Traditional Chinese medicine composition and application thereof

Abstract

The traditional Chinese medicine composition is prepared from the following raw material components in parts by weight: 8 to 30 parts of radix scrophulariae, 5 to 20 parts of bulbus fritillariae thunbergii, 5 to 20 parts of radix ophiopogonis, 10 to 20 parts of radix platycodonis, 5 to 20 parts of periostracum cicada, 10 to 20 parts of raw liquorice root, 5 to 20 parts of processed rhizoma pinelliae, 5 to 20 parts of pericarpium citri reticulatae, 3 to 12 parts of semen sterculiae lychnophorae and 3 to 12 parts of semen oroxyli. The traditional Chinese medicine composition for treating acute and chronic pharyngolaryngitis fully follows the syndrome differentiation and treatment principle of traditional Chinese medicine, has obvious advantages especially for acute and chronic pharyngolaryngitis, is reliable in curative effect, and is beneficial to treatment of acute and chronic pharyngolaryngitis with complex pathogenesis and reduction of recurrence rate.

Description

Technical Field

[0001] The present invention relates to the field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition and its application. Background Art

[0002] Pharyngitis is a non-specific inflammation of the pharynx, usually divided into acute pharyngitis and chronic pharyngitis. Acute pharyngitis is an acute inflammation of the pharyngeal mucosa and submucosal tissues. Pharyngeal lymphoid tissues are often involved. The inflammation may be localized in the early stage, and may often involve the entire pharyngeal cavity as the disease progresses. It is more common in autumn and winter and the turn of winter and spring. The main manifestations are dryness, burning, pain in the pharynx, obvious pain when swallowing, congestion and swelling of the pharynx, etc. Chronic pharyngitis can be divided into chronic simple pharyngitis, chronic hypertrophic pharyngitis and atrophic pharyngitis. Among them, chronic simple pharyngitis is more common. The lesions are mainly in the mucosal layer, manifested as chronic congestion of the pharyngeal mucosa, hyperplasia of the mucosal and submucosal connective tissue, hypertrophy of the mucous glands, hypersecretion, and increased mucus secretion. Patients often cough up sticky phlegm in the pharynx, or feel a foreign body sensation in the pharynx, which cannot be coughed up or swallowed. The course of the disease is long, prone to recurrence, and the symptoms are stubborn. In recent years, with the diversification of lifestyle and diet, bad living habits have become increasingly common. Pharyngitis, as a common disease in respiratory and otolaryngology departments, has a long course of illness and symptoms that are prone to recurrence and difficult to cure. It also causes symptoms such as dry cough, sore throat, and itchy throat, affecting sleep and work quality.

[0003] The causes of chronic pharyngitis are varied, mainly including the following categories: Recurrent infection: Chronic pharyngitis may be caused by repeated attacks of acute pharyngitis, which causes the mucosa to be continuously stimulated by inflammation and thicken and degenerate. Environmental factors: Long-term exposure to polluted air, smoke, chemicals and other environments can easily cause damage to the pharyngeal mucosa, which in turn causes chronic inflammation. Lifestyle: Smoking and drinking are important factors that lead to chronic pharyngitis. The chemical components in tobacco will directly irritate the pharyngeal mucosa, while alcohol will have a corrosive effect on the mucosa. Occupational factors: Certain occupations, such as teachers, singers, salespersons, etc., are prone to damage to the pharynx due to the long-term use of the voice. Gastroesophageal reflux disease (GERD): Reflux of gastric acid into the pharynx can cause chronic irritation of the mucosa, leading to chronic pharyngitis. Allergies: Allergic reactions can cause edema and inflammation of the pharynx, which in turn causes chronic pharyngitis.

[0004] The main clinical treatment methods are: 1. Remove the cause of the disease and eliminate various pathogenic factors, such as quitting smoking and drinking, improving the working environment, and actively treating chronic inflammatory lesions of the nose and nasopharynx and related systemic diseases. Strengthen physical fitness, improve the body's immunity, and prevent acute upper respiratory tract infections. Pay attention to rest, drink plenty of water, and eat light and easily digestible food. 2. Symptomatic treatment. If fever and sore throat occur, physical cooling (such as warm water or 75% alcohol bath, placing ice packs on the head, etc.) and antipyretic measures such as drugs should be used in time. Commonly used drugs are oral APC or intramuscular injection of antonidine, etc. Keep the mouth clean, and use alkaline gargles to appropriately dissolve the viscous secretions of the pharynx. Compound borax solution is often used for gargling. 3. Anti-inflammatory treatment. In the early stage of the disease, 1% iodine glycerol or 2% silver nitrate can be used to rub the pharyngeal wall, which has the effect of promoting the disappearance of inflammation. If the inflammation invades the larynx or trachea, appropriate antibiotics or hormone atomization inhalation treatment can be selected. For severe cases, intramuscular injection or intravenous drip of penicillin is the first choice, and strong antibiotics should be replaced at any time. If it is caused by a viral infection, antiviral drugs should be used. 4. Local treatment: Chronic pharyngitis is mainly treated locally. When gargling, tilt your head back so that the gargle can clean the back wall of the pharynx. In addition to the above-mentioned drug treatments, chronic hypertrophic pharyngitis can be treated with laser. Atrophic pharyngitis can be treated by applying 2% iodine glycerol to the pharynx, which can improve local blood circulation and promote glandular secretion.

[0005] Existing treatment methods mostly use antibiotics, antiviral drugs and other drugs, which will produce side effects to varying degrees. It is necessary to solve the problem that the safety of drugs cannot be guaranteed while treating pharyngitis. Summary of the invention

[0006] In order to solve the above technical problems, the Chinese medicine composition for treating acute and chronic pharyngitis prepared in the present application fully follows the principle of syndrome differentiation and treatment in traditional Chinese medicine, and is especially invented for acute and chronic inflammation of the pharynx.

