Method for scanning brain of animal in any posture

Abstract

The invention discloses a system for scanning the brain of an animal in any posture. The system is characterized by comprising an animal carrying box, a carrying table, a binocular camera, a PET / CT scanning system, a positioning frame and a computer. At least one surface of the animal carrying box is transparent, and the binocular camera is placed outside the transparent surface and faces the animal carrying box; the carrying platform carries the animal carrying box from below; the positioning frame is an RFS rigid tool and comprises a connecting frame and at least four small balls fixed to different positions of the connecting frame. A PET / CT image processing system and binocular positioning software are stored in the computer. The invention discloses a method for scanning the brain of an animal in any posture. The method comprises a preparation step, a scanning step, a corresponding step, a discrimination step, a coordinate adjustment step and a PET / CT image generation step.

Description

Technical Field

[0001] The invention relates to the technical field of nuclear medicine detection support, and in particular to a method for scanning the brain of an animal in any posture. Background Art

[0002] Nowadays, various medical-related work requires the use and examination of experimental animals in large quantities, which requires a large number of PET, CT and PET / CT devices suitable for experimental animals. For radiation scanning devices used for small animals, especially PET / CT, using living small animals as objects for testing is the main purpose of small animal PET / CT detection.

[0003] However, in the prior art, when scanning small animals, generally small animals will not stay still in one place, and it is basically impossible to lock them with a locking device in a waking state. Small animals will move around and will not cooperate. Therefore, they generally need to be anesthetized and placed on a box or a flat plate after anesthesia, and fixed with some specific fixing facilities, which is very cumbersome. If you want to ensure that the small animals will not wake up or move around, you often have to continue to introduce anesthetic gas. This is the only way to ensure that the small animals remain motionless during the whole process. In general, although the imaging effect can be guaranteed. However, the operation is cumbersome and expensive. Moreover, there is a practical problem that the body functions of animals under anesthesia are actually different. Sometimes a state diagram of the animal when awake is more needed, and the reference value under anesthesia may be limited. For example, at this time, its nervous system and cerebral cortex are not active.

[0004] In reality, PET / CT images of experimental animals can only be obtained by fixation after general anesthesia. First, the operation is cumbersome, second, the cost is high, and third, the images under anesthesia may not be ideal. In many cases, it is more desirable to obtain images in the awake state. But how to obtain them? In the awake state, the small animals cannot be fixed and will not be still. There is no solution in the existing technology, nor is there any technical inspiration. Summary of the invention

[0005] The purpose of the present invention is to provide a method and a device, which are mainly aimed at the fact that the prior art lacks a method for directly detecting and obtaining effective images of experimental animals that are moving around in a waking state. Furthermore, a method for obtaining images that can be normally analyzed when experimental animals are in a waking state and may move around is solved in a low-cost (no anesthesia is required, and no facilities, drugs, and instruments related to anesthesia) and easy-to-operate manner. This method is original to the present application and is not inspired by the prior art.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a brain scanning system for animals in arbitrary postures, characterized in that it includes an animal carrier box and a carrier, a binocular camera, a PET / CT scanning system, a positioning frame, and a computer.

[0007] At least one side of the animal carrier box is transparent except for the bottom side, and the binocular camera is placed outside the transparent side and faces the animal carrier box. The carrier platform carries the animal carrier box from below.

[0008] The positioning frame is an RFS rigid body tool, which includes a connecting frame and at least four small balls fixed at different positions on the connecting frame.

[0009] The computer stores the PET / CT image processing system and binocular positioning software.

[0010] Further, the animal carrier is made of polyester and has an opening.

[0011] At least four balls are visually distinguishable pairwise by the stereo camera.

[0012] The binocular camera is carried by a movable camera frame.

[0013] The connecting frame is made of low-density material suitable for PET / CT.

[0014] A method for scanning the brain of an animal in any posture is performed using an animal brain scanning system in any posture, and is characterized by: (1) a preparation step: testing the working status of a binocular camera, a PET / CT scanning system, and a computer, placing the animal to be tested in an animal carrier, closing the opening and locking it.

[0015] (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer.

[0016] (3) Correspondence step: The scanned images are matched one by one through the PET / CT image processing system and the binocular positioning software to ensure that each PET / CT scan image has a corresponding image taken by the binocular camera.

