Application of GTP binding protein Septin9 as Ebola virus disease treatment target

By using the GTP-binding protein Septin9 as a therapeutic target for Ebola virus disease and using siRNA and other methods to inhibit its expression or activity, the problem of difficulty in preventing and treating Ebola virus disease in the prior art has been solved, and a significant inhibition of Ebola virus replication has been achieved.

CN119688984APending Publication Date: 2025-03-25ACADEMY OF MILITARY MEDICAL SCIENCES
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Patent Information

Application Number
CN202411886000.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-20
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The prior art is difficult to effectively prevent and treat Ebola virus disease and lacks effective therapeutic targets.

Method used

The GTP-binding protein Septin9 is used as a therapeutic target for Ebola virus disease, and the expression or activity of Septin9 is inhibited through siRNA and other methods, thereby affecting the replication of Ebola virus.

Benefits of technology

By inhibiting Septin9, significantly reducing the replication level of Ebola virus in cells provides a new strategy for treating Ebola virus disease.

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Abstract

The invention relates to the technical field of biological medicines, and particularly discloses application of a GTP binding protein Septin9 as a treatment target of Ebola virus diseases. The invention provides a new target spot for treating the Ebola virus disease, namely the GTP binding protein Septin9, research shows that after siRNA of the GTP binding protein Septin9 is used for treatment, Ebola virus replication is remarkably reduced, Ebola virus proliferation in cells is effectively inhibited, and the GTP binding protein Septin9 is expected to become a potential treatment target spot for Ebola virus infection; the application provides a new strategy for prevention and treatment of acute infectious diseases caused by Ebola virus infection, and has important application value in the aspects of drug research and development and vaccine development.
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