Flexible cold plasma treatment device based on surface dielectric barrier discharge

Abstract

The invention relates to a flexible cold plasma treatment device based on surface dielectric barrier discharge, a special electrode unit strictly divides the device into a discharge area and a non-discharge area which appear alternately, a through hole capable of being used for drainage and drug application is designed in the non-discharge area, the safety is greatly improved, the connection design of the electrode unit is variable, and the application range is wide. And by matching with a power supply, the same treatment device can perform regional targeted treatment according to wound surface distribution and injury degree. Besides, the device discharge layer, the supporting layer, the waterproof breathable layer and the skin contact layer jointly form a laminated layer with a special function, most of wound exudate is absorbed by the skin contact layer, and a small amount of wound exudate is difficult to continuously immerse into discharge holes in the supporting layer to influence discharge due to obstruction of the waterproof breathable layer, so that plasmas can be smoothly generated on the surface of the device discharge layer, and the wound exudate is prevented from being damaged. And then the liquid permeates through the waterproof breathable layer, or directly penetrates through the skin contact layer to enter the wound surface, or is dissolved in the seepage area and then acts on the wound surface.

Description

Technical Field

[0001] The invention relates to the technical field of cold plasma medical equipment, in particular to a flexible cold plasma treatment device based on surface dielectric barrier discharge. Background Art

[0002] Plasma is the fourth state of matter in nature besides solid, liquid and gas. It has a high degree of ionization and is quasi-neutral to the outside. Cold atmospheric pressure plasma (CAP) is characterized by a high electron temperature and a low macroscopic gas temperature, which can come into contact with the human body surface without causing skin burns. CAP contains components such as ultraviolet rays, charged particles and active particles, which can destroy the surface structure of bacteria, change the structure or properties of macromolecules such as proteins and genetic materials (DNA, RNA), and ultimately inactivate bacteria. Compared with antibiotics, CAP is less likely to cause bacterial resistance and has fewer side effects. Therefore, CAP has shown great application prospects in medical fields such as infectious wound treatment.

[0003] At present, plasma treatment devices used for surface treatment of humans and / or animals mainly include two forms: plasma jet and dielectric barrier discharge. Plasma treatment devices used clinically are mostly in the form of jets, which have the disadvantages of bulky equipment, strong restrictions on the use of places, and a single target, which greatly limits the scope of application of plasma treatment. Dielectric barrier discharge (DBD) can produce a large area of ​​uniform plasma in the air, but when encountering wounds with uneven surfaces, large curvature changes, and large areas, the rigid structure of DBD is often difficult to apply. If flexible materials are used as the medium, the plasma treatment device can have the advantages of being soft, light, and bendable. In this way, the plasma treatment device can be used as a patch attached to the body surface for rapid and efficient treatment of large areas.

[0004] The publication number is CN114390766A, which discloses an atmospheric cold plasma treatment device based on surface dielectric barrier discharge. Unlike the device based on body dielectric barrier discharge, this device comes with a high-voltage electrode and a grounding electrode, which are separated by a layer of dielectric material and can generate plasma by itself. The high-voltage electrode is covered with an insulating layer to prevent electric shock. The grounding electrode side faces the surface to be treated, and an insulating layer, a honeycomb spacer layer and a skin contact layer are arranged in sequence, wherein the cavity formed by the spacer layer provides sufficient gas for generating plasma. However, this solution still has the following problems: First, the device is not designed with an integral through hole, which reduces the air permeability and comfort of the device, and cannot achieve external drug combination treatment. Furthermore, once the device is used for exudate wounds, the exudate cannot be transferred in time, and it is very easy to penetrate the skin contact layer into the cavity of the spacer layer, hindering the generation of plasma and weakening the therapeutic effect of the device. In addition, the electrode as a whole has a fixed discharge area, so that the treatment component cannot perform precise treatment in different areas and intensities according to the specific conditions of the surface to be treated.

[0005] The devices disclosed in publication numbers CN109069849A and CN110692284A both have through holes in the discharge area, so that the devices can be applied to the treatment of wounds containing exudate. However, setting the through holes for drainage in the discharge area not only reduces the discharge area, but also factors such as exudate adhesion and dielectric mutation will affect the electric field distribution in the discharge area, weakening the discharge effect of the device, and in severe cases will cause direct discharge breakdown in the area. In addition, only silicone is used as the dielectric material, and its dielectric strength is much lower than conventional dielectric materials such as polyimide and polytetrafluoroethylene, which poses a risk of insulation breakdown.