[0017] (4) Identification step: By analyzing the images taken by the binocular camera one by one, the images are divided into images with unchanged position and posture and images with translation according to the positioning information of at least four small balls.

[0018] (5) Coordinate adjustment step: For all images that have undergone translation in step 4, the direction and distance of their translation are calculated one by one, and the coordinate information of the PET / CT scan images corresponding to all images that have undergone translation are adjusted according to a preset calculation ratio to generate translation-corrected images.

[0019] (6) PET / CT image generation step: All images with unchanged position and posture and all images with corrected translation are re-sorted according to their acquisition time, as a PET / CT image processing data group, and image processing is performed to obtain a corrected PET / CT image.

[0020] A method for scanning the brain of an animal in any posture is performed using an animal brain scanning system in any posture, and is characterized by: (1) a preparation step: testing the working status of a binocular camera, a PET / CT scanning system, and a computer, placing the animal to be tested in an animal carrier, closing the opening and locking it.

[0021] (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer.

[0022] (3) Correspondence step: The scanned images are matched one by one through the PET / CT image processing system and the binocular positioning software to ensure that each PET / CT scan image has a corresponding image taken by the binocular camera.

[0023] (4) Identification step: By analyzing the images taken by the binocular camera one by one, the images are divided into images with unchanged position and posture and images with changed posture according to the positioning information of at least four small balls.

[0024] (5) Coordinate adjustment step: For all the posture change images in step 4, calculate the amount of posture change one by one, and reversely calculate the coordinate change of translation and rotation that needs to be corrected based on the position change of at least four small balls in front and behind. Then, adjust the coordinate information of the PET / CT scan images corresponding to all the posture change images according to the preset calculation ratio to generate posture change correction images.

[0025] (6) PET / CT image generation step: All images with unchanged position and posture and all images with corrected posture changes are re-sorted in time according to their acquisition time, as a PET / CT image processing data group, and image processing is performed to obtain a corrected PET / CT image.

[0026] A method for scanning the brain of an animal in any posture is performed using an animal brain scanning system in any posture, and is characterized by: (1) a preparation step: testing the working status of a binocular camera, a PET / CT scanning system, and a computer, placing the animal to be tested in an animal carrier, closing the opening and locking it.

[0027] (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer.

[0028] (3) Correspondence step: The scanned images are matched one by one through the PET / CT image processing system and the binocular positioning software to ensure that each PET / CT scan image has a corresponding image taken by the binocular camera.

[0029] (4) Identification step: By analyzing the images taken by the binocular camera one by one, according to the positioning information of at least four small balls, the images are divided into images with unchanged position and posture, images with only translation, and images with posture change. The images with posture change are those in which both translation and rotation of the experimental animal have occurred.

[0030] (5) Coordinate adjustment step: For all images that have only undergone translation in step 4, the direction and distance of their translation are calculated one by one, and the coordinate information of the PET / CT scan images corresponding to all images that have undergone translation are adjusted according to a preset calculation ratio to generate translation-corrected images.

[0031] For all the images that have undergone posture changes in step 4, the amount of posture change is calculated one by one, and the coordinate changes of translation and rotation that need to be corrected are reversed according to the position changes of at least four small balls in front and behind. According to the preset calculation ratio, the coordinate information of the PET / CT scan images corresponding to all the images that have undergone posture changes is adjusted to generate posture change correction images.

[0032] (6) PET / CT image generation step: all images with unchanged position and posture, all images corrected for translation, and all images corrected for posture change are re-sorted in time according to their acquisition time, and used as a PET / CT image processing data group, and image processing is performed to obtain a corrected PET / CT image.

[0033] Furthermore, the above three methods all have the following characteristics: for step (2), the binocular camera and the PET / CT scanning system are started to scan synchronously according to a preset time period, the PET / CT scanning system is translated onto the animal carrier in advance, and the animal carrier is placed in the area of ​​interest during scanning. The binocular camera is located on the side of the opening of the PET / CT scanning system, and after the scan is completed, the PET / CT scanning system is translated away from the animal carrier.