[0007] The present application provides a traditional Chinese medicine composition, comprising the following raw material components by weight: 8-30 parts of Scrophularia ningpoensis, 5-20 parts of Fritillaria thunbergii, 5-20 parts of Ophiopogon japonicus, 10-20 parts of Platycodon grandiflorum, 5-20 parts of Periostracum cicadae, 10-20 parts of raw licorice, 5-20 parts of processed Pinellia ternata, 5-20 parts of dried tangerine peel, 3-12 parts of Sterculia lychnophora, and 3-12 parts of Oroxylum indicum.

[0008] The present application also provides a Chinese medicine preparation, which is prepared using the above-mentioned Chinese medicine composition as raw material.

[0009] The present application also provides use of the above-mentioned Chinese medicine composition or the above-mentioned Chinese medicine preparation in preparing a medicine for preventing and / or treating pharyngeal diseases.

[0010] The beneficial effects brought by this application include but are not limited to: the Chinese medicine composition or Chinese medicine preparation provided by this application can significantly relieve the symptoms of dry throat, sore throat, itchy throat, foreign body sensation in the throat and hoarseness caused by acute and chronic pharyngitis. Compared with other Chinese medicine formulas, this preparation pays more attention to moistening without being greasy, clearing without being laxative, warming without being dry in the compatibility of Chinese medicine. It has the characteristics of wide indications, small side effects such as gastrointestinal discomfort, and good taste. It has therapeutic and preventive effects and can be used for a long time. BRIEF DESCRIPTION OF THE DRAWINGS

[0011] The present application will be further described in the form of exemplary embodiments, which will be described in detail with reference to the accompanying drawings. These embodiments are not restrictive, and include:

[0012] Figure 1 This is a visual analog scale for symptoms according to some embodiments of the present application. DETAILED DESCRIPTION

[0013] As shown in this specification and claims, unless the context clearly indicates an exception, the words "a", "an", "an" and / or "the" do not refer to the singular and may also include the plural. Generally speaking, the terms "comprise" and "include" only indicate the inclusion of the steps and elements that have been clearly identified, and these steps and elements do not constitute an exclusive list. The method or device may also include other steps or elements.

[0014] Flowcharts are used in this specification to illustrate the operations performed by the system according to the embodiments of this specification. It should be understood that the preceding or following operations are not necessarily performed precisely in order. Instead, the steps may be processed in reverse order or simultaneously. At the same time, other operations may also be added to these processes, or one or more operations may be removed from these processes.

[0015] The present application provides a Chinese medicine composition, which comprises the following raw material components by weight: 8-30 parts of Scrophularia ningpoensis Hemsl., 5-20 parts of Fritillaria thunbergii Miq., 5-20 parts of Ophiopogon japonicus (Linn.f.) Ker Gawl., 10-20 parts of Platycodon grandiflorus (Jacq.) A.DC., 5-20 parts of Cryptotympana pustulata Fabr, 10-20 parts of Glycyrrhiza uralensis, 5-20 parts of Processed Pinellia ternata (Thunb.) Breit.], 5-20 parts of Pericarpium Citri Reticulatae, 5-20 parts of Scaphium lycopersicum, 10-20 parts of Radix Angelicae Pubescentis, 10-20 parts of Radix Angelicae Pubescentis, 10-20 parts of Radix Angelicae Pubescentis, 10-20 parts of Radix Angelicae Sinensis ... wallichii (Wall.exG.Don) Schott&Endl.) 3-12 parts, wood butterfly (Oroxylum indicum (L.) Kurz) 3-12 parts.

[0016] Scrophularia: sweet, bitter, salty, slightly cold; enters the spleen, stomach, and kidney meridians; clears heat and cools blood, nourishes yin and reduces fire, detoxifies and disperses nodules.

[0017] Fritillaria thunbergii: bitter in taste, cold in nature. Enters the lung and heart meridians. Clears away heat, resolves phlegm, relieves cough, detoxifies, disperses stagnation, and eliminates carbuncle.

[0018] Ophiopogon japonicus: sweet, slightly bitter, slightly cold. Enters the heart, lung, and stomach meridians. Nourishes yin and produces body fluid, moistens the lungs and relieves cough: used for lung and stomach yin deficiency with thirst, dry cough and hemoptysis; palpitations and easy fright due to heart yin deficiency, and late stage of fever with heat damage to body fluid. Combined with Adenophora Root and Fritillaria cirrhosa, it can treat dry cough due to lung yin deficiency.

[0019] Platycodon grandiflorum: bitter, pungent, neutral in nature. Enters the lung meridian. Clears the lungs, relieves sore throat, removes phlegm, and discharges pus. Used for cough with a lot of phlegm, chest tightness, sore throat, hoarseness, and lung abscess with vomiting pus.

[0020] Cicada slough: sweet and salty in taste, cool in nature. Enters the lung and liver meridians. Disperses wind-heat, relieves sore throat and relieves voice, clears rashes, brightens eyes and removes cataracts, calms wind and stops spasms. Used for wind-heat cold, initial stage of febrile disease, sore throat and hoarseness, measles that does not clear up, itchy rubella, red eyes and cataracts, acute and chronic convulsions, tetanus, and night crying and restlessness in children.

[0021] Raw licorice: sweet in taste, neutral in nature, enters the heart, lung, spleen, and stomach meridians. It has the effects of tonifying the spleen and replenishing qi, clearing away heat and detoxifying, removing phlegm and relieving cough, relieving acute pain, and harmonizing various medicines. It is often used to treat spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal pain, cramps and pain in the limbs, carbuncles, sores, and other symptoms.