[0006] The device disclosed in Publication No. 117295221A is provided with a flexible contact layer with a micro-nano structure on the surface and a flexible conductive layer with a continuous surface to ensure a uniform discharge effect, generate a uniform atmospheric pressure cold plasma, and avoid the infiltration of liquid secretions. However, the structure based on body dielectric barrier discharge relies on the surface to be treated as a grounding electrode, which is inconvenient to operate. In addition, the design without through holes will make it impossible to remove the wound exudate, which will gradually accumulate and cause problems such as bacterial growth, affecting the treatment effect. Summary of the invention

[0007] In view of the shortcomings of the above-mentioned existing production technology, the applicant provides a flexible cold plasma treatment device based on surface dielectric barrier discharge, which effectively solves the problems of difficulty in treating wound exudate and too single treatment form, and meets the use requirements.

[0008] The technical solution adopted by the present invention is as follows:

[0009] A flexible cold plasma treatment device based on surface dielectric barrier discharge comprises a device, wherein the device comprises a multilayer structure, the multilayer structure has a device-facing side and a device-facing side, and the multilayer structure comprises, from one end to the other end, an auxiliary functional layer, a first flexible insulating layer, a high-voltage electrode, a flexible dielectric layer, a grounding electrode, a second flexible insulating layer, a supporting layer, a waterproof and breathable layer, and a skin contact layer, wherein the high-voltage electrode and the grounding electrode are located on both sides of the flexible dielectric layer, the exposed surfaces of the electrodes are filled with insulating glue, and the first flexible insulating layer and the second flexible insulating layer are respectively attached, and the five-layer structure is closely attached to each other to form a device discharge layer together, wherein the high-voltage electrode and the grounding electrode together form a discharge electrode, and the discharge electrode is formed by a plurality of basic discharge units connected in series and / or in parallel.

[0010] Its further technical solution is:

[0011] The structure of the basic discharge unit is as follows: it includes four annular electrode modules arranged in a diamond shape. No other annular electrode modules exist in the diamond area formed by the four annular electrode modules as vertices. The plasma used for treatment is only generated on the annular electrode modules located at the four vertices of the diamond, which are called the discharge area. The area inside the diamond except the electrodes is the non-discharge area. The discharge area and the non-discharge area are arranged with gaps and are independent of each other.

[0012] A single annular electrode module consists of a pair of centrally symmetrical high-voltage electrode modules and a grounding electrode module. The high-voltage electrode module is connected by a number of high-voltage annular electrodes, and the grounding electrode module is connected by a number of grounding annular electrodes. The high-voltage annular electrodes and the grounding annular electrodes are parallel to each other and extend from inside to outside in opposite directions in a spiral shape. Several annular electrode lead-out points of the same polarity are connected to form a single electrode chain structure, and several single electrode chain structures of the same polarity are connected to the same bus in parallel.

[0013] The grounding electrode is composed of several single electrode chain structures connected in parallel and then connected to the same bus; the high-voltage electrode can be divided into several blocks, each of which is composed of several single electrode chain structures connected in parallel. The bus of each block can be independently connected to the power supply. The target block can be selected by controlling the power supply and giving excitation with specific parameters and duration, thereby controlling different blocks to discharge with different intensities and durations.

[0014] The material of the support layer includes at least one of silicone rubber, silica gel, polyimide, and polydimethylsiloxane, with a thickness of 0.5mm to 1mm. An array of circular through holes is distributed on the support layer, which corresponds one-to-one to the annular electrode modules in the discharge layer of the device and has a similar diameter. Such through holes are called first-type through holes, which provide an air cavity for discharge.

[0015] The non-discharge area of ​​the device discharge layer is provided with a plurality of through holes, and the support layer and the waterproof breathable layer are provided with through holes of the same size, position and number as the device discharge layer. Such through holes are called second-class through holes and are used for the conduction of external drugs and wound exudate.

[0016] The device's discharge layer, support layer, waterproof and breathable layer and skin contact layer together form a laminate with special functions.

