetramethylpiperidine amine 5 g, white carbon black 6 g, kaolin to 100%.

[0109] Preparation Example 25: 5% Flupyroxystrobin·Fenthion Suspension Concentrate

[0110] Flupyroxystrobin 4 g, Fenthion 1 g, sodium dodecyl sulfate salt 3 g, alkylphenol polyoxyethylene ether 1.5 g, potassium polycarboxylate 4 g, naphthalene sulfonate formaldehyde condensate sodium salt 3 g, potassium sorbate 0.4 g, magnesium aluminum silicate 0.7 g, xanthan gum 0.3 g, diethylene glycol ester 0.2 g, ethylene glycol 2 g, propylene glycol 3 g, sodium alginate propylene glycol 5 g, roe fish powder 6 g, water to 100%.

[0111] Application Example Two: Indoor efficacy test for controlling mosquitoes and flies

[0112] Test target: Culex pipiens pallens (local resistant mosquito species in Yangzhou), unfed female adults at 3-5 days after emergence;

[0113] Musca domestica (local resistant housefly in Yangzhou), adults at 3-4 days after emergence, half male and half female;

[0114] Test method: Refer to GB / T 13917.1-2009, forced contact method;

[0115] Test surface: glass plate, varnished wood plate, gypsum board;

[0116] Dose setting: The total concentration of active ingredients in the preparation example is diluted to 200 mg / L (the actual use is generally 400 mg / L);

[0117] Control sample 1: 50% Fenthion EC (Jiangsu Gongcheng Biological Technology Co., Ltd.) diluted to 200 mg / L;

[0118] Control sample 2: 500 g / L Pirimiphos-methyl EC (Syngenta (UK) Limited) diluted to 200 mg / L;

[0119] Test results:

[0120] Table 4 Efficacy test of preparation examples against mosquitoes and flies (glass plate)

[0121]

[0122]

[0123] Table 5 Formulation Examples for efficacy test against mosquito, fly (varnish wood board)

[0124]

[0125] Table 6 Formulation Examples for efficacy test against mosquito, fly (gypsum board)

[0126]

[0127] The test results show that the dosage is reduced by half, and on the glass surface, the difference in efficacy between the formulations can be clearly seen. The efficacy of Formulation Examples 1, 4, 8, 11, 14, 17, and 20 is better than that of Control Sample 1 and Control Sample 2 (see Table 4);

[0128] On semi-absorbing varnish wood boards and absorbing gypsum boards, the efficacy of the formulation examples decreased, mainly due to the absorption of some of the agents by the material, resulting in fewer surface agents. However, from the efficacy data, the formulation examples have good persistence, with a 30-day efficacy mortality rate of more than 75% on varnish surfaces and more than 60% on gypsum surfaces, which is better than that of Control Sample 1 and Control Sample 2 (see Tables 5 and 6).

[0129] Application Example Three: Efficacy determination of food attractants in formulation examples

[0130] Test target: housefly (Yanzhou local resistant housefly), 3rd to 4th day after emergence, half male and half female;

[0131] Test method: use a 1.2m*1.2m*1.2m glass square box, dilute the agent, soak a 20cm*20cm filter paper, dry it and lay it flat in the glass square box, put 30 houseflies in it, observe the longest stay time of houseflies on the surface of the filter paper and the contact frequency;

[0132] Test agent: Formulation Example 10, Formulation Example 10 (without milk fragrance), Formulation Example 20, Formulation Example 20 (without N-methyl acetamide);

[0133] Dose setting: total concentration of active ingredients is diluted to 200mg / L (actual use is generally 400mg / L);

[0134] Table 7 Effect of food attractants on the efficacy of houseflies

[0135]

[0136] The test results show that the addition of milk flavor in preparation example 11 improves the frequency of housefly contacting the pesticide, and the efficacy is relatively better; the addition of N-methylacetamide in preparation example 20 improves the residence time of housefly on the filter paper surface, increases the licking frequency of housefly, and causes housefly to ingest more pesticide, so the final efficacy performance is better (see Table 7).

[0137] Application Example Four: Efficacy Comparison Test of Fly Control

[0138] Test target: housefly

[0139] Test method: select the wall of the breeding farm building as the test object and divide it into zones, spray the pesticide on the surface of the wall, and record the fly density reduction rate after 1 day, 2 days and 3 days of each treatment group; the area of the room in the breeding farm is about 50 m2, and the area of each wall is about 20 m2.

