Alkaloid compounds isolated from kadsura coccinea and preparation method and application thereof

Alkaloid compounds were isolated from *Smilax glabra* using gradient ethanol extraction and multi-step purification methods, filling the gap in the application of the traditional Chinese medicine *Smilax glabra* in the field of anti-liver fibrosis. This method achieved a significant effect in inhibiting the migration of hepatic stellate cells and provided a novel anti-liver fibrosis drug.

CN119859151BActive Publication Date: 2026-07-24BEIJING ZHENDONG GUANGMING PHARMA RES INST
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Patent Information

Application Number
CN202311353218.0
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2023-10-19
Publication Date
2026-07-24
Estimated Expiration
2043-10-19

AI Technical Summary

Technical Problem

Alkaloids have not yet been isolated from the traditional Chinese medicine Smilax glabra, and there are no reports of their anti-liver fibrosis activity. Therefore, there is a lack of effective candidate drugs for the treatment of liver fibrosis.

Method used

Alkaloids were isolated from *Smilax glabra* using a method involving volume fraction gradient reflux extraction with aqueous ethanol, organic solvent extraction, alcohol precipitation, macroporous resin column chromatography, gel column chromatography, and liquid chromatography purification, thus preparing compounds with anti-hepatic fibrosis activity.

Benefits of technology

The isolated alkaloid compounds significantly inhibited the RhoA-GTP activity of hepatic stellate cells, limiting their motility and migration ability, and exhibited good anti-hepatic fibrosis activity, providing a novel candidate drug for anti-hepatic fibrosis.

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Abstract

The application relates to the technical field of medicines, in particular to an alkaloid compound separated from white earth and a preparation method and application thereof. The alkaloid compound or a pharmaceutically acceptable salt thereof has a structure as shown in formula I or formula II: wherein R is H or methoxy. The novel alkaloid compound is separated from white earth, and is verified by experiments to have good anti-hepatic fibrosis activity and has a good application prospect in the field of anti-hepatic fibrosis drugs.
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