Adsorption resin for blood perfusion and preparation method thereof

By using adsorption resins prepared by components such as polystyrene, diethylenebenzene, dimethylaminoethyl methacrylate, acrylamide and chitosan in the blood perfusion technology, the problem of poor adsorption of organophosphorus pesticides in the prior art is solved, and efficient adsorption of organophosphorus toxins and protecting beneficial components in the blood is achieved.

CN119701889APending Publication Date: 2025-03-28SISHUI XIERKANG PHARMACELICAL CO LTD
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Patent Information

Application Number
CN202411836089.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-13
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

In the existing blood perfusion technology, commonly used activated carbon adsorbents have poor adsorption selectivity for organophosphorus pesticides, and while adsorbing organophosphorus pesticides, they will also absorb beneficial components in the blood, weakening their adsorption capacity.

Method used

An adsorption resin for blood perfusion is used, and its components include polystyrene, diethylene benzene, dimethylaminoethyl methacrylate, acrylamide and chitosan. Through the reasonable combination and copolymerization of these components, an adsorption resin with high efficiency adsorption of organophosphorus toxins and reducing adsorption of beneficial components in the blood is formed.

Benefits of technology

It has achieved efficient adsorption of organophosphorus toxins, while minimizing the adsorption of beneficial components such as coagulation factors and white blood cells in the blood, and protecting the normal physiological functions of the blood.

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Abstract

The invention relates to the field of blood purification, and particularly discloses adsorption resin for blood perfusion and a preparation method of the adsorption resin. The adsorption resin for blood perfusion is prepared from polystyrene, divinylbenzene, dimethylaminoethyl methacrylate, acrylamide, chitosan and a pore-foaming agent. The preparation method comprises the following steps: uniformly stirring polystyrene, divinylbenzene, dimethylaminoethyl methacrylate and acrylamide at normal temperature to form a mixture; adding an initiator and a pore-foaming agent into the mixture, and stirring, wherein the use amount of the initiator is 0.5-1.5% of the total mass of the mixture; heating the mixture to 60-80 DEG C in a nitrogen environment, and reacting for 12-16 hours to obtain adsorption resin; placing adsorption resin in the chitosan solution, heating to 50 DEG C, and reacting for 3 hours; and after the reaction is finished, washing and drying a product to obtain the adsorbent resin for blood perfusion. The adsorbent resin for blood perfusion has the advantages that organic phosphorus is efficiently adsorbed, and blood cell adsorption damage is reduced.
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