Leakage compensation method, device and system for high-frequency ventilation and medium

Abstract

The invention discloses a leakage compensation method, device and system for high-frequency ventilation and a medium. The method comprises the steps that the real-time flow speed and the real-time pressure of a breathing machine are obtained; integrating the real-time flow rate in a first time period, and after the direction of the real-time pressure is confirmed, calling a preset pressure formula with sign symbols to integrate the real-time pressure in the first time period; when a second time period is reached, calculating a leakage factor according to the integral result of the current real-time flow rate and the integral result of the real-time pressure, and emptying the integral results; and calling a leakage flow velocity formula with sign symbols according to the leakage factor to calculate a leakage flow velocity, and performing leakage compensation on the breathing machine according to the leakage flow velocity. By confirming the real-time pressure direction and carrying out integration and leakage factor calculation through a formula with symbols, leakage can still be accurately compensated when a large amount of negative pressure is generated due to high-frequency oscillation in high-frequency ventilation, and the reliability of high-frequency ventilation is improved.

Description

Technical Field

[0001] The present invention relates to the technical field of medical equipment, and in particular to a leakage compensation method, device, system and medium for high-frequency ventilation. Background Art

[0002] In neonatal mechanical ventilation, the lungs of neonates are not yet developed, and their compliance is much less than that of adults. To achieve a certain tidal volume, a higher pressure is required. However, the lungs of neonates are very fragile, and excessive pressure will damage the patient's lungs. Therefore, in order to ensure the minute ventilation volume of neonates, the ventilation pressure is often reduced as much as possible by increasing the frequency. In addition, the pulmonary expiratory time constant of neonates is very small, which can ensure that the exhalation time is very short and easy to complete. High-frequency ventilation HFO (High Frequency Oscillation) has become a suitable mechanical ventilation option for neonates.

[0003] Leakage is a very common phenomenon in mechanical ventilation. Common intubation positions and leaks on the pipeline can cause leakage in the pipeline. In order to correctly estimate the flow rate entering the patient's lungs, to correctly trigger the flow rate and calculate the tidal volume, almost all ventilators have an automatic leak compensation function.

[0004] In traditional leakage compensation calculations, negative airway pressure is not allowed. For normal-frequency ventilation, the range of spontaneous breathing to negative numbers is often very small and can be ignored. Therefore, it has little effect on the accuracy of leakage compensation. However, in high-frequency ventilation, since high-frequency ventilation is generated by the high-frequency vibration of the oscillator, the exhalation is the forced exhalation of the ventilator rather than the active exhalation of the patient. Therefore, when the average pressure is low, the oscillator can frequently generate negative pressure, that is, during high-frequency ventilation, the ventilator actively draws negative pressure, which can occur periodically in large quantities. Therefore, if the traditional leakage compensation method is used during high-frequency ventilation, it will cause the problem of insufficient leakage compensation accuracy. Summary of the invention

[0005] In view of the above-mentioned deficiencies in the prior art, an object of the present invention is to provide a leakage compensation method, device, system and medium for high-frequency ventilation, aiming to improve the accuracy of leakage compensation under high-frequency ventilation.

[0006] The technical solution of the present invention is as follows:

[0007] A leakage compensation method for high frequency ventilation, comprising:

[0008] Get the real-time flow rate and real-time pressure of the ventilator;

[0009] Integrate the real-time flow rate in a first time period, and after confirming the direction of the real-time pressure, call a preset pressure formula with positive and negative signs to integrate the real-time pressure in the first time period;

[0010] When the second time period is reached, the leakage factor is calculated according to the integration result of the current real-time flow rate and the integration result of the real-time pressure, and the integration result is cleared;

[0011] The leakage flow rate formula with positive and negative signs is called according to the leakage factor to calculate the leakage flow rate, and the ventilator is leak compensated according to the leakage flow rate.

[0012] In one embodiment, the second time period is much greater than the first time period.

[0013] In one embodiment, integrating the real-time flow rate over a first time period and, after confirming the direction of the real-time pressure, calling a preset pressure formula with positive and negative signs to integrate the real-time pressure over a first time period includes:

[0014] By formula Integrating the real-time flow rate over a first time period, wherein Flow is the real-time flow rate and t is time;

[0015] Confirming that the real-time pressure is positive pressure or negative pressure, and obtaining the positive and negative signs of the real-time pressure;

[0016] By pre-set pressure formula with positive and negative signs The real-time pressure is integrated over a first time period, where sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, t is time, and T is the time containing an integer multiple of a complete high frequency cycle.