[0034] Compared with the prior art, this application has many non-obvious advantages: First, it avoids the complicated steps and consumables of anesthesia operation. If the experimental animal is anesthetized, it is generally necessary to inject anesthesia at multiple points as a whole, and it is also necessary to ensure that the animal does not wake up. The introduction of anesthetic gas during instrument detection is not only troublesome and cumbersome, but also easy to collide with the detection instrument, and the risk cannot be ignored; second, the test results of animals under anesthesia may not be what you really want. When the animal is under anesthesia, the circulatory system and nervous system are different from those when awake, and the anesthesia data may not meet the analysis requirements of actual pharmacy or scientific research. Third, the device design is not complicated, but it solves the problem. It only requires the installation of a binocular camera. The subsequent main operation is at the data processing end. As long as each PET / CT image has a corresponding binocular camera image with the same timestamp, the operation can completely realize image correction, that is, to change the test results into image data as if the experimental animal has not moved. Fourth, within the animal carrier box, only the experimental animal itself and at least four small balls used for positioning are meaningful for PET / CT detection. Other objects are made of low-density materials and have no effect on the detection, or can be ignored in image processing and do not need to be paid attention to. This simple and direct result is that there is no additional impact on the detection results. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] Figure 1 This is a schematic diagram of the basic structure of the scanning system.

[0036] Figure 2 This is a real picture of the animal carrier.

[0037] Figure 3 This is a real picture of the binocular camera.

[0038] Figure 4 This is a model diagram of the positioning frame.

[0039] Reference numerals: 1, animal carrier box; 2, carrier platform; 3, binocular camera; 4, scanning system; 5, positioning frame; 6, computer; 11, top plate; 12, side plate; 13, bottom plate; 31, lens; 32, body; 51, connecting frame; 52, small ball. DETAILED DESCRIPTION

[0040] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0041] Example 1

[0042] A system for scanning the brain of an animal in any posture, characterized by comprising an animal carrier and a carrier, a binocular camera, a PET / CT scanning system, a positioning frame, and a computer. The animal carrier is made of, for example, a transparent or translucent hard polyester material, and the material is not limited. For the convenience of taking and placing, the opening is, for example, at the top, and also prevents the animal from escaping. One side of the opening is, for example, connected by a hinge, which is convenient for rotation to open and close, and there may be auxiliary closing measures, such as a polyester buckle.

[0043] The animal carrier box has at least one transparent surface other than the bottom surface, and the binocular camera is placed outside the transparent surface and facing the animal carrier box. The platform carries the animal carrier box from below. In order not to affect the PET / CT scan being performed simultaneously, generally speaking, it is better to place the binocular camera on the side.

[0044] The positioning frame is an RFS rigid body tool, which includes a connecting frame and at least four small balls fixed at different positions on the connecting frame. Here, it is generally set that the small balls should be easy to capture for the binocular camera, and in order to distinguish, the colors or grayscale values ​​displayed by the small balls in the camera field of view should be different, or the visual colors can be different, and the black and white depths can be different.

[0045] The computer stores a PET / CT image processing system and binocular positioning software. This image processing system must be able to meet the basic requirements of image processing. Compared with the PET / CT image processing system, the binocular camera's shooting interval must be short enough, and the image resolution must be sufficient. For each time stamp image of the PET / CT, there must be one (or actually two) binocular camera images corresponding to it. The resolution is, for example, 1080p, 2k, 4k. The resolution must be sufficient to distinguish how much the center of each ball has moved and what the coordinates of the displacement are.

[0046] Further, the animal carrier is made of polyester and has an opening.

[0047] At least four balls should be visually distinguishable from each other for the binocular camera. Note that if the difference is color or grayscale, the difference should be large enough, for example, the grayscale difference should be more than 10, for example, one grayscale is 110 and the other grayscale is 121. If they are set to 110 and 112, it will be difficult to distinguish the two balls and the calculation may be wrong. Try not to use colors that are too similar, such as all orange, all pink, etc. Try to use colors from different color systems.

[0048] The binocular camera is carried by a movable camera stand. The camera stand itself has a base that can be moved and fixed, and can also have a counterweight on the other side of the camera to prevent the camera from falling.

[0049] The connecting frame is made of low-density material suitable for PET / CT.

[0050] The connecting frame is also equipped with a hat / crown-shaped fixing cap for wearing / fixing it on the head of the experimental animal. The material of the hat / crown-shaped fixing cap is, for example, transparent or translucent for a binocular camera, and is a low-density material or a material that is almost impossible to image for PET / CT.