[0017] The exudate generated by the wound surface is first absorbed by the skin contact layer. A small amount of unabsorbed exudate is blocked by the waterproof and breathable layer and partially drained by the second type of through holes, making it difficult to continue to penetrate into the first type of through holes on the supporting layer to affect discharge. Therefore, plasma can be continuously generated on the surface of the discharge layer of the device corresponding to the annular electrode module, and smoothly pass through the waterproof and breathable layer to reach the skin contact layer, or directly penetrate into the wound surface, or dissolve in the exudate area and then act on the wound surface.

[0018] The auxiliary functional layer is at least one of a self-adhesive polyurethane film, a self-adhesive non-woven fabric, a wound dressing with medicine, and a self-adhesive polyamide mesh containing silicone, and is selected according to the specific conditions of the surface to be treated.

[0019] The beneficial effects of the present invention are as follows:

[0020] The invention has a compact and reasonable structure and is easy to operate. By combining with a traditional medical dressing, an auxiliary functional layer and a skin contact layer are provided, so that the device can be flexibly attached to the body surface. The special electrode unit strictly divides the device into alternating discharge areas and non-discharge areas. The through holes that can be used for drainage and drug application are designed in the non-discharge area, which greatly improves the safety. The variable connection design between the electrode units enables the device to perform targeted treatment in different regions according to the distribution of the wound surface and the degree of injury. In addition, the discharge layer, the support layer, the waterproof and breathable layer and the skin contact layer of the device together form a laminate with special functions. Most of the wound exudate is absorbed by the skin contact layer. A small amount of exudate is difficult to continue to penetrate into the discharge holes on the support layer to affect the discharge due to the barrier of the waterproof and breathable layer. Therefore, plasma can be smoothly generated on the surface of the discharge layer of the device, and then penetrate through the waterproof and breathable layer, or directly penetrate through the skin contact layer to enter the wound surface, or dissolve in the exudate area and then act on the wound surface, effectively solving the problems of difficult wound exudate treatment and too single treatment form.

[0021] At the same time, the present invention also has the following advantages:

[0022] (1) The present invention adopts the surface dielectric barrier discharge mode, which can discharge autonomously, and the grounding electrode faces the human body, reducing the safety risks during use.

[0023] (2) The present invention designs a special discharge unit. A discharge unit is composed of four annular electrode modules, arranged in a diamond shape and in a 1-2-1 manner. The two annular electrode modules in the middle layer are connected in series. The annular electrode modules in the upper, middle and lower layers all have high voltage and grounding lead-out terminals, which are convenient for connecting to other discharge units. There are no other annular electrode modules in the diamond area formed by the four annular electrode modules as the vertices. Plasma is only generated in the annular electrode modules located at the four vertices of the diamond. The area inside the diamond except the electrode is a non-discharge area, and through holes can be set for drainage or drug application.

[0024] (3) The discharge electrode of the present invention adopts a ring electrode module, which can be designed and adjusted by mirror flipping, increasing or decreasing the number of rings, etc. The number, arrangement and interface bus design of the ring electrode modules are also flexible and changeable. The same treatment device can achieve variable discharge area, variable treatment intensity and variable treatment object.

[0025] (4) The device discharge layer, support layer, waterproof breathable layer and skin contact layer in the present invention together form a laminate with special functions. The exudate generated by the wound first penetrates into the skin contact layer, and then due to the barrier of the waterproof breathable layer, it is difficult to continue to penetrate into the discharge holes on the support layer, and part of it is drained through the exudate holes. Plasma can be smoothly generated on the surface of the device discharge layer corresponding to the annular electrode module, and then penetrate the waterproof breathable layer to reach the skin contact layer, or directly penetrate the dry area to enter the wound, or dissolve in the exudate area and then act on the wound.

[0026] (5) The plasma treatment device provided by the present invention is light, compact and can be attached. The auxiliary functional layer has various forms and can adapt to various different surfaces to be treated. In addition, the device is powered by a portable pulse power supply and does not affect the daily activities of the user during the treatment. It is efficient and convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 Schematic diagram of the layered structure of Example 1 of the treatment device according to the present invention.

[0028] Figure 2 Schematic diagram of the annular electrode module of the present invention.

[0029] Figure 3a This is a schematic diagram of the structure of the discharge layer of the device in Example 1 of the present invention.

