Veterinary traditional Chinese medicine granular preparation and preparation method thereof

Abstract

The invention discloses a veterinary traditional Chinese medicine granular preparation and a preparation method thereof, and the traditional Chinese medicine granular preparation comprises, by weight, 10-15 parts of artemisia apiacea, 10-20 parts of mung bean extract, 10-15 parts of honeysuckle, 15-20 parts of houttuynia cordata, 15-20 parts of red peony root, 15-20 parts of madder extract and the balance auxiliary materials. The components of the formula supplement each other, have a synergistic effect, are good in antipyretic curative effect and few in side effects, can treat and relieve fever symptoms of animal bodies, and are proved by tests to have the characteristics of remarkable functions, safety, no toxicity, good stability, high bioavailability and the like. The traditional Chinese medicine can treat animal high fever and relieve summer-heat, and has definite curative effect and small side effect.

Description

Technical Field

[0001] The present invention relates to a veterinary traditional Chinese medicine granule preparation and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background Art

[0002] While the poultry industry is developing towards intensification and large-scale operation, various infectious diseases often prevail. Among them, viral infectious diseases are a kind of diseases that develop rapidly and are difficult to cure, accounting for 1 / 4 of poultry diseases and causing huge economic losses every year. Currently, the phenomenon of adding chemical drugs or antibiotics to livestock and poultry feed is extremely common. The abuse of drugs and unreasonable compatibility also increase the risks of livestock and poultry breeding day by day, resulting in immunosuppression, reproductive disorders, and low birth survival rates. At the same time, due to long-term use and increasing dosage, the virus even mutates and infects humans, posing a serious threat to human life. The effect of western medicine is very limited and drug residues have been caused.

[0003] Artemisia annua is bitter, pungent, and cold in nature. It is recorded in "Shennong Ben Cao Jing" that Artemisia annua has the effects of clearing deficiency heat, cooling blood, relieving summer heat, and treating malaria. At the same time, it also has the effects of antiviral, anti-malaria parasite, cholagogic, antipyretic, analgesic, anti-inflammatory, anti-tumor, blood pressure lowering, and anti-arrhythmia. However, it is contraindicated for those with weak spleen and stomach and loose stools.

[0004] Rubia cordifolia, also known as Qiancao, Xuejianchou, Disumu, Huoxuedan, Tudanshen, Hongneixiao, etc. Rubia cordifolia is one of the earliest red dyes used by humans and has been recorded in ancient literature. It is a perennial climbing herb, growing on hillside roadsides, ditch edges, fieldsides, thickets, and forest edges, and is dug in spring and autumn. It has the effects of cooling blood to stop bleeding and promoting blood circulation to remove blood stasis. It is mainly used to treat symptoms such as hematemesis due to blood heat, abdominal pain due to postpartum blood stasis, traumatic injury, and rheumatic arthralgia. Many medical works such as "Ben Cao Hui Yan" and "Fujian Pharmacopoeia" record that Rubia cordifolia is cold in nature and bitter in taste, has the effects of cooling blood and removing stasis, stopping bleeding and dredging meridians, and is mainly used to treat bleeding syndromes caused by blood heat running amok, blood stasis amenorrhea, traumatic injury, and rheumatic arthralgia.

[0005] Mung bean is the seed of the leguminous plant Vigna radiata, also known as Qingxiaodou, Lvdou, Zhidou, etc., and has a cultivation history of more than two thousand years in China. Mung bean has pharmacological effects such as reducing blood lipid, cholesterol, anti-allergy, antibacterial, anti-tumor, enhancing appetite, protecting the liver and kidneys. Mung bean contains a kind of globulin and polysaccharide, which can promote the decomposition of cholesterol in the liver of animals into cholalic acid, accelerate the secretion of bile salts in bile, and reduce the absorption of cholesterol in the small intestine. The active ingredients of mung bean have anti-allergy effects and can assist in the treatment of allergic reactions such as urticaria. Mung bean has an inhibitory effect on Staphylococcus aureus. The protein and phospholipids contained in mung bean can both excite the nerves and enhance appetite. Mung bean contains rich trypsin inhibitors, which can protect the liver, reduce protein decomposition, reduce azotemia, and thus protect the kidneys.