[0051] Example 2

[0052] A method for scanning the brain of an animal in any posture is performed using an animal brain scanning system in any posture, and is characterized by: (1) a preparation step: testing the working status of a binocular camera, a PET / CT scanning system, and a computer, placing the animal to be tested in an animal carrier, closing the opening and locking it.

[0053] (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer.

[0054] (3) Correspondence step: The scanned images are matched one by one through the PET / CT image processing system and the binocular positioning software to ensure that each PET / CT scan image has a corresponding image taken by the binocular camera.

[0055] (4) Identification step: By analyzing the images taken by the binocular camera one by one, the images are divided into images with unchanged position and posture and images with translation according to the positioning information of at least four small balls.

[0056] (5) Coordinate adjustment step: For all images that have undergone translation in step 4, the direction and distance of their translation are calculated one by one, and the coordinate information of the PET / CT scan images corresponding to all images that have undergone translation are adjusted according to a preset calculation ratio to generate translation-corrected images.

[0057] (6) PET / CT image generation step: All images with unchanged position and posture and all images with corrected translation are re-sorted according to their acquisition time, as a PET / CT image processing data group, and image processing is performed to obtain a corrected PET / CT image.

[0058] The method of this embodiment is based on the special case that during the PET / CT scan, the experimental animal (such as a mouse) did not move, or only moved in translation. In this case, the translated image can be found by comparison, and the coordinates can be calculated and corrected according to the shooting results of the binocular camera. Each frame of the corrected PET / CT image will be the same as the case when the experimental animal did not move, and the final detection result can be obtained at this time.

[0059] Example 3

[0060] A method for scanning the brain of an animal in any posture is performed using an animal brain scanning system in any posture, and is characterized by: (1) a preparation step: testing the working status of a binocular camera, a PET / CT scanning system, and a computer, placing the animal to be tested in an animal carrier, closing the opening and locking it.

[0061] (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer.

[0062] (3) Correspondence step: The scanned images are matched one by one through the PET / CT image processing system and the binocular positioning software to ensure that each PET / CT scan image has a corresponding image taken by the binocular camera.

[0063] (4) Identification step: By analyzing the images taken by the binocular camera one by one, the images are divided into images with unchanged position and posture and images with changed posture according to the positioning information of at least four small balls.

[0064] (5) Coordinate adjustment step: For all the posture change images in step 4, calculate the amount of posture change one by one, and reversely calculate the coordinate change of translation and rotation that needs to be corrected based on the position change of at least four small balls in front and behind. Then, adjust the coordinate information of the PET / CT scan images corresponding to all the posture change images according to the preset calculation ratio to generate posture change correction images.

[0065] (6) PET / CT image generation step: All images with unchanged position and posture and all images with corrected posture changes are re-sorted in time according to their acquisition time, as a PET / CT image processing data group, and image processing is performed to obtain a corrected PET / CT image.

[0066] In this embodiment, all images that have undergone unknown changes are treated as "posture changes", which can be understood as translation and rotation. This operation is necessary for images whose postures have indeed undergone translation and rotation. However, if some of the images have only undergone translation, the amount of calculation for this part will actually increase, but it can still meet the needs and obtain reasonable calculation results.

[0067] Example 4

[0068] A method for scanning the brain of an animal in any posture is performed using an animal brain scanning system in any posture, and is characterized by: (1) a preparation step: testing the working status of a binocular camera, a PET / CT scanning system, and a computer, placing the animal to be tested in an animal carrier, closing the opening and locking it.

[0069] (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer.

[0070] (3) Correspondence step: The scanned images are matched one by one through the PET / CT image processing system and the binocular positioning software to ensure that each PET / CT scan image has a corresponding image taken by the binocular camera.

[0071] (4) Identification step: By analyzing the images taken by the binocular camera one by one, according to the positioning information of at least four small balls, the images are divided into images with unchanged position and posture, images with only translation, and images with posture change. The images with posture change are those in which both translation and rotation of the experimental animal have occurred.

[0072] (5) Coordinate adjustment step: For all images that have only undergone translation in step 4, the direction and distance of their translation are calculated one by one, and the coordinate information of the PET / CT scan images corresponding to all images that have undergone translation are adjusted according to a preset calculation ratio to generate translation-corrected images.

[0073] For all the images that have undergone posture changes in step 4, the amount of posture change is calculated one by one, and the coordinate changes of translation and rotation that need to be corrected are reversed according to the position changes of at least four small balls in front and behind. According to the preset calculation ratio, the coordinate information of the PET / CT scan images corresponding to all the images that have undergone posture changes is adjusted to generate posture change correction images.