[0030] Figure 3b for Figure 3a Schematic diagram of the basic discharge unit of the device.

[0031] Figure 3c for Figure 3a Schematic diagram of the zoned discharge of the device (I).

[0032] Figure 3d for Figure 3a Schematic diagram of the zoned discharge of the device (II).

[0033] Figure 3e for Figure 3a Schematic diagram of the zoned discharge of the medium device (III).

[0034] Figure 4 It is a schematic diagram of the structure of the special stack in Example 1 of the present invention.

[0035] Figure 5 This is a schematic diagram of the structure of the support layer in Example 1 of the present invention.

[0036] Among them: 1. Device;

[0037] 11. Device discharge layer; 12. Special lamination;

[0038] 13. Basic discharge unit;

[0039] 2. Multi-layer structure;

[0040] 21. Auxiliary functional layer; 22. First flexible insulating layer; 23. High voltage electrode;

[0041] 231, a first high voltage electrode; 232, a second high voltage electrode; 233, a third high voltage electrode; 234, a ground electrode bus;

[0042] 24. Flexible dielectric layer; 25. Ground electrode; 26. Second flexible insulating layer; 27. Support layer; 28. Waterproof and breathable layer; 29. ​​Skin contact layer; 30. First type through hole; 31. Second type through hole;

[0043] 3. Device facing side; 4. Device facing away side; 5. Interface; 6. High-voltage ring electrode; 7. Ground ring electrode; 8. Ring electrode module; 9. Ground bus via. DETAILED DESCRIPTION

[0044] The specific implementation of the present invention will be described below in conjunction with the accompanying drawings.

[0045] like Figure 1-Figure 5As shown, the flexible cold plasma treatment device based on surface dielectric barrier discharge of this embodiment includes a device 1, which includes a multilayer structure 2, and the multilayer structure 2 has a device-facing side 3 and a device-facing side 4. The multilayer structure 2 includes an auxiliary functional layer 21, a first flexible insulating layer 22, a high-voltage electrode 23, a flexible dielectric layer 24, a grounding electrode 25, a second flexible insulating layer 26, a supporting layer 27, a waterproof and breathable layer 28 and a skin contact layer 29 from one end to the other. The high-voltage electrode 23 and the grounding electrode 25 are located on both sides of the flexible dielectric layer 24, and the exposed surfaces of the electrodes are filled with insulating glue, and the first flexible insulating layer 22 and the second flexible insulating layer 26 are respectively attached. The five-layer structure is closely attached to each other and together constitutes a device discharge layer 11. The high-voltage electrode 23 and the grounding electrode 25 together constitute a discharge electrode, and the discharge electrode is composed of a number of basic discharge units 13 connected in series and / or in parallel.

[0046] The structure of the basic discharge unit 13 is as follows: it includes four annular electrode modules 8, which are arranged in a diamond shape. There are no other annular electrode modules in the diamond area formed by the four annular electrode modules 8 as vertices. The plasma used for treatment is only generated on the annular electrode modules located at the four vertices of the diamond, which are called discharge areas. The area inside the diamond except the electrodes is a non-discharge area. The discharge area and the non-discharge area are arranged with gaps and are independent of each other.

[0047] A single annular electrode module 8 is composed of a pair of centrally symmetrical high-voltage electrode modules and a grounding electrode module. The high-voltage electrode module is formed by connecting a number of high-voltage annular electrodes 6, and the grounding electrode module is formed by connecting a number of grounding annular electrodes 7. The high-voltage annular electrodes 6 and the grounding annular electrodes 7 are parallel to each other and extend from the inside to the outside in opposite directions in a spiral shape. Several annular electrode lead-out points of the same polarity are connected to form a single electrode chain structure, and several single electrode chain structures of the same polarity are connected to the same bus in parallel.

[0048] The grounding electrode 25 is composed of several single electrode chain structures connected in parallel and then connected to the same bus; the high-voltage electrode 23 can be divided into several blocks, each of which is composed of several single electrode chain structures connected in parallel. The bus of each block can be independently connected to the power supply. The target block can be selected by controlling the power supply and giving excitation with specific parameters and duration, thereby controlling different blocks to discharge with different intensities and durations.