[0006] At present, chemical drugs are mostly used to treat animal fever in clinical practice. However, long-term use of chemical drugs can easily make animals develop drug resistance, and if the dosage is continuously increased, chemical drugs are likely to accumulate in the animal's body, threatening human health. Traditional Chinese medicine preparations do not have these adverse effects. The application of traditional Chinese medicine has been recognized by veterinary clinics, and the use of traditional Chinese medicine preparations in the prevention and treatment of animal diseases has become a trend in the animal husbandry industry.

[0007] Patent CN104474007A discloses a kind of veterinary antipyretic artemisia annua licorice granules and soluble powder preparation and its preparation method. The prepared artemisia annua licorice preparation is used for summer heat fever, yin deficiency fever, night heat and morning coolness, bone steaming and fatigue fever, malaria cold and heat, damp heat jaundice, and infection caused by erythrocytes in livestock and poultry and aquaculture animals. It has the characteristics of significant function, safety and non-toxicity, good stability, high bioavailability, etc.

[0008] The present invention is proposed in view of the above problems. Summary of the invention

[0009] In view of the shortcomings of the prior art, the first object of the present invention is to provide a veterinary Chinese medicine granule preparation.

[0010] The second object of the present invention is to provide a preparation method comprising the above-mentioned preparation.

[0011] In order to achieve the first purpose, the present invention is implemented through the following technical scheme: a veterinary Chinese medicine granule preparation, which comprises 10-15 weight parts of Artemisia annua, 10-20 weight parts of mung bean extract, 10-15 weight parts of honeysuckle, 15-20 weight parts of Houttuynia cordata, 15-20 weight parts of red peony root, 15-20 weight parts of madder extract and the remainder of auxiliary materials based on 100 weight parts.

[0012] By adopting the above technical scheme, the formula components complement each other, have synergistic effects, have good antipyretic effects, have few side effects, and treat and relieve fever symptoms in animals. Tests have shown that it has the characteristics of significant functions, safety and non-toxicity, good stability, and high bioavailability. It can treat high fever and relieve summer heat in animals with definite effects and few side effects.

[0013] Preferably, the auxiliary materials consist of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose.

[0014] Preferably, the mass ratio of the citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 2-3:3-5:4-6:1.

[0015] Preferably, the extraction method of the Rubia cordifolia extract comprises the following steps:

[0016] S1: crushing madder, adjusting the water content, placing in a screw extruder for extrusion spray treatment, and obtaining extruded madder;

[0017] S2: Place the squeezed madder in distilled water, cook for 1-5 hours, collect filtrate A by filtration, add distilled water to the residue and continue cooking for 1-5 hours, collect filtrate B by filtration;

[0018] S3: Combine filtrate A and filtrate B, rotary evaporate until the filtrate is 20-50 ml, and dry to obtain Rubia cordifolia extract.

[0019] Preferably, in step S1, the particle size of madder is 50-100 mesh, the water content thereof is adjusted to 10%-30%, and the extrusion spraying conditions are an extrusion temperature of 150-180° C. and an extrusion speed of 150-200 r / min.

[0020] Preferably, in step S2, citric acid is used to adjust the pH to 5.0-5.5 before each cooking.

[0021] Preferably, the extraction method of mung bean extract comprises the following steps: crushing mung beans to 100-150 mesh, adding 10-15 times of distilled water by weight, boiling at 40-50°C for 2-5h, filtering, washing the filter residue, combining the filtrate, concentrating under reduced pressure to 20-50ml, adding 4-6 times of ethanol solution, standing overnight, filtering, taking the filtrate, concentrating, and drying to obtain the mung bean extract.

