Protein FDX1 related to remission of reproductive injury as well as coding gene and application of protein FDX1
By constructing the RNA interference sequence of the FDX1 gene, the expression of the FDX1 gene in granule cells is regulated, the reproductive damage caused by environmental pollutants is solved, the resistance of granule cells to oxidative stress is significantly improved, and the normal state of hormone levels is restored.
CN119776386APending Publication Date: 2025-04-08CAPITAL UNIVERSITY OF MEDICAL SCIENCES
Patent Information
- Application Number
- CN202510000194.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-01-02
- Publication Date
- 2025-04-08
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Figure CN119776386A_ABST
Abstract
The invention discloses a protein FDX1 related to remission of reproductive injury as well as a coding gene and application thereof. The invention provides a nucleotide sequence for remission of reproductive injury, wherein the nucleotide sequence is shown as SEQ ID NO. 1. By transfecting the FDX1 gene, the level of glutathione (GSH) in human ovarian granulosa cells is remarkably improved, the resistance of the granulosa cells to oxidative stress is enhanced, oxidative damage caused by BDE-209 is relieved, and reproductive damage is relieved; the transfection of FDX1 can significantly regulate the secretion of AMH, E2, INHB and PROG in granular cells, help to recover the normal state of hormone level, maintain the balance of reproductive endocrine, and relieve reproductive injury; the FDX1 lentivirus sequence disclosed by the invention is a promising drug with clinical application prospect and targeting granular cell function integrity, and has important value for evaluation and treatment of reproductive injury.
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Citation Information
Patent Citations
siRNA for inhibiting gene expression of mice gonadotropin inhibitory hormone and application of siRNA
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