[0017] In one embodiment, when the second time period is reached, the leakage factor is calculated based on the integration result of the current real-time flow rate and the integration result of the real-time pressure, and the integration result is cleared, specifically:

[0018] When the second time period is reached, the formula The leakage factor is calculated and the integration result of the current integration period is cleared, where LeakFactor is the leakage factor.

[0019] In one embodiment, the method of calculating the leakage flow rate by calling a leakage flow rate formula with positive and negative signs according to the leakage factor, and performing leakage compensation on the ventilator according to the leakage flow rate includes:

[0020] Based on the leakage factor, the leakage flow rate formula with positive and negative signs is The leakage flow rate is calculated, where Flow leakis the leakage velocity, LeakFactor is the leakage factor, sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, and t is time;

[0021] Leakage compensation is performed on the real-time flow rate of the ventilator according to the leakage flow rate.

[0022] In one embodiment, the method further comprises:

[0023] Confirm whether the ventilator is in high-frequency ventilation mode where high-frequency oscillator oscillates to generate ventilation.

[0024] In one embodiment, the first time period is 1 ms, and the second time period is 3 s.

[0025] A leakage compensation device for high-frequency ventilation, characterized in that it comprises:

[0026] An acquisition module, used for acquiring the real-time flow rate and real-time pressure of the ventilator;

[0027] An integration module, used to integrate the real-time flow rate in a first time period, and after confirming the direction of the real-time pressure, call a preset pressure formula with positive and negative signs to integrate the real-time pressure in the first time period;

[0028] A calculation module, configured to calculate a leakage factor according to an integration result of the current real-time flow velocity and an integration result of the real-time pressure when a second time period is reached, and clear the integration result;

[0029] The leakage compensation module is used to calculate the leakage flow rate by calling the leakage flow rate formula with positive and negative signs according to the leakage factor, and perform leakage compensation on the ventilator according to the leakage flow rate.

[0030] A leakage compensation system for high frequency ventilation, the system comprising at least one processor; and

[0031] a memory communicatively connected to the at least one processor; wherein,

[0032] The memory stores instructions that can be executed by the at least one processor, and the instructions are executed by the at least one processor so that the at least one processor can perform the leakage compensation method for high-frequency ventilation.

[0033] A non-volatile computer-readable storage medium stores computer-executable instructions. When the computer-executable instructions are executed by one or more processors, the one or more processors can execute the above-mentioned leakage compensation method for high-frequency ventilation.

[0034] Beneficial effects: The present invention discloses a leakage compensation method, device, system and medium for high-frequency ventilation. Compared with the prior art, the embodiments of the present invention confirm the real-time pressure direction and integrate and calculate the leakage factor with a signed formula, so that when a large amount of negative pressure is generated due to high-frequency oscillation during high-frequency ventilation, the leakage can still be accurately compensated, thereby improving the reliability of high-frequency ventilation. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The present invention will be further described below with reference to the accompanying drawings and embodiments, in which:

[0036] Figure 1 A flow chart of a leakage compensation method for high frequency ventilation provided by an embodiment of the present invention;

[0037] Figure 2 A schematic diagram of a functional module of a leakage compensation device for high-frequency ventilation provided by an embodiment of the present invention;

[0038] Figure 3 A schematic diagram of the hardware structure of a leakage compensation system for high-frequency ventilation provided in an embodiment of the present invention. DETAILED DESCRIPTION

[0039] In order to make the purpose, technical solution and effect of the present invention clearer and more specific, the present invention is further described in detail below. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. The embodiments of the present invention are described below in conjunction with the accompanying drawings.

[0040] See also Figure 1 , Figure 1 Flow chart of an embodiment of the leakage compensation method for high frequency ventilation provided by the present invention. Figure 1 As shown, the method specifically comprises the following steps:

[0041] S100, obtaining the real-time flow rate and real-time pressure of the ventilator;

[0042] S200, integrating the real-time flow rate in a first time period, and after confirming the direction of the real-time pressure, calling a preset pressure formula with positive and negative signs to integrate the real-time pressure in the first time period;

[0043] S300, when the second time period is reached, the leakage factor is calculated according to the integration result of the current real-time flow velocity and the integration result of the real-time pressure, and the integration result is cleared;

[0044] S400, calling a leakage flow rate formula with positive and negative signs according to the leakage factor to calculate the leakage flow rate, and performing leakage compensation on the ventilator according to the leakage flow rate.