[0022] In order to achieve the second object, the present invention is implemented by the following technical scheme: a method for preparing a veterinary Chinese medicine granule preparation, comprising the following steps:

[0023] Step 1: Weigh Artemisia annua, honeysuckle, houttuynia cordata, and red peony root respectively, crush them, put them in an extraction tank, and add 10-15 times the amount of distilled water, vacuum extract at low temperature for 2-5 hours, filter, take the filtrate, and continue to concentrate to half the volume of the filtrate to obtain a thick paste;

[0024] Step 2: Add auxiliary materials to the thick paste, stir for 0.5-1h, mix and granulate with a boiling drying granulator, and dry.

[0025] Preferably, the relative density of the thick paste is 1.25-1.30.

[0026] Preferably, the particle size after granulation is 30-50 mesh.

[0027] Beneficial effects of the present invention:

[0028] The formula components of the present application complement each other, have synergistic effects, have good antipyretic effects, have few side effects, treat and relieve fever symptoms in animals, and tests have shown that it has significant functions, is safe and non-toxic, has good stability, and has high bioavailability. It can treat high fever and relieve summer heat in animals with definite effects and few side effects. DETAILED DESCRIPTION

[0029] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further explained below in conjunction with specific implementation methods.

[0030] Example 1

[0031] A veterinary Chinese medicine granule preparation comprises 10kg of Artemisia annua, 10kg of mung bean extract, 15kg of honeysuckle, 20kg of houttuynia cordata, 20kg of red peony root, 15kg of madder extract and 10kg of auxiliary materials.

[0032] In this embodiment, the auxiliary materials are composed of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 2:3:6:1.

[0033] In this embodiment, the extraction method of Rubia cordifolia extract comprises the following steps:

[0034] S1: crushing madder to 50 mesh, adjusting the water content to 15%, placing in a screw extruder for extrusion spray treatment, wherein the extrusion spray conditions are an extrusion temperature of 150° C. and an extrusion speed of 200 r / min to obtain extruded madder;

[0035] S2: Place the squeezed madder in distilled water, adjust the pH to 5.0 with citric acid, cook for 2 hours, filter and collect filtrate A, add distilled water to the residue, adjust the pH to 5.0 with citric acid, continue to cook for 5 hours, and filter and collect filtrate B;

[0036] S3: Combine filtrate A and filtrate B, rotary evaporate until the filtrate is 20 ml, and dry to obtain Rubia cordifolia extract.

[0037] In this embodiment, the extraction method of mung bean extract includes the following steps: crushing mung beans into 150 mesh, adding 10 times distilled water by weight, boiling at 50°C for 5 hours, filtering, washing the filter residue, combining the filtrate, concentrating under reduced pressure to 20 ml, adding 6 times ethanol solution, standing overnight, filtering, taking the filtrate, concentrating, and drying to obtain mung bean extract.

[0038] A method for preparing a veterinary Chinese medicine granule preparation comprises the following steps:

[0039] Step 1: Weigh Artemisia annua, honeysuckle, houttuynia cordata, and red peony root respectively, crush to 50 mesh, place in an extraction tank, and add 10 times the amount of distilled water, vacuum extract at low temperature for 5 hours, filter, take the filtrate, and continue to concentrate to half the volume of the filtrate to obtain a thick paste, the relative density of the thick paste is 1.25;

[0040] Step 2: Add auxiliary materials to the thick paste, stir for 1 hour, mix and granulate using a boiling drying granulator, and dry to a particle size of 30 mesh.

[0041] Example 2

[0042] A veterinary Chinese medicine granule preparation comprises 15kg of Artemisia annua, 15kg of mung bean extract, 10kg of honeysuckle, 16kg of houttuynia cordata, 15kg of red peony root, 20kg of madder extract and 9kg of auxiliary materials.

[0043] In this embodiment, the auxiliary materials are composed of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 3:3:5:1.

