A method for preparing deuterated paraformaldehyde

By employing multiple rounds of deuteration reactions and acetate esterification hydrolysis steps, deuterated polyoxymethylene (POM) is prepared using a phase transfer catalyst. This solves the problems of high cost and low efficiency in the preparation of deuterated POM in existing technologies, and achieves efficient and low-cost preparation of deuterated POM.

CN119875043BActive Publication Date: 2026-05-26SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
Filing Date
2025-01-17
Publication Date
2026-05-26

AI Technical Summary

Technical Problem

The existing technology lacks a method for the large-scale preparation of deuterated formaldehyde that is mild, requires low equipment, and is cost-effective, which makes it difficult to meet the development needs of deuterated drugs.

Method used

Deuterated polyoxymethylene was prepared by a deuteration reaction of dibromomethane and heavy water, combined with phase transfer catalysts such as crown ethers and alkali metal deuteroxides, through multiple rounds of deuteration reactions, esterification involving acetate, and hydrolysis steps.

Benefits of technology

It achieves high deuteration efficiency, with a deuteration rate of over 98%, simplifies the separation process, reduces production costs, and is suitable for industrial production.

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Abstract

This invention provides a method for preparing deuterated paraoxymethylene. Specifically, this invention provides a method for preparing deuterated paraoxymethylene comprising the following steps: (S1) deuteration of dibromomethane; (S2) synthesis of deuterated methylene diacetate; and (S3) synthesis of deuterated paraoxymethylene.
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