[0045] In this embodiment, the leakage compensation function usually assumes that the leakage port has a fixed aperture, and the leakage flow rate is related to the pressure difference between the inside and outside of the leakage port and the leakage factor. During leakage compensation, the leakage factor needs to be accurately estimated to accurately compensate for the leakage flow rate. In high-frequency invasive ventilation, in order to meet the needs of rapid oscillation of pressure and flow rate, the calculation of the leakage factor needs to be performed at a sufficiently high sampling frequency. Therefore, after obtaining the real-time flow rate and real-time pressure of the ventilator, the real-time flow rate and real-time pressure are respectively integrated in a very short first time period to ensure the accuracy of high-frequency integration. In particular, when integrating the real-time pressure, it is necessary to confirm the direction of the real-time pressure, that is, whether the current pressure in the pipeline is positive or negative. After confirmation, the preset pressure formula with positive and negative signs is called to integrate the real-time pressure in the first time period.

[0046] In order to ensure the stability of the parameters, the leakage factor will not be settled every cycle, but a longer time will be selected. That is, when the longer second time period is reached, the leakage factor is calculated based on the integral result of the current real-time flow rate and the integral result of the real-time pressure, and the integral result is cleared to enter the parameter calculation of the next cycle. That is, on the basis of high-frequency sampling, the leakage factor is calculated and updated every longer second time period, so as to obtain a more stable leakage factor and avoid the influence of too high frequency leakage factor update on parameter stability.

[0047] Based on the leakage factor calculated in the current cycle, the leakage flow rate formula with the same positive and negative signs can be called to calculate the leakage flow rate, so as to compensate for the leakage of the ventilator, and the tidal volume, minute ventilation, gas transport coefficient of carbon dioxide during high-frequency ventilation, i.e. DCO2 and other patient-related parameters can be further calculated by the flow rate after leakage compensation, thereby solving the problem that the pressure in high-frequency oscillation can generate a large amount of negative pressure, and the existing leakage model cannot perform leakage compensation for negative pressure, thereby improving the accuracy of leakage compensation under this working condition, thereby improving the accuracy of parameters such as high-frequency tidal volume and minute ventilation under leakage conditions.

[0048] In one embodiment, the second time period is much longer than the first time period. In order to meet the needs of rapid oscillation of pressure and flow rate, the calculation of the leakage factor needs to be performed at a sufficiently high sampling frequency. At the same time, in order to ensure the stability of the parameters, the leakage factor will not be calculated immediately after each integral sampling, but will be settled once in a longer time period. Therefore, the second time period is much longer than the first time period, wherein the second time period is in the order of seconds, and the first time period is in the order of milliseconds, for example, the first time period is 1ms, and the second time period is 3s, that is, based on the acquired real-time flow rate and real-time pressure, the flow rate and pressure are integrated with a period of 1ms to ensure the accuracy of high-frequency integration. When it reaches 3s, the leakage factor of the current period is calculated based on the integral result of the complete 3s and the integral is cleared. The second time period is in the order of seconds, for example, it is set to 3s, considering that the frequency of the high frequency is set in Hz. If an integer second is selected, it must always be an integer multiple of a complete breath. A fixed 3s can use data of sufficient length to increase stability, thereby obtaining a more stable leakage factor.

[0049] In one embodiment, step S200 includes:

[0050] By formula Integrating the real-time flow rate over a first time period, wherein Flow is the real-time flow rate and t is time;

[0051] Confirming that the real-time pressure is positive pressure or negative pressure, and obtaining the positive and negative signs of the real-time pressure;

[0052] By pre-set pressure formula with positive and negative signs The real-time pressure is integrated over a first time period, where sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, t is time, and T is the time containing an integer multiple of a complete high frequency cycle.

[0053] In this embodiment, the formula The real-time flow rate is integrated for the first time period (1 ms in this embodiment), and the real-time pressure in the pipeline is confirmed to be positive or negative. When the pressure in the pipeline is greater than the atmospheric pressure of the environment outside the pipeline, it is positive pressure, and when the pressure in the pipeline is less than the atmospheric pressure of the environment outside the pipeline, it is negative pressure. aw (t)) as the positive and negative signs of the real-time pressure participate in the pressure integration, through the formula The real-time pressure is integrated for a first time period (1 ms in this embodiment) so that the flow rate and pressure can still be accurately sampled when a large amount of negative pressure is generated during high-frequency ventilation. At this time, the integration time Δt is taken as the first time period of milliseconds, thereby meeting the needs of rapid oscillation of pressure and flow rate and improving sampling accuracy.