[0044] In this embodiment, the extraction method of Rubia cordifolia extract comprises the following steps:

[0045] S1: crushing madder to 100 mesh, adjusting the water content to 25%, placing in a screw extruder for extrusion spray treatment, wherein the extrusion spray conditions are an extrusion temperature of 150° C. and an extrusion speed of 150 r / min to obtain extruded madder;

[0046] S2: Place the squeezed madder in distilled water, adjust the pH to 5.5 with citric acid, boil for 1 hour, filter and collect filtrate A, add distilled water to the residue, adjust the pH to 5.0 with citric acid, continue to boil for 1 hour, and filter and collect filtrate B;

[0047] S3: Combine filtrate A and filtrate B, rotary evaporate until the filtrate is 30 ml, and dry to obtain Rubia cordifolia extract.

[0048] In this embodiment, the extraction method of mung bean extract includes the following steps: crushing mung beans into 100 mesh, adding 15 times of distilled water by weight, boiling at 40°C for 3 hours, filtering, washing the filter residue, combining the filtrate, concentrating under reduced pressure to 30 ml, adding 4 times of ethanol solution, standing overnight, filtering, taking the filtrate, concentrating, and drying to obtain mung bean extract.

[0049] A method for preparing a veterinary Chinese medicine granule preparation comprises the following steps:

[0050] Step 1: Weigh Artemisia annua, honeysuckle, houttuynia cordata, and red peony root respectively, crush to 100 mesh, place in an extraction tank, and add 10 times the amount of distilled water, vacuum extract at low temperature for 3 hours, filter, take the filtrate, and continue to concentrate to half the volume of the filtrate to obtain a thick paste, the relative density of the thick paste is 1.30;

[0051] Step 2: Add auxiliary materials to the thick paste, stir for 0.5h, mix and granulate using a boiling drying granulator, and dry to a particle size of 40 mesh.

[0052] Example 3

[0053] A veterinary Chinese medicine granule preparation comprises 12kg of Artemisia annua, 15kg of mung bean extract, 12kg of honeysuckle, 20kg of houttuynia cordata, 16kg of red peony root, 20kg of madder extract and 5kg of auxiliary materials.

[0054] In this embodiment, the auxiliary materials are composed of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 3:5:4:1.

[0055] In this embodiment, the extraction method of Rubia cordifolia extract is the same as that of Example 1.

[0056] In this embodiment, the extraction method of mung bean extract includes the following steps: crushing mung beans into 100 mesh, adding 15 times of distilled water by weight, boiling at 40°C for 2h, filtering, washing the filter residue, combining the filtrate, concentrating under reduced pressure to 50ml, adding 4 times of ethanol solution, standing overnight, filtering, taking the filtrate, concentrating, and drying to obtain mung bean extract.

[0057] A method for preparing a veterinary Chinese medicine granule preparation comprises the following steps:

[0058] Step 1: Weigh Artemisia annua, honeysuckle, houttuynia cordata, and red peony root respectively, crush to 100 mesh, place in an extraction tank, and add 10 times the amount of distilled water, vacuum extract at low temperature for 2 hours, filter, take the filtrate, and continue to concentrate to half the volume of the filtrate to obtain a thick paste, the relative density of the thick paste is 1.30;

[0059] Step 2: Add auxiliary materials to the thick paste, stir for 1 hour, mix and granulate using a boiling drying granulator, and dry to a particle size of 50 mesh.

[0060] Example 4

[0061] A veterinary Chinese medicine granule preparation comprises 13kg of Artemisia annua, 20kg of mung bean extract, 15kg of honeysuckle, 15kg of houttuynia cordata, 18kg of red peony root, 16kg of madder extract and 3kg of auxiliary materials.

[0062] In this embodiment, the auxiliary materials are composed of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 2:3:4:1.

[0063] In this embodiment, the extraction method of Rubia cordifolia extract is the same as that of Example 1.