[0022] Processed Pinellia: pungent, warm. Enters the spleen, stomach, and lung meridians. Drys dampness and resolves phlegm. Indications: cough and asthma due to excessive phlegm, dizziness and palpitations due to phlegm and fluid, dizziness due to wind and phlegm, and headache due to phlegm and syncope.

[0023] Tangerine peel: bitter, pungent, warm in nature. Enters the lung and spleen meridians. Regulates qi and strengthens the spleen, dries dampness and resolves phlegm. Indications: abdominal distension, loss of appetite, vomiting and diarrhea, cough and excessive phlegm.

[0024] Sterculia lychnophora: sweet, cold. Enters the lung and large intestine meridians. Clears heat and moistens the lungs, relieves sore throat and relieves voice, moistens the intestines and relieves constipation. Indications: hoarseness due to lung heat, dry cough without sputum, dry and sore throat, constipation due to heat, headache and red eyes.

[0025] Oroxylum butterfly: bitter, sweet, cool. Enters the lung, liver, and stomach meridians. Clears the lungs and relieves sore throat, soothes the liver and harmonizes the stomach. Indications: cough due to lung heat, sore throat, hoarseness, and pain in the liver and stomach.

[0026] In some embodiments, the Chinese medicine composition comprises the following raw material components by weight:

[0027] 8-30 parts of Scrophularia ningpoensis, for example 10-28 parts, 12-26 parts, 14-24 parts, 16-22 parts, 18-20 parts;

[0028] 5-20 parts of Fritillaria thunbergii, for example 7-18 parts, 9-16 parts, 11-14 parts, 13-14 parts;

[0029] 5-20 parts of Radix Ophiopogonis, for example 7-18 parts, 9-16 parts, 11-14 parts, 13-14 parts;

[0030] 10-20 parts of Platycodon grandiflorum, for example, 12-18 parts, 14-16 parts;

[0031] 5-20 parts of cicada molts, for example 7-18 parts, 9-16 parts, 11-14 parts, 13-14 parts;

[0032] 10-20 parts of raw liquorice, for example 12-18 parts, 14-16 parts;

[0033] 5 to 20 portions of processed pinellia, such as 7 to 18 portions, 9 to 16 portions, 11 to 14 portions, 13 to 14 portions;

[0034] 5-20 parts of dried tangerine peel, for example 7-18 parts, 9-16 parts, 11-14 parts, 13-14 parts;

[0035] 3-12 portions of Sterculia lychnophora, for example 5-10 portions, 7-8 portions;

[0036] 3 to 12 portions of Oroxylum butterfly, for example, 5 to 10 portions, 7 to 8 portions.

[0037] The Chinese medicine composition for treating acute and chronic pharyngitis of the present application fully follows the principle of syndrome differentiation and treatment of traditional Chinese medicine, and is invented especially for acute and chronic inflammation of the throat. The following Chinese medicines are mutually compatible, and can exert their synergistic curative effect, and the components of the Chinese medicine raw materials used have interweaving, mutual promotion and coordination of drug effects. Specifically, this side reuses Scrophularia and Fritillaria thunbergii as the monarch, Scrophularia detoxifies and relieves throat, Fritillaria thunbergii disperses and resolves phlegm, and the two are used together to play the effect of detoxification, throat relieving and resolving stagnation. Assisted by Ophiopogon japonicus, Licorice, Periostracum Cicadae, Platycodon grandiflorum, Ophiopogon japonicus and Licorice moisturize and detoxify, which can strengthen the effect of Scrophularia thunbergii detoxification, moisturizing and relieving throat. Platycodon grandiflorum and Periostracum Cicadae promote lung function and open sound, which can strengthen the function of Fritillaria thunbergii dispersing and opening sound; Pinellia ternata and dried tangerine peel belong to anti-adjuvant drugs, which seek yin in yang, warm and regulate qi, dry dampness and resolve phlegm, and can be used together with the previous medicine to moisten but not greasy, clear but not diarrhea, warm but not dry. Plantago asiatica and Oroxylum bungeana are special medicines for the throat. Light use can lead the meridians to the throat, making the effect focused and gentle.

[0038] In some embodiments, preferably, the Chinese medicine composition comprises the following raw material components by weight: 8-20 parts of Scrophularia ningpoensis, 5-15 parts of Fritillaria thunbergii, 5-15 parts of Ophiopogon japonicus, 10-15 parts of Platycodon grandiflorum, 5-15 parts of Periostracum cicadae, 10-15 parts of raw licorice, 5-10 parts of processed Pinellia ternata, 5-10 parts of dried tangerine peel, 3-10 parts of Sterculia lychnophora, and 3-10 parts of Oroxylum indicum.

[0039] In some embodiments, more preferably, the Chinese medicine composition comprises the following raw material components by weight: 15 parts of Scrophularia ningpoensis, 10 parts of Fritillaria thunbergii, 10 parts of Ophiopogon japonicus, 10 parts of Platycodon grandiflorum, 10 parts of Periostracum cicadae, 10 parts of raw licorice, 10 parts of processed Pinellia ternata, 10 parts of dried tangerine peel, 6 parts of Sterculia lychnophora, and 6 parts of Oroxylum indicum.

[0040] The present application also provides a Chinese medicine preparation, which is prepared using the above-mentioned Chinese medicine composition as raw material.

[0041] In some embodiments, the above-mentioned traditional Chinese medicine composition can be decocted with water and filtered to obtain the traditional Chinese medicine preparation.

[0042] In some embodiments, the traditional Chinese medicine preparation comprises a traditional Chinese medicine decoction.