[0054] In one embodiment, when the second time period is reached, the leakage factor is calculated based on the integration result of the current real-time flow rate and the integration result of the real-time pressure, and the integration result is cleared, specifically:

[0055] When the second time period is reached, the formula The leakage factor is calculated and the integration result of the current integration period is cleared, where LeakFactor is the leakage factor.

[0056] In this embodiment, the relationship between the pressure difference and the flow rate at the fixed aperture leak is approximately the square root relationship:

[0057]

[0058] Flow leak is the leakage flow rate through the fixed aperture leakage port, A is the area of ​​the leakage port, C d is the flow coefficient, which can be considered a constant, ρ is the gas density, which can be considered constant, and ΔP is the pressure difference inside and outside the leak. Considering the direction of the flow rate and the pressure difference, the formula should be:

[0059]

[0060] The sign is the positive or negative value, which is converted into a formula for a fixed aperture leakage factor, assuming that the atmospheric pressure is 0 and the pressure in the pipeline is P aw (t), that is, ΔP=P aw (t), we can get:

[0061]

[0062] Where LeakFactor is the leakage factor combined from all coefficients, which is a constant when the aperture of the leak port is fixed. When estimating the leakage factor, it is generally assumed that the patient's tidal volume inhaled in one or more breaths is equal to the patient's tidal volume exhaled, that is:

[0063]

[0064] Where T represents an integer multiple of a complete breathing cycle time, which can be fixed to 3s, i.e., the second time period in this embodiment, Flow pat is the patient flow rate, which is the real-time flow rate Flow monitored by the ventilator minus the leakage flow rate:

[0065] Flow pat (t)=Flow(t)-Flow leak (t)

[0066] The leakage factor can be obtained by the above formula: Therefore, after integrating the flow rate and pressure at the millisecond level, when a longer second time period is reached, the formula is called The leakage factor is calculated so that it can be accurately updated in each leakage factor settlement cycle regardless of positive or negative pressure during high-frequency ventilation, thereby improving the accuracy of leakage compensation under high-frequency ventilation, and further improving the accuracy of high-frequency tidal volume and minute ventilation under leakage conditions.

[0067] In one embodiment, step S400 includes:

[0068] Based on the leakage factor, the leakage flow rate formula with positive and negative signs is The leakage flow rate is calculated, where Flow leak is the leakage velocity, LeakFactor is the leakage factor, sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, and t is time;

[0069] Leakage compensation is performed on the real-time flow rate of the ventilator according to the leakage flow rate.

[0070] In this embodiment, after accurately integrating the flow rate and pressure based on the formula with positive and negative signs and calculating the leakage factor, the leakage flow rate formula with positive and negative signs can be used to calculate the leakage factor. The leakage flow rate is updated under the new leakage factor, thereby adjusting the real-time flow rate of the current ventilator and performing leakage compensation on the flow rate of the ventilator. This effectively solves the problem that a large amount of negative pressure can be generated by high-frequency oscillations and leakage compensation is required for the negative pressure. This allows the ventilator flow rate to be accurately compensated for leakage on a cycle during high-frequency ventilation.

[0071] In one embodiment, the method further comprises:

[0072] Confirm whether the ventilator is in high-frequency ventilation mode where high-frequency oscillator oscillates to generate ventilation.

[0073] In this embodiment, based on different application scenarios of the ventilator, in the high-frequency ventilation mode, machine-controlled inhalation and exhalation are performed by using a special high-frequency oscillator oscillation. Only high-frequency oscillator oscillation can generate a stable negative pressure. It is possible to first confirm whether the ventilator is in the high-frequency ventilation mode in which the high-frequency oscillator oscillates to generate ventilation. If it is high-frequency ventilation, the ventilator is accurately leak compensated through the steps in the above embodiment. If it is not high-frequency ventilation, leakage compensation can be performed through the existing compensation method of the ventilator, thereby adapting to the leakage compensation needs in different application scenarios.

[0074] Another embodiment of the present invention provides a leakage compensation device for high frequency ventilation, such as Figure 2 As shown, the device 1 comprises:

[0075] An acquisition module 11 is used to acquire the real-time flow rate and real-time pressure of the ventilator;

[0076] An integration module 12 is used to integrate the real-time flow rate in a first time period, and after confirming the direction of the real-time pressure, call a preset pressure formula with positive and negative signs to integrate the real-time pressure in the first time period;

[0077] The calculation module 13 is used to calculate the leakage factor according to the integration result of the current real-time flow velocity and the integration result of the real-time pressure when the second time period is reached, and clear the integration result;

[0078] The leakage compensation module 14 is used to calculate the leakage flow rate by calling the leakage flow rate formula with positive and negative signs according to the leakage factor, and perform leakage compensation on the ventilator according to the leakage flow rate.