[0064] In this embodiment, the extraction method of mung bean extract is the same as that in Example 1.

[0065] The preparation method of a veterinary Chinese medicine granule preparation is the same as that of Example 1.

[0066] Example 5

[0067] A veterinary Chinese medicine granule preparation comprises 15kg of Artemisia annua, 15kg of mung bean extract, 14kg of honeysuckle, 18kg of houttuynia cordata, 15kg of red peony root, 18kg of madder extract and 5kg of auxiliary materials.

[0068] In this embodiment, the auxiliary materials are composed of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 3:3:6:1.

[0069] In this embodiment, the extraction method of Rubia cordifolia extract comprises the following steps:

[0070] S1: crushing madder to 100 mesh, adjusting the water content to 30%, placing in a screw extruder for extrusion spray treatment, wherein the extrusion spray conditions are an extrusion temperature of 180° C. and an extrusion speed of 150 r / min to obtain extruded madder;

[0071] S2: Place the squeezed madder in distilled water, adjust the pH to 5.5 with citric acid, cook for 5 hours, filter and collect filtrate A, add distilled water to the residue, adjust the pH to 5.0 with citric acid, continue to cook for 5 hours, and filter and collect filtrate B;

[0072] S3: Combine filtrate A and filtrate B, evaporate to 50 ml of filtrate, and dry to obtain Rubia cordifolia extract.

[0073] In this embodiment, the extraction method of mung bean extract is the same as that in Example 1.

[0074] The preparation method of a veterinary Chinese medicine granule preparation is the same as that of Example 1.

[0075] Example 6

[0076] A veterinary Chinese medicine granule preparation comprises 10kg of Artemisia annua, 10kg of mung bean extract, 20kg of honeysuckle, 15kg of houttuynia cordata, 20kg of red peony root, 20kg of madder extract and 5kg of auxiliary materials.

[0077] In this embodiment, the auxiliary materials are composed of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose, and the mass ratio of citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 3:4:4:1.

[0078] In this embodiment, the extraction method of Rubia cordifolia extract is the same as that of Example 1.

[0079] In this embodiment, the extraction method of mung bean extract is the same as that in Example 1.

[0080] The preparation method of a veterinary Chinese medicine granule preparation is the same as that of Example 1.

[0081] Test Example 1 Product Stability

[0082] The stability of the product of the present invention was investigated according to the accelerated test and long-term stability test operation methods of the Veterinary Drug Stability Test Guidelines of the 2010 Edition of the Veterinary Pharmacopoeia of the People's Republic of China. See Table 1 and Table 2 for details.

[0083] Table 1 Accelerated test results of products obtained from Examples 1 to 6

[0084]

[0085] Table 2 Long-term stability test results of products obtained from Examples 1 to 6

[0086]

[0087]

[0088] Combining Table 1 and Table 2, through accelerated tests and long-term tests, the product prepared by the present invention does not change in appearance characteristics within a specified time under specific inspection conditions.

[0089] Test Example 2 Efficacy Test

[0090] Thirty pyrogenic rats were selected and randomly divided into three groups, with 10 rats in each group, which were recorded as a test group, a control group and a blank group. The test group was fed with the product prepared in Example 1 at 5 g / kg body weight, the control group was fed with aspirin at 100 mg / kg body weight, and the blank group was fed with normal saline at 5 g / kg body weight. After the dry yeast was injected, the body temperature of the rats showed the same trend of change, and each group showed a decrease first and then an increase. There was no significant difference in body temperature among the groups 6 hours after pyrogenicity; 3 hours before administration, the antipyretic effect of the product of the present invention was equivalent to that of the control group; 3 hours after administration, the antipyretic effect of the product of the present invention was stronger than that of the control group.