[0049] The material of the support layer 27 includes at least one of silicone rubber, silica gel, polyimide, and polydimethylsiloxane of the present embodiment, with a thickness of 0.5 mm to 1 mm. An array of circular through holes is distributed on the support layer 27, which corresponds one-to-one to the annular electrode modules 8 in the device discharge layer 11 and has a similar diameter. Such through holes are called first-type through holes 30, which provide an air cavity for discharge.

[0050] The non-discharge area of ​​the device discharge layer 11 is provided with a plurality of through holes, and the support layer 27 and the waterproof breathable layer 28 are provided with through holes of the same size, position and number as the device discharge layer 11. Such through holes are called second-type through holes 31, which are used for conduction of external drugs and wound exudate.

[0051] The device discharge layer 11, the support layer 27, the waterproof and breathable layer 28 and the skin contact layer 29 together form a laminate with special functions.

[0052] The exudate generated by the wound surface is first absorbed by the skin contact layer 29. A small amount of unabsorbed exudate is blocked by the waterproof and breathable layer 28 and partially drained by the second type of through holes 31, making it difficult to continue to penetrate into the first type of through holes 30 on the support layer 27 to affect discharge. Therefore, plasma can be continuously generated on the surface of the device discharge layer 11 corresponding to the annular electrode module 8, and smoothly pass through the waterproof and breathable layer 28 to reach the skin contact layer 29, or directly penetrate into the wound surface, or dissolve in the exudate area and then act on the wound surface.

[0053] The auxiliary functional layer 21 is at least one of the self-adhesive polyurethane film, the self-adhesive non-woven fabric, the wound dressing with medicine, and the self-adhesive polyamide mesh containing silicone in the present embodiment, and is selected according to the specific conditions of the surface to be treated.

[0054] In the device discharge layer 11, the materials of the first flexible insulating layer 22, the flexible dielectric layer 24 and the second flexible insulating layer 26 include but are not limited to at least one of silicone rubber, silicone, polyimide, and polydimethylsiloxane, with a thickness of 25μm to 50μm and the thickness of the second flexible insulating layer 26 must be less than the thickness of the first flexible insulating layer 22.

[0055] The waterproof breathable layer 28 is made of a material with a microporous structure including but not limited to at least one of expanded polytetrafluoroethylene (ePTFE) and polydimethylsiloxane, with a maximum pore diameter of less than or equal to 100 μm and a thickness of 50 μm to 100 μm.

[0056] The material of the skin contact layer 29 includes but is not limited to at least one of medical gauze, foam dressing, and alginate dressing, all of which have water absorption and air permeability properties.

[0057] Figure 1 Embodiment 1 is shown, in which the device 1 is a plasma source for surface treatment of humans and / or animals, and is mainly used for treating infected wounds.

[0058] The device 1 includes a multilayer structure 2, having a side facing the surface to be treated (device facing side 3) and a side away from the surface to be treated (device away from side 4). The square area where the discharge electrode is located is the discharge main area, and the side length is generally 5cm to 20cm, preferably 12cm×12cm. The extended handle-shaped part is the interface area, the width of which is less than the side length of the discharge main area, and the length can be adjusted according to the application scenario. Without limiting the present invention, the shape of the discharge main area of ​​the device 1 is Figure 1 In addition to the square shape shown, other shapes can also be made according to the specific conditions of the surface to be treated, so as to more accurately match the surface to be treated, such as the face of a patient.

[0059] like Figure 1 As shown, the auxiliary functional layer 21 of the device 1 can be replaced and adjusted according to the type of the surface to be treated. If the surface to be treated is relatively dry, a self-adhesive polyurethane film or self-adhesive non-woven fabric with good air permeability is generally used to adhere the device 1 to the wound surface; if there is obvious exudate on the surface to be treated or medication is required, a functional dressing is required, such as a medical gauze block or a silicone-containing self-adhesive polyamide mesh (Mepitel), which can not only fix the device on the wound surface, but also absorb exudate to serve as a carrier of therapeutic drugs.