[0079] The modules and units referred to in the present invention refer to a series of computer program instruction segments that can perform specific functions, which are more suitable for describing the execution process of leakage compensation of high-frequency ventilation than programs. For the specific implementation methods of each module, please refer to the corresponding method embodiments above, which will not be repeated here.

[0080] Another embodiment of the present invention provides a leakage compensation system for high frequency ventilation, such as Figure 3 As shown, the system 10 includes:

[0081] One or more processors 110 and memory 120, Figure 3 A processor 110 is used as an example for description. The processor 110 and the memory 120 may be connected via a bus or other means. Figure 3 The example of connecting through bus is taken in the following.

[0082] The processor 110 is used to complete various control logics of the system 10, and it can be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA), a single-chip microcomputer, an ARM (Acorn RISC Machine) or other programmable logic device, a discrete gate or transistor logic, a discrete hardware component, or any combination of these components. In addition, the processor 110 can also be any traditional processor, microprocessor or state machine. The processor 110 can also be implemented as a combination of computing devices, for example, a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors combined with a DSP and / or any other such configuration.

[0083] The memory 120, as a non-volatile computer-readable storage medium, can be used to store non-volatile software programs, non-volatile computer executable programs and modules, such as program instructions corresponding to the leakage compensation method for high-frequency ventilation in the embodiment of the present invention. The processor 110 executes various functional applications and data processing of the system 10 by running the non-volatile software programs, instructions and units stored in the memory 120, that is, the leakage compensation method for high-frequency ventilation in the above method embodiment is implemented.

[0084] The memory 120 may include a program storage area and a data storage area, wherein the program storage area may store an operating system and an application required by at least one function; the data storage area may store data created according to the use of the system 10, etc. In addition, the memory 120 may include a high-speed random access memory, and may also include a non-volatile memory, such as at least one disk storage device, a flash memory device, or other non-volatile solid-state storage device. In some embodiments, the memory 120 may optionally include a memory remotely arranged relative to the processor 110, and these remote memories may be connected to the system 10 via a network. Examples of the above-mentioned network include, but are not limited to, the Internet, an intranet, a local area network, a mobile communication network, and combinations thereof.

[0085] One or more units are stored in the memory 120, and when executed by one or more processors 110, the leakage compensation method for high-frequency ventilation in any of the above method embodiments is executed, for example, the above described method is executed. Figure 1 The method comprises steps S100 to S400.

[0086] An embodiment of the present invention provides a non-volatile computer-readable storage medium, wherein the computer-readable storage medium stores computer-executable instructions, and the computer-executable instructions are executed by one or more processors, for example, to execute the above-described Figure 1 The method comprises steps S100 to S400.

[0087] As an example, non-volatile storage media can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM), or flash memory. Volatile memory can include random access memory (RAM) as external cache memory. By way of illustration and not limitation, RAM can be obtained in many forms such as synchronous RAM (SRAM), dynamic RAM, (DRAM), synchronous DRAM (SDRAM), double data rate SDRAM (DDRSDRAM), enhanced SDRAM (ESDRAM), Synchlink DRAM (SLDRAM), and direct Rambus RAM (DRRAM). The disclosed memory components or memories of the operating environment described herein are intended to include one or more of these and / or any other suitable types of memory.

[0088] In summary, the present invention discloses a leakage compensation method, device, system and medium for high-frequency ventilation. The method obtains the real-time flow rate and real-time pressure of the ventilator; integrates the real-time flow rate in a first time period, and calls a preset pressure formula with positive and negative signs to integrate the real-time pressure in a first time period after confirming the direction of the real-time pressure; when the second time period is reached, the leakage factor is calculated according to the integral result of the current real-time flow rate and the integral result of the real-time pressure, and the integral result is cleared; the leakage flow rate formula with positive and negative signs is called according to the leakage factor to calculate the leakage flow rate, and the ventilator is leak compensated according to the leakage flow rate. By confirming the direction of the real-time pressure and integrating with a formula with a sign and calculating the leakage factor, the leakage can still be accurately compensated when a large amount of negative pressure is generated due to high-frequency oscillation in high-frequency ventilation, thereby improving the reliability of high-frequency ventilation.