[0074] (7) PET / CT image generation steps: all images with unchanged position and posture, all images with corrected translation, and all images with corrected posture changes are re-sorted in time according to their acquisition time, and used as the PET / CT image processing data group, and image processing is performed to obtain the restored PET / CT image.

[0075] In this embodiment, all images that have undergone unknown changes are divided into "posture changes" and only translation processing, which can be understood as, for posture changes, both translation and rotation have occurred. This operation is necessary for images in which all postures have indeed undergone translation and rotation. For some images, only translation has occurred, and the amount of calculation is relatively small. Compared with the method in Example 3, the actual amount of calculation of the method in this embodiment is generally smaller, but reasonable results can also be obtained.

[0076] Example 5

[0077] Furthermore, the above three methods all have the following characteristics: for step (2), the binocular camera and the PET / CT scanning system are started to scan synchronously according to a preset time period, the PET / CT scanning system is translated onto the animal carrier in advance, and the animal carrier is placed in the area of ​​interest during scanning. The binocular camera is located on the side of the opening of the PET / CT scanning system, and after the scan is completed, the PET / CT scanning system is translated away from the animal carrier.

[0078] The foregoing embodiments 2-4 may all be based on a setting in which the PET / CT scanning system, the binocular camera, and the animal carrier are all stationary. However, in actual operation, the PET / CT scanning system is often moved over when needed and moved out when not needed for detection. This embodiment can be considered as an alternative variant of embodiments 2-4, that is, the PET / CT scanning system needs to be switched horizontally, moved over when detecting, and moved back when not needed.

[0079] The purpose of this application is to obtain image data of experimental animals. The image data itself does not represent the disease or pathological results, but is only intermediate data, generally PET, CT data, or other common detection data involved in nuclear medicine.

[0080] right Figure 1-4 To explain, Figure 1 This is the overall schematic diagram of the present application. Please note that if the binocular camera is set on the side and affects the PET / CT, it should be set at the PET / CT opening. Figure 2 This is a real picture of an animal carrier box, where the experimental animals are, for example, mice. It can be seen that the test is performed without anesthesia. Figure 3 This is a schematic diagram of a binocular camera, which can be purchased commercially, but its resolution, response speed, and minimum shooting interval should be able to meet the implementation requirements of this application. An advanced camera can also be a multi-eye camera. Figure 4 This is a diagram of a rigid body tool. In practice, the most common one is a cross with four small balls. Or a similar shape like the central carbon atom of a diamond with four covalent bonds, with a small ball on each vertex.

[0081] The above is only an embodiment of the present invention, and the common sense such as the known specific structure and characteristics in the scheme is not described in detail here. For those skilled in the art, it is obvious that the present invention is not limited to the details of the above exemplary embodiments, and the present invention can be implemented in other specific forms without departing from the spirit or basic characteristics of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive, and the scope of the present invention is defined by the attached claims rather than the above description, so it is intended to include all changes within the meaning and scope of the equivalent elements of the claims. Any figure mark in the claims should not be regarded as limiting the claims involved.

Claims

1. A brain scanning system for animals in any posture, characterized in that : Includes animal carrier and stage, binocular camera, PET / CT scanning system, positioning frame, computer; The animal carrying box has at least one transparent surface except the bottom surface, and the binocular camera is placed outside the transparent surface and faces the animal carrying box; The platform carries the animal carrier from below; The positioning frame is an RFS rigid body tool, which includes a connecting frame and at least four small balls fixed at different positions on the connecting frame; The computer stores the PET / CT image processing system and binocular positioning software.

2. The system for scanning the brain of an animal in any posture as claimed in claim 1, characterized in that ； The animal carrier is made of polyester and has an opening; At least four balls are visually distinguishable from each other by the stereo camera; The binocular camera is carried by a movable camera stand; The connecting frame is made of low-density material suitable for PET / CT.