[0091] Test Example 3: Efficacy Test

[0092] 120 qualified piglets were selected and randomly divided into 6 groups, which were recorded as the low-dose group of Example 1, the medium-dose group of Example 1, the high-dose group of Example 1, the analgin control group, the positive control group and the blank control group, with 20 in each group, and each group (except the blank control group) established a fever model by the method of LPS intraperitoneal injection. According to the fever model established, drug treatment was carried out after the body temperature rose steadily. The dosage of the low-dose group, the medium-dose group and the high-dose group of the product of the present invention was respectively gavaged with 0.25g / kg, 0.5g / kg, and 1.0g / kg body weight, once a day, for 3 days. The positive control group and the blank control group were gavaged with 1mL / kg of normal saline by body weight. The treatment results are shown in Table 3.

[0093] Table 3 Efficacy results

[0094] Group invalid efficient Significant effect cure Blank control group — — — — Positive control group — — — — Analgin Group 0 3 6 11 Example 1 Low dose group 0 2 6 12 Example 1 Dose Group 0 2 2 16 Example 1 High dose group 0 1 1 18

[0095] in:

[0096] Cure: After medication, clinical symptoms completely disappear and mental state and appetite return to normal, which is considered cured. The number of cures is counted to calculate the cure rate.

[0097] Marked effect: The patients with clinical symptoms significantly alleviated and mental state and appetite improved after medication treatment are considered to have markedly improved. The number of markedly effective patients is counted to calculate the markedly effective rate.

[0098] Effective: It is the sum of cure rate and marked efficacy;

[0099] Ineffectiveness: Those whose symptoms do not disappear or whose condition does not improve after medication treatment, as well as those who die from the disease during treatment, are considered ineffective. The number of ineffectiveness will be counted and the inefficiency will be calculated.

[0100] It can be seen from Table 3 that the low-dose, medium-dose and high-dose groups of the product of the present invention all have obvious antipyretic effects on febrile pigs.

[0101] Experimental Example 4 Effect of the Extraction Process of Rubia cordifolia Extract on Product Efficacy

[0102] Test groups: Example 1 and comparative group 1, in which the madder in comparative group 1 was not subjected to extrusion spraying treatment during the extraction process. Others were the same as in Example 1.

[0103] Test method: Same as Test Example 3.

[0104] Test results: See Table 4 for details.

[0105] Table 4 Efficacy results

[0106] Group invalid efficient Significant effect cure Blank control group — — — — Positive control group — — — — Analgin Group 0 3 6 11 Example 1 Low dose group 0 2 6 12 Example 1 Dose Group 0 2 2 16 Example 1 High dose group 0 1 1 18 Comparative group 1 low dose group 1 3 8 8 Comparative group 1 medium dose group 0 3 4 13 Comparative group 1 high dose group 0 2 2 16

[0107] Referring to Table 4, it can be seen that the therapeutic efficacy of the product is improved after the madder is treated with extrusion spray before extraction. This may be because after the extrusion spray treatment, the cells of the madder are broken, which is more conducive to the precipitation of effective ingredients during the extraction process, thereby improving the therapeutic efficacy of the product.

[0108] Experimental Example 5 Effect of the combination of Artemisia annua, Mung Bean Extract and Rubia cordifolia Extract on the efficacy of the product

[0109] Test groups: Example 1, test groups 1-3, test group 1 does not contain mung bean extract and madder extract, test group 2 does not contain Artemisia annua and madder extract, test group 3 does not contain Artemisia annua and mung bean extract, and the rest is the same as Example 1.

[0110] Test method: Same as Test Example 3.

[0111] Test results: See Table 5 for details.