[0089] Of course, those skilled in the art can understand that all or part of the processes in the above-mentioned embodiments can be implemented by instructing related hardware (such as a processor, a controller, etc.) through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium, and the computer program can include the processes of the above-mentioned method embodiments when executed. The storage medium can be a memory, a disk, a floppy disk, a flash memory, an optical storage device, etc.

[0090] It should be understood that the application of the present invention is not limited to the above examples. For ordinary technicians in this field, improvements or changes can be made based on the above description. All these improvements and changes should fall within the scope of protection of the claims attached to the present invention.

Claims

1. A leakage compensation method for high frequency ventilation, characterized in that: include: Get the real-time flow rate and real-time pressure of the ventilator; Integrate the real-time flow rate in a first time period, and after confirming the direction of the real-time pressure, call a preset pressure formula with positive and negative signs to integrate the real-time pressure in the first time period; When the second time period is reached, the leakage factor is calculated according to the integration result of the current real-time flow rate and the integration result of the real-time pressure, and the integration result is cleared; The leakage flow rate formula with positive and negative signs is called according to the leakage factor to calculate the leakage flow rate, and the ventilator is leak compensated according to the leakage flow rate.

2. The leakage compensation method for high frequency ventilation according to claim 1, characterized in that: The second time period is much longer than the first time period.

3. The leakage compensation method for high frequency ventilation according to claim 1, characterized in that: The step of integrating the real-time flow rate in a first time period and invoking a preset pressure formula with positive and negative signs to integrate the real-time pressure in a first time period after confirming the direction of the real-time pressure includes: By formula Integrating the real-time flow rate over a first time period, wherein Flow is the real-time flow rate and t is time; Confirming that the real-time pressure is positive pressure or negative pressure, and obtaining the positive and negative signs of the real-time pressure; By pre-set pressure formula with positive and negative signs The real-time pressure is integrated over a first time period, where sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, and t is time.

4. The leakage compensation method for high frequency ventilation according to claim 3, characterized in that: When the second time period is reached, the leakage factor is calculated according to the integration result of the current real-time flow rate and the integration result of the real-time pressure, and the integration result is cleared, specifically: When the second time period is reached, the formula The leakage factor is calculated and the integration result of the current integration period is cleared, where LeakFactor is the leakage factor.

5. The leakage compensation method for high frequency ventilation according to claim 4, characterized in that: The method of calculating the leakage flow rate by calling a leakage flow rate formula with positive and negative signs according to the leakage factor, and performing leakage compensation on the ventilator according to the leakage flow rate, comprises: Based on the leakage factor, the leakage flow rate formula with positive and negative signs is The leakage flow rate is calculated, where Flow leak is the leakage velocity, LeakFactor is the leakage factor, sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, and t is time; Leakage compensation is performed on the real-time flow rate of the ventilator according to the leakage flow rate.

6. The leakage compensation method for high frequency ventilation according to claim 1, characterized in that: The method further comprises: Confirm whether the ventilator is in high-frequency ventilation mode where high-frequency oscillator oscillates to generate ventilation.

7. The leakage compensation method for high frequency ventilation according to claim 1, characterized in that: The first time period is 1 ms, and the second time period is 3 s.

8. A leakage compensation device for high-frequency ventilation, characterized in that: include: An acquisition module, used for acquiring the real-time flow rate and real-time pressure of the ventilator; An integration module, used to integrate the real-time flow rate in a first time period, and after confirming the direction of the real-time pressure, call a preset pressure formula with positive and negative signs to integrate the real-time pressure in the first time period; A calculation module, configured to calculate a leakage factor according to an integration result of the current real-time flow velocity and an integration result of the real-time pressure when a second time period is reached, and clear the integration result; The leakage compensation module is used to calculate the leakage flow rate by calling the leakage flow rate formula with positive and negative signs according to the leakage factor, and perform leakage compensation on the ventilator according to the leakage flow rate.

9. A leakage compensation system for high frequency ventilation, characterized in that: The system includes at least one processor; and, a memory communicatively connected to the at least one processor; wherein, The memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor so that the at least one processor can execute the leakage compensation method for high-frequency ventilation according to any one of claims 1-7.

10. A non-volatile computer-readable storage medium, characterized in that: The non-volatile computer-readable storage medium stores computer-executable instructions, which, when executed by one or more processors, enable the one or more processors to execute the leakage compensation method for high-frequency ventilation according to any one of claims 1-7.

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