[0140] Test treatment: dilute preparation examples 2, 9, 17 and 24 by 100 times, and spray them on the four corners of the wall and the ground when applying the pesticide, covering 40% of the total area, with a dosage of 20 mg of active ingredient / m2;

[0141] Control sample 3: according to the preparation example 2 formula, remove the food attractant component, dilute by 100 times, and the dosage is 20 mg of active ingredient / m2;

[0142] Control sample 4: according to the preparation example 9 formula, remove the food attractant component, dilute by 100 times, and the dosage is 20 mg of active ingredient / m2;

[0143] Control sample 5: according to the preparation example 17 formula, remove the food attractant component, dilute by 100 times, and the dosage is 20 mg of active ingredient / m2;

[0144] Control sample 6: according to the preparation example 24 formula, remove the food attractant component, dilute by 100 times, and the dosage is 20 mg of active ingredient / m2;

[0145] Control samples 3, 4, 5 and 6 are sprayed on the overall surface of the wall and the ground;

[0146] Table 8: Application treatment of preparation examples 2, 9, 17 and 24

[0147] Treatment Application site Application method Formulation Example 2 Wall corners, 20% of area Residual spray Formulation Example 9 Wall corners, 40% of area Residual spray Formulation Example 17 Wall corners, 20% of area Residual spray Formulation Example 24 Wall corners, 40% of area Residual spray Control 1 Whole wall, full application Residual spray Control 2 Whole wall, full application Residual spray Control 3 Whole wall, full application Residual spray Control 4 Whole wall, full application Residual spray

[0148] Test results:

[0149] Table 9: Efficacy comparison test of preparation examples 2, 9, 17 and 24 on flies

[0150] Treatment 1 d density reduction 2 d density reduction 3 d density reduction Formulation Example 2 67.1％ 85.6％ 95.7％ Formulation Example 9 66.3％ 89.7％ 96.8％ Formulation Example 17 63.9％ 89.3％ 94.2％ Formulation Example 24 65.6％ 90.2％ 98.7％ Control 1 58.5％ 79.4％ 86.5％ Control 2 53.5％ 79.9％ 83.3％ Control 3 52.5％ 78.3％ 85.8％ Control 4 56.3％ 80.1％ 86.2％

[0151] Results shown in Table 9, the application by adding the bait component, strong attraction, the conventional passive control to active attraction, the application area is 20% and 40% of the conventional application, application location selection wall corners, preparation examples 2, 9, 17, 24 on the fly control effect is obvious, 1d density decline rate more than 80%, 3d density decline rate more than 94%, all better than the control sample 3, 4, 5, 6. Preparation examples 2, 9, 17, 24 added the attraction component, through the fly to the attraction component of the contact liquid after the gathering is killed; it can be seen that the effect of Flupyroxystrobin and organophosphorus insecticide compound for controlling flies by adding the bait component is better than that of Flupyroxystrobin and organophosphorus insecticide compound without adding the bait component, and the dosage is less than that of the composition without adding the bait component.

[0152] The above examples are only for illustrating the technical concept and technical features of the present application, and cannot limit the protection scope of the present application. Any equivalent transformation or modification according to the essence of the present application should be covered in the protection scope of the present application.

Claims

1. A hygienic pesticidal complex composition characterized in that: The composition is a mixture of component A and component B in a mass ratio of 20:1 to 1:10, wherein component A is a methoxy acrylate compound shown in formula I, and component B is bisultap or fenthion; Formula I.

2. Use of the hygienic insecticidal complex composition according to claim 1, characterized in that: Application of the hygienic insecticidal compound composition in preventing and treating hygienic pests.

3. Use of a hygienic insecticidal complex composition according to claim 2, characterized in that: The composition is suitable for corresponding areas by local application, and the hygienic pests are one or more of Musca domestica, Muscina stabulans, Chrysomya megacephala, Lucilia silvarum, Lucilia cuprina, Calliphora luctuosa, Fannia scalaris, Fannia canicularis, Calliphora erythrocephala and Phorbia antiqua.

4. A sanitary insecticidal complex formulation, characterized by: The preparation is an active ingredient and an auxiliary material, wherein the active ingredient is the composition of claim 1, and the active ingredient accounts for 2% to 50% of the total weight of the preparation.

5. The bio-pesticidal formulation as claimed in claim 4, wherein: The auxiliary material is one or more of dispersants, wetting agents, antifoaming agents, antifreezing agents, preservatives, disintegrants, thickening agents, binding agents, pheromones, stabilizers, fillers, and water.

6. The hygiene insecticidal complex formulation according to claim 4 or 5, characterized in that: The preparation is in the form of wettable powder, water dispersible granules, or suspension.

7. The bio-pesticidal formulation as claimed in claim 5, wherein: The pheromone is one or more of anisic aldehyde, N-methyl acetamide, furanone, dimethyl disulfide, brown sugar, fatty acid dimethyl disulfide ester, tilapia powder, maltose, honey, and milk essence.

8. The bio-pesticidal formulation as claimed in claim 5, wherein: The stabilizer is one or more of urea-formaldehyde resin, polyalkylene glycol, polyacrylic acid, ethylene oxide-propylene oxide block polyether, vinyl acetate, ethyl acrylate, tetramethylpiperidinamine, sodium alginate propylene glycol ester, methyl ethyl sulfonate, and n-acylated alkyl alcohol amine.

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