[0060] The discharge layer 11 of the device generates plasma by dielectric barrier discharge along the surface. The flexible PCB technology is used to deposit the high-voltage electrode 23 (including the first high-voltage electrode 231, the second high-voltage electrode 232 and the third high-voltage electrode 233) and the ground electrode 25 on both sides of the flexible dielectric layer 24 through the copper deposition process. The first flexible insulating layer 22 is attached with insulating glue on the side facing the high-voltage electrode 23, and is tightly fitted with the high-voltage electrode 23 by rolling. The high temperature and high pressure during rolling melt the insulating glue, and the liquid insulating glue fills the gap in the high-voltage electrode 23, completely exhausting the air to prevent inter-electrode discharge. The second flexible insulating layer 26 facing the ground electrode 25 also adopts this process. The thickness of the discharge electrode (high voltage electrode 23 and grounding electrode 25) is generally 25μm to 35μm, the flexible dielectric layer 24 is generally made of PI, PET, with a thickness of 25μm to 50μm, the first flexible insulating layer 22 and the second flexible insulating layer 26 are generally made of PI, PET with insulating glue on one side, with a total thickness of 25μm to 50μm, and the thickness of the second flexible insulating layer 26 must be less than that of the first flexible insulating layer 22 to ensure that plasma is generated on the grounding electrode side.

[0061] like Figure 3a As shown, the high voltage electrode 23 in the discharge layer 11 of the device is composed of a plurality of annular electrode modules 8 connected in series and / or in parallel. The basic structure of the annular electrode module 8 is as follows: Figure 2, mirror flipping, increase or decrease in the number of rings and other design adjustments can be performed. The diameter of the annular body is generally 3mm to 5mm, and it is formed by the high-voltage annular electrode and the grounding annular electrode 7 extending in parallel from the inside to the outside in a spiral shape, and the two are symmetrical at the center. The width of the high-voltage annular electrode 6 and the grounding annular electrode 7 is generally 0.1mm to 0.5mm, and the spacing between the high-voltage annular electrode 6 and the grounding annular electrode 7 inside the annular electrode module 8 is generally 0.1mm to 0.3mm. The spacing between the high-voltage connection electrode and the grounding connection electrode as the connection part between the annular electrode modules is generally 0.4mm to 1mm, ensuring that plasma is only generated on the medium surface corresponding to the annular electrode module 8.

[0062] like Figure 3a As shown, multiple annular electrode modules 8 have the same polarity electrode interfaces connected end to end to form a double electrode chain structure, and several double electrode chain structures connect the same polarity electrode interfaces to the same bus in parallel to form a high voltage electrode bus (first high voltage electrode 231, second high voltage electrode 232 and third high voltage electrode 233) and a ground electrode bus 234. The width of the electrode bus is generally 1 mm to 5 mm.

[0063] like Figure 3b As shown, its structure can be regarded as the basic unit of this special electrode arrangement. The basic unit contains four annular electrode modules 8, arranged in 1-2-1, belonging to three parallel double electrode chain structures, with a total of six metal electrode strips. Figure 3b The six metal electrode strips are named in order from top to bottom, namely, electrode strip a, electrode strip b, electrode strip c, electrode strip d, electrode strip e, and electrode strip f, wherein electrode strip a, electrode strip d, and electrode strip e are all high-voltage annular electrodes 6, and electrode strip b, electrode strip c, and electrode strip f are all grounding annular electrodes 7. In the basic unit, electrode strip b and electrode strip c, electrode strip d and electrode strip e are the two closest electrode strips in two adjacent double-electrode chain structures, and electrode strip b (d) and electrode strip c (e) are of the same polarity, and the electric field between the two is very weak, insufficient to support discharge, and no plasma will be generated on the corresponding medium surface. This special electrode arrangement can ensure that there is a non-discharge area between the chain structures, and the discharge area corresponding to the annular electrode body is arranged in an interspersed manner and is independent of each other.

[0064] See also Figure 3a The high-voltage electrode 23 has three independent high-voltage electrodes, which can control the three electrode areas respectively, so that the device 1 can perform precise treatment in different areas and in different intensities according to the specific conditions of the surface to be treated. Figure 3c-3e As shown, 11-1 shows the discharge area controlled by the high-voltage electrode bus (the highlighted part in the figure), and 11-2 and 11-3 correspond to the discharge areas controlled by the high-voltage electrode bus respectively.

