Preparation method of 2-acetyl-6-hydroxybenzoic acid

By preparing 2-acetyl-6-hydroxybenzoic acid, the problem of lack of the preparation method of this compound in the prior art is solved, and a safe, economical and high yield preparation process is achieved.

CN119707667APending Publication Date: 2025-03-28JIANGSU ZHIRONG BIOLOGICAL RESEARCH & DEVELOPMENT CO LTD
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Patent Information

Application Number
CN202411829892.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-12
Publication Date
2025-03-28

AI Technical Summary

Technical Problem

The lack of preparation methods for 2-acetyl-6-hydroxybenzoic acid in the prior art limits its potential application in drug development.

Method used

2-acetyl-6-hydroxybenzoic acid was successfully prepared through a series of steps including the preparation of 2,6-dichlorobenzaldehyde, oxidation reaction, and subsequent extraction, washing, drying and crystallization.

Benefits of technology

The process of this method is simple to operate, mild production process, no natural hazardous reagents are used, the reaction process is safer, and the catalyst can be reused, with a yield of up to 92%.

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Abstract

The invention relates to the technical field of organic synthesis, in particular to a preparation method of 2-acetyl-6-hydroxybenzoic acid. Comprising the following steps: S1, preparing 2-chloro-6-hydroxybenzaldehyde from 2, 6-dichlorobenzaldehyde; s2, the 2-chloro-6-hydroxybenzaldehyde prepared in the step S13 is oxidized by an oxidizing agent, and 2-chloro-6-hydroxybenzoic acid is obtained; s3, adding the 2-chloro-6-hydroxybenzoic acid prepared in the step S2, acetic anhydride and alkali into a solvent for reaction, adding acid after the reaction is completed to enable a reaction system to be acidic, and sequentially performing extraction, washing, drying and crystallization to obtain 2-acetyl-6-hydroxybenzoic acid; according to the method, boric acid groups are removed in 30% hydrogen peroxide, acidic alumina is used as a catalyst, and arylboronic acid can be efficiently converted into corresponding phenol under the aerobic condition at room temperature. The method is simple and convenient to operate, the catalyst can be repeatedly used, and the yield is up to 98%.
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