Probe set for judging triple negative breast cancer systemic tumor burden and application thereof
CN119799891BActive Publication Date: 2026-08-28SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV +1
Patent Information
- Application Number
- CN202411834280.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Patents(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-12
- Publication Date
- 2026-08-28
- Estimated Expiration
- 2044-12-12
AI Technical Summary
Technical Problem
不过，由于肿瘤具有异质性，组织检测可能并不能覆盖所有突变，并且对于治疗引起的选择压力及其他因素导致的肿瘤克隆进化而出现的新发突变，个性化定制ctDNA检测并不能实现有效监测
Benefits of technology
[0034]本公开基于大样本TNBC临床队列，设计了一种TNBC特异探针组，可与个性化探针组叠加使用进行靶向捕获，用于TNBC的个性化ctDNA检测，评估全身肿瘤负荷。TNBC特异探针组包括TNBC特异的高频突变，在ctDNA检测过程中可一定程度上克服肿瘤的时空异质性，同时还可稳定实验体系、提高捕获效率。
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Smart Images
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Abstract
The present disclosure provides a probe set for judging the systemic tumor burden of triple-negative breast cancer and application thereof, the probe set provided by the present disclosure can be used for detecting the gene markers of triple-negative breast cancer and for evaluating the systemic tumor burden, and can achieve good coverage and capture of the target region, obtain sufficient read information on the target region, and overcome the spatial and temporal heterogeneity of tumors to a certain extent, while improving the capture efficiency, stabilizing the experimental system, and meeting the requirements of clinical detection.
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Citation Information
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