[0112] Table 5 Efficacy results

[0113] Group invalid efficient Significant effect cure Blank control group — — — — Positive control group — — — — Analgin Group 0 3 6 11 Example 1 Low dose group 0 2 6 12 Example 1 Dose Group 0 2 2 16 Example 1 High dose group 0 1 1 18 Experimental group 1 low dose group 1 3 7 9 Experimental group 1 medium dose group 0 2 5 13 Experimental group 1 high dose group 0 2 3 15 Experimental group 2 low dose group 1 2 6 12 Experimental group 2 medium dose group 1 2 5 13 Experimental group 2 high dose group 0 1 4 15 Experimental group 3 low dose group 1 3 5 12 Experimental group 3 medium dose group 0 2 5 13 Experimental group 3 high dose group 0 1 4 15

[0114] Referring to Table 5, it can be seen that the antipyretic effect of the products prepared from Test Groups 1 to 3 on febrile pigs is weaker than that of the product prepared in Example 1, indicating that the synergistic effect between the ingredients is more conducive to the antipyretic effect.

[0115] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0116] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

Claims

1. A Chinese medicine granule preparation for veterinary use, characterized in that: Based on 100 parts by weight, the composition includes 10-15 parts by weight of Artemisia annua, 10-20 parts by weight of mung bean extract, 10-15 parts by weight of honeysuckle, 15-20 parts by weight of houttuynia cordata, 15-20 parts by weight of red peony root, 15-20 parts by weight of madder extract and the remainder of auxiliary materials.

2. A Chinese medicine granule preparation for veterinary use according to claim 1, characterized in that: The auxiliary materials consist of citric acid, maltodextrin, sucrose and hydroxypropyl cellulose.

3. A Chinese medicine granule preparation for veterinary use according to claim 2, characterized in that: The mass ratio of the citric acid, hydroxypropyl cellulose, maltodextrin and sucrose is 2-3:3-5:4-6:

1.

4. A Chinese medicine granule preparation for veterinary use as claimed in claim 3, characterized in that: The extraction method of the Rubia cordifolia extract comprises the following steps: S1: crushing madder, adjusting the water content, placing in a screw extruder for extrusion spray treatment, and obtaining extruded madder; S2: Place the squeezed madder in distilled water, cook for 1-5 hours, collect filtrate A by filtration, add distilled water to the residue and continue cooking for 1-5 hours, collect filtrate B by filtration; S3: Combine filtrate A and filtrate B, rotary evaporate until the filtrate is 20-50 ml, and dry to obtain Rubia cordifolia extract.

5. A Chinese medicine granule preparation for veterinary use according to claim 4, characterized in that: In step S1, the particle size of madder is 50-100 mesh, the water content is adjusted to 10%-30%, and the extrusion spraying conditions are extrusion temperature 150-180° C. and extrusion speed 150-200 r / min.

6. A Chinese medicine granule preparation for veterinary use according to claim 5, characterized in that: In step S2, citric acid is used to adjust the pH to 5.0-5.5 before each cooking.

7. The veterinary Chinese medicine granule preparation according to claim 4, characterized in that: The extraction method of the mung bean extract comprises the following steps: crushing the mung bean into 100-150 meshes, adding 10-15 times of distilled water by weight, boiling at 40-50°C for 2-5h, filtering, washing the filter residue, combining the filtrate, concentrating under reduced pressure to 20-50ml, adding 4-6 times of ethanol solution, standing overnight, filtering, taking the filtrate, concentrating, and drying to obtain the mung bean extract.

8. A method for preparing the veterinary Chinese medicine granule preparation according to any one of claims 1 to 7, characterized in that: The following steps are involved: Step 1: Weigh Artemisia annua, honeysuckle, houttuynia cordata, and red peony root respectively, crush them, put them in an extraction tank, and add 10-15 times the amount of distilled water, vacuum extract at low temperature for 2-5 hours, filter, take the filtrate, and continue to concentrate to half the volume of the filtrate to obtain a thick paste; Step 2: Add auxiliary materials to the thick paste, stir for 0.5-1h, mix and granulate with a boiling drying granulator, and dry.

9. The method for preparing a veterinary Chinese medicine granule preparation according to claim 8, characterized in that: The relative density of the thick paste is 1.25-1.

30.

10. The method for preparing a veterinary Chinese medicine granule preparation according to claim 9, characterized in that: The particle size after granulation is 30-50 meshes.

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