3. A method for scanning the brain of an animal in any posture, performed by using a system for scanning the brain of an animal in any posture as claimed in claim 1 or 2, characterized in that : (1) Preparation steps: Test the working status of the binocular camera, PET / CT scanning system, and computer, place the animal to be tested in the animal carrier, close the opening and lock it; (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer; (3) Matching step: Use the PET / CT image processing system and binocular positioning software to match the scanned images one by one, ensuring that each PET / CT scanned image has a corresponding image taken by the binocular camera; (4) Identification step: By analyzing the images taken by the binocular camera one by one, the images are divided into images with unchanged position and posture and images with translation according to the positioning information of at least four balls; (5) Coordinate adjustment step: for all images that have undergone translation in step 4, the direction and distance of translation are calculated one by one, and the coordinate information of the PET / CT scan images corresponding to all images that have undergone translation are adjusted according to a preset calculation ratio to generate translation-corrected images; (6) PET / CT image generation step: All images with unchanged position and posture and all images with corrected translation are re-sorted according to their acquisition time, as a PET / CT image processing data group, and image processing is performed to obtain a corrected PET / CT image.

4. A method for scanning the brain of an animal in any posture, performed by using a system for scanning the brain of an animal in any posture as claimed in claim 1 or 2, characterized in that : (1) Preparation steps: Test the working status of the binocular camera, PET / CT scanning system, and computer, place the animal to be tested in the animal carrier, close the opening and lock it; (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer; (3) Matching step: Use the PET / CT image processing system and binocular positioning software to match the scanned images one by one, ensuring that each PET / CT scanned image has a corresponding image taken by the binocular camera; (4) Identification step: By analyzing the images taken by the binocular camera one by one, the images are divided into images with unchanged position and posture and images with changed posture according to the positioning information of at least four balls; (5) Coordinate adjustment step: for all the posture change images in step 4, the amount of posture change is calculated one by one, and the coordinate change amount of translation and rotation that needs to be corrected is calculated based on the position change of at least four small balls in front and behind, and the coordinate information of the PET / CT scan images corresponding to all the posture change images is adjusted according to a preset calculation ratio to generate posture change correction images; (6) PET / CT image generation step: All images with unchanged position and posture and all images with corrected posture changes are re-sorted in time according to their acquisition time, as a PET / CT image processing data group, and image processing is performed to obtain a corrected PET / CT image.

5. A method for scanning the brain of an animal in any posture, performed by using a system for scanning the brain of an animal in any posture as claimed in claim 1 or 2, characterized in that : (1) Preparation steps: Test the working status of the binocular camera, PET / CT scanning system, and computer, place the animal to be tested in the animal carrier, close the opening and lock it; (2) Scanning steps: For experimental animals in an awake state, the binocular camera and the PET / CT scanning system are synchronized to start scanning according to a preset time period. After the preset time period expires, the scanning is terminated and the data is transmitted to the computer; (3) Matching step: Use the PET / CT image processing system and binocular positioning software to match the scanned images one by one, ensuring that each PET / CT scanned image has a corresponding image taken by the binocular camera; (4) Identification step: By analyzing the images taken by the binocular camera one by one, according to the positioning information of at least four small balls, the images are divided into images with unchanged position and posture, images with only translation, and images with posture change. The images with posture change are those in which the experimental animal has undergone both translation and rotation; (5) Coordinate adjustment step: for all images that have only undergone translation in step 4, the direction and distance of translation are calculated one by one, and the coordinate information of the PET / CT scan images corresponding to all images that have undergone translation are adjusted according to a preset calculation ratio to generate translation-corrected images; For all the posture change images in step 4, the amount of posture change is calculated one by one, and the coordinate change amount of translation and rotation that needs to be corrected is calculated inversely according to the position change of at least four small balls in front and behind, and the coordinate information of the PET / CT scan images corresponding to all the posture change images is adjusted according to the preset calculation ratio to generate posture change correction images; (7) PET / CT image generation steps: all images with unchanged position and posture, all images with corrected translation, and all images with corrected posture changes are re-sorted in time according to their acquisition time, and used as the PET / CT image processing data group, and image processing is performed to obtain the restored PET / CT image.

6. The method for scanning the brain of an animal in any posture according to any one of claims 3 to 5, characterized in that: For step (2) of synchronizing the binocular camera and the PET / CT scanning system to start scanning at a preset time period, the PET / CT scanning system is translated onto the animal carrier in advance, and the animal carrier is positioned in the area of ​​interest during scanning. The binocular camera is positioned on the side of the opening of the PET / CT scanning system, and after the scan is completed, the PET / CT scanning system is translated away from the animal carrier.

Images