[0043] In some embodiments, before decocting, the Chinese medicine composition can be soaked in water for 20 minutes to 1 hour.

[0044] The present application also provides use of the above-mentioned Chinese medicine composition or the above-mentioned Chinese medicine preparation in preparing a medicine for preventing and / or treating pharyngeal diseases.

[0045] The term "prevention and / or treatment" (and grammatical variations thereof) refers to an attempt to alter the natural course of a disease in a treated individual, and may be a clinical intervention performed for prevention or during the course of clinical pathology. Desired effects of treatment include, but are not limited to, preventing the occurrence or recurrence of the disease, alleviating symptoms, reducing any direct or indirect pathological consequences of the disease, preventing metastasis, slowing the rate of disease progression, ameliorating or alleviating the disease state, and eliminating or improving prognosis.

[0046] In some embodiments, the pharyngeal disease can be pharyngitis. In some embodiments, preferably, the pharyngeal disease can be acute or chronic pharyngitis.

[0047] In some embodiments, the pharyngeal disease may include at least one of dry throat, itchy throat, hoarseness, foreign body sensation in the throat, cough, or sore throat.

[0048] In some embodiments, the drug can reduce the level of inflammatory factors in serum. In some embodiments, preferably, the drug can reduce the level of interleukin 6 or tumor necrosis factor α in serum.

[0049] In some embodiments, the Chinese medicine preparation or drug can be an oral drug.

[0050] The present application also provides a method for treating pharyngeal diseases, which comprises administering an effective amount of the Chinese medicine preparation of the present application to a subject in need thereof.

[0051] The experimental methods in the following examples are conventional methods unless otherwise specified. The experimental materials used in the following examples are purchased from conventional biochemical reagent companies unless otherwise specified. The quantitative tests in the following examples are repeated three times, and the results are averaged.

[0052] Example 1

[0053] Chinese medicine composition 1#: Scrophularia 15g, Fritillaria thunbergii 10g, Ophiopogon japonicus 10g, Platycodon grandiflorum 10g, Periostracum cicadae 10g, Raw Licorice root 10g, Processed Pinellia 10g, Tangerine peel 10g, Sterculia lychnophora 6g, Oroxylum indica 6g.

[0054] Chinese medicine composition 2#: Scrophularia 20g, Fritillaria thunbergii 20g, Ophiopogon japonicus 20g, Platycodon grandiflorum 15g, Periostracum cicadae 20g, raw licorice 15g, processed Pinellia 10g, dried tangerine peel 10g, Sterculia lychnophora 12g, Oroxylum indica 12g.

[0055] Chinese medicine composition 3#: Scrophularia 8g, Fritillaria thunbergii 15g, Ophiopogon japonicus 5g, Platycodon grandiflorum 10g, Periostracum cicadae 5g, Raw Licorice root 10g, Processed Pinellia 20g, Tangerine peel 20g, Sterculia lychnophora 3g, Oroxylum indica 3g.

[0056] Chinese medicine composition 4#: Scrophularia 30g, Fritillaria thunbergii 5g, Ophiopogon japonicus 15g, Platycodon grandiflorum 20g, Periostracum cicadae 15g, Raw Licorice root 20g, Processed Pinellia 5g, Tangerine peel 5g, Sterculia lychnophora 10g, Oroxylum indica 10g.

[0057] Decoction steps:

[0058] Soak the medicine in 600ml of water in a casserole or glass pot for 20 minutes, boil it on medium-low heat for 20 minutes, filter out the juice, add 400ml of water to the residue, boil it on medium-low heat for 15 minutes, filter out the juice, mix the juices boiled twice and divide them into two equal portions of about 100ml, and take them warm half an hour after meals in the morning and evening. The Chinese medicine is boiled by our hospital.

[0059] Correspondingly, we obtain Chinese herbal decoction 1#, Chinese herbal decoction 2#, Chinese herbal decoction 3#, and Chinese herbal decoction 4#.

[0060] Example 2

[0061] In order to verify the effect of the present invention in treating acute and chronic pharyngitis, the present invention carried out the following clinical trials.

[0062] 1. Patient selection According to the random number table method, 500 patients with acute and chronic pharyngitis who visited Shanghai Seventh People's Hospital from January 2020 to June 2021 were divided into experimental group 1, experimental group 2, experimental group 3, experimental group 4 and control group, with 100 cases in each group. There was no statistically significant difference in the baseline data of each group (P>0.05), which was comparable. See Table 1

[0063] Table 1 Comparison of general conditions at enrollment

[0064]

[0065] 2. Diagnostic criteria

[0066] Inclusion criteria: ① Patients with clinical diagnosis in accordance with the diagnostic criteria for acute and chronic pharyngitis, and with 2 or more symptoms of pharyngitis, including sore throat, dry throat, foreign body sensation in the throat, hoarseness, and itchy throat; ② Clinical signs showing chronic diffuse congestion, hypertrophy, and hyperplasia of the posterior pharyngeal wall lymphoid follicles in the pharyngeal mucosa; ③ Signed informed consent.

[0067] Exclusion criteria: ① Patients during pregnancy and lactation; ② Patients with epiglottic cysts, tonsil hypertrophy, other pharyngeal tumors, and reflux esophagitis; ③ Patients allergic to the ingredients of Chinese and Western medicines; ④ Patients with severe cardiovascular, diabetes, liver and kidney failure; ⑤ Patients with mental illness, hysteria, pharyngeal foreign bodies, esophageal diseases, etc. ⑥ Aged 18 to 60 years old.