[0065] Figure 3aThe interface 5 and the ground bus via 9 of the device 1 are also shown, and specifically include the interfaces of three high-voltage electrode bus interfaces and the ground electrode bus 234. The ground electrode bus 234 adopts a via process so that its interface gold finger is coplanar with the three high-voltage electrode bus interface gold fingers. The device 1 is connected to the power supply using an FPC dedicated adapter board. A 40P FPC adapter board with a spacing of 1mm between adjacent pins can be selected. On the basis of ensuring insulation and reliable connection, the width of the interface of the high-voltage electrode bus interface and the ground electrode bus 234 must be strictly smaller than the pin spacing, generally 0.5mm to 0.8mm, and the spacing between the high-voltage electrode and the ground electrode must be greater than the creepage distance, generally set to 12mm.

[0066] Figure 3a and Figure 3b It is shown that the discharge layer 11 of the device is provided with a second type of through hole 31 in the non-discharge area, and the therapeutic drug and wound exudate can be conducted through the second type of through hole 31 without affecting the normal and safe discharge of the discharge layer 11 of the device. The diameter of the second type of through hole 31 is generally 0.5mm to 3mm, and the edge of the hole needs to maintain a distance from the edge of the electrode to prevent the insulation of the electrode part from being damaged.

[0067] like Figure 4 As shown, the device discharge layer 11, the support layer 27, the waterproof breathable layer 28 and the skin contact layer 29 together constitute a special laminate 12. The support layer 27 is made of a soft and supportive material, and is bonded to the device discharge layer 11 by an adhesive, and generally has a thickness of 0.1mm to 0.3mm. The support layer 27 and the waterproof breathable layer 28 are both provided with second-class through holes 31, which are consistent in position, size and number with the second-class through holes 31 in the non-discharge area of ​​the device discharge layer 11, and therapeutic drugs and wound exudates can be conducted through the second-class through holes 31. In addition, the support layer 27 is provided with a first-class through hole 30, the diameter of which is equivalent to the diameter of the annular electrode module 8, and the center of the former coincides with the center of the latter, one-to-one corresponding. The waterproof breathable layer 28 is made of a material with a microporous structure, and the maximum pore diameter is less than or equal to 100μm, which can effectively prevent droplet intrusion. After the exudate generated by the wound surface penetrates into the skin contact layer 29, it is difficult to penetrate into the support layer 27 due to the barrier of the waterproof and breathable layer 28, and occupies the "gas cavity" formed by the first type of through holes 30, so that the first type of through holes 30 can provide a stable gas source for discharge. Plasma is generated on the surface of the device discharge layer 11 corresponding to the annular electrode module 8, and can smoothly penetrate the waterproof and breathable layer 28 to reach the wound surface for treatment.

[0068] In actual work, the specific usage process is as follows:

[0069] During normal operation, the device 1 is first flattened on the side close to the skin and pressed against the wound surface. Then, the self-adhesive auxiliary functional layer 21 is pressed against the device discharge layer 11, gently fitting from the center to the surrounding areas, and extending to the skin surface around the wound and compacting and fitting, so as to ensure that the device 1 as a whole can be stably fixed on the wound surface. At the same time, the power cable is connected to the plug-in power terminal interface of the FPC adapter board, and the power is turned on to power the treatment device 1, so that a large area of ​​uniform cold plasma can be generated in the air cavity of the support layer 27 to act on the wound surface.

[0070] The above description is an explanation of the present invention, not a limitation of the present invention. The scope of the present invention is defined in the claims. Any form of modification may be made within the scope of protection of the present invention.

Claims

1. A flexible cold plasma treatment device based on surface dielectric barrier discharge, characterized in that: The invention comprises a device (1), wherein the device (1) comprises a multilayer structure (2), wherein the multilayer structure (2) has a device-facing side (3) and a device-facing side (4), wherein the multilayer structure (2) comprises, from one end to the other end, an auxiliary functional layer (21), a first flexible insulating layer (22), a high-voltage electrode (23), a flexible dielectric layer (24), a grounding electrode (25), a second flexible insulating layer (26), a supporting layer (27), a waterproof and breathable layer (28) and a skin contact layer (29), wherein the high-voltage electrode (23) and the grounding electrode (25) are located on both sides of the flexible dielectric layer (24), wherein the exposed surfaces of the electrodes are filled with insulating glue and are respectively attached with the first flexible insulating layer (22) and the second flexible insulating layer (26), wherein the five-layer structure is closely attached to each other and together constitutes a device discharge layer (11), wherein the high-voltage electrode (23) and the grounding electrode (25) together constitute a discharge electrode, and the discharge electrode is composed of a plurality of basic discharge units (13) connected in series and / or in parallel.

