A five-membered double-spiro indoline derivative, and a preparation method and application thereof

Abstract

The application discloses a five-membered double-spiro indoline derivative and a preparation method and application thereof, and a structure formula of the five-membered double-spiro indoline derivative is shown as formula (III); wherein, R 1 is selected from hydrogen, an alkyl group or halogen; R 2 is selected from hydrogen, an alkyl group, an allyl group, a benzyl group or a benzoyl group; R 3 is selected from a phenyl group, a naphthyl group, a biphenyl group, a thienyl group, a furanyl group, an alkylphenyl group, a halogenphenyl group, an alkoxyphenyl group, a nitrophenyl group or a trifluoromethylphenyl group; R 4 is selected from an alkylphenyl group, a halogenphenyl group or a nitrophenyl group. The five-membered double-spiro indoline derivative of the application is synthesized by a one-step method, high atom economy and high yield, not only simplifying a synthesis route, but also reducing production cost, and because of the green chemical characteristics, reducing the influence on the environment. The five-membered double-spiro indoline derivative is found to have an antifungal and antibacterial effect.

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