[0068] TCM diagnosis: laryngeal congestion, Yin deficiency and lung dryness type (dry tongue, little or thin coating, thready pulse), or combined with Qi stagnation and phlegm stagnation (pale red tongue, slightly greasy and dry coating).

[0069] Western medicine diagnosis: consistent with the symptoms and physical examination findings of acute pharyngitis and chronic pharyngitis. Traditional Chinese medicine diagnosis: Traditional Chinese medicine symptoms and signs are consistent with the third edition of "Otorhinolaryngology of Integrated Traditional Chinese and Western Medicine", edited by Tian Daofa and Li Yunying, China Traditional Chinese Medicine Press.

[0070] 3. Treatment methods

[0071] The control group took the classic prescription Xuanmai Juegan Decoction with modified Chinese medicine decoction orally, one dose a day, for 4 consecutive weeks.

[0072] Specific composition and dosage: Scrophularia 10g, Ophiopogon 10g, Platycodon 10g, Raw Licorice 10g, Processed Pinellia 10g, Tangerine Peel 10g, Sterculia lychnophora 6g, Oroxylum indica 6g.

[0073] Soak the above in 600ml of water in a casserole or glass pot for 20min, boil it on medium-low heat for 20min, filter out the juice, add 400ml of water to the residue, boil it on medium-low heat for 15min, filter out the juice, mix the juices boiled twice and divide them into two equal portions of about 100ml, take warm in the morning and evening half an hour after meals. Chinese medicine decoctions are boiled by our hospital.

[0074] Experimental Group:

[0075] Experimental Group 1: Patients orally took the Chinese medicine decoction 1# in Example 1 of the present application, one dose per day, for 4 consecutive weeks.

[0076] Experimental Group 2: Patients orally took the Chinese medicine decoction 2# in Example 1 of the present application, one dose per day, for 4 consecutive weeks.

[0077] Experimental Group 3: Patients orally took the Chinese medicine decoction 3# in Example 1 of the present application, one dose per day, for 4 consecutive weeks.

[0078] Experimental Group 4: Patients orally took the Chinese medicine decoction 4# in Example 1 of the present application, one dose per day, for 4 consecutive weeks.

[0079] 4. Efficacy

[0080] Efficacy evaluation:

[0081] (1) Use Figure 1 Symptoms were scored using a visual analogue scale as shown:

[0082] Description: VAS is widely used in clinical pain assessment in China, and is also widely used to assess other subjective symptoms. Basic method: Use a 10cm long floating ruler with 10 scales on one side, with "0" at the end and "10" at the other end.

[0083] The score ranged from 0 points indicating no discomfort to 10 points indicating the most severe discomfort that is unbearable.

[0084] For pharyngeal pain: The VAS scoring standard for the degree of pain is as follows:

[0085] ①0 points: The patient does not feel any pain.

[0086] ② Below 3 points: The patient has slight pain but can still bear it.

[0087] ③4-6 points: The patient has obvious pain, which affects the quality of sleep, but is still tolerable.

[0088] ④7-10 points: The patient experiences severe pain that is unbearable and affects sleep quality and appetite.

[0089] For dry throat: The VAS scoring standard defines the degree of dry throat as follows:

[0090] ①0 points: means the patient does not have any dry throat.

[0091] ② Below 3 points: The patient has a mild dry throat, which can be significantly improved by drinking water and is still tolerable.

[0092] ③4-6 points: The patient has obvious dry throat, which can be improved by drinking water frequently. It will affect the sleep quality but is still tolerable.

[0093] ④7-10 points: The patient has severe dry throat, which is not improved by drinking water and is unbearable, affecting appetite and sleep quality.

[0094] For throat itching: The VAS scoring standard for the degree of throat itching is as follows:

[0095] ①0 points: The patient does not have any throat itch.

[0096] ② Below 3 points: It means that the patient has a slight throat itching, no obvious choking or slight choking, but it is still tolerable.

[0097] ③4-6 points: The patient has obvious throat itching, which causes frequent choking and coughing, affecting the quality of sleep, but is still tolerable.

[0098] ④7-10 points: The patient experiences severe throat itching and paroxysmal choking coughs, which are unbearable and affect the quality of sleep.

[0099] For foreign body sensation in the pharynx: The VAS scoring standard for the degree of foreign body sensation in the pharynx is as follows:

[0100] ①0 points: It means that the patient has no foreign body sensation in the throat.

[0101] ② Below 3 points: The patient has a slight foreign body sensation in the throat, which can disappear with exercise or diverting attention and is still tolerable.

[0102] ③4-6 points: The patient has an obvious foreign body sensation in the throat and is prone to dry heaving when brushing teeth. This condition may improve with exercise or distraction, but does affect sleep but is still tolerable.

[0103] ④7-10 points: The patient has a strong foreign body sensation in the throat and frequent dry heaving, which is difficult to improve with exercise or diverting attention and is unbearable. It is obvious before bedtime, affecting sleep and is unbearable.

[0104] For hoarseness: The VAS scoring standard stipulates the degree of hoarseness as follows:

[0105] ①0 points: means that the patient does not have any pharyngeal hoarseness.

[0106] ② Below 3 points: It means that the patient has mild hoarseness, which can disappear after sound rest.

[0107] ③4-6 points: The patient has obvious persistent hoarseness, which can be improved by voice rest.

[0108] ④7-10 points: The patient has persistent hoarseness and difficulty in speaking, which is not improved by voice rest.

[0109] Cured: The patient's symptoms disappear and the VAS score decreases by more than 95%.

[0110] Markedly effective: symptoms were significantly improved, with a VAS score reduction rate of 70%≤<95%.

[0111] Effective: Symptoms improved compared to before, 30%≤VAS score reduction rate<70%;.