2. A flexible cold plasma treatment device based on surface dielectric barrier discharge according to claim 1, characterized in that: The structure of the basic discharge unit (13) is as follows: it comprises four annular electrode modules (8) arranged in a rhombus shape, no other annular electrode modules exist in the rhombus area formed by the four annular electrode modules (8) as vertices, the plasma used for treatment is only generated on the annular electrode modules located at the four vertices of the rhombus, which are called the discharge area, and the area inside the rhombus excluding the electrodes is the non-discharge area, and the discharge area and the non-discharge area are arranged with gaps and are independent of each other.

3. A flexible cold plasma treatment device based on surface dielectric barrier discharge according to claim 2, characterized in that: A single annular electrode module (8) is composed of a pair of centrally symmetrical high-voltage electrode modules and a grounding electrode module. The high-voltage electrode module is formed by connecting a plurality of high-voltage annular electrodes (6), and the grounding electrode module is formed by connecting a plurality of grounding annular electrodes (7). The high-voltage annular electrodes (6) and the grounding annular electrodes (7) are parallel to each other and extend from inside to outside in opposite directions in a spiral shape. Leading points of a plurality of annular electrodes of the same polarity are connected to form a single electrode chain structure. The plurality of single electrode chain structures of the same polarity are connected to the same bus in a parallel form.

4. A flexible cold plasma treatment device based on surface dielectric barrier discharge according to claim 1, characterized in that: The grounding electrode (25) is composed of a plurality of single electrode chain structures connected in parallel and then connected to the same bus; the high voltage electrode (23) can be divided into a plurality of blocks, each of which is composed of a plurality of single electrode chain structures connected in parallel, and the bus of each block can be independently connected to a power supply, and the target block can be selected by controlling the power supply and giving an excitation with specific parameters and duration, thereby controlling different blocks to discharge with different intensities and durations.

5. The flexible cold plasma treatment device based on surface dielectric barrier discharge according to claim 1, characterized in that: The material of the support layer (27) includes at least one of silicone rubber, silica gel, polyimide, and polydimethylsiloxane, and has a thickness of 0.5 mm to 1 mm. The support layer (27) is provided with an array of circular through holes, which correspond one to one with the annular electrode modules (8) in the discharge layer (11) of the device and have a similar diameter. Such through holes are called first-type through holes (30) and provide air cavities for discharge.

6. A flexible cold plasma treatment device based on creeping dielectric barrier discharge as claimed in claim 1, characterized in that: The non-discharge area of ​​the device discharge layer (11) is provided with a plurality of through holes, and the support layer (27) and the waterproof and breathable layer (28) are provided with through holes of the same size, position and number as the device discharge layer (11). Such through holes are referred to as second-type through holes (31) and are used for conducting external medicines and wound exudate.

7. The flexible cold plasma treatment device based on creeping dielectric barrier discharge according to claim 1, characterized in that: The device discharge layer (11), the support layer (27), the waterproof and breathable layer (28) and the skin contact layer (29) together form a laminate with special functions.

8. A flexible cold plasma treatment device based on creeping dielectric barrier discharge as claimed in claim 7, characterized in that: The exudate generated by the wound surface is first absorbed by the skin contact layer (29), and a small amount of exudate that is not absorbed is blocked by the waterproof and breathable layer (28) and partially drained by the second type of through holes (31), making it difficult to continue to penetrate into the first type of through holes (30) on the support layer (27) to affect discharge. Therefore, plasma can be continuously generated on the surface of the device discharge layer (11) corresponding to the annular electrode module (8), and smoothly penetrate the waterproof and breathable layer (28) to reach the skin contact layer (29), or directly penetrate into the wound surface, or dissolve in the exudate area and then act on the wound surface.

9. The flexible cold plasma treatment device based on creeping dielectric barrier discharge according to claim 1, characterized in that: The auxiliary functional layer (21) is at least one of a self-adhesive polyurethane film, a self-adhesive non-woven fabric, a wound dressing with medicine, and a self-adhesive polyamide net containing silicone, and is selected according to the specific conditions of the surface to be treated.

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