[0112] Ineffective: No significant improvement in symptoms, VAS score reduction rate <30%.

[0113] SPSS 25.0 was used for data processing. The chi-square test was used for count data, and one-way analysis of variance or rank sum test was used for measurement data. P < 0.05 was considered statistically significant.

[0114] Auxiliary indicators: serum interleukin-6 and serum tumor necrosis factor-α levels.

[0115] 5. Results

[0116] 5.1 There was no statistically significant difference in the proportion of dry throat, itchy throat, hoarseness, foreign body sensation in the throat, and sore throat between the experimental group and the control group at the time of enrollment, P>0.05, see Table 2.

[0117] Table 2 Number of cases with pharyngitis symptoms in each group at the time of enrollment

[0118]

[0119] 5.2 At the end of treatment, the improvement of dry throat, itchy throat, hoarseness, foreign body sensation in throat and sore throat in the experimental group was better than that in the control group, P<0.05, see Tables 3, 4, 5, 6, 7

[0120] Table 3 Comparison of clinical efficacy of dry throat

[0121]

[0122] Table 4 Comparison of clinical efficacy of pharyngeal itch

[0123]

[0124] Table 5 Comparison of clinical efficacy of hoarseness

[0125]

[0126] Table 6 Comparison of clinical efficacy of foreign body sensation in pharynx

[0127]

[0128] Table 7 Comparison of clinical efficacy of sore throat

[0129]

[0130] 5.3 Before medication, there was no significant difference in interleukin-6 and tumor necrosis factor-α between the experimental group and the control group, P>0.05. After medication, there was a statistical difference between the experimental group and the control group. The decrease in interleukin-6 and tumor necrosis factor-α in the experimental group was more obvious than that in the control group, P<0.05, see Tables 8 and 9.

[0131] Table 8 Comparison of interleukin 6 in two groups before and after medication

[0132]

[0133] Table 9 Comparison of tumor necrosis factor α between the two groups before and after medication

[0134]

[0135] Example 3

[0136] Case 1

[0137] Wang Moumou, female, 42 years old, Shanghai Seventh People's Hospital, outpatient number: P8910**28

[0138] Chief complaint: dry throat and itchy throat for more than one month.

[0139] Current medical history: The patient had a cold one month ago and felt dry and itchy throat, accompanied by paroxysmal cough, which was more obvious at night, dry cough, no sputum, which could be temporarily relieved after drinking water, accompanied by dry mouth and thirst, and dry stool. After conventional western medicine treatment, the symptoms did not improve, so he came to our outpatient clinic for treatment and was diagnosed with "chronic pharyngitis". In recent days, the patient has dry mouth, dry throat, thirst and thirst, good appetite, slightly dry stool, short yellow urine, and poor sleep at night.

[0140] Tongue and pulse: red tongue with little coating. Fine and rapid pulse.

[0141] Physical examination: chronic congestion of the throat mucosa, hyperplasia of the posterior pharyngeal wall lymphoid follicles, no enlargement of the bilateral tonsils, hyperplasia of the lymphoid follicles at the root of the tongue under electronic laryngoscopy, no edema of the epiglottis, and slight hypertrophy of the vocal cords and ventricular bands. VAS score: dry throat 7 points, itchy throat 8 points, cough 8 points. Interleukin 6: 5.42pg / mL, tumor necrosis factor α: 12.60pg / mL.

[0142] Diagnosis: Chronic laryngeal paralysis

[0143] Syndrome differentiation: Yin deficiency and lung dryness type

[0144] Treatment principle: Nourish yin, moisten the lungs and relieve sore throat.

[0145] Prescription: Chinese herbal decoction group 1#*14 doses.

[0146] Second visit: After taking the medicine, the patient's symptoms of dry throat and itchy throat were significantly improved, and the frequency of coughing was reduced compared with before. VAS score: dry throat 3 points, itchy throat 5 points, cough 3 points, interleukin 6: 4.62pg / mL, tumor necrosis factor α: 7.43pg / mL. Dry stool improved, sleep improved, red tongue coating less pulse thin. Still follow the above method, and give 14 doses of the above prescription.

[0147] Follow-up: After taking the medicine for one month, the patient's dry throat and itchy throat were basically improved, with no obvious cough, no dry stool, and good sleep at night. VAS score: dry throat 1 point, itchy throat 2 points, cough 0 points, interleukin 6: 3.22pg / mL, tumor necrosis factor α: 5.98pg / mL. The tongue was pale red with thin white fur and slow pulse.

[0148] Case 2

[0149] Shi, male, 36 years old, Shanghai Seventh People's Hospital, outpatient number: P30282**61

[0150] Chief complaint: Hoarseness for more than 3 months.

[0151] Current medical history: The patient developed hoarseness without obvious cause 3 months ago, which worsened after fatigue or continuous pronunciation, and could be relieved after rest or drinking water. Electronic laryngoscope in an external hospital showed that the bilateral vocal cords and ventricular bands were swollen and hypertrophic, and the closure was poor. The patient usually spoke a lot and drank little water due to work reasons. After conventional western medicine treatment, the hoarseness did not improve. So he came to our outpatient clinic for treatment and was diagnosed with "chronic hypertrophic laryngitis". In recent days, the patient has persistent hoarseness, accompanied by dry throat, no itchy throat, no cough, no foreign body sensation in the throat, likes to drink, good appetite, constipation, one bowel movement every two days, short yellow urine, and good sleep at night.

[0152] Tongue and pulse: The tongue is dark red, the tongue coating is thin and cracked, and the pulse is stringy.

[0153] Physical examination: chronic congestion and hypertrophy of laryngeal mucosa, hyperplasia of lymphoid follicles, no enlargement of bilateral tonsils, no edema of epiglottis under electronic laryngoscopy, hyperemia and hypertrophy of vocal cords and ventricular zones. VAS score: hoarseness 8 points, dry throat 7 points. Interleukin 6: 5.39pg / mL, tumor necrosis factor α: 11.84pg / mL.

[0154] Diagnosis: Chronic laryngeal paralysis

[0155] Syndrome differentiation: Yin deficiency and lung dryness type

[0156] Treatment principle: Nourish yin, moisten the lungs and relieve sore throat.

[0157] Prescription: Chinese herbal decoction group 2#*14 doses.

[0158] Second visit: After taking the medicine, the patient's symptoms of dry throat and hoarseness were significantly improved, VAS score: hoarseness 6 points, dry throat 3 points, interleukin 6: 4.32pg / mL, tumor necrosis factor α: 8.02pg / mL. The constipation was improved, sleep was good at night, the tongue was red and thin, the cracks were improved, and the pulse was stringy. Still follow the above method, and give 14 doses of the above prescription.

[0159] Follow-up: After taking the medicine for one month, the patient's hoarseness was basically improved. There was mild hoarseness after talking more, which could be relieved after rest. The dry throat was not obvious, there was no obvious cough, the bowel movement was one time a day, and the patient slept well at night. VAS score: dry throat 1 point, hoarseness 2 points, interleukin 6: 3.12pg / mL, tumor necrosis factor α: 5.69pg / mL. The tongue was light red with a thin and moist coating, and the pulse was normal.

[0160] Case 3

[0161] Xu, female, 52 years old, Shanghai Seventh People's Hospital, outpatient number: P14073**7X

[0162] Chief complaint: Foreign body sensation in the throat for more than 1 year

[0163] Current medical history: The patient had a foreign body sensation in the throat without obvious cause 1 year ago. He could not cough or swallow. The sensation was obvious before going to bed late at night. It could be relieved during exercise or when diverting attention. There was a small amount of sticky phlegm in the throat, which was difficult to cough up. He ate normally, had no acid reflux, and breathed smoothly. The electronic laryngoscope in our hospital showed: hyperplasia of lymphoid follicles on the posterior pharyngeal wall and the root of the tongue, and no new organisms were found in the epiglottis and glottis. The patient was diagnosed with chronic pharyngitis. There was no obvious relief after conventional treatment. So he came to our hospital for Chinese medicine conditioning. In recent days, the patient had a foreign body sensation in the throat, smooth eating and breathing, a little sticky phlegm in the throat, which was difficult to cough up, a slightly dry throat, poor sleep at night, constipation, urination was OK, and appetite was normal.

[0164] Tongue and pulse: The tongue is pale red, the tongue coating is slightly greasy and dry, and the pulse is stringy and fine.

[0165] Physical examination: chronic congestion and hypertrophy of pharyngeal mucosa, hyperplasia of lymphoid follicles, no enlargement of bilateral tonsils, no neoplasms were found in epiglottis, vocal cords, ventricular bands, arytenoid region and pyriform sinus under electronic laryngoscopy. VAS score: foreign body sensation in pharynx 8 points, dry throat 6 points. Interleukin 6: 5.06pg / mL, tumor necrosis factor α: 11.46pg / mL.

[0166] Diagnosis: Chronic laryngeal paralysis

[0167] Syndrome differentiation: Yin deficiency and lung dryness with qi stagnation and phlegm stagnation

[0168] Treatment principle: Nourish yin and moisten the lungs, promote qi and resolve phlegm.

[0169] Prescription: Chinese herbal decoction group 3#*14 doses.

[0170] Second visit: After taking the medicine, the patient's foreign body sensation in the throat was significantly improved, VAS score: foreign body sensation in the throat 5 points, dry throat 5 points, interleukin 6: 4.18pg / mL, tumor necrosis factor α: 7.65pg / mL. The constipation was improved, the sleep was slightly better, the tongue was red with a slightly greasy coating, and the pulse was stringy and thin. The above prescription was still followed and 14 doses were given.

[0171] Follow-up: After taking the medicine for one month, the patient's foreign body sensation was basically improved, there was no obvious dry throat, no obvious cough, bowel movement once a day, and good sleep at night. VAS score: foreign body sensation in the throat 2 points, dry throat 1 point, interleukin 6: 3.09pg / mL, tumor necrosis factor α: 5.73pg / mL. The tongue was pale red with thin fur and fine pulse.

[0172] Case 4

[0173] Qin, male, 46 years old, Shanghai Seventh People's Hospital, outpatient number: P27136**53

[0174] Chief complaint: Dry and painful throat for more than 2 months.

[0175] Current medical history: The patient developed dry and sore throat and burning sensation in the throat after eating spicy food 2 months ago, which was slightly relieved by drinking water and aggravated at night, with no fever, cough, sputum, or hoarseness. Accompanied by restless sleep, poor appetite, dry stool, frequent urination, irritability, and hot flashes.

[0176] Tongue and pulse: The tongue is red with little coating, and the pulse is thready and weak.

[0177] Physical examination: The throat mucosa was atrophic and dry, and the mucosa was thin. Lymph follicles were hyperplastic, and the bilateral tonsils were not enlarged. Under electronic laryngoscopy, no neoplasms were found in the epiglottis, vocal cords, ventricular bands, arytenoids, and pyriform sinuses. VAS score: 8 points for sore throat, 6 points for dry throat. Interleukin 6: 5.06pg / mL, tumor necrosis factor α: 11.46pg / mL.

[0178] Diagnosis: Chronic laryngeal paralysis

[0179] Syndrome differentiation: Yin deficiency and lung dryness type

[0180] Treatment principle: Nourish yin and moisten the lungs, detoxify and relieve sore throat.

[0181] Prescription: Chinese herbal decoction group 4#*14 doses.

[0182] Second visit: After taking the medicine, the patient's throat burning pain was significantly improved, VAS score: 5 points for sore throat, 5 points for dry throat, interleukin 6: 4.18pg / mL, tumor necrosis factor α: 7.65pg / mL. The constipation was improved, the night sleep was slightly better, the tongue was red and moist, and the pulse was stringy and thin. The above prescription was still followed and 14 doses were given.

[0183] Follow-up: After taking the medicine for one month, the patient's dryness and pain were basically improved, with no obvious dry throat, no obvious cough, bowel movement once a day, and good sleep at night. VAS score: 2 points for sore throat, 1 point for dry throat, interleukin 6: 3.09pg / mL, tumor necrosis factor α: 5.73pg / mL. The tongue was pale red with thin coating and fine pulse.

[0184] The basic concepts have been described above. Obviously, for those skilled in the art, the above detailed disclosure is only for example and does not constitute a limitation of this specification. Although not explicitly stated here, those skilled in the art may make various modifications, improvements and corrections to this specification. Such modifications, improvements and corrections are suggested in this specification, so such modifications, improvements and corrections still belong to the spirit and scope of the exemplary embodiments of this specification.

[0185] At the same time, this specification uses specific words to describe the embodiments of this specification. For example, "one embodiment", "an embodiment", and / or "some embodiments" refer to a certain feature, structure or characteristic related to at least one embodiment of this specification. Therefore, it should be emphasized and noted that "one embodiment" or "an embodiment" or "an alternative embodiment" mentioned twice or more in different positions in this specification does not necessarily refer to the same embodiment. In addition, certain features, structures or characteristics in one or more embodiments of this specification can be appropriately combined.

[0186] In some embodiments, numbers describing the number of components and attributes are used. It should be understood that such numbers used in the description of the embodiments are modified by the modifiers "about", "approximately" or "substantially" in some examples. Unless otherwise specified, "about", "approximately" or "substantially" indicate that the numbers are allowed to vary by ±20%. Accordingly, in some embodiments, the numerical parameters used in the specification and claims are approximate values, which may change according to the required features of individual embodiments. In some embodiments, the numerical parameters should take into account the specified significant digits and adopt the general method of retaining digits. Although the numerical domains and parameters used to confirm the breadth of their range in some embodiments of this specification are approximate values, in specific embodiments, the setting of such numerical values ​​is as accurate as possible within the feasible range.

[0187] Finally, it should be understood that the embodiments described in this specification are only used to illustrate the principles of the embodiments of this specification. Other variations may also fall within the scope of this specification. Therefore, as an example and not a limitation, alternative configurations of the embodiments of this specification may be considered consistent with the teachings of this specification. Accordingly, the embodiments of this specification are not limited to the embodiments explicitly introduced and described in this specification.

Claims

1. A Chinese medicine composition, comprising the following raw material components by weight: 8-30 parts of Scrophularia, 5-20 parts of Fritillaria, 5-20 parts of Ophiopogon, 10-20 parts of Platycodon, 5-20 parts of Periostracum Cicadae, 10-20 parts of Raw Licorice, 5-20 parts of Processed Pinellia, 5-20 parts of Tangerine Peel, 3-12 parts of Sterculia lychnophora, and 3-12 parts of Oroxylum indica.

2. The Chinese medicine composition according to claim 1, characterized in that The raw material components include: 8-20 parts of Scrophularia, 5-15 parts of Fritillaria thunbergii, 5-15 parts of Ophiopogon japonicus, 10-15 parts of Platycodon grandiflorum, 5-15 parts of Periostracum cicadae, 10-15 parts of raw liquorice, 5-10 parts of processed Pinellia, 5-10 parts of dried tangerine peel, 3-10 parts of Sterculia lychnophora, and 3-10 parts of Oroxylum indica.

3. The Chinese medicine composition according to claim 1, characterized in that: The raw material components include: 15 parts of Scrophulariae, 10 parts of Fritillaria thunbergii, 10 parts of Ophiopogon japonicus, 10 parts of Platycodon grandiflorum, 10 parts of Periostracum cicadae, 10 parts of Radix Glycyrrhizae, 10 parts of Processed Pinellia, 10 parts of Citrus reticulatae, 6 parts of Sterculia lychnophora, and 4. A Chinese medicine preparation, prepared from the Chinese medicine composition according to any one of claims 1 to 3 as a raw material.

5. The Chinese medicine preparation according to claim 4, characterized in that: The Chinese medicine composition according to any one of claims 1 to 3 is decocted with water and filtered to obtain the Chinese medicine preparation.

6. The Chinese medicine preparation according to claim 4, characterized in that: The Chinese medicine preparations include Chinese medicine decoctions; And / or, before decocting, water is added to soak the Chinese medicine composition for 20 minutes to 1 hour.

7. Use of the Chinese medicine composition according to any one of claims 1 to 3 or the Chinese medicine preparation according to claim 4 in the preparation of drugs for preventing and / or treating pharyngeal diseases.

8. The use according to claim 7, characterized in that The pharyngeal disease is pharyngitis, and preferably, the pharyngeal disease is acute or chronic pharyngitis.

9. The use according to claim 7, characterized in that The pharyngeal disease includes at least one of dry throat, itchy throat, hoarseness, foreign body sensation in the throat, cough or sore throat.

10. The use according to claim 7, characterized in that The drug reduces the level of inflammatory factors in serum. Preferably, the drug reduces the level of interleukin 6 or tumor necrosis